MHD1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HG91_LEIBR

TriTrypDb:

LbrM.28.0530 , LBRM2903_280010800

Length:

385

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HG91

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HG91

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	207	209	PF00675	0.499
CLV_NRD_NRD_1	226	228	PF00675	0.390
CLV_NRD_NRD_1	272	274	PF00675	0.503
CLV_NRD_NRD_1	280	282	PF00675	0.323
CLV_PCSK_FUR_1	355	359	PF00082	0.504
CLV_PCSK_KEX2_1	207	209	PF00082	0.273
CLV_PCSK_KEX2_1	226	228	PF00082	0.390
CLV_PCSK_KEX2_1	272	274	PF00082	0.413
CLV_PCSK_KEX2_1	357	359	PF00082	0.483
CLV_PCSK_PC1ET2_1	357	359	PF00082	0.483
CLV_PCSK_SKI1_1	141	145	PF00082	0.436
CLV_PCSK_SKI1_1	281	285	PF00082	0.470
CLV_PCSK_SKI1_1	357	361	PF00082	0.465
CLV_PCSK_SKI1_1	60	64	PF00082	0.360
DEG_Nend_UBRbox_2	1	3	PF02207	0.512
DEG_SPOP_SBC_1	28	32	PF00917	0.522
DOC_CDC14_PxL_1	297	305	PF14671	0.511
DOC_CDC14_PxL_1	332	340	PF14671	0.528
DOC_CYCLIN_RxL_1	354	364	PF00134	0.525
DOC_MAPK_DCC_7	150	160	PF00069	0.321
DOC_MAPK_gen_1	176	186	PF00069	0.402
DOC_MAPK_gen_1	207	213	PF00069	0.497
DOC_MAPK_gen_1	281	288	PF00069	0.358
DOC_MAPK_gen_1	325	332	PF00069	0.509
DOC_PP4_FxxP_1	315	318	PF00568	0.466
DOC_PP4_MxPP_1	316	319	PF00568	0.503
DOC_USP7_MATH_1	106	110	PF00917	0.369
DOC_WW_Pin1_4	160	165	PF00397	0.546
DOC_WW_Pin1_4	6	11	PF00397	0.461
LIG_14-3-3_CanoR_1	145	152	PF00244	0.501
LIG_14-3-3_CanoR_1	18	24	PF00244	0.497
LIG_14-3-3_CanoR_1	182	187	PF00244	0.222
LIG_14-3-3_CanoR_1	226	232	PF00244	0.494
LIG_14-3-3_CanoR_1	281	286	PF00244	0.351
LIG_14-3-3_CanoR_1	287	292	PF00244	0.399
LIG_14-3-3_CanoR_1	327	331	PF00244	0.589
LIG_14-3-3_CanoR_1	337	343	PF00244	0.359
LIG_14-3-3_CanoR_1	358	367	PF00244	0.472
LIG_Actin_WH2_2	212	228	PF00022	0.349
LIG_BRCT_BRCA1_1	236	240	PF00533	0.293
LIG_Clathr_ClatBox_1	76	80	PF01394	0.312
LIG_deltaCOP1_diTrp_1	137	147	PF00928	0.362
LIG_FHA_1	155	161	PF00498	0.533
LIG_FHA_1	189	195	PF00498	0.460
LIG_FHA_1	327	333	PF00498	0.520
LIG_FHA_2	293	299	PF00498	0.384
LIG_FHA_2	318	324	PF00498	0.592
LIG_FHA_2	349	355	PF00498	0.361
LIG_LIR_Apic_2	312	318	PF02991	0.448
LIG_LIR_Nem_3	101	107	PF02991	0.371
LIG_LIR_Nem_3	137	143	PF02991	0.373
LIG_LIR_Nem_3	2	6	PF02991	0.571
LIG_LYPXL_SIV_4	106	114	PF13949	0.414
LIG_NRBOX	110	116	PF00104	0.435
LIG_NRBOX	261	267	PF00104	0.322
LIG_NRBOX	72	78	PF00104	0.317
LIG_Pex14_2	377	381	PF04695	0.411
LIG_Pex14_2	58	62	PF04695	0.431
LIG_Rb_pABgroove_1	371	379	PF01858	0.512
LIG_SH2_CRK	3	7	PF00017	0.332
LIG_SH2_SRC	121	124	PF00017	0.468
LIG_SH2_STAP1	107	111	PF00017	0.313
LIG_SH2_STAP1	121	125	PF00017	0.337
LIG_SH2_STAT3	167	170	PF00017	0.537
LIG_SH2_STAT5	104	107	PF00017	0.357
LIG_SH2_STAT5	138	141	PF00017	0.333
LIG_SH2_STAT5	167	170	PF00017	0.537
LIG_SH2_STAT5	277	280	PF00017	0.395
LIG_SH3_3	248	254	PF00018	0.373
LIG_SH3_3	339	345	PF00018	0.451
