ANK_REP_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ankyrin repeats (3 copies), putative

Species:

Leishmania braziliensis

UniProt:

A4HGA8_LEIBR

TriTrypDb:

LbrM.28.0700 , LBRM2903_280012500

Length:

233

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HGA8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGA8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	16	20	PF00656	0.459
CLV_C14_Caspase3-7	45	49	PF00656	0.379
CLV_NRD_NRD_1	188	190	PF00675	0.744
CLV_PCSK_KEX2_1	188	190	PF00082	0.608
CLV_PCSK_SKI1_1	121	125	PF00082	0.417
DEG_APCC_DBOX_1	11	19	PF00400	0.556
DEG_Nend_UBRbox_2	1	3	PF02207	0.599
DOC_MAPK_gen_1	207	215	PF00069	0.438
DOC_MAPK_MEF2A_6	207	215	PF00069	0.533
DOC_PP2B_LxvP_1	159	162	PF13499	0.472
DOC_PP4_FxxP_1	11	14	PF00568	0.586
DOC_USP7_MATH_1	155	159	PF00917	0.446
DOC_USP7_MATH_1	203	207	PF00917	0.688
LIG_APCC_ABBA_1	1	6	PF00400	0.651
LIG_Clathr_ClatBox_1	212	216	PF01394	0.438
LIG_Clathr_ClatBox_1	73	77	PF01394	0.179
LIG_FHA_1	216	222	PF00498	0.566
LIG_FHA_1	28	34	PF00498	0.179
LIG_FHA_2	14	20	PF00498	0.507
LIG_LIR_Apic_2	147	152	PF02991	0.608
LIG_LIR_Apic_2	2	7	PF02991	0.651
LIG_LIR_Apic_2	8	14	PF02991	0.615
LIG_LIR_Gen_1	129	140	PF02991	0.503
LIG_RPA_C_Fungi	94	106	PF08784	0.379
LIG_SH2_PTP2	149	152	PF00017	0.599
LIG_SH2_SRC	149	152	PF00017	0.600
LIG_SH2_STAP1	128	132	PF00017	0.502
LIG_SH2_STAT3	128	131	PF00017	0.485
LIG_SH2_STAT5	149	152	PF00017	0.544
LIG_SH2_STAT5	39	42	PF00017	0.322
LIG_SH3_1	188	194	PF00018	0.666
LIG_SH3_2	194	199	PF14604	0.631
LIG_SH3_3	188	194	PF00018	0.712
LIG_SH3_3	208	214	PF00018	0.625
LIG_SH3_3	77	83	PF00018	0.264
LIG_SUMO_SIM_anti_2	32	37	PF11976	0.379
LIG_TRAF2_1	178	181	PF00917	0.614
MOD_CK2_1	138	144	PF00069	0.504
MOD_GlcNHglycan	225	228	PF01048	0.542
MOD_GlcNHglycan	23	26	PF01048	0.445
MOD_GSK3_1	138	145	PF00069	0.525
MOD_N-GLC_1	27	32	PF02516	0.316
MOD_NEK2_1	119	124	PF00069	0.478
MOD_NEK2_1	21	26	PF00069	0.474
MOD_NEK2_1	223	228	PF00069	0.652
MOD_Plk_1	142	148	PF00069	0.595
MOD_Plk_2-3	13	19	PF00069	0.485
MOD_Plk_4	145	151	PF00069	0.495
MOD_SUMO_rev_2	175	185	PF00179	0.650
TRG_DiLeu_BaEn_1	134	139	PF01217	0.429
TRG_ENDOCYTIC_2	132	135	PF00928	0.492
TRG_ER_diArg_1	188	190	PF00400	0.544

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8F3	Leptomonas seymouri	73%	100%
A0A1X0NYH9	Trypanosomatidae	50%	95%
A0A3R7KXF5	Trypanosoma rangeli	43%	100%
A0A3S7X195	Leishmania donovani	85%	100%
A4I3E2	Leishmania infantum	85%	100%
E9AZM9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	99%
Q06527	Allochromatium vinosum (strain ATCC 17899 / DSM 180 / NBRC 103801 / NCIMB 10441 / D)	30%	72%
Q4Q8K2	Leishmania major	86%	100%
Q9TU71	Oryctolagus cuniculus	29%	73%
V5BQC3	Trypanosoma cruzi	44%	98%