LeishMANIAdb
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Carbonic anhydrase-like protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Carbonic anhydrase-like protein
Gene product:
carbonic anhydrase-like protein
Species:
Leishmania braziliensis
UniProt:
A4HG87_LEIBR
TriTrypDb:
LbrM.28.0490 , LBRM2903_280010300 * , LBRM2903_280010400 *
Length:
615

Annotations

LeishMANIAdb annotations

Carbonic anhydrase protein (luminal). Based on its distant eukaryotic relatives, it probably has a signal peptide on its N-terminus and a membrane anchor at the C-terminus

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 5
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 8
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 6, no: 0
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0016020 membrane 2 5
GO:0110165 cellular anatomical entity 1 5

Expansion

Sequence features

A4HG87
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HG87

Function

Biological processes
Term Name Level Count
GO:0006730 one-carbon metabolic process 3 1
GO:0008152 metabolic process 1 1
GO:0009987 cellular process 1 1
GO:0044237 cellular metabolic process 2 1
GO:0044281 small molecule metabolic process 2 1
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 7
GO:0004089 carbonate dehydratase activity 5 7
GO:0005488 binding 1 7
GO:0008270 zinc ion binding 6 7
GO:0016829 lyase activity 2 7
GO:0016835 carbon-oxygen lyase activity 3 7
GO:0016836 hydro-lyase activity 4 7
GO:0043167 ion binding 2 7
GO:0043169 cation binding 3 7
GO:0046872 metal ion binding 4 7
GO:0046914 transition metal ion binding 5 7

