Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HG88_LEIBR

TriTrypDb:

LbrM.28.0500 , LBRM2903_280010500

Length:

220

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

A4HG88

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HG88

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	138	142	PF00656	0.573
CLV_C14_Caspase3-7	39	43	PF00656	0.408
CLV_NRD_NRD_1	200	202	PF00675	0.425
CLV_PCSK_SKI1_1	95	99	PF00082	0.598
DEG_Nend_UBRbox_4	1	3	PF02207	0.419
DEG_SPOP_SBC_1	96	100	PF00917	0.411
DOC_CKS1_1	14	19	PF01111	0.410
DOC_CKS1_1	165	170	PF01111	0.622
DOC_USP7_MATH_1	15	19	PF00917	0.511
DOC_USP7_MATH_1	163	167	PF00917	0.676
DOC_USP7_MATH_1	67	71	PF00917	0.474
DOC_USP7_MATH_2	64	70	PF00917	0.404
DOC_USP7_UBL2_3	27	31	PF12436	0.369
DOC_WW_Pin1_4	13	18	PF00397	0.523
DOC_WW_Pin1_4	164	169	PF00397	0.679
DOC_WW_Pin1_4	6	11	PF00397	0.521
LIG_FHA_1	126	132	PF00498	0.316
LIG_FHA_1	181	187	PF00498	0.634
LIG_FHA_1	89	95	PF00498	0.602
LIG_FHA_1	97	103	PF00498	0.474
LIG_FHA_2	37	43	PF00498	0.463
LIG_Pex14_1	117	121	PF04695	0.315
LIG_SH2_STAP1	25	29	PF00017	0.376
LIG_SH3_3	162	168	PF00018	0.623
LIG_SH3_3	169	175	PF00018	0.606
LIG_SUMO_SIM_anti_2	107	113	PF11976	0.395
LIG_SUMO_SIM_anti_2	128	133	PF11976	0.252
MOD_CDK_SPxxK_3	6	13	PF00069	0.463
MOD_CK1_1	107	113	PF00069	0.421
MOD_CK1_1	142	148	PF00069	0.671
MOD_CK1_1	164	170	PF00069	0.685
MOD_CK1_1	176	182	PF00069	0.692
MOD_CK1_1	200	206	PF00069	0.581
MOD_CK1_1	57	63	PF00069	0.440
MOD_CK1_1	82	88	PF00069	0.461
MOD_CK2_1	98	104	PF00069	0.390
MOD_GlcNHglycan	141	144	PF01048	0.460
MOD_GlcNHglycan	176	179	PF01048	0.487
MOD_GlcNHglycan	204	207	PF01048	0.421
MOD_GlcNHglycan	216	219	PF01048	0.383
MOD_GlcNHglycan	56	59	PF01048	0.656
MOD_GSK3_1	135	142	PF00069	0.600
MOD_GSK3_1	173	180	PF00069	0.747
MOD_GSK3_1	210	217	PF00069	0.691
MOD_GSK3_1	23	30	PF00069	0.409
MOD_GSK3_1	44	51	PF00069	0.446
MOD_GSK3_1	62	69	PF00069	0.461
MOD_GSK3_1	75	82	PF00069	0.520
MOD_GSK3_1	96	103	PF00069	0.475
MOD_N-GLC_1	27	32	PF02516	0.678
MOD_N-GLC_1	37	42	PF02516	0.651
MOD_N-GLC_1	44	49	PF02516	0.706
MOD_N-GLC_1	6	11	PF02516	0.613
MOD_N-GLC_1	79	84	PF02516	0.687
MOD_N-GLC_2	133	135	PF02516	0.395
MOD_NEK2_1	185	190	PF00069	0.646
MOD_NEK2_1	197	202	PF00069	0.625
MOD_NEK2_1	48	53	PF00069	0.453
MOD_NEK2_1	75	80	PF00069	0.525
MOD_NEK2_1	97	102	PF00069	0.517
MOD_PIKK_1	135	141	PF00454	0.433
MOD_PIKK_1	50	56	PF00454	0.442
MOD_PIKK_1	79	85	PF00454	0.405
MOD_PKA_2	200	206	PF00069	0.690
MOD_Plk_1	37	43	PF00069	0.465
MOD_Plk_1	44	50	PF00069	0.487
MOD_Plk_4	107	113	PF00069	0.426
MOD_Plk_4	125	131	PF00069	0.264
MOD_Plk_4	67	73	PF00069	0.404
MOD_ProDKin_1	13	19	PF00069	0.521
MOD_ProDKin_1	164	170	PF00069	0.676
MOD_ProDKin_1	6	12	PF00069	0.524
TRG_DiLeu_BaEn_4	104	110	PF01217	0.371
TRG_DiLeu_BaLyEn_6	181	186	PF01217	0.663

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4Z6	Leptomonas seymouri	44%	96%
A0A3Q8IQC4	Leishmania donovani	53%	97%
E9AHH3	Leishmania infantum	53%	79%
E9AZK9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	55%	100%
Q4Q8M2	Leishmania major	52%	100%