LeishMANIAdb
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TPR_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
TPR_REGION domain-containing protein
Gene product:
TPR repeat, putative
Species:
Leishmania braziliensis
UniProt:
A4HG90_LEIBR
TriTrypDb:
LbrM.28.0520 , LBRM2903_280010700
Length:
713

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 1, no: 10
NetGPI no yes: 0, no: 11
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HG90
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HG90

Function

Biological processes
Term Name Level Count
GO:0006457 protein folding 2 12
GO:0009987 cellular process 1 12
Molecular functions
Term Name Level Count
GO:0005488 binding 1 12
GO:0005515 protein binding 2 12
GO:0030544 Hsp70 protein binding 4 12
GO:0031072 heat shock protein binding 3 12
GO:0051879 Hsp90 protein binding 4 12

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 209 211 PF00675 0.467
CLV_NRD_NRD_1 217 219 PF00675 0.411
CLV_NRD_NRD_1 550 552 PF00675 0.592
CLV_NRD_NRD_1 86 88 PF00675 0.528
CLV_PCSK_FUR_1 333 337 PF00082 0.567
CLV_PCSK_KEX2_1 208 210 PF00082 0.507
CLV_PCSK_KEX2_1 217 219 PF00082 0.452
CLV_PCSK_KEX2_1 225 227 PF00082 0.439
CLV_PCSK_KEX2_1 335 337 PF00082 0.540
CLV_PCSK_KEX2_1 550 552 PF00082 0.585
CLV_PCSK_KEX2_1 85 87 PF00082 0.554
CLV_PCSK_PC1ET2_1 225 227 PF00082 0.595
CLV_PCSK_PC1ET2_1 335 337 PF00082 0.609
CLV_PCSK_SKI1_1 135 139 PF00082 0.484
CLV_PCSK_SKI1_1 292 296 PF00082 0.438
CLV_PCSK_SKI1_1 318 322 PF00082 0.488
CLV_PCSK_SKI1_1 415 419 PF00082 0.529
CLV_PCSK_SKI1_1 551 555 PF00082 0.516
DEG_APCC_DBOX_1 134 142 PF00400 0.713
DEG_APCC_DBOX_1 607 615 PF00400 0.351
DEG_COP1_1 22 30 PF00400 0.714
DOC_ANK_TNKS_1 641 648 PF00023 0.547
DOC_CYCLIN_RxL_1 315 325 PF00134 0.493
DOC_CYCLIN_RxL_1 412 420 PF00134 0.596
DOC_CYCLIN_yCln2_LP_2 151 157 PF00134 0.697
DOC_MAPK_gen_1 333 342 PF00069 0.496
DOC_MAPK_gen_1 459 468 PF00069 0.544
DOC_MAPK_gen_1 550 558 PF00069 0.462
DOC_MAPK_gen_1 587 595 PF00069 0.418
DOC_MAPK_gen_1 606 613 PF00069 0.502
DOC_MAPK_JIP1_4 153 159 PF00069 0.487
DOC_PP1_RVXF_1 57 64 PF00149 0.645
DOC_PP2B_LxvP_1 638 641 PF13499 0.470
DOC_PP4_FxxP_1 81 84 PF00568 0.668
DOC_USP7_MATH_1 178 182 PF00917 0.692
DOC_USP7_MATH_1 278 282 PF00917 0.515
DOC_USP7_MATH_1 429 433 PF00917 0.536
DOC_USP7_MATH_1 67 71 PF00917 0.669
DOC_USP7_UBL2_3 335 339 PF12436 0.597
DOC_WW_Pin1_4 176 181 PF00397 0.616
DOC_WW_Pin1_4 491 496 PF00397 0.631
DOC_WW_Pin1_4 616 621 PF00397 0.680
DOC_WW_Pin1_4 625 630 PF00397 0.559
LIG_14-3-3_CanoR_1 110 116 PF00244 0.566
LIG_14-3-3_CanoR_1 117 123 PF00244 0.579
LIG_14-3-3_CanoR_1 129 138 PF00244 0.480
LIG_14-3-3_CanoR_1 208 213 PF00244 0.514
LIG_14-3-3_CanoR_1 248 257 PF00244 0.507
LIG_14-3-3_CanoR_1 505 515 PF00244 0.494
LIG_14-3-3_CanoR_1 522 528 PF00244 0.472
LIG_14-3-3_CanoR_1 606 614 PF00244 0.557
LIG_14-3-3_CanoR_1 690 695 PF00244 0.553
LIG_APCC_ABBA_1 340 345 PF00400 0.334
LIG_APCC_ABBA_1 578 583 PF00400 0.518
LIG_APCC_ABBAyCdc20_2 339 345 PF00400 0.337