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 283 287 PF00656 0.312
CLV_C14_Caspase3-7 422 426 PF00656 0.438
CLV_C14_Caspase3-7 429 433 PF00656 0.422
CLV_NRD_NRD_1 186 188 PF00675 0.407
CLV_NRD_NRD_1 324 326 PF00675 0.703
CLV_NRD_NRD_1 334 336 PF00675 0.653
CLV_NRD_NRD_1 576 578 PF00675 0.484
CLV_PCSK_KEX2_1 324 326 PF00082 0.673
CLV_PCSK_KEX2_1 576 578 PF00082 0.484
CLV_PCSK_SKI1_1 106 110 PF00082 0.471
CLV_PCSK_SKI1_1 188 192 PF00082 0.468
CLV_PCSK_SKI1_1 211 215 PF00082 0.405
CLV_PCSK_SKI1_1 43 47 PF00082 0.668
DEG_APCC_DBOX_1 274 282 PF00400 0.207
DEG_SCF_TRCP1_1 378 383 PF00400 0.424
DEG_SPOP_SBC_1 198 202 PF00917 0.246
DEG_SPOP_SBC_1 446 450 PF00917 0.429
DEG_SPOP_SBC_1 482 486 PF00917 0.526
DOC_CYCLIN_yCln2_LP_2 390 396 PF00134 0.425
DOC_MAPK_gen_1 165 175 PF00069 0.209
DOC_MAPK_gen_1 183 192 PF00069 0.383
DOC_MAPK_gen_1 573 581 PF00069 0.671
DOC_MAPK_MEF2A_6 168 177 PF00069 0.251
DOC_MAPK_MEF2A_6 185 194 PF00069 0.235
DOC_MAPK_MEF2A_6 548 556 PF00069 0.253
DOC_PP1_RVXF_1 93 99 PF00149 0.271
DOC_USP7_MATH_1 142 146 PF00917 0.255
DOC_USP7_MATH_1 235 239 PF00917 0.273
DOC_USP7_MATH_1 242 246 PF00917 0.264
DOC_USP7_MATH_1 320 324 PF00917 0.471
DOC_USP7_MATH_1 371 375 PF00917 0.588
DOC_USP7_MATH_1 382 386 PF00917 0.403
DOC_USP7_MATH_1 426 430 PF00917 0.489
DOC_USP7_MATH_1 444 448 PF00917 0.467
DOC_USP7_MATH_1 454 458 PF00917 0.466
DOC_USP7_MATH_1 463 467 PF00917 0.431
DOC_USP7_MATH_1 468 472 PF00917 0.420
DOC_USP7_MATH_1 49 53 PF00917 0.483
DOC_USP7_MATH_1 504 508 PF00917 0.461
DOC_USP7_MATH_1 610 614 PF00917 0.602
DOC_WW_Pin1_4 127 132 PF00397 0.207
DOC_WW_Pin1_4 266 271 PF00397 0.304
DOC_WW_Pin1_4 389 394 PF00397 0.528
DOC_WW_Pin1_4 491 496 PF00397 0.556
DOC_WW_Pin1_4 520 525 PF00397 0.437
DOC_WW_Pin1_4 72 77 PF00397 0.286
LIG_14-3-3_CanoR_1 187 193 PF00244 0.207
LIG_14-3-3_CanoR_1 222 230 PF00244 0.268
LIG_14-3-3_CanoR_1 275 279 PF00244 0.207
LIG_14-3-3_CanoR_1 300 306 PF00244 0.207
LIG_14-3-3_CanoR_1 389 393 PF00244 0.555
LIG_14-3-3_CanoR_1 553 559 PF00244 0.280
LIG_14-3-3_CanoR_1 95 105 PF00244 0.248
LIG_14-3-3_CterR_2 611 615 PF00244 0.592
LIG_Actin_WH2_2 269 284 PF00022 0.207
LIG_BIR_III_4 397 401 PF00653 0.428
LIG_BRCT_BRCA1_1 268 272 PF00533 0.205
LIG_eIF4E_1 39 45 PF01652 0.448
LIG_FHA_1 1 7 PF00498 0.444
LIG_FHA_1 187 193 PF00498 0.246
LIG_FHA_1 225 231 PF00498 0.301
LIG_FHA_1 235 241 PF00498 0.298
LIG_FHA_1 257 263 PF00498 0.373
LIG_FHA_1 266 272 PF00498 0.216
LIG_FHA_1 385 391 PF00498 0.429
LIG_FHA_1 39 45 PF00498 0.404
LIG_FHA_1 508 514 PF00498 0.438
LIG_FHA_1 532 538 PF00498 0.487
LIG_FHA_1 602 608 PF00498 0.680
LIG_FHA_2 136 142 PF00498 0.296
LIG_FHA_2 176 182 PF00498 0.207
LIG_LIR_Gen_1 121 131 PF02991 0.296
LIG_LIR_Gen_1 292 301 PF02991 0.257
LIG_LIR_Gen_1 526 537 PF02991 0.353
LIG_LIR_Gen_1 55 65 PF02991 0.351
LIG_LIR_Gen_1 78 87 PF02991 0.268
LIG_LIR_Nem_3 121 127 PF02991 0.296
LIG_LIR_Nem_3 148 154 PF02991 0.332
LIG_LIR_Nem_3 161 167 PF02991 0.221
LIG_LIR_Nem_3 244 249 PF02991 0.296
LIG_LIR_Nem_3 292 296 PF02991 0.257
LIG_LIR_Nem_3 515 520 PF02991 0.474
LIG_LIR_Nem_3 526 532 PF02991 0.365
LIG_LIR_Nem_3 55 61 PF02991 0.355
LIG_LIR_Nem_3 595 601 PF02991 0.590
LIG_LIR_Nem_3 63 67 PF02991 0.277
LIG_LIR_Nem_3 78 82 PF02991 0.281
LIG_PDZ_Class_1 610 615 PF00595 0.591
LIG_Pex14_2 531 535 PF04695 0.306
LIG_SH2_CRK 58 62 PF00017 0.383
LIG_SH2_GRB2like 58 61 PF00017 0.334
LIG_SH2_NCK_1 546 550 PF00017 0.398
LIG_SH2_STAT5 246 249 PF00017 0.268
LIG_SH2_STAT5 580 583 PF00017 0.675
LIG_SH3_2 495 500 PF14604 0.440
LIG_SH3_2 606 611 PF14604 0.583
LIG_SH3_3 136 142 PF00018 0.312
LIG_SH3_3 402 408 PF00018 0.441
LIG_SH3_3 492 498 PF00018 0.493
LIG_SH3_3 588 594 PF00018 0.644
LIG_SH3_3 603 609 PF00018 0.585
