WD_REPEATS_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HG86_LEIBR

TriTrypDb:

LbrM.28.0480 , LBRM2903_280010200

Length:

795

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HG86

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HG86

Function

Biological processes
Term	Name	Level	Count
GO:0006355	regulation of DNA-templated transcription	6	1
GO:0006356	regulation of transcription by RNA polymerase I	7	1
GO:0009889	regulation of biosynthetic process	4	1
GO:0009891	positive regulation of biosynthetic process	5	1
GO:0009893	positive regulation of metabolic process	4	1
GO:0010468	regulation of gene expression	5	1
GO:0010556	regulation of macromolecule biosynthetic process	5	1
GO:0010557	positive regulation of macromolecule biosynthetic process	6	1
GO:0010604	positive regulation of macromolecule metabolic process	5	1
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	1
GO:0019222	regulation of metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031325	positive regulation of cellular metabolic process	5	1
GO:0031326	regulation of cellular biosynthetic process	5	1
GO:0031328	positive regulation of cellular biosynthetic process	6	1
GO:0045893	positive regulation of DNA-templated transcription	7	1
GO:0045935	positive regulation of nucleobase-containing compound metabolic process	6	1
GO:0045943	positive regulation of transcription by RNA polymerase I	8	1
GO:0048518	positive regulation of biological process	3	1
GO:0048522	positive regulation of cellular process	4	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051173	positive regulation of nitrogen compound metabolic process	5	1
GO:0051252	regulation of RNA metabolic process	5	1
GO:0051254	positive regulation of RNA metabolic process	6	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0080090	regulation of primary metabolic process	4	1
GO:1902680	positive regulation of RNA biosynthetic process	7	1
GO:1903506	regulation of nucleic acid-templated transcription	7	1
GO:1903508	positive regulation of nucleic acid-templated transcription	8	1
GO:2000232	regulation of rRNA processing	6	1
GO:2000234	positive regulation of rRNA processing	7	1
GO:2001141	regulation of RNA biosynthetic process	6	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	607	611	PF00656	0.292
CLV_C14_Caspase3-7	739	743	PF00656	0.629
CLV_NRD_NRD_1	249	251	PF00675	0.436
CLV_NRD_NRD_1	28	30	PF00675	0.526
CLV_NRD_NRD_1	451	453	PF00675	0.497
CLV_NRD_NRD_1	654	656	PF00675	0.525
CLV_PCSK_KEX2_1	249	251	PF00082	0.436
CLV_PCSK_KEX2_1	476	478	PF00082	0.453
CLV_PCSK_KEX2_1	654	656	PF00082	0.525
CLV_PCSK_PC1ET2_1	476	478	PF00082	0.487
CLV_PCSK_SKI1_1	199	203	PF00082	0.386
CLV_PCSK_SKI1_1	306	310	PF00082	0.484
CLV_PCSK_SKI1_1	480	484	PF00082	0.306
CLV_PCSK_SKI1_1	53	57	PF00082	0.422
CLV_Separin_Metazoa	651	655	PF03568	0.428
DEG_APCC_DBOX_1	554	562	PF00400	0.395
DEG_APCC_DBOX_1	660	668	PF00400	0.514
DEG_Nend_UBRbox_3	1	3	PF02207	0.527
DEG_SCF_FBW7_1	318	323	PF00400	0.348
DEG_SPOP_SBC_1	48	52	PF00917	0.370
DOC_CKS1_1	516	521	PF01111	0.352
DOC_CKS1_1	90	95	PF01111	0.458
DOC_MAPK_gen_1	224	232	PF00069	0.285
DOC_MAPK_gen_1	249	257	PF00069	0.407
DOC_MAPK_gen_1	306	312	PF00069	0.471
DOC_MAPK_MEF2A_6	224	232	PF00069	0.310
DOC_MAPK_MEF2A_6	249	257	PF00069	0.466
DOC_MAPK_MEF2A_6	40	48	PF00069	0.386
DOC_MAPK_MEF2A_6	466	474	PF00069	0.438
DOC_MAPK_MEF2A_6	84	91	PF00069	0.368
DOC_PP2B_LxvP_1	689	692	PF13499	0.520
DOC_PP4_FxxP_1	173	176	PF00568	0.358
DOC_PP4_FxxP_1	22	25	PF00568	0.325
DOC_USP7_MATH_1	107	111	PF00917	0.542
DOC_USP7_MATH_1	121	125	PF00917	0.591
DOC_USP7_MATH_1	152	156	PF00917	0.561
DOC_USP7_MATH_1	320	324	PF00917	0.400
DOC_USP7_MATH_1	464	468	PF00917	0.408
DOC_USP7_MATH_1	517	521	PF00917	0.427
DOC_USP7_MATH_1	530	534	PF00917	0.367
DOC_USP7_MATH_1	6	10	PF00917	0.455
DOC_USP7_MATH_1	698	702	PF00917	0.698
DOC_USP7_MATH_1	781	785	PF00917	0.396
DOC_USP7_MATH_2	107	113	PF00917	0.467
DOC_USP7_UBL2_3	26	30	PF12436	0.370
DOC_WW_Pin1_4	235	240	PF00397	0.432
DOC_WW_Pin1_4	269	274	PF00397	0.372
DOC_WW_Pin1_4	316	321	PF00397	0.439
DOC_WW_Pin1_4	370	375	PF00397	0.532
DOC_WW_Pin1_4	407	412	PF00397	0.559
DOC_WW_Pin1_4	460	465	PF00397	0.358
DOC_WW_Pin1_4	515	520	PF00397	0.336
DOC_WW_Pin1_4	574	579	PF00397	0.481
DOC_WW_Pin1_4	89	94	PF00397	0.661
LIG_14-3-3_CanoR_1	209	218	PF00244	0.535
LIG_14-3-3_CanoR_1	346	356	PF00244	0.507
LIG_14-3-3_CanoR_1	426	432	PF00244	0.344
LIG_14-3-3_CanoR_1	480	485	PF00244	0.304
LIG_14-3-3_CterR_2	793	795	PF00244	0.432
LIG_Actin_WH2_2	649	667	PF00022	0.529
LIG_APCC_ABBA_1	170	175	PF00400	0.292
LIG_APCC_ABBA_1	253	258	PF00400	0.428
LIG_BIR_III_4	712	716	PF00653	0.510
LIG_BRCT_BRCA1_1	532	536	PF00533	0.330
LIG_Clathr_ClatBox_1	254	258	PF01394	0.457
LIG_FHA_1	112	118	PF00498	0.687
LIG_FHA_1	120	126	PF00498	0.553
LIG_FHA_1	186	192	PF00498	0.342
LIG_FHA_1	205	211	PF00498	0.508
LIG_FHA_1	332	338	PF00498	0.365
LIG_FHA_1	361	367	PF00498	0.436
LIG_FHA_1	456	462	PF00498	0.441
LIG_FHA_1	566	572	PF00498	0.455
LIG_FHA_1	620	626	PF00498	0.392
LIG_FHA_1	629	635	PF00498	0.355
LIG_FHA_1	723	729	PF00498	0.619
LIG_FHA_1	777	783	PF00498	0.607
LIG_FHA_1	78	84	PF00498	0.504
LIG_FHA_2	347	353	PF00498	0.440
LIG_FHA_2	496	502	PF00498	0.567
LIG_FHA_2	62	68	PF00498	0.392
LIG_FHA_2	761	767	PF00498	0.568
LIG_LIR_Apic_2	775	781	PF02991	0.481
LIG_LIR_Gen_1	178	187	PF02991	0.257
LIG_LIR_Gen_1	200	210	PF02991	0.479
LIG_LIR_Gen_1	430	439	PF02991	0.397
LIG_LIR_Gen_1	64	74	PF02991	0.255
LIG_LIR_Gen_1	701	711	PF02991	0.481
LIG_LIR_LC3C_4	188	192	PF02991	0.440
LIG_LIR_Nem_3	178	184	PF02991	0.539
LIG_LIR_Nem_3	200	206	PF02991	0.377
LIG_LIR_Nem_3	430	434	PF02991	0.337
LIG_LIR_Nem_3	501	506	PF02991	0.556
LIG_LIR_Nem_3	554	559	PF02991	0.435
LIG_LIR_Nem_3	64	69	PF02991	0.235
LIG_LIR_Nem_3	684	689	PF02991	0.392
LIG_LIR_Nem_3	701	707	PF02991	0.575
LIG_MYND_1	221	225	PF01753	0.501
LIG_PCNA_yPIPBox_3	135	145	PF02747	0.407
LIG_Pex14_2	202	206	PF04695	0.401
LIG_Pex14_2	265	269	PF04695	0.354
LIG_REV1ctd_RIR_1	731	739	PF16727	0.678
LIG_SH2_CRK	503	507	PF00017	0.562
LIG_SH2_CRK	778	782	PF00017	0.480
LIG_SH2_PTP2	256	259	PF00017	0.348
LIG_SH2_PTP2	45	48	PF00017	0.323
LIG_SH2_SRC	256	259	PF00017	0.355
LIG_SH2_STAP1	149	153	PF00017	0.353
LIG_SH2_STAP1	397	401	PF00017	0.370
LIG_SH2_STAT3	391	394	PF00017	0.511
LIG_SH2_STAT3	545	548	PF00017	0.490
LIG_SH2_STAT5	181	184	PF00017	0.503
LIG_SH2_STAT5	256	259	PF00017	0.477
LIG_SH2_STAT5	287	290	PF00017	0.370
LIG_SH2_STAT5	391	394	PF00017	0.511
LIG_SH2_STAT5	45	48	PF00017	0.411
LIG_SH2_STAT5	565	568	PF00017	0.536
LIG_SH2_STAT5	57	60	PF00017	0.330
LIG_SH2_STAT5	778	781	PF00017	0.483
LIG_SH2_STAT5	790	793	PF00017	0.486
LIG_SH3_3	190	196	PF00018	0.413
LIG_SH3_3	212	218	PF00018	0.572
LIG_SH3_3	384	390	PF00018	0.330
LIG_SH3_3	406	412	PF00018	0.506
LIG_SH3_3	435	441	PF00018	0.478
LIG_SH3_3	572	578	PF00018	0.494
LIG_SH3_3	87	93	PF00018	0.496
LIG_SUMO_SIM_anti_2	188	194	PF11976	0.349
LIG_SUMO_SIM_anti_2	292	298	PF11976	0.354
LIG_SUMO_SIM_par_1	334	341	PF11976	0.432
LIG_TYR_ITIM	254	259	PF00017	0.312
LIG_UBA3_1	138	145	PF00899	0.383
LIG_WRC_WIRS_1	431	436	PF05994	0.505
LIG_WRC_WIRS_1	730	735	PF05994	0.685
LIG_WRC_WIRS_1	737	742	PF05994	0.684
LIG_WW_3	410	414	PF00397	0.485
MOD_CDC14_SPxK_1	410	413	PF00782	0.551
MOD_CDC14_SPxK_1	463	466	PF00782	0.410
MOD_CDK_SPxK_1	407	413	PF00069	0.563
MOD_CDK_SPxK_1	460	466	PF00069	0.410
MOD_CDK_SPxxK_3	574	581	PF00069	0.442
MOD_CK1_1	163	169	PF00069	0.501
MOD_CK1_1	204	210	PF00069	0.492
MOD_CK1_1	219	225	PF00069	0.444
MOD_CK1_1	323	329	PF00069	0.372
MOD_CK1_1	331	337	PF00069	0.373
MOD_CK1_1	395	401	PF00069	0.479
MOD_CK1_1	427	433	PF00069	0.451
MOD_CK1_1	611	617	PF00069	0.370
MOD_CK2_1	346	352	PF00069	0.481
MOD_CK2_1	400	406	PF00069	0.447
MOD_CK2_1	61	67	PF00069	0.432
MOD_CK2_1	629	635	PF00069	0.390
MOD_CK2_1	699	705	PF00069	0.701
MOD_Cter_Amidation	247	250	PF01082	0.422
MOD_GlcNHglycan	111	114	PF01048	0.614
MOD_GlcNHglycan	154	157	PF01048	0.587
MOD_GlcNHglycan	165	168	PF01048	0.425
MOD_GlcNHglycan	282	286	PF01048	0.372
MOD_GlcNHglycan	322	325	PF01048	0.399
MOD_GlcNHglycan	349	352	PF01048	0.415
MOD_GlcNHglycan	466	469	PF01048	0.503
MOD_GlcNHglycan	506	509	PF01048	0.496
MOD_GlcNHglycan	528	531	PF01048	0.389
MOD_GlcNHglycan	616	619	PF01048	0.361
MOD_GlcNHglycan	642	645	PF01048	0.454
MOD_GlcNHglycan	711	716	PF01048	0.742
MOD_GlcNHglycan	94	97	PF01048	0.649
MOD_GSK3_1	107	114	PF00069	0.641
MOD_GSK3_1	159	166	PF00069	0.515
MOD_GSK3_1	204	211	PF00069	0.500
MOD_GSK3_1	231	238	PF00069	0.456
MOD_GSK3_1	281	288	PF00069	0.472
MOD_GSK3_1	316	323	PF00069	0.442
MOD_GSK3_1	328	335	PF00069	0.289
MOD_GSK3_1	395	402	PF00069	0.405
MOD_GSK3_1	430	437	PF00069	0.504
MOD_GSK3_1	460	467	PF00069	0.381
MOD_GSK3_1	492	499	PF00069	0.467
MOD_GSK3_1	511	518	PF00069	0.334
MOD_GSK3_1	526	533	PF00069	0.355
MOD_GSK3_1	604	611	PF00069	0.469
MOD_GSK3_1	690	697	PF00069	0.391
MOD_GSK3_1	707	714	PF00069	0.785
MOD_GSK3_1	73	80	PF00069	0.444
MOD_GSK3_1	736	743	PF00069	0.680
MOD_GSK3_1	755	762	PF00069	0.638
MOD_GSK3_1	781	788	PF00069	0.479
MOD_N-GLC_1	36	41	PF02516	0.429
MOD_N-GLC_1	422	427	PF02516	0.381
MOD_N-GLC_1	511	516	PF02516	0.399
MOD_N-GLC_1	657	662	PF02516	0.487
MOD_N-GLC_1	707	712	PF02516	0.492
MOD_NEK2_1	201	206	PF00069	0.399
MOD_NEK2_1	281	286	PF00069	0.532
MOD_NEK2_1	328	333	PF00069	0.463
MOD_NEK2_1	345	350	PF00069	0.495
MOD_NEK2_1	36	41	PF00069	0.529
MOD_NEK2_1	399	404	PF00069	0.438
MOD_NEK2_1	422	427	PF00069	0.443
MOD_NEK2_1	434	439	PF00069	0.393
MOD_NEK2_1	619	624	PF00069	0.487
MOD_NEK2_1	628	633	PF00069	0.467
MOD_NEK2_1	77	82	PF00069	0.414
MOD_NEK2_1	782	787	PF00069	0.448
MOD_NEK2_2	61	66	PF00069	0.529
MOD_NEK2_2	699	704	PF00069	0.476
MOD_PIKK_1	323	329	PF00454	0.323
MOD_PIKK_1	389	395	PF00454	0.364
MOD_PIKK_1	400	406	PF00454	0.447
MOD_PIKK_1	455	461	PF00454	0.400
MOD_PIKK_1	496	502	PF00454	0.391
MOD_PIKK_1	517	523	PF00454	0.532
MOD_PIKK_1	565	571	PF00454	0.425
MOD_PIKK_1	6	12	PF00454	0.397
MOD_PIKK_1	740	746	PF00454	0.635
MOD_PIKK_1	760	766	PF00454	0.469
MOD_PK_1	79	85	PF00069	0.439
MOD_PKA_2	208	214	PF00069	0.504
MOD_PKA_2	216	222	PF00069	0.612
MOD_PKA_2	345	351	PF00069	0.490
MOD_PKB_1	655	663	PF00069	0.323
MOD_Plk_1	15	21	PF00069	0.384
MOD_Plk_1	511	517	PF00069	0.498
MOD_Plk_1	61	67	PF00069	0.401
MOD_Plk_1	620	626	PF00069	0.476
MOD_Plk_1	629	635	PF00069	0.464
MOD_Plk_1	657	663	PF00069	0.483
MOD_Plk_2-3	736	742	PF00069	0.681
MOD_Plk_4	121	127	PF00069	0.479
MOD_Plk_4	201	207	PF00069	0.377
MOD_Plk_4	392	398	PF00069	0.447
MOD_Plk_4	434	440	PF00069	0.470
MOD_Plk_4	457	463	PF00069	0.454
MOD_Plk_4	601	607	PF00069	0.423
MOD_Plk_4	61	67	PF00069	0.424
MOD_Plk_4	620	626	PF00069	0.356
MOD_Plk_4	629	635	PF00069	0.348
MOD_Plk_4	699	705	PF00069	0.635
MOD_Plk_4	729	735	PF00069	0.686
MOD_Plk_4	73	79	PF00069	0.493
MOD_Plk_4	782	788	PF00069	0.464
MOD_ProDKin_1	235	241	PF00069	0.435
MOD_ProDKin_1	269	275	PF00069	0.372
MOD_ProDKin_1	316	322	PF00069	0.443
MOD_ProDKin_1	370	376	PF00069	0.524
MOD_ProDKin_1	407	413	PF00069	0.562
MOD_ProDKin_1	460	466	PF00069	0.366
MOD_ProDKin_1	515	521	PF00069	0.345
MOD_ProDKin_1	574	580	PF00069	0.481
MOD_ProDKin_1	89	95	PF00069	0.663
MOD_SUMO_rev_2	546	552	PF00179	0.293
TRG_AP2beta_CARGO_1	200	209	PF09066	0.417
TRG_DiLeu_BaEn_1	292	297	PF01217	0.331
TRG_DiLeu_BaLyEn_6	438	443	PF01217	0.401
TRG_DiLeu_BaLyEn_6	557	562	PF01217	0.409
TRG_DiLeu_LyEn_5	554	559	PF01217	0.479
TRG_ENDOCYTIC_2	181	184	PF00928	0.386
TRG_ENDOCYTIC_2	203	206	PF00928	0.404
TRG_ENDOCYTIC_2	256	259	PF00928	0.323
TRG_ENDOCYTIC_2	431	434	PF00928	0.377
TRG_ENDOCYTIC_2	45	48	PF00928	0.323
TRG_ENDOCYTIC_2	503	506	PF00928	0.402
TRG_ENDOCYTIC_2	704	707	PF00928	0.477
TRG_ER_diArg_1	223	226	PF00400	0.486
TRG_ER_diArg_1	653	655	PF00400	0.536
TRG_NLS_MonoExtC_3	28	34	PF00514	0.370
TRG_NLS_MonoExtN_4	26	33	PF00514	0.380
TRG_Pf-PMV_PEXEL_1	560	564	PF00026	0.372
TRG_Pf-PMV_PEXEL_1	767	771	PF00026	0.575

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4K6	Leptomonas seymouri	67%	97%
A0A0S4J855	Bodo saltans	34%	100%
A0A1X0NYJ9	Trypanosomatidae	41%	99%
A0A3Q8IGL7	Leishmania donovani	84%	100%
A0A422P1N8	Trypanosoma rangeli	41%	100%
A4I3A1	Leishmania infantum	84%	100%
D0A824	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	95%
E9AZK7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4Q8M4	Leishmania major	84%	100%