Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function (DUF4539), putative

Species:

Leishmania braziliensis

UniProt:

A4HGB1_LEIBR

TriTrypDb:

LbrM.28.0730 , LBRM2903_280012800

Length:

248

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HGB1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGB1

Function

Biological processes
Term	Name	Level	Count
GO:0000725	recombinational repair	6	7
GO:0006139	nucleobase-containing compound metabolic process	3	7
GO:0006259	DNA metabolic process	4	7
GO:0006281	DNA repair	5	7
GO:0006310	DNA recombination	5	7
GO:0006725	cellular aromatic compound metabolic process	3	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0006950	response to stress	2	7
GO:0006974	DNA damage response	4	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0033554	cellular response to stress	3	7
GO:0034641	cellular nitrogen compound metabolic process	3	7
GO:0043170	macromolecule metabolic process	3	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0044260	obsolete cellular macromolecule metabolic process	3	7
GO:0046483	heterocycle metabolic process	3	7
GO:0050896	response to stimulus	1	7
GO:0051716	cellular response to stimulus	2	7
GO:0071704	organic substance metabolic process	2	7
GO:0090304	nucleic acid metabolic process	4	7
GO:1901360	organic cyclic compound metabolic process	3	7

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	209	213	PF00656	0.500
CLV_C14_Caspase3-7	48	52	PF00656	0.309
CLV_NRD_NRD_1	210	212	PF00675	0.622
CLV_PCSK_KEX2_1	210	212	PF00082	0.705
CLV_PCSK_KEX2_1	218	220	PF00082	0.686
CLV_PCSK_PC1ET2_1	218	220	PF00082	0.707
CLV_PCSK_SKI1_1	141	145	PF00082	0.654
CLV_PCSK_SKI1_1	30	34	PF00082	0.415
CLV_PCSK_SKI1_1	43	47	PF00082	0.241
DEG_Nend_UBRbox_3	1	3	PF02207	0.362
DOC_CKS1_1	136	141	PF01111	0.502
DOC_CYCLIN_yCln2_LP_2	201	207	PF00134	0.495
DOC_MAPK_RevD_3	197	211	PF00069	0.496
DOC_PP2B_LxvP_1	113	116	PF13499	0.309
DOC_USP7_MATH_1	125	129	PF00917	0.688
DOC_USP7_MATH_1	185	189	PF00917	0.742
DOC_USP7_MATH_1	192	196	PF00917	0.599
DOC_USP7_MATH_1	197	201	PF00917	0.533
DOC_USP7_MATH_1	49	53	PF00917	0.309
DOC_WW_Pin1_4	135	140	PF00397	0.496
LIG_14-3-3_CanoR_1	219	228	PF00244	0.481
LIG_EVH1_2	139	143	PF00568	0.497
LIG_FHA_1	158	164	PF00498	0.467
LIG_FHA_1	40	46	PF00498	0.309
LIG_FHA_1	51	57	PF00498	0.315
LIG_FHA_1	79	85	PF00498	0.399
LIG_FHA_1	89	95	PF00498	0.241
LIG_LIR_Gen_1	62	71	PF02991	0.309
LIG_LIR_LC3C_4	91	95	PF02991	0.229
LIG_LIR_Nem_3	62	67	PF02991	0.333
LIG_LIR_Nem_3	72	78	PF02991	0.309
LIG_LYPXL_yS_3	75	78	PF13949	0.309
LIG_MYND_2	100	104	PF01753	0.381
LIG_NRBOX	109	115	PF00104	0.309
LIG_SH2_CRK	64	68	PF00017	0.309
LIG_SH2_STAP1	28	32	PF00017	0.461
LIG_SH2_STAT5	64	67	PF00017	0.309
LIG_SUMO_SIM_anti_2	240	247	PF11976	0.538
LIG_SUMO_SIM_anti_2	88	94	PF11976	0.309
LIG_SUMO_SIM_par_1	51	58	PF11976	0.309
LIG_SUMO_SIM_par_1	88	97	PF11976	0.309
LIG_WW_3	138	142	PF00397	0.495
MOD_CDK_SPxK_1	135	141	PF00069	0.503
MOD_CK1_1	128	134	PF00069	0.565
MOD_CK1_1	22	28	PF00069	0.312
MOD_CK2_1	177	183	PF00069	0.576
MOD_CK2_1	185	191	PF00069	0.555
MOD_GlcNHglycan	128	131	PF01048	0.590
MOD_GlcNHglycan	179	182	PF01048	0.486
MOD_GlcNHglycan	183	186	PF01048	0.503
MOD_GlcNHglycan	194	197	PF01048	0.544
MOD_GlcNHglycan	212	215	PF01048	0.608
MOD_GlcNHglycan	30	33	PF01048	0.395
MOD_GlcNHglycan	47	50	PF01048	0.309
MOD_GlcNHglycan	58	62	PF01048	0.309
MOD_GSK3_1	119	126	PF00069	0.590
MOD_GSK3_1	128	135	PF00069	0.595
MOD_GSK3_1	173	180	PF00069	0.590
MOD_GSK3_1	181	188	PF00069	0.532
MOD_GSK3_1	19	26	PF00069	0.322
MOD_GSK3_1	39	46	PF00069	0.309
MOD_NEK2_1	93	98	PF00069	0.339
MOD_NEK2_2	59	64	PF00069	0.309
MOD_PIKK_1	132	138	PF00454	0.513
MOD_PKA_1	210	216	PF00069	0.496
MOD_PKA_2	210	216	PF00069	0.502
MOD_Plk_1	50	56	PF00069	0.299
MOD_Plk_1	88	94	PF00069	0.309
MOD_Plk_4	50	56	PF00069	0.299
MOD_ProDKin_1	135	141	PF00069	0.497
TRG_DiLeu_BaEn_1	240	245	PF01217	0.541
TRG_ENDOCYTIC_2	64	67	PF00928	0.337
TRG_ENDOCYTIC_2	75	78	PF00928	0.378

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1R0	Leptomonas seymouri	49%	96%
A0A3S7X1B4	Leishmania donovani	75%	99%
A4I3E5	Leishmania infantum	73%	99%
E9AZN2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	99%
Q4Q8J9	Leishmania major	72%	100%