EF-hand domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

SNARE associated Golgi protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HGB2_LEIBR

TriTrypDb:

LbrM.28.0740 , LBRM2903_280012900

Length:

585

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10
GO:0005635	nuclear envelope	4	1
GO:0012505	endomembrane system	2	1
GO:0031967	organelle envelope	3	1
GO:0031975	envelope	2	1

Expansion

Sequence features

A4HGB2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGB2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	10
GO:0005509	calcium ion binding	5	10
GO:0043167	ion binding	2	10
GO:0043169	cation binding	3	10
GO:0046872	metal ion binding	4	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	109	111	PF00675	0.577
CLV_NRD_NRD_1	19	21	PF00675	0.372
CLV_NRD_NRD_1	309	311	PF00675	0.336
CLV_NRD_NRD_1	465	467	PF00675	0.366
CLV_PCSK_FUR_1	17	21	PF00082	0.262
CLV_PCSK_KEX2_1	108	110	PF00082	0.509
CLV_PCSK_KEX2_1	19	21	PF00082	0.372
CLV_PCSK_KEX2_1	309	311	PF00082	0.298
CLV_PCSK_KEX2_1	414	416	PF00082	0.412
CLV_PCSK_KEX2_1	465	467	PF00082	0.348
CLV_PCSK_KEX2_1	53	55	PF00082	0.280
CLV_PCSK_PC1ET2_1	108	110	PF00082	0.509
CLV_PCSK_PC1ET2_1	414	416	PF00082	0.412
CLV_PCSK_PC1ET2_1	53	55	PF00082	0.280
CLV_PCSK_SKI1_1	399	403	PF00082	0.314
CLV_PCSK_SKI1_1	414	418	PF00082	0.401
CLV_PCSK_SKI1_1	494	498	PF00082	0.343
CLV_PCSK_SKI1_1	520	524	PF00082	0.336
CLV_PCSK_SKI1_1	53	57	PF00082	0.315
CLV_PCSK_SKI1_1	569	573	PF00082	0.557
DEG_APCC_DBOX_1	29	37	PF00400	0.556
DEG_SCF_FBW7_2	228	235	PF00400	0.478
DOC_CYCLIN_yCln2_LP_2	387	393	PF00134	0.539
DOC_MAPK_FxFP_2	191	194	PF00069	0.345
DOC_MAPK_gen_1	17	24	PF00069	0.517
DOC_MAPK_gen_1	223	230	PF00069	0.553
DOC_MAPK_gen_1	27	36	PF00069	0.565
DOC_MAPK_gen_1	538	546	PF00069	0.258
DOC_MAPK_MEF2A_6	223	230	PF00069	0.616
DOC_MAPK_MEF2A_6	352	359	PF00069	0.297
DOC_MAPK_MEF2A_6	569	576	PF00069	0.356
DOC_PP4_FxxP_1	191	194	PF00568	0.345
DOC_PP4_FxxP_1	219	222	PF00568	0.541
DOC_PP4_FxxP_1	337	340	PF00568	0.242
DOC_USP7_MATH_1	408	412	PF00917	0.581
DOC_USP7_MATH_1	428	432	PF00917	0.509
DOC_USP7_MATH_1	504	508	PF00917	0.610
DOC_USP7_UBL2_3	352	356	PF12436	0.279
DOC_WW_Pin1_4	137	142	PF00397	0.354
DOC_WW_Pin1_4	228	233	PF00397	0.503
DOC_WW_Pin1_4	74	79	PF00397	0.391
LIG_14-3-3_CanoR_1	242	246	PF00244	0.627
LIG_14-3-3_CanoR_1	27	36	PF00244	0.571
LIG_14-3-3_CanoR_1	375	381	PF00244	0.627
LIG_14-3-3_CanoR_1	538	548	PF00244	0.314
LIG_14-3-3_CanoR_1	54	64	PF00244	0.414
LIG_BRCT_BRCA1_1	341	345	PF00533	0.296
