Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HGA7_LEIBR

TriTrypDb:

LbrM.28.0690 , LBRM2903_280012400

Length:

360

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HGA7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGA7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	283	287	PF00656	0.521
CLV_NRD_NRD_1	342	344	PF00675	0.471
CLV_PCSK_SKI1_1	256	260	PF00082	0.378
CLV_PCSK_SKI1_1	280	284	PF00082	0.379
DEG_SCF_FBW7_1	290	296	PF00400	0.635
DOC_CKS1_1	290	295	PF01111	0.643
DOC_CYCLIN_yCln2_LP_2	331	337	PF00134	0.470
DOC_MAPK_MEF2A_6	327	335	PF00069	0.419
DOC_MAPK_RevD_3	329	344	PF00069	0.433
DOC_PP1_RVXF_1	336	343	PF00149	0.563
DOC_PP2B_LxvP_1	235	238	PF13499	0.453
DOC_PP2B_LxvP_1	331	334	PF13499	0.485
DOC_PP4_FxxP_1	140	143	PF00568	0.321
DOC_PP4_FxxP_1	295	298	PF00568	0.497
DOC_USP7_MATH_1	103	107	PF00917	0.615
DOC_USP7_MATH_1	112	116	PF00917	0.525
DOC_USP7_MATH_1	285	289	PF00917	0.604
DOC_WW_Pin1_4	24	29	PF00397	0.525
DOC_WW_Pin1_4	286	291	PF00397	0.703
LIG_14-3-3_CanoR_1	280	285	PF00244	0.647
LIG_Actin_WH2_2	159	177	PF00022	0.450
LIG_Actin_WH2_2	247	262	PF00022	0.419
LIG_APCC_ABBA_1	186	191	PF00400	0.437
LIG_CaM_IQ_9	268	283	PF13499	0.490
LIG_FHA_1	181	187	PF00498	0.518
LIG_FHA_2	242	248	PF00498	0.486
LIG_FHA_2	272	278	PF00498	0.578
LIG_FHA_2	281	287	PF00498	0.519
LIG_GBD_Chelix_1	170	178	PF00786	0.468
LIG_LIR_Apic_2	292	298	PF02991	0.536
LIG_LIR_Gen_1	14	21	PF02991	0.558
LIG_LIR_Gen_1	247	254	PF02991	0.269
LIG_LIR_Nem_3	129	134	PF02991	0.439
LIG_LIR_Nem_3	14	19	PF02991	0.503
LIG_LIR_Nem_3	247	251	PF02991	0.541
LIG_LIR_Nem_3	346	352	PF02991	0.422
LIG_LIR_Nem_3	355	359	PF02991	0.454
LIG_LIR_Nem_3	53	58	PF02991	0.468
LIG_LIR_Nem_3	63	67	PF02991	0.531
LIG_PTB_Apo_2	133	140	PF02174	0.567
LIG_PTB_Apo_2	4	11	PF02174	0.341
LIG_REV1ctd_RIR_1	129	139	PF16727	0.461
LIG_SH2_GRB2like	349	352	PF00017	0.309
LIG_SH2_STAP1	263	267	PF00017	0.434
LIG_SH2_STAT5	138	141	PF00017	0.396
LIG_SH2_STAT5	349	352	PF00017	0.479
LIG_SH2_STAT5	58	61	PF00017	0.483
LIG_SH2_STAT5	99	102	PF00017	0.460
LIG_SH3_3	121	127	PF00018	0.480
LIG_SH3_3	193	199	PF00018	0.672
LIG_SH3_3	287	293	PF00018	0.661
LIG_SH3_3	351	357	PF00018	0.602
LIG_SUMO_SIM_par_1	180	187	PF11976	0.435
LIG_TRAF2_2	199	204	PF00917	0.514
LIG_TRFH_1	295	299	PF08558	0.489
LIG_TRFH_1	58	62	PF08558	0.480
MOD_CK1_1	115	121	PF00069	0.714
MOD_CK1_1	146	152	PF00069	0.407
MOD_CK1_1	233	239	PF00069	0.522
MOD_CK1_1	24	30	PF00069	0.578
MOD_CK1_1	288	294	PF00069	0.642
MOD_CK1_1	69	75	PF00069	0.542
MOD_CK2_1	19	25	PF00069	0.606
MOD_CK2_1	241	247	PF00069	0.498
MOD_CK2_1	271	277	PF00069	0.305
MOD_CK2_1	69	75	PF00069	0.467
MOD_GlcNHglycan	148	151	PF01048	0.346
MOD_GlcNHglycan	232	235	PF01048	0.446
MOD_GlcNHglycan	318	321	PF01048	0.452
MOD_GlcNHglycan	322	325	PF01048	0.431
MOD_GlcNHglycan	68	71	PF01048	0.448
MOD_GSK3_1	108	115	PF00069	0.707
MOD_GSK3_1	180	187	PF00069	0.462
MOD_GSK3_1	20	27	PF00069	0.508
MOD_GSK3_1	259	266	PF00069	0.375
MOD_GSK3_1	285	292	PF00069	0.564
MOD_GSK3_1	316	323	PF00069	0.480
MOD_GSK3_1	65	72	PF00069	0.425
MOD_GSK3_1	98	105	PF00069	0.507
MOD_N-GLC_1	225	230	PF02516	0.290
MOD_NEK2_1	19	24	PF00069	0.599
MOD_NEK2_1	50	55	PF00069	0.487
MOD_NEK2_1	65	70	PF00069	0.577
MOD_PIKK_1	11	17	PF00454	0.447
MOD_PIKK_1	225	231	PF00454	0.455
MOD_PIKK_1	236	242	PF00454	0.487
MOD_PIKK_1	37	43	PF00454	0.535
MOD_PKA_2	103	109	PF00069	0.683
MOD_PKA_2	259	265	PF00069	0.433
MOD_Plk_1	180	186	PF00069	0.486
MOD_Plk_1	263	269	PF00069	0.443
MOD_Plk_2-3	159	165	PF00069	0.606
MOD_Plk_4	241	247	PF00069	0.360
MOD_Plk_4	263	269	PF00069	0.439
MOD_ProDKin_1	24	30	PF00069	0.533
MOD_ProDKin_1	286	292	PF00069	0.703
TRG_ER_diArg_1	173	176	PF00400	0.443
TRG_ER_diArg_1	194	197	PF00400	0.657
TRG_Pf-PMV_PEXEL_1	276	281	PF00026	0.503

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IA55	Leptomonas seymouri	52%	75%
A0A3Q8IQE0	Leishmania donovani	77%	71%
A4I3E1	Leishmania infantum	77%	100%
E9AZM8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%
Q4Q8K3	Leishmania major	74%	100%