Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HG99_LEIBR

TriTrypDb:

LbrM.28.0610 , LBRM2903_280011600

Length:

523

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HG99

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HG99

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	379	383	PF00656	0.535
CLV_MEL_PAP_1	473	479	PF00089	0.601
CLV_NRD_NRD_1	418	420	PF00675	0.532
CLV_NRD_NRD_1	468	470	PF00675	0.623
CLV_NRD_NRD_1	512	514	PF00675	0.803
CLV_PCSK_KEX2_1	417	419	PF00082	0.588
CLV_PCSK_KEX2_1	468	470	PF00082	0.623
CLV_PCSK_KEX2_1	512	514	PF00082	0.761
CLV_PCSK_PC1ET2_1	417	419	PF00082	0.588
CLV_PCSK_SKI1_1	274	278	PF00082	0.555
CLV_PCSK_SKI1_1	289	293	PF00082	0.464
CLV_PCSK_SKI1_1	317	321	PF00082	0.502
CLV_PCSK_SKI1_1	323	327	PF00082	0.550
CLV_PCSK_SKI1_1	419	423	PF00082	0.580
CLV_PCSK_SKI1_1	50	54	PF00082	0.434
DEG_SCF_FBW7_1	28	34	PF00400	0.504
DOC_CKS1_1	28	33	PF01111	0.508
DOC_CYCLIN_RxL_1	135	145	PF00134	0.473
DOC_PP2B_LxvP_1	148	151	PF13499	0.486
DOC_PP2B_LxvP_1	92	95	PF13499	0.598
DOC_PP4_MxPP_1	426	429	PF00568	0.625
DOC_USP7_MATH_1	120	124	PF00917	0.523
DOC_USP7_MATH_1	13	17	PF00917	0.548
DOC_USP7_MATH_1	195	199	PF00917	0.531
DOC_USP7_MATH_1	217	221	PF00917	0.593
DOC_USP7_MATH_1	260	264	PF00917	0.636
DOC_USP7_MATH_1	325	329	PF00917	0.428
DOC_USP7_MATH_1	380	384	PF00917	0.513
DOC_USP7_MATH_1	393	397	PF00917	0.610
DOC_USP7_MATH_1	5	9	PF00917	0.596
DOC_USP7_MATH_1	516	520	PF00917	0.781
DOC_USP7_MATH_1	66	70	PF00917	0.552
DOC_WW_Pin1_4	182	187	PF00397	0.608
DOC_WW_Pin1_4	211	216	PF00397	0.750
DOC_WW_Pin1_4	250	255	PF00397	0.620
DOC_WW_Pin1_4	267	272	PF00397	0.610
DOC_WW_Pin1_4	27	32	PF00397	0.588
DOC_WW_Pin1_4	274	279	PF00397	0.634
DOC_WW_Pin1_4	461	466	PF00397	0.648
DOC_WW_Pin1_4	493	498	PF00397	0.622
DOC_WW_Pin1_4	8	13	PF00397	0.529
DOC_WW_Pin1_4	86	91	PF00397	0.632
LIG_14-3-3_CanoR_1	243	247	PF00244	0.540
LIG_14-3-3_CanoR_1	360	367	PF00244	0.569
LIG_14-3-3_CanoR_1	418	424	PF00244	0.588
LIG_14-3-3_CanoR_1	468	472	PF00244	0.611
LIG_14-3-3_CanoR_1	476	485	PF00244	0.449
LIG_14-3-3_CanoR_1	490	498	PF00244	0.468
LIG_14-3-3_CanoR_1	512	520	PF00244	0.643
LIG_Actin_WH2_2	219	236	PF00022	0.529
LIG_CtBP_PxDLS_1	95	99	PF00389	0.544
LIG_EVH1_2	428	432	PF00568	0.652
LIG_FHA_1	125	131	PF00498	0.678
LIG_FHA_1	178	184	PF00498	0.593
LIG_FHA_1	279	285	PF00498	0.533
LIG_FHA_1	324	330	PF00498	0.577
LIG_FHA_1	386	392	PF00498	0.592
LIG_FHA_1	433	439	PF00498	0.533
LIG_FHA_1	468	474	PF00498	0.632
LIG_FHA_1	83	89	PF00498	0.592
LIG_FHA_2	150	156	PF00498	0.495
LIG_FHA_2	21	27	PF00498	0.602
LIG_FHA_2	311	317	PF00498	0.400
LIG_FHA_2	335	341	PF00498	0.659
LIG_GBD_Chelix_1	140	148	PF00786	0.566
LIG_LIR_Gen_1	101	110	PF02991	0.588
LIG_LIR_Gen_1	519	523	PF02991	0.669
LIG_LIR_LC3C_4	89	94	PF02991	0.469
LIG_LIR_Nem_3	519	523	PF02991	0.696
LIG_PDZ_Class_1	518	523	PF00595	0.515
LIG_SH2_CRK	202	206	PF00017	0.619
LIG_SH2_STAT3	375	378	PF00017	0.663
LIG_SH2_STAT5	136	139	PF00017	0.476
LIG_SH2_STAT5	47	50	PF00017	0.516
LIG_SH3_3	116	122	PF00018	0.532
LIG_SH3_3	25	31	PF00018	0.501
LIG_SH3_3	435	441	PF00018	0.664
LIG_SH3_3	9	15	PF00018	0.536
LIG_SH3_3	90	96	PF00018	0.448
LIG_SUMO_SIM_anti_2	228	235	PF11976	0.524
LIG_TRAF2_1	23	26	PF00917	0.545
LIG_TRAF2_1	236	239	PF00917	0.439
LIG_TRAF2_1	398	401	PF00917	0.557
MOD_CDK_SPxxK_3	267	274	PF00069	0.556