LIG_BRCT_BRCA1_1 370 374 PF00533 0.501
LIG_BRCT_BRCA1_1 564 568 PF00533 0.548
LIG_FHA_1 218 224 PF00498 0.516
LIG_FHA_1 285 291 PF00498 0.476
LIG_FHA_1 412 418 PF00498 0.544
LIG_FHA_1 502 508 PF00498 0.509
LIG_FHA_1 575 581 PF00498 0.487
LIG_FHA_1 646 652 PF00498 0.557
LIG_FHA_1 96 102 PF00498 0.495
LIG_FHA_2 161 167 PF00498 0.759
LIG_FHA_2 168 174 PF00498 0.746
LIG_FHA_2 613 619 PF00498 0.653
LIG_FHA_2 666 672 PF00498 0.696
LIG_FHA_2 679 685 PF00498 0.580
LIG_LIR_Apic_2 78 84 PF02991 0.657
LIG_LIR_Gen_1 106 116 PF02991 0.333
LIG_LIR_Gen_1 128 138 PF02991 0.712
LIG_LIR_Gen_1 559 568 PF02991 0.422
LIG_LIR_Gen_1 577 585 PF02991 0.345
LIG_LIR_Gen_1 60 67 PF02991 0.664
LIG_LIR_Gen_1 94 105 PF02991 0.483
LIG_LIR_Nem_3 106 111 PF02991 0.343
LIG_LIR_Nem_3 128 134 PF02991 0.711
LIG_LIR_Nem_3 211 215 PF02991 0.540
LIG_LIR_Nem_3 371 377 PF02991 0.467
LIG_LIR_Nem_3 559 564 PF02991 0.409
LIG_LIR_Nem_3 577 581 PF02991 0.356
LIG_LIR_Nem_3 598 603 PF02991 0.423
LIG_LIR_Nem_3 60 66 PF02991 0.605
LIG_LIR_Nem_3 70 76 PF02991 0.498
LIG_LIR_Nem_3 704 710 PF02991 0.611
LIG_LIR_Nem_3 94 100 PF02991 0.489
LIG_RPA_C_Fungi 248 260 PF08784 0.525
LIG_SH2_CRK 131 135 PF00017 0.708
LIG_SH2_CRK 561 565 PF00017 0.437
LIG_SH2_CRK 97 101 PF00017 0.468
LIG_SH2_GRB2like 234 237 PF00017 0.532
LIG_SH2_NCK_1 344 348 PF00017 0.487
LIG_SH2_SRC 344 347 PF00017 0.547
LIG_SH2_STAP1 304 308 PF00017 0.404
LIG_SH2_STAP1 344 348 PF00017 0.582
LIG_SH2_STAP1 97 101 PF00017 0.475
LIG_SH2_STAT5 257 260 PF00017 0.478
LIG_SH2_STAT5 284 287 PF00017 0.384
LIG_SH2_STAT5 438 441 PF00017 0.405
LIG_SH2_STAT5 476 479 PF00017 0.441
LIG_SH2_STAT5 97 100 PF00017 0.479
LIG_SH3_3 25 31 PF00018 0.640
LIG_SH3_3 39 45 PF00018 0.460
LIG_SH3_3 421 427 PF00018 0.473
LIG_SUMO_SIM_anti_2 609 615 PF11976 0.546
LIG_TRAF2_1 238 241 PF00917 0.538
LIG_TRAF2_1 243 246 PF00917 0.571
LIG_TRAF2_1 485 488 PF00917 0.622
LIG_TRAF2_1 529 532 PF00917 0.615
LIG_TRAF2_1 698 701 PF00917 0.668
LIG_TRFH_1 17 21 PF08558 0.509
LIG_WRC_WIRS_1 679 684 PF05994 0.599
MOD_CK1_1 133 139 PF00069 0.655
MOD_CK1_1 186 192 PF00069 0.690
MOD_CK1_1 193 199 PF00069 0.685
MOD_CK1_1 211 217 PF00069 0.436
MOD_CK1_1 251 257 PF00069 0.405
MOD_CK1_1 442 448 PF00069 0.430
MOD_CK1_1 562 568 PF00069 0.545
MOD_CK1_1 570 576 PF00069 0.447
MOD_CK1_1 660 666 PF00069 0.623
MOD_CK1_1 685 691 PF00069 0.328
MOD_CK2_1 136 142 PF00069 0.739
MOD_CK2_1 160 166 PF00069 0.703
MOD_CK2_1 167 173 PF00069 0.732
MOD_CK2_1 33 39 PF00069 0.552
MOD_CK2_1 651 657 PF00069 0.476
MOD_CK2_1 665 671 PF00069 0.632
MOD_CK2_1 678 684 PF00069 0.599
MOD_CK2_1 68 74 PF00069 0.686
MOD_Cter_Amidation 223 226 PF01082 0.595
MOD_GlcNHglycan 135 138 PF01048 0.693
MOD_GlcNHglycan 180 183 PF01048 0.726
MOD_GlcNHglycan 195 198 PF01048 0.733
MOD_GlcNHglycan 202 205 PF01048 0.614
MOD_GlcNHglycan 313 316 PF01048 0.570
MOD_GlcNHglycan 377 380 PF01048 0.533
MOD_GlcNHglycan 384 387 PF01048 0.565
MOD_GlcNHglycan 684 687 PF01048 0.512
MOD_GSK3_1 125 132 PF00069 0.715
MOD_GSK3_1 160 167 PF00069 0.583