LIG_BRCT_BRCA1_1	430	434	PF00533	0.515
LIG_BRCT_BRCA1_1	51	55	PF00533	0.543
LIG_BRCT_BRCA1_1	542	546	PF00533	0.326
LIG_CaM_NSCaTE_8	314	321	PF13499	0.322
LIG_deltaCOP1_diTrp_1	161	170	PF00928	0.384
LIG_FHA_1	102	108	PF00498	0.331
LIG_FHA_1	113	119	PF00498	0.321
LIG_FHA_1	29	35	PF00498	0.518
LIG_FHA_1	3	9	PF00498	0.572
LIG_FHA_1	517	523	PF00498	0.549
LIG_FHA_1	545	551	PF00498	0.370
LIG_FHA_1	56	62	PF00498	0.361
LIG_FHA_2	422	428	PF00498	0.718
LIG_FHA_2	468	474	PF00498	0.640
LIG_FHA_2	487	493	PF00498	0.442
LIG_FHA_2	93	99	PF00498	0.352
LIG_GBD_Chelix_1	577	585	PF00786	0.492
LIG_LIR_Apic_2	135	141	PF02991	0.272
LIG_LIR_Apic_2	216	222	PF02991	0.546
LIG_LIR_Apic_2	71	76	PF02991	0.410
LIG_LIR_Gen_1	101	107	PF02991	0.326
LIG_LIR_Gen_1	224	232	PF02991	0.501
LIG_LIR_Gen_1	543	554	PF02991	0.325
LIG_LIR_Nem_3	101	106	PF02991	0.330
LIG_LIR_Nem_3	166	172	PF02991	0.255
LIG_LIR_Nem_3	224	230	PF02991	0.578
LIG_LIR_Nem_3	32	38	PF02991	0.605
LIG_LIR_Nem_3	490	496	PF02991	0.449
LIG_LIR_Nem_3	543	549	PF02991	0.291
LIG_LIR_Nem_3	58	63	PF02991	0.440
LIG_MLH1_MIPbox_1	341	345	PF16413	0.296
LIG_Pex14_2	134	138	PF04695	0.320
LIG_Pex14_2	337	341	PF04695	0.254
LIG_Pex14_2	364	368	PF04695	0.351
LIG_Pex14_2	56	60	PF04695	0.197
LIG_PTB_Apo_2	54	61	PF02174	0.384
LIG_SH2_CRK	103	107	PF00017	0.358
LIG_SH2_CRK	403	407	PF00017	0.485
LIG_SH2_CRK	482	486	PF00017	0.648
LIG_SH2_CRK	518	522	PF00017	0.532
LIG_SH2_GRB2like	482	485	PF00017	0.490
LIG_SH2_NCK_1	46	50	PF00017	0.612
LIG_SH2_PTP2	73	76	PF00017	0.540
LIG_SH2_SRC	482	485	PF00017	0.490
LIG_SH2_SRC	553	556	PF00017	0.246
LIG_SH2_STAP1	103	107	PF00017	0.340
LIG_SH2_STAP1	275	279	PF00017	0.458
LIG_SH2_STAP1	46	50	PF00017	0.612
LIG_SH2_STAP1	518	522	PF00017	0.532
LIG_SH2_STAT5	103	106	PF00017	0.327
LIG_SH2_STAT5	148	151	PF00017	0.442
LIG_SH2_STAT5	248	251	PF00017	0.580
LIG_SH2_STAT5	271	274	PF00017	0.451
LIG_SH2_STAT5	46	49	PF00017	0.523
LIG_SH2_STAT5	518	521	PF00017	0.511
LIG_SH2_STAT5	553	556	PF00017	0.385
LIG_SH2_STAT5	582	585	PF00017	0.419
LIG_SH2_STAT5	73	76	PF00017	0.540
LIG_SH3_3	22	28	PF00018	0.466
LIG_SUMO_SIM_par_1	467	475	PF11976	0.451
LIG_TRAF2_1	461	464	PF00917	0.569
LIG_WRC_WIRS_1	341	346	PF05994	0.242
LIG_WRC_WIRS_1	455	460	PF05994	0.541
MOD_CK1_1	101	107	PF00069	0.374
MOD_CK1_1	140	146	PF00069	0.458
MOD_CK1_1	241	247	PF00069	0.574
MOD_CK1_1	298	304	PF00069	0.496
MOD_CK1_1	379	385	PF00069	0.630
MOD_CK2_1	231	237	PF00069	0.596
MOD_CK2_1	3	9	PF00069	0.631
MOD_CK2_1	421	427	PF00069	0.719
