WD_REPEATS_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein transport protein SEC13, putative

Species:

Leishmania braziliensis

UniProt:

A4HGA5_LEIBR

TriTrypDb:

LbrM.28.0670 , LBRM2903_280012200

Length:

358

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005643	nuclear pore	3	11
GO:0005794	Golgi apparatus	5	1
GO:0005840	ribosome	5	1
GO:0030117	membrane coat	3	12
GO:0030120	vesicle coat	4	12
GO:0030127	COPII vesicle coat	5	12
GO:0031080	nuclear pore outer ring	3	1
GO:0032991	protein-containing complex	1	12
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	1

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Expansion

Sequence features

A4HGA5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGA5

Function

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Biological processes
Term	Name	Level	Count
GO:0006606	protein import into nucleus	5	1
GO:0006810	transport	3	12
GO:0006886	intracellular protein transport	4	1
GO:0006900	vesicle budding from membrane	5	12
GO:0006913	nucleocytoplasmic transport	5	1
GO:0006996	organelle organization	4	12
GO:0008104	protein localization	4	12
GO:0009966	regulation of signal transduction	4	12
GO:0009967	positive regulation of signal transduction	5	12
GO:0009987	cellular process	1	12

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Molecular functions
Term	Name	Level	Count
GO:0005198	structural molecule activity	1	12

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	329	333	PF00656	0.467
CLV_NRD_NRD_1	114	116	PF00675	0.455
CLV_PCSK_SKI1_1	211	215	PF00082	0.288
CLV_PCSK_SKI1_1	219	223	PF00082	0.292
DOC_CKS1_1	122	127	PF01111	0.297
DOC_CKS1_1	255	260	PF01111	0.522
DOC_CYCLIN_yCln2_LP_2	269	275	PF00134	0.413
DOC_CYCLIN_yCln2_LP_2	302	305	PF00134	0.449
DOC_PP1_RVXF_1	259	266	PF00149	0.317
DOC_PP1_RVXF_1	314	320	PF00149	0.330

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEP1	Leptomonas seymouri	79%	100%
A0A0S4JEG3	Bodo saltans	36%	100%
A0A1X0NYI1	Trypanosomatidae	47%	100%
A0A3Q8IDS6	Leishmania donovani	90%	100%
A0A422P1N5	Trypanosoma rangeli	46%	100%
A1CGS0	Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107)	29%	100%
A2QHM1	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	29%	100%
A3LNW3	Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545)	28%	100%
A4I3D9	Leishmania infantum	90%	100%
A4REK3	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	29%	100%

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