Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HGA6_LEIBR

TriTrypDb:

LbrM.28.0680 , LBRM2903_280012300

Length:

340

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10
GO:0005635	nuclear envelope	4	1
GO:0005737	cytoplasm	2	1
GO:0031967	organelle envelope	3	1
GO:0031975	envelope	2	1
GO:0005929	cilium	4	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

A4HGA6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGA6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	108	112	PF00656	0.559
CLV_NRD_NRD_1	19	21	PF00675	0.391
CLV_NRD_NRD_1	322	324	PF00675	0.401
CLV_NRD_NRD_1	337	339	PF00675	0.448
CLV_NRD_NRD_1	4	6	PF00675	0.500
CLV_PCSK_FUR_1	17	21	PF00082	0.513
CLV_PCSK_KEX2_1	19	21	PF00082	0.392
CLV_PCSK_KEX2_1	321	323	PF00082	0.407
CLV_PCSK_KEX2_1	4	6	PF00082	0.499
CLV_PCSK_PC1ET2_1	321	323	PF00082	0.486
CLV_PCSK_SKI1_1	152	156	PF00082	0.323
CLV_PCSK_SKI1_1	210	214	PF00082	0.395
CLV_PCSK_SKI1_1	28	32	PF00082	0.381
DEG_Nend_UBRbox_2	1	3	PF02207	0.681
DOC_MAPK_FxFP_2	58	61	PF00069	0.603
DOC_MAPK_gen_1	17	26	PF00069	0.645
DOC_MAPK_gen_1	188	196	PF00069	0.589
DOC_MAPK_gen_1	210	219	PF00069	0.622
DOC_MAPK_gen_1	227	237	PF00069	0.462
DOC_MAPK_gen_1	321	330	PF00069	0.635
DOC_MAPK_MEF2A_6	230	239	PF00069	0.506
DOC_MAPK_MEF2A_6	321	328	PF00069	0.658
DOC_MAPK_RevD_3	324	339	PF00069	0.651
DOC_PP4_FxxP_1	10	13	PF00568	0.628
DOC_PP4_FxxP_1	58	61	PF00568	0.589
DOC_USP7_MATH_1	211	215	PF00917	0.610
DOC_WW_Pin1_4	183	188	PF00397	0.524
LIG_14-3-3_CanoR_1	17	27	PF00244	0.619
LIG_14-3-3_CanoR_1	210	219	PF00244	0.623
LIG_14-3-3_CanoR_1	269	275	PF00244	0.429
LIG_14-3-3_CterR_2	338	340	PF00244	0.572
LIG_Actin_WH2_2	138	154	PF00022	0.542
LIG_Actin_WH2_2	195	212	PF00022	0.589
LIG_BRCT_BRCA1_1	240	244	PF00533	0.408
LIG_deltaCOP1_diTrp_1	221	228	PF00928	0.542
LIG_EH_1	11	15	PF12763	0.633
LIG_EH1_1	232	240	PF00400	0.405
LIG_FHA_1	178	184	PF00498	0.626
LIG_FHA_1	19	25	PF00498	0.678
LIG_FHA_1	198	204	PF00498	0.391
LIG_FHA_1	31	37	PF00498	0.643
LIG_FHA_1	331	337	PF00498	0.716
LIG_FHA_1	63	69	PF00498	0.549
LIG_FHA_2	199	205	PF00498	0.531
LIG_LIR_Apic_2	56	61	PF02991	0.590
LIG_LIR_Apic_2	70	75	PF02991	0.613
LIG_LIR_Gen_1	105	115	PF02991	0.572
LIG_LIR_Gen_1	241	252	PF02991	0.341
LIG_LIR_Gen_1	276	287	PF02991	0.307
LIG_LIR_Gen_1	291	300	PF02991	0.263
LIG_LIR_Gen_1	325	335	PF02991	0.644
LIG_LIR_Gen_1	47	58	PF02991	0.680
LIG_LIR_Nem_3	105	110	PF02991	0.581
LIG_LIR_Nem_3	126	130	PF02991	0.532
LIG_LIR_Nem_3	21	26	PF02991	0.682
LIG_LIR_Nem_3	241	247	PF02991	0.329
LIG_LIR_Nem_3	276	282	PF02991	0.295
LIG_LIR_Nem_3	291	295	PF02991	0.286
LIG_LIR_Nem_3	325	330	PF02991	0.674
LIG_LIR_Nem_3	47	53	PF02991	0.674
LIG_Pex14_1	6	10	PF04695	0.688
LIG_Pex14_2	10	14	PF04695	0.631
LIG_Pex14_2	240	244	PF04695	0.364
LIG_Pex14_2	248	252	PF04695	0.330
LIG_Pex14_2	288	292	PF04695	0.349
LIG_PTB_Apo_2	66	73	PF02174	0.608
LIG_PTB_Phospho_1	66	72	PF10480	0.602
LIG_REV1ctd_RIR_1	28	34	PF16727	0.579
LIG_SH2_CRK	264	268	PF00017	0.412
LIG_SH2_CRK	50	54	PF00017	0.661
LIG_SH2_STAP1	279	283	PF00017	0.447
LIG_SH2_STAT5	127	130	PF00017	0.506
LIG_SH2_STAT5	218	221	PF00017	0.536
LIG_SH2_STAT5	23	26	PF00017	0.676
LIG_SH2_STAT5	249	252	PF00017	0.337
LIG_SH2_STAT5	300	303	PF00017	0.584
LIG_SH2_STAT5	316	319	PF00017	0.606
LIG_SH2_STAT5	72	75	PF00017	0.646
LIG_SH3_3	253	259	PF00018	0.447
LIG_SH3_3	58	64	PF00018	0.624
LIG_TYR_ITIM	48	53	PF00017	0.653
LIG_UBA3_1	202	208	PF00899	0.555
LIG_WRC_WIRS_1	289	294	PF05994	0.314
MOD_CDK_SPK_2	183	188	PF00069	0.524
MOD_CK1_1	143	149	PF00069	0.547
MOD_CK1_1	186	192	PF00069	0.639
MOD_CK1_1	273	279	PF00069	0.429
MOD_CK1_1	76	82	PF00069	0.633
MOD_CK2_1	198	204	PF00069	0.524
MOD_Cter_Amidation	17	20	PF01082	0.359
MOD_GlcNHglycan	102	105	PF01048	0.490
MOD_GlcNHglycan	292	295	PF01048	0.458
MOD_GSK3_1	179	186	PF00069	0.680
MOD_LATS_1	150	156	PF00433	0.535
MOD_NEK2_1	141	146	PF00069	0.478
MOD_NEK2_1	270	275	PF00069	0.462
MOD_NEK2_1	288	293	PF00069	0.392
MOD_NEK2_1	30	35	PF00069	0.650
MOD_PKA_2	18	24	PF00069	0.619
MOD_PKA_2	226	232	PF00069	0.655
MOD_PKA_2	268	274	PF00069	0.375
MOD_Plk_1	152	158	PF00069	0.585
MOD_Plk_1	192	198	PF00069	0.561
MOD_Plk_1	223	229	PF00069	0.570
MOD_Plk_2-3	179	185	PF00069	0.567
MOD_Plk_4	198	204	PF00069	0.524
MOD_Plk_4	53	59	PF00069	0.598
MOD_Plk_4	92	98	PF00069	0.553
MOD_ProDKin_1	183	189	PF00069	0.526
TRG_DiLeu_BaLyEn_6	110	115	PF01217	0.631
TRG_ENDOCYTIC_2	11	14	PF00928	0.682
TRG_ENDOCYTIC_2	127	130	PF00928	0.511
TRG_ENDOCYTIC_2	23	26	PF00928	0.596
TRG_ENDOCYTIC_2	249	252	PF00928	0.324
TRG_ENDOCYTIC_2	264	267	PF00928	0.337
TRG_ENDOCYTIC_2	27	30	PF00928	0.513
TRG_ENDOCYTIC_2	279	282	PF00928	0.353
TRG_ENDOCYTIC_2	316	319	PF00928	0.615
TRG_ENDOCYTIC_2	50	53	PF00928	0.631
TRG_ER_diArg_1	17	20	PF00400	0.605
TRG_ER_diArg_1	3	5	PF00400	0.699
TRG_ER_diArg_1	305	308	PF00400	0.609
TRG_ER_diArg_1	322	324	PF00400	0.601
TRG_ER_diArg_1	6	9	PF00400	0.694
TRG_ER_diArg_1	77	80	PF00400	0.684

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM72	Leptomonas seymouri	84%	100%
A0A0S4JAZ2	Bodo saltans	46%	100%
A0A1X0NZ41	Trypanosomatidae	62%	100%
A0A3S7X196	Leishmania donovani	85%	100%
A4I3E0	Leishmania infantum	85%	100%
D0A807	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	64%	100%
E9AZM7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4Q8K4	Leishmania major	85%	100%
V5BG88	Trypanosoma cruzi	62%	100%