MOD_CK2_1	450	456	PF00069	0.511
MOD_CK2_1	458	464	PF00069	0.514
MOD_CK2_1	467	473	PF00069	0.513
MOD_CK2_1	486	492	PF00069	0.444
MOD_CK2_1	92	98	PF00069	0.397
MOD_GlcNHglycan	186	189	PF01048	0.293
MOD_GlcNHglycan	289	292	PF01048	0.373
MOD_GlcNHglycan	345	348	PF01048	0.410
MOD_GlcNHglycan	368	371	PF01048	0.299
MOD_GlcNHglycan	558	561	PF01048	0.667
MOD_GlcNHglycan	83	86	PF01048	0.621
MOD_GSK3_1	180	187	PF00069	0.302
MOD_GSK3_1	339	346	PF00069	0.296
MOD_GSK3_1	450	457	PF00069	0.570
MOD_GSK3_1	540	547	PF00069	0.399
MOD_GSK3_1	98	105	PF00069	0.398
MOD_N-GLC_1	301	306	PF02516	0.336
MOD_NEK2_1	238	243	PF00069	0.567
MOD_NEK2_1	287	292	PF00069	0.576
MOD_NEK2_1	34	39	PF00069	0.505
MOD_NEK2_1	345	350	PF00069	0.279
MOD_NEK2_1	450	455	PF00069	0.532
MOD_NEK2_1	516	521	PF00069	0.633
MOD_NEK2_1	544	549	PF00069	0.332
MOD_NEK2_1	55	60	PF00069	0.376
MOD_NEK2_1	68	73	PF00069	0.277
MOD_NEK2_2	340	345	PF00069	0.242
MOD_PKA_2	18	24	PF00069	0.530
MOD_PKA_2	241	247	PF00069	0.455
MOD_PKA_2	29	35	PF00069	0.529
MOD_PKA_2	408	414	PF00069	0.562
MOD_PKA_2	539	545	PF00069	0.365
MOD_PKB_1	538	546	PF00069	0.258
MOD_Plk_1	301	307	PF00069	0.521
MOD_Plk_1	467	473	PF00069	0.550
MOD_Plk_2-3	127	133	PF00069	0.251
MOD_Plk_2-3	467	473	PF00069	0.544
MOD_Plk_4	29	35	PF00069	0.579
MOD_Plk_4	340	346	PF00069	0.259
MOD_Plk_4	430	436	PF00069	0.566
MOD_Plk_4	443	449	PF00069	0.535
MOD_Plk_4	450	456	PF00069	0.419
MOD_Plk_4	467	473	PF00069	0.513
MOD_Plk_4	98	104	PF00069	0.391
MOD_ProDKin_1	137	143	PF00069	0.360
MOD_ProDKin_1	228	234	PF00069	0.507
MOD_ProDKin_1	74	80	PF00069	0.386
TRG_DiLeu_BaEn_1	492	497	PF01217	0.440
TRG_DiLeu_BaLyEn_6	517	522	PF01217	0.618
TRG_ENDOCYTIC_2	103	106	PF00928	0.338
TRG_ENDOCYTIC_2	169	172	PF00928	0.410
TRG_ENDOCYTIC_2	294	297	PF00928	0.442
TRG_ENDOCYTIC_2	403	406	PF00928	0.481
TRG_ENDOCYTIC_2	513	516	PF00928	0.616
TRG_ENDOCYTIC_2	518	521	PF00928	0.594
TRG_ENDOCYTIC_2	582	585	PF00928	0.417
TRG_ER_diArg_1	308	310	PF00400	0.536
TRG_ER_diArg_1	406	409	PF00400	0.632
TRG_ER_diArg_1	478	481	PF00400	0.603
TRG_Pf-PMV_PEXEL_1	552	557	PF00026	0.558

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7S3	Leptomonas seymouri	62%	100%
A0A1X0NYV6	Trypanosomatidae	49%	100%
A0A3Q8IAW4	Leishmania donovani	81%	100%
A0A422P1M7	Trypanosoma rangeli	46%	100%
A4I3E6	Leishmania infantum	81%	100%
D0A801	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
E9AZN3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4Q8J8	Leishmania major	81%	100%
V5B0S4	Trypanosoma cruzi	47%	100%