MOD_GSK3_1 183 190 PF00069 0.561
MOD_GSK3_1 518 525 PF00069 0.418
MOD_GSK3_1 556 563 PF00069 0.490
MOD_GSK3_1 566 573 PF00069 0.491
MOD_GSK3_1 612 619 PF00069 0.608
MOD_GSK3_1 657 664 PF00069 0.541
MOD_GSK3_1 665 672 PF00069 0.623
MOD_GSK3_1 678 685 PF00069 0.567
MOD_GSK3_1 91 98 PF00069 0.552
MOD_N-GLC_1 183 188 PF02516 0.649
MOD_N-GLC_1 665 670 PF02516 0.683
MOD_N-GLC_2 665 667 PF02516 0.652
MOD_NEK2_1 1 6 PF00069 0.701
MOD_NEK2_1 303 308 PF00069 0.493
MOD_NEK2_1 33 38 PF00069 0.683
MOD_NEK2_1 417 422 PF00069 0.534
MOD_NEK2_1 523 528 PF00069 0.591
MOD_NEK2_1 556 561 PF00069 0.461
MOD_NEK2_1 661 666 PF00069 0.538
MOD_NEK2_1 678 683 PF00069 0.620
MOD_NEK2_2 130 135 PF00069 0.710
MOD_NEK2_2 439 444 PF00069 0.398
MOD_PIKK_1 454 460 PF00454 0.494
MOD_PIKK_1 545 551 PF00454 0.318
MOD_PIKK_1 562 568 PF00454 0.292
MOD_PK_1 589 595 PF00069 0.453
MOD_PKA_1 208 214 PF00069 0.561
MOD_PKA_1 217 223 PF00069 0.545
MOD_PKA_2 208 214 PF00069 0.561
MOD_PKA_2 217 223 PF00069 0.545
MOD_PKA_2 249 255 PF00069 0.513
MOD_PKA_2 278 284 PF00069 0.500
MOD_PKA_2 91 97 PF00069 0.587
MOD_Plk_1 183 189 PF00069 0.514
MOD_Plk_1 68 74 PF00069 0.686
MOD_Plk_1 95 101 PF00069 0.470
MOD_Plk_2-3 574 580 PF00069 0.474
MOD_Plk_2-3 701 707 PF00069 0.385
MOD_Plk_4 111 117 PF00069 0.538
MOD_Plk_4 167 173 PF00069 0.607
MOD_Plk_4 183 189 PF00069 0.715
MOD_Plk_4 211 217 PF00069 0.393
MOD_Plk_4 523 529 PF00069 0.570
MOD_Plk_4 589 595 PF00069 0.439
MOD_Plk_4 657 663 PF00069 0.546
MOD_Plk_4 95 101 PF00069 0.474
MOD_ProDKin_1 176 182 PF00069 0.617
MOD_ProDKin_1 491 497 PF00069 0.622
MOD_ProDKin_1 616 622 PF00069 0.681
MOD_ProDKin_1 625 631 PF00069 0.549
MOD_SUMO_for_1 698 701 PF00179 0.641
MOD_SUMO_rev_2 121 125 PF00179 0.613
MOD_SUMO_rev_2 548 556 PF00179 0.312
TRG_DiLeu_BaEn_1 552 557 PF01217 0.513
TRG_DiLeu_BaEn_1 657 662 PF01217 0.536
TRG_DiLeu_BaLyEn_6 372 377 PF01217 0.325
TRG_ENDOCYTIC_2 131 134 PF00928 0.704
TRG_ENDOCYTIC_2 337 340 PF00928 0.540
TRG_ENDOCYTIC_2 537 540 PF00928 0.467
TRG_ENDOCYTIC_2 561 564 PF00928 0.377
TRG_ENDOCYTIC_2 97 100 PF00928 0.471
TRG_ER_diArg_1 208 210 PF00400 0.516
TRG_ER_diArg_1 216 218 PF00400 0.472
TRG_ER_diArg_1 459 462 PF00400 0.502
TRG_ER_diArg_1 689 692 PF00400 0.516
TRG_ER_diArg_1 84 87 PF00400 0.672
TRG_NLS_MonoExtC_3 334 339 PF00514 0.632
TRG_NLS_MonoExtN_4 333 339 PF00514 0.631
TRG_Pf-PMV_PEXEL_1 237 241 PF00026 0.544
TRG_Pf-PMV_PEXEL_1 265 269 PF00026 0.549
TRG_Pf-PMV_PEXEL_1 318 322 PF00026 0.523

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I228 Leptomonas seymouri 70% 100%
A0A0S4JB35 Bodo saltans 29% 96%
A0A1X0NZW8 Trypanosomatidae 29% 92%
A0A3Q8IAV8 Leishmania donovani 87% 100%
A0A3R7KXE4 Trypanosoma rangeli 33% 100%
A4I3C4 Leishmania infantum 87% 100%
D0A822 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 30% 97%
E9AZL1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 85% 100%
Q4Q8M0 Leishmania major 86% 100%
V5DH70 Trypanosoma cruzi 32% 95%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS