VPS37 C-terminal domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HG97_LEIBR

TriTrypDb:

LbrM.28.0590 , LBRM2903_280011400

Length:

286

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 10
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0000813	ESCRT I complex	3	12
GO:0032991	protein-containing complex	1	12
GO:0036452	ESCRT complex	2	12
GO:0098796	membrane protein complex	2	12

Expansion

Sequence features

A4HG97

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HG97

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	12
GO:0008104	protein localization	4	12
GO:0008152	metabolic process	1	12
GO:0009056	catabolic process	2	12
GO:0009987	cellular process	1	12
GO:0015031	protein transport	4	12
GO:0033036	macromolecule localization	2	12
GO:0044237	cellular metabolic process	2	12
GO:0044248	cellular catabolic process	3	12
GO:0045184	establishment of protein localization	3	12
GO:0051179	localization	1	12
GO:0051234	establishment of localization	2	12
GO:0051641	cellular localization	2	12
GO:0070727	cellular macromolecule localization	3	12
GO:0071702	organic substance transport	4	12
GO:0071705	nitrogen compound transport	4	12

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	13	15	PF00675	0.559
CLV_NRD_NRD_1	158	160	PF00675	0.484
CLV_NRD_NRD_1	230	232	PF00675	0.473
CLV_PCSK_KEX2_1	13	15	PF00082	0.556
CLV_PCSK_KEX2_1	242	244	PF00082	0.379
CLV_PCSK_KEX2_1	275	277	PF00082	0.439
CLV_PCSK_PC1ET2_1	242	244	PF00082	0.414
CLV_PCSK_PC1ET2_1	275	277	PF00082	0.455
CLV_PCSK_SKI1_1	102	106	PF00082	0.518
DEG_SPOP_SBC_1	92	96	PF00917	0.328
DOC_CKS1_1	216	221	PF01111	0.392
DOC_CKS1_1	74	79	PF01111	0.547
DOC_MAPK_gen_1	231	240	PF00069	0.376
DOC_USP7_MATH_1	17	21	PF00917	0.540
DOC_USP7_UBL2_3	156	160	PF12436	0.223
DOC_USP7_UBL2_3	263	267	PF12436	0.401
DOC_USP7_UBL2_3	59	63	PF12436	0.458
DOC_WW_Pin1_4	215	220	PF00397	0.362
DOC_WW_Pin1_4	37	42	PF00397	0.551
DOC_WW_Pin1_4	73	78	PF00397	0.493
LIG_14-3-3_CanoR_1	163	172	PF00244	0.437
LIG_14-3-3_CanoR_1	276	280	PF00244	0.557
LIG_FHA_1	122	128	PF00498	0.553
LIG_FHA_1	129	135	PF00498	0.519
LIG_FHA_1	17	23	PF00498	0.584
LIG_FHA_1	92	98	PF00498	0.501
LIG_FHA_2	163	169	PF00498	0.369
LIG_FHA_2	223	229	PF00498	0.469
LIG_FHA_2	94	100	PF00498	0.508
LIG_IRF3_LxIS_1	33	40	PF10401	0.459
LIG_LIR_Gen_1	254	262	PF02991	0.358
LIG_LIR_Gen_1	48	58	PF02991	0.425
LIG_LIR_Nem_3	110	115	PF02991	0.502
LIG_LIR_Nem_3	254	258	PF02991	0.358
LIG_LIR_Nem_3	48	53	PF02991	0.409
LIG_PCNA_yPIPBox_3	151	163	PF02747	0.475