LIG_SUMO_SIM_anti_2	130	137	PF11976	0.322
LIG_SUMO_SIM_anti_2	191	198	PF11976	0.270
LIG_SUMO_SIM_anti_2	75	80	PF11976	0.318
LIG_SUMO_SIM_par_1	130	137	PF11976	0.339
LIG_SUMO_SIM_par_1	156	163	PF11976	0.351
LIG_SUMO_SIM_par_1	328	333	PF11976	0.513
LIG_TRAF2_1	309	312	PF00917	0.399
LIG_WRC_WIRS_1	20	25	PF05994	0.508
LIG_WRC_WIRS_1	59	64	PF05994	0.462
MOD_CK1_1	361	367	PF00069	0.541
MOD_CK2_1	21	27	PF00069	0.518
MOD_CK2_1	311	317	PF00069	0.458
MOD_CK2_1	348	354	PF00069	0.325
MOD_GlcNHglycan	199	202	PF01048	0.477
MOD_GlcNHglycan	2	6	PF01048	0.361
MOD_GlcNHglycan	227	230	PF01048	0.545
MOD_GlcNHglycan	236	239	PF01048	0.524
MOD_GSK3_1	141	148	PF00069	0.292
MOD_GSK3_1	150	157	PF00069	0.497
MOD_GSK3_1	361	368	PF00069	0.490
MOD_N-GLC_1	150	155	PF02516	0.458
MOD_N-GLC_1	292	297	PF02516	0.377
MOD_N-GLC_2	44	46	PF02516	0.362
MOD_NEK2_1	1	6	PF00069	0.373
MOD_NEK2_1	225	230	PF00069	0.537
MOD_NEK2_1	292	297	PF00069	0.376
MOD_NEK2_1	326	331	PF00069	0.501
MOD_NEK2_1	58	63	PF00069	0.450
MOD_NEK2_2	13	18	PF00069	0.477
MOD_PIKK_1	245	251	PF00454	0.538
MOD_PIKK_1	275	281	PF00454	0.396
MOD_PK_1	182	188	PF00069	0.206
MOD_PK_1	21	27	PF00069	0.306
MOD_PKA_1	281	287	PF00069	0.427
MOD_PKA_2	225	231	PF00069	0.478
MOD_PKA_2	326	332	PF00069	0.624
MOD_Plk_1	13	19	PF00069	0.449
MOD_Plk_1	292	298	PF00069	0.383
MOD_Plk_1	311	317	PF00069	0.323
MOD_Plk_2-3	311	317	PF00069	0.520
MOD_Plk_4	106	112	PF00069	0.390
MOD_Plk_4	236	242	PF00069	0.519
MOD_Plk_4	292	298	PF00069	0.383
MOD_Plk_4	311	317	PF00069	0.323
MOD_Plk_4	326	332	PF00069	0.493
MOD_Plk_4	58	64	PF00069	0.500
MOD_Plk_4	98	104	PF00069	0.441
MOD_ProDKin_1	160	166	PF00069	0.541
MOD_ProDKin_1	6	12	PF00069	0.459
MOD_SUMO_rev_2	317	326	PF00179	0.499
TRG_DiLeu_BaEn_2	310	316	PF01217	0.432
TRG_DiLeu_BaLyEn_6	355	360	PF01217	0.500
TRG_ENDOCYTIC_2	107	110	PF00928	0.329
TRG_ENDOCYTIC_2	121	124	PF00928	0.401
TRG_ENDOCYTIC_2	3	6	PF00928	0.345
TRG_ER_diArg_1	206	208	PF00400	0.266
TRG_ER_diArg_1	225	227	PF00400	0.366
TRG_ER_diArg_1	286	289	PF00400	0.353
TRG_ER_diArg_1	82	85	PF00400	0.349
TRG_NES_CRM1_1	67	80	PF08389	0.324
TRG_Pf-PMV_PEXEL_1	289	294	PF00026	0.406
TRG_Pf-PMV_PEXEL_1	308	312	PF00026	0.258
TRG_Pf-PMV_PEXEL_1	358	362	PF00026	0.523

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB59	Leptomonas seymouri	75%	97%
A0A0S4JB68	Bodo saltans	51%	93%
A0A1X0NYX9	Trypanosomatidae	56%	94%
A0A3Q8IEP5	Leishmania donovani	86%	100%
A0A422P1Q9	Trypanosoma rangeli	56%	99%
A4I3C5	Leishmania infantum	86%	100%
D0A821	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	97%
E9AZL2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
F1QN74	Danio rerio	27%	86%
O75800	Homo sapiens	32%	88%
Q4Q8L9	Leishmania major	87%	100%
Q5FWU8	Xenopus laevis	34%	88%
Q6AXZ5	Rattus norvegicus	32%	88%
Q99ML0	Mus musculus	33%	88%
Q9VU41	Drosophila melanogaster	31%	85%
V5B0T6	Trypanosoma cruzi	55%	98%