MOD_CDK_SPxxK_3	461	468	PF00069	0.631
MOD_CDK_SPxxK_3	493	500	PF00069	0.509
MOD_CK1_1	164	170	PF00069	0.622
MOD_CK1_1	204	210	PF00069	0.557
MOD_CK1_1	211	217	PF00069	0.652
MOD_CK1_1	29	35	PF00069	0.632
MOD_CK1_1	434	440	PF00069	0.813
MOD_CK1_1	459	465	PF00069	0.652
MOD_CK1_1	505	511	PF00069	0.631
MOD_CK1_1	7	13	PF00069	0.581
MOD_CK2_1	149	155	PF00069	0.525
MOD_CK2_1	20	26	PF00069	0.604
MOD_CK2_1	310	316	PF00069	0.495
MOD_CK2_1	334	340	PF00069	0.657
MOD_CK2_1	43	49	PF00069	0.478
MOD_CK2_1	489	495	PF00069	0.515
MOD_DYRK1A_RPxSP_1	267	271	PF00069	0.508
MOD_GlcNHglycan	121	125	PF01048	0.652
MOD_GlcNHglycan	186	189	PF01048	0.724
MOD_GlcNHglycan	197	200	PF01048	0.513
MOD_GlcNHglycan	208	211	PF01048	0.638
MOD_GlcNHglycan	459	462	PF01048	0.657
MOD_GlcNHglycan	478	481	PF01048	0.582
MOD_GlcNHglycan	491	494	PF01048	0.727
MOD_GlcNHglycan	514	517	PF01048	0.659
MOD_GlcNHglycan	7	10	PF01048	0.590
MOD_GSK3_1	1	8	PF00069	0.597
MOD_GSK3_1	120	127	PF00069	0.595
MOD_GSK3_1	160	167	PF00069	0.638
MOD_GSK3_1	204	211	PF00069	0.605
MOD_GSK3_1	217	224	PF00069	0.481
MOD_GSK3_1	238	245	PF00069	0.566
MOD_GSK3_1	27	34	PF00069	0.574
MOD_GSK3_1	274	281	PF00069	0.602
MOD_GSK3_1	350	357	PF00069	0.646
MOD_GSK3_1	455	462	PF00069	0.667
MOD_GSK3_1	489	496	PF00069	0.712
MOD_GSK3_1	507	514	PF00069	0.623
MOD_GSK3_1	82	89	PF00069	0.566
MOD_LATS_1	182	188	PF00433	0.558
MOD_LATS_1	474	480	PF00433	0.583
MOD_N-GLC_1	5	10	PF02516	0.600
MOD_NEK2_1	110	115	PF00069	0.572
MOD_NEK2_1	201	206	PF00069	0.566
MOD_NEK2_1	345	350	PF00069	0.588
MOD_NEK2_1	43	48	PF00069	0.529
MOD_NEK2_1	432	437	PF00069	0.614
MOD_NEK2_2	260	265	PF00069	0.580
MOD_NEK2_2	368	373	PF00069	0.499
MOD_OFUCOSY	275	280	PF10250	0.574
MOD_PIKK_1	238	244	PF00454	0.528
MOD_PIKK_1	310	316	PF00454	0.461
MOD_PIKK_1	317	323	PF00454	0.473
MOD_PIKK_1	499	505	PF00454	0.669
MOD_PKA_1	512	518	PF00069	0.802
MOD_PKA_2	124	130	PF00069	0.633
MOD_PKA_2	242	248	PF00069	0.710
MOD_PKA_2	351	357	PF00069	0.607
MOD_PKA_2	359	365	PF00069	0.654
MOD_PKA_2	467	473	PF00069	0.608
MOD_PKA_2	475	481	PF00069	0.451
MOD_PKA_2	489	495	PF00069	0.596
MOD_PKA_2	499	505	PF00069	0.510
MOD_PKA_2	511	517	PF00069	0.644
MOD_PKA_2	66	72	PF00069	0.561
MOD_Plk_1	260	266	PF00069	0.506
MOD_Plk_1	368	374	PF00069	0.500
MOD_Plk_2-3	155	161	PF00069	0.503
MOD_Plk_4	201	207	PF00069	0.640
MOD_Plk_4	368	374	PF00069	0.504
MOD_Plk_4	43	49	PF00069	0.533
MOD_Plk_4	73	79	PF00069	0.489
MOD_Plk_4	88	94	PF00069	0.426
MOD_ProDKin_1	182	188	PF00069	0.608
MOD_ProDKin_1	211	217	PF00069	0.749
MOD_ProDKin_1	250	256	PF00069	0.620
MOD_ProDKin_1	267	273	PF00069	0.608
MOD_ProDKin_1	27	33	PF00069	0.584
MOD_ProDKin_1	274	280	PF00069	0.632
MOD_ProDKin_1	461	467	PF00069	0.645
MOD_ProDKin_1	493	499	PF00069	0.621
MOD_ProDKin_1	8	14	PF00069	0.529
MOD_ProDKin_1	86	92	PF00069	0.629
MOD_SUMO_for_1	105	108	PF00179	0.601
TRG_DiLeu_BaEn_1	228	233	PF01217	0.507
TRG_ENDOCYTIC_2	102	105	PF00928	0.612
TRG_ENDOCYTIC_2	202	205	PF00928	0.642
TRG_ER_diArg_1	264	267	PF00400	0.565
TRG_ER_diArg_1	467	469	PF00400	0.718
TRG_Pf-PMV_PEXEL_1	299	303	PF00026	0.444

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7S4	Leptomonas seymouri	42%	99%
A0A3Q8IHY9	Leishmania donovani	70%	100%
A4I3D3	Leishmania infantum	71%	100%
E9AZM0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	70%	100%
Q4Q8L1	Leishmania major	69%	100%