LIG_SH2_CRK	150	154	PF00017	0.344
LIG_SH2_PTP2	50	53	PF00017	0.431
LIG_SH2_STAP1	45	49	PF00017	0.426
LIG_SH2_STAT3	148	151	PF00017	0.344
LIG_SH2_STAT3	262	265	PF00017	0.410
LIG_SH2_STAT3	279	282	PF00017	0.528
LIG_SH2_STAT5	148	151	PF00017	0.449
LIG_SH2_STAT5	50	53	PF00017	0.413
LIG_SH2_STAT5	68	71	PF00017	0.355
LIG_SH3_3	111	117	PF00018	0.481
LIG_SH3_3	136	142	PF00018	0.385
LIG_SH3_3	213	219	PF00018	0.410
LIG_SH3_3	48	54	PF00018	0.424
LIG_SH3_3	71	77	PF00018	0.561
LIG_TRAF2_1	25	28	PF00917	0.600
LIG_UBA3_1	271	275	PF00899	0.399
MOD_CK1_1	119	125	PF00069	0.509
MOD_CK1_1	128	134	PF00069	0.474
MOD_CK1_1	162	168	PF00069	0.385
MOD_CK1_1	20	26	PF00069	0.520
MOD_CK1_1	215	221	PF00069	0.385
MOD_CK1_1	91	97	PF00069	0.539
MOD_CK2_1	162	168	PF00069	0.417
MOD_CK2_1	22	28	PF00069	0.489
MOD_CK2_1	93	99	PF00069	0.524
MOD_Cter_Amidation	240	243	PF01082	0.446
MOD_GlcNHglycan	127	130	PF01048	0.578
MOD_GlcNHglycan	24	27	PF01048	0.546
MOD_GSK3_1	121	128	PF00069	0.544
MOD_GSK3_1	16	23	PF00069	0.511
MOD_GSK3_1	211	218	PF00069	0.312
MOD_GSK3_1	45	52	PF00069	0.487
MOD_GSK3_1	88	95	PF00069	0.582
MOD_N-GLC_1	175	180	PF02516	0.449
MOD_NEK2_1	212	217	PF00069	0.354
MOD_NEK2_1	49	54	PF00069	0.426
MOD_NEK2_2	45	50	PF00069	0.477
MOD_PIKK_1	199	205	PF00454	0.449
MOD_PKA_1	159	165	PF00069	0.223
MOD_PKA_1	231	237	PF00069	0.456
MOD_PKA_1	275	281	PF00069	0.562
MOD_PKA_2	162	168	PF00069	0.453
MOD_PKA_2	275	281	PF00069	0.562
MOD_Plk_1	174	180	PF00069	0.409
MOD_Plk_2-3	182	188	PF00069	0.463
MOD_Plk_4	17	23	PF00069	0.496
MOD_Plk_4	26	32	PF00069	0.431
MOD_Plk_4	45	51	PF00069	0.204
MOD_Plk_4	93	99	PF00069	0.468
MOD_ProDKin_1	215	221	PF00069	0.362
MOD_ProDKin_1	37	43	PF00069	0.549
MOD_ProDKin_1	73	79	PF00069	0.503
MOD_SUMO_rev_2	182	190	PF00179	0.223
MOD_SUMO_rev_2	268	277	PF00179	0.203
TRG_DiLeu_BaEn_1	130	135	PF01217	0.575
TRG_DiLeu_BaLyEn_6	208	213	PF01217	0.213
TRG_DiLeu_LyEn_5	130	135	PF01217	0.575
TRG_ENDOCYTIC_2	50	53	PF00928	0.403
TRG_ER_diArg_1	12	14	PF00400	0.539
TRG_Pf-PMV_PEXEL_1	133	137	PF00026	0.449

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1Q4	Leptomonas seymouri	78%	100%
A0A0S4JBQ7	Bodo saltans	30%	100%
A0A1X0NYI9	Trypanosomatidae	42%	100%
A0A3S7X186	Leishmania donovani	86%	100%
A0A422P1P4	Trypanosoma rangeli	38%	100%
A4I3D0	Leishmania infantum	86%	100%
D0A814	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9AZL7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4Q8L4	Leishmania major	85%	100%
V5DH66	Trypanosoma cruzi	41%	93%