Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HG85_LEIBR

TriTrypDb:

LbrM.28.0470 , LBRM2903_280010100

Length:

311

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HG85

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HG85

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	44	48	PF00656	0.542
CLV_NRD_NRD_1	49	51	PF00675	0.611
CLV_NRD_NRD_1	54	56	PF00675	0.589
CLV_PCSK_FUR_1	52	56	PF00082	0.594
CLV_PCSK_KEX2_1	29	31	PF00082	0.585
CLV_PCSK_KEX2_1	51	53	PF00082	0.637
CLV_PCSK_KEX2_1	54	56	PF00082	0.635
CLV_PCSK_PC1ET2_1	29	31	PF00082	0.585
CLV_PCSK_PC1ET2_1	51	53	PF00082	0.637
CLV_PCSK_PC7_1	50	56	PF00082	0.513
CLV_PCSK_SKI1_1	22	26	PF00082	0.587
DEG_COP1_1	169	180	PF00400	0.581
DEG_Nend_UBRbox_2	1	3	PF02207	0.532
DEG_SPOP_SBC_1	285	289	PF00917	0.495
DEG_SPOP_SBC_1	40	44	PF00917	0.517
DOC_CKS1_1	140	145	PF01111	0.576
DOC_MAPK_gen_1	181	189	PF00069	0.610
DOC_USP7_MATH_1	120	124	PF00917	0.504
DOC_USP7_MATH_1	267	271	PF00917	0.544
DOC_USP7_MATH_1	283	287	PF00917	0.550
DOC_USP7_MATH_1	41	45	PF00917	0.716
DOC_WW_Pin1_4	139	144	PF00397	0.645
DOC_WW_Pin1_4	157	162	PF00397	0.532
DOC_WW_Pin1_4	241	246	PF00397	0.587
DOC_WW_Pin1_4	258	263	PF00397	0.496
LIG_14-3-3_CanoR_1	273	283	PF00244	0.543
LIG_BIR_III_4	271	275	PF00653	0.518
LIG_BRCT_BRCA1_1	286	290	PF00533	0.544
LIG_CSL_BTD_1	140	143	PF09270	0.581
LIG_FHA_1	161	167	PF00498	0.519
LIG_FHA_1	184	190	PF00498	0.714
LIG_FHA_1	231	237	PF00498	0.471
LIG_FHA_2	10	16	PF00498	0.468
LIG_FHA_2	169	175	PF00498	0.687
LIG_FHA_2	190	196	PF00498	0.620
LIG_FHA_2	241	247	PF00498	0.586
LIG_SH2_SRC	147	150	PF00017	0.593
LIG_SH2_STAT3	107	110	PF00017	0.501
LIG_SH2_STAT5	107	110	PF00017	0.519
LIG_SH2_STAT5	147	150	PF00017	0.571
LIG_SH3_3	123	129	PF00018	0.551
LIG_SH3_3	305	311	PF00018	0.526
LIG_SUMO_SIM_anti_2	163	169	PF11976	0.465
LIG_SUMO_SIM_par_1	211	217	PF11976	0.495
LIG_TRAF2_1	66	69	PF00917	0.552
MOD_CDK_SPxK_1	241	247	PF00069	0.586
MOD_CK1_1	160	166	PF00069	0.572
MOD_CK1_1	258	264	PF00069	0.496
MOD_CK1_1	266	272	PF00069	0.661
MOD_CK1_1	286	292	PF00069	0.597
MOD_CK1_1	303	309	PF00069	0.592
MOD_CK1_1	39	45	PF00069	0.519
MOD_CK1_1	53	59	PF00069	0.538
MOD_CK1_1	9	15	PF00069	0.475
MOD_CK2_1	166	172	PF00069	0.559
MOD_CK2_1	303	309	PF00069	0.633
MOD_GlcNHglycan	236	239	PF01048	0.587
MOD_GlcNHglycan	25	28	PF01048	0.658
MOD_GlcNHglycan	257	260	PF01048	0.572
MOD_GlcNHglycan	265	268	PF01048	0.591
MOD_GlcNHglycan	276	279	PF01048	0.671
MOD_GlcNHglycan	43	46	PF01048	0.526
MOD_GlcNHglycan	55	58	PF01048	0.693
MOD_GlcNHglycan	78	81	PF01048	0.490
MOD_GSK3_1	153	160	PF00069	0.571
MOD_GSK3_1	230	237	PF00069	0.601
MOD_GSK3_1	263	270	PF00069	0.640
MOD_GSK3_1	284	291	PF00069	0.541
MOD_GSK3_1	299	306	PF00069	0.570
MOD_GSK3_1	36	43	PF00069	0.588
MOD_N-GLC_1	76	81	PF02516	0.556
MOD_NEK2_1	166	171	PF00069	0.486
MOD_NEK2_1	183	188	PF00069	0.549
MOD_NEK2_1	239	244	PF00069	0.543
MOD_NEK2_1	255	260	PF00069	0.515
MOD_NEK2_1	6	11	PF00069	0.536
MOD_PIKK_1	231	237	PF00454	0.618
MOD_PKA_1	50	56	PF00069	0.513
MOD_PKA_2	183	189	PF00069	0.551
MOD_PKA_2	272	278	PF00069	0.712
MOD_PKA_2	53	59	PF00069	0.590
MOD_PKA_2	7	13	PF00069	0.545
MOD_Plk_4	248	254	PF00069	0.627
MOD_ProDKin_1	139	145	PF00069	0.642
MOD_ProDKin_1	157	163	PF00069	0.530
MOD_ProDKin_1	241	247	PF00069	0.586
MOD_ProDKin_1	258	264	PF00069	0.499
MOD_SUMO_rev_2	15	19	PF00179	0.489
MOD_SUMO_rev_2	277	286	PF00179	0.540
TRG_ER_diArg_1	52	55	PF00400	0.593
TRG_NLS_MonoExtC_3	49	54	PF00514	0.600
TRG_NLS_MonoExtN_4	50	55	PF00514	0.513

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HV17	Leptomonas seymouri	66%	99%
A0A3Q8IDN4	Leishmania donovani	80%	100%
A4I3A2	Leishmania infantum	79%	100%
E9AZK6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
Q4Q8M5	Leishmania major	80%	100%