LIG_SUMO_SIM_anti_2 191 196 PF11976 0.205
LIG_SUMO_SIM_par_1 391 397 PF11976 0.425
LIG_WRC_WIRS_1 532 537 PF05994 0.302
MOD_CDK_SPxxK_3 520 527 PF00069 0.346
MOD_CK1_1 135 141 PF00069 0.233
MOD_CK1_1 145 151 PF00069 0.239
MOD_CK1_1 176 182 PF00069 0.268
MOD_CK1_1 199 205 PF00069 0.262
MOD_CK1_1 206 212 PF00069 0.258
MOD_CK1_1 274 280 PF00069 0.267
MOD_CK1_1 353 359 PF00069 0.426
MOD_CK1_1 374 380 PF00069 0.507
MOD_CK1_1 431 437 PF00069 0.548
MOD_CK1_1 447 453 PF00069 0.455
MOD_CK1_1 462 468 PF00069 0.475
MOD_CK1_1 469 475 PF00069 0.574
MOD_CK1_1 477 483 PF00069 0.505
MOD_CK1_1 484 490 PF00069 0.491
MOD_CK1_1 505 511 PF00069 0.513
MOD_CK1_1 52 58 PF00069 0.379
MOD_CK1_1 523 529 PF00069 0.395
MOD_CK1_1 72 78 PF00069 0.290
MOD_CK2_1 176 182 PF00069 0.207
MOD_CK2_1 30 36 PF00069 0.496
MOD_GlcNHglycan 297 300 PF01048 0.425
MOD_GlcNHglycan 339 342 PF01048 0.610
MOD_GlcNHglycan 343 346 PF01048 0.628
MOD_GlcNHglycan 352 355 PF01048 0.651
MOD_GlcNHglycan 378 381 PF01048 0.726
MOD_GlcNHglycan 382 385 PF01048 0.783
MOD_GlcNHglycan 441 444 PF01048 0.718
MOD_GlcNHglycan 452 455 PF01048 0.649
MOD_GlcNHglycan 461 464 PF01048 0.644
MOD_GlcNHglycan 470 474 PF01048 0.734
MOD_GlcNHglycan 50 54 PF01048 0.644
MOD_GlcNHglycan 514 517 PF01048 0.639
MOD_GlcNHglycan 89 92 PF01048 0.451
MOD_GSK3_1 145 152 PF00069 0.296
MOD_GSK3_1 197 204 PF00069 0.275
MOD_GSK3_1 337 344 PF00069 0.414
MOD_GSK3_1 346 353 PF00069 0.473
MOD_GSK3_1 374 381 PF00069 0.516
MOD_GSK3_1 384 391 PF00069 0.593
MOD_GSK3_1 431 438 PF00069 0.630
MOD_GSK3_1 444 451 PF00069 0.449
MOD_GSK3_1 459 466 PF00069 0.448
MOD_GSK3_1 477 484 PF00069 0.571
MOD_GSK3_1 485 492 PF00069 0.527
MOD_GSK3_1 502 509 PF00069 0.468
MOD_GSK3_1 63 70 PF00069 0.321
MOD_N-GLC_1 143 148 PF02516 0.468
MOD_N-GLC_1 202 207 PF02516 0.468
MOD_N-GLC_1 341 346 PF02516 0.676
MOD_N-GLC_1 438 443 PF02516 0.677
MOD_N-GLC_1 459 464 PF02516 0.703
MOD_N-GLC_1 477 482 PF02516 0.642
MOD_N-GLC_1 502 507 PF02516 0.701
MOD_NEK2_1 143 148 PF00069 0.268
MOD_NEK2_1 17 22 PF00069 0.568
MOD_NEK2_1 173 178 PF00069 0.268
MOD_NEK2_1 196 201 PF00069 0.271
MOD_NEK2_1 234 239 PF00069 0.293
MOD_NEK2_1 531 536 PF00069 0.358
MOD_NEK2_1 567 572 PF00069 0.492
MOD_NEK2_1 67 72 PF00069 0.304
MOD_NEK2_1 96 101 PF00069 0.248
MOD_NEK2_2 224 229 PF00069 0.268
MOD_NEK2_2 384 389 PF00069 0.525
MOD_PIKK_1 249 255 PF00454 0.296
MOD_PK_1 533 539 PF00069 0.361
MOD_PKA_1 337 343 PF00069 0.413
MOD_PKA_2 186 192 PF00069 0.207
MOD_PKA_2 242 248 PF00069 0.281
MOD_PKA_2 274 280 PF00069 0.207
MOD_PKA_2 388 394 PF00069 0.589
MOD_PKA_2 400 406 PF00069 0.448
MOD_PKB_1 346 354 PF00069 0.426
MOD_Plk_1 135 141 PF00069 0.295
MOD_Plk_1 202 208 PF00069 0.234
MOD_Plk_1 314 320 PF00069 0.380
MOD_Plk_4 135 141 PF00069 0.405
MOD_Plk_4 235 241 PF00069 0.283
MOD_Plk_4 242 248 PF00069 0.306
MOD_Plk_4 554 560 PF00069 0.234
MOD_ProDKin_1 127 133 PF00069 0.207
MOD_ProDKin_1 266 272 PF00069 0.304
MOD_ProDKin_1 389 395 PF00069 0.528
MOD_ProDKin_1 491 497 PF00069 0.552
MOD_ProDKin_1 520 526 PF00069 0.431
MOD_ProDKin_1 72 78 PF00069 0.286
MOD_SUMO_rev_2 477 482 PF00179 0.435
TRG_ENDOCYTIC_2 58 61 PF00928 0.334
TRG_ER_diArg_1 575 577 PF00400 0.683
TRG_NLS_Bipartite_1 324 340 PF00514 0.399
TRG_NLS_MonoCore_2 334 339 PF00514 0.404
TRG_NLS_MonoExtN_4 324 329 PF00514 0.408
TRG_NLS_MonoExtN_4 335 340 PF00514 0.394
TRG_Pf-PMV_PEXEL_1 165 170 PF00026 0.468

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PBI8 Leptomonas seymouri 49% 97%
A0A3Q8IDR5 Leishmania donovani 61% 98%
A4I3A0 Leishmania infantum 61% 98%
E9AZK8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 57% 100%
Q4Q8M3 Leishmania major 59% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS