Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HG83_LEIBR

TriTrypDb:

LbrM.28.0450 , LBRM2903_280009900

Length:

789

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HG83

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HG83

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	300	304	PF00656	0.687
CLV_C14_Caspase3-7	757	761	PF00656	0.455
CLV_MEL_PAP_1	11	17	PF00089	0.564
CLV_NRD_NRD_1	193	195	PF00675	0.589
CLV_NRD_NRD_1	291	293	PF00675	0.672
CLV_NRD_NRD_1	364	366	PF00675	0.619
CLV_NRD_NRD_1	388	390	PF00675	0.443
CLV_PCSK_KEX2_1	193	195	PF00082	0.683
CLV_PCSK_KEX2_1	291	293	PF00082	0.672
CLV_PCSK_KEX2_1	387	389	PF00082	0.445
CLV_PCSK_KEX2_1	418	420	PF00082	0.690
CLV_PCSK_KEX2_1	585	587	PF00082	0.640
CLV_PCSK_PC1ET2_1	418	420	PF00082	0.527
CLV_PCSK_PC1ET2_1	585	587	PF00082	0.676
CLV_PCSK_PC7_1	414	420	PF00082	0.466
CLV_PCSK_SKI1_1	179	183	PF00082	0.516
CLV_PCSK_SKI1_1	510	514	PF00082	0.536
DEG_SPOP_SBC_1	591	595	PF00917	0.493
DOC_ANK_TNKS_1	13	20	PF00023	0.562
DOC_CKS1_1	427	432	PF01111	0.428
DOC_CKS1_1	518	523	PF01111	0.627
DOC_CYCLIN_yCln2_LP_2	458	464	PF00134	0.662
DOC_CYCLIN_yCln2_LP_2	518	524	PF00134	0.625
DOC_MAPK_gen_1	291	298	PF00069	0.634
DOC_MAPK_gen_1	585	592	PF00069	0.517
DOC_MAPK_gen_1	694	703	PF00069	0.447
DOC_MAPK_MEF2A_6	454	462	PF00069	0.648
DOC_MAPK_MEF2A_6	527	535	PF00069	0.338
DOC_MAPK_MEF2A_6	694	703	PF00069	0.619
DOC_PP2B_LxvP_1	156	159	PF13499	0.411
DOC_PP2B_LxvP_1	458	461	PF13499	0.659
DOC_PP2B_LxvP_1	533	536	PF13499	0.445
DOC_PP2B_LxvP_1	730	733	PF13499	0.475
DOC_PP4_FxxP_1	228	231	PF00568	0.623
DOC_PP4_FxxP_1	473	476	PF00568	0.466
DOC_USP7_MATH_1	116	120	PF00917	0.616
DOC_USP7_MATH_1	173	177	PF00917	0.618
DOC_USP7_MATH_1	270	274	PF00917	0.712
DOC_USP7_MATH_1	29	33	PF00917	0.730
DOC_USP7_MATH_1	474	478	PF00917	0.605
DOC_USP7_MATH_1	512	516	PF00917	0.510
DOC_USP7_MATH_1	591	595	PF00917	0.745
DOC_USP7_MATH_1	677	681	PF00917	0.582
DOC_USP7_MATH_1	692	696	PF00917	0.658
DOC_USP7_MATH_1	780	784	PF00917	0.579
DOC_USP7_UBL2_3	8	12	PF12436	0.707
DOC_WW_Pin1_4	142	147	PF00397	0.451
DOC_WW_Pin1_4	25	30	PF00397	0.786
DOC_WW_Pin1_4	355	360	PF00397	0.595
DOC_WW_Pin1_4	423	428	PF00397	0.753
DOC_WW_Pin1_4	517	522	PF00397	0.499
DOC_WW_Pin1_4	619	624	PF00397	0.503
DOC_WW_Pin1_4	631	636	PF00397	0.601
DOC_WW_Pin1_4	77	82	PF00397	0.550
LIG_14-3-3_CanoR_1	117	127	PF00244	0.504
LIG_14-3-3_CanoR_1	179	184	PF00244	0.426
LIG_14-3-3_CanoR_1	389	399	PF00244	0.606
LIG_14-3-3_CanoR_1	725	733	PF00244	0.740
LIG_14-3-3_CanoR_1	752	762	PF00244	0.632
LIG_Actin_WH2_2	314	331	PF00022	0.516
LIG_Actin_WH2_2	375	393	PF00022	0.613
LIG_Actin_WH2_2	401	416	PF00022	0.373
LIG_APCC_ABBAyCdc20_2	128	134	PF00400	0.468
LIG_BIR_III_4	493	497	PF00653	0.556
LIG_BRCT_BRCA1_1	211	215	PF00533	0.607
LIG_BRCT_BRCA1_1	476	480	PF00533	0.527
LIG_BRCT_BRCA1_1	679	683	PF00533	0.679
LIG_Clathr_ClatBox_1	617	621	PF01394	0.575
LIG_Clathr_ClatBox_1	638	642	PF01394	0.713
LIG_CSL_BTD_1	533	536	PF09270	0.504
LIG_deltaCOP1_diTrp_1	467	473	PF00928	0.402
LIG_FHA_1	273	279	PF00498	0.519
LIG_FHA_1	349	355	PF00498	0.702
LIG_FHA_1	377	383	PF00498	0.374
LIG_FHA_1	408	414	PF00498	0.574
LIG_FHA_1	426	432	PF00498	0.398
LIG_FHA_1	450	456	PF00498	0.591
LIG_FHA_1	664	670	PF00498	0.728
LIG_FHA_1	716	722	PF00498	0.580
LIG_FHA_2	128	134	PF00498	0.502
LIG_FHA_2	483	489	PF00498	0.623
LIG_FHA_2	567	573	PF00498	0.656
LIG_FHA_2	74	80	PF00498	0.584
LIG_FHA_2	743	749	PF00498	0.645
LIG_FHA_2	755	761	PF00498	0.624
LIG_GBD_Chelix_1	180	188	PF00786	0.472
LIG_IRF3_LxIS_1	655	662	PF10401	0.393
LIG_LIR_Apic_2	470	476	PF02991	0.440
LIG_LIR_Gen_1	176	184	PF02991	0.468
LIG_LIR_Gen_1	212	223	PF02991	0.521
LIG_LIR_Gen_1	702	711	PF02991	0.633
LIG_LIR_Gen_1	72	82	PF02991	0.548
LIG_LIR_Nem_3	176	180	PF02991	0.481
LIG_LIR_Nem_3	212	218	PF02991	0.550
LIG_LIR_Nem_3	237	243	PF02991	0.791
LIG_LIR_Nem_3	680	686	PF02991	0.638
LIG_LIR_Nem_3	702	706	PF02991	0.611
LIG_LIR_Nem_3	72	78	PF02991	0.549
LIG_NRBOX	183	189	PF00104	0.588
LIG_NRP_CendR_1	788	789	PF00754	0.618
LIG_PTB_Apo_2	222	229	PF02174	0.567
LIG_SH2_CRK	293	297	PF00017	0.722
LIG_SH2_CRK	546	550	PF00017	0.616
LIG_SH2_STAP1	132	136	PF00017	0.588
LIG_SH2_STAP1	399	403	PF00017	0.584
LIG_SH2_STAP1	41	45	PF00017	0.780
LIG_SH2_STAT5	191	194	PF00017	0.627
LIG_SH2_STAT5	327	330	PF00017	0.390
LIG_SH3_1	284	290	PF00018	0.736
LIG_SH3_2	287	292	PF14604	0.781
LIG_SH3_3	240	246	PF00018	0.581
LIG_SH3_3	284	290	PF00018	0.619
LIG_SH3_3	424	430	PF00018	0.493
LIG_SH3_3	483	489	PF00018	0.582
LIG_SH3_3	539	545	PF00018	0.545
LIG_SH3_3	604	610	PF00018	0.677
LIG_SH3_3	75	81	PF00018	0.755
LIG_SH3_CIN85_PxpxPR_1	286	291	PF14604	0.780
LIG_SUMO_SIM_anti_2	294	300	PF11976	0.712
LIG_SUMO_SIM_par_1	409	415	PF11976	0.482
LIG_SUMO_SIM_par_1	487	493	PF11976	0.548
LIG_SUMO_SIM_par_1	497	502	PF11976	0.474
LIG_TRFH_1	703	707	PF08558	0.466
LIG_WW_3	608	612	PF00397	0.582
MOD_CDC14_SPxK_1	80	83	PF00782	0.544
MOD_CDK_SPK_2	142	147	PF00069	0.639
MOD_CDK_SPxK_1	77	83	PF00069	0.551
MOD_CDK_SPxxK_3	355	362	PF00069	0.591
MOD_CK1_1	164	170	PF00069	0.659
MOD_CK1_1	21	27	PF00069	0.671
MOD_CK1_1	229	235	PF00069	0.552
MOD_CK1_1	251	257	PF00069	0.569
MOD_CK1_1	272	278	PF00069	0.665
MOD_CK1_1	297	303	PF00069	0.602
MOD_CK1_1	376	382	PF00069	0.426
MOD_CK1_1	421	427	PF00069	0.773
MOD_CK1_1	561	567	PF00069	0.499
MOD_CK1_1	714	720	PF00069	0.689
MOD_CK1_1	728	734	PF00069	0.596
MOD_CK1_1	754	760	PF00069	0.599
MOD_CK2_1	127	133	PF00069	0.557
MOD_CK2_1	142	148	PF00069	0.449
MOD_CK2_1	73	79	PF00069	0.538
MOD_CK2_1	742	748	PF00069	0.642
MOD_DYRK1A_RPxSP_1	77	81	PF00069	0.550
MOD_GlcNHglycan	163	166	PF01048	0.616
MOD_GlcNHglycan	168	171	PF01048	0.581
MOD_GlcNHglycan	20	23	PF01048	0.674
MOD_GlcNHglycan	220	223	PF01048	0.528
MOD_GlcNHglycan	31	34	PF01048	0.650
MOD_GlcNHglycan	422	426	PF01048	0.576
MOD_GlcNHglycan	436	439	PF01048	0.511
MOD_GlcNHglycan	564	567	PF01048	0.488
MOD_GlcNHglycan	84	88	PF01048	0.538
MOD_GSK3_1	116	123	PF00069	0.630
MOD_GSK3_1	138	145	PF00069	0.509
MOD_GSK3_1	21	28	PF00069	0.729
MOD_GSK3_1	259	266	PF00069	0.674
MOD_GSK3_1	344	351	PF00069	0.646
MOD_GSK3_1	421	428	PF00069	0.700
MOD_GSK3_1	512	519	PF00069	0.723
MOD_GSK3_1	558	565	PF00069	0.517
MOD_GSK3_1	659	666	PF00069	0.581
MOD_GSK3_1	711	718	PF00069	0.675
MOD_GSK3_1	721	728	PF00069	0.659
MOD_GSK3_1	73	80	PF00069	0.686
MOD_GSK3_1	738	745	PF00069	0.493
MOD_N-GLC_1	226	231	PF02516	0.620
MOD_N-GLC_1	373	378	PF02516	0.491
MOD_N-GLC_1	561	566	PF02516	0.533
MOD_N-GLC_1	659	664	PF02516	0.669
MOD_N-GLC_1	738	743	PF02516	0.557
MOD_N-GLC_2	308	310	PF02516	0.538
MOD_NEK2_1	1	6	PF00069	0.553
MOD_NEK2_1	154	159	PF00069	0.415
MOD_NEK2_1	166	171	PF00069	0.453
MOD_NEK2_1	218	223	PF00069	0.511
MOD_NEK2_1	390	395	PF00069	0.363
MOD_NEK2_1	441	446	PF00069	0.492
MOD_NEK2_1	659	664	PF00069	0.669
MOD_NEK2_1	721	726	PF00069	0.543
MOD_NEK2_2	665	670	PF00069	0.507
MOD_PIKK_1	739	745	PF00454	0.493
MOD_PKA_1	418	424	PF00069	0.543
MOD_PKA_2	116	122	PF00069	0.629
MOD_PKA_2	127	133	PF00069	0.470
MOD_PKA_2	390	396	PF00069	0.613
MOD_PKA_2	418	424	PF00069	0.543
MOD_PKA_2	578	584	PF00069	0.579
MOD_PKA_2	751	757	PF00069	0.649
MOD_PKB_1	389	397	PF00069	0.608
MOD_Plk_1	302	308	PF00069	0.371
MOD_Plk_1	373	379	PF00069	0.499
MOD_Plk_1	441	447	PF00069	0.500
MOD_Plk_1	482	488	PF00069	0.552
MOD_Plk_1	659	665	PF00069	0.667
MOD_Plk_1	728	734	PF00069	0.574
MOD_Plk_4	127	133	PF00069	0.470
MOD_Plk_4	173	179	PF00069	0.536
MOD_Plk_4	294	300	PF00069	0.610
MOD_Plk_4	34	40	PF00069	0.718
MOD_Plk_4	407	413	PF00069	0.572
MOD_Plk_4	49	55	PF00069	0.748
MOD_Plk_4	566	572	PF00069	0.601
MOD_Plk_4	613	619	PF00069	0.604
MOD_Plk_4	732	738	PF00069	0.750
MOD_Plk_4	754	760	PF00069	0.481
MOD_ProDKin_1	142	148	PF00069	0.453
MOD_ProDKin_1	25	31	PF00069	0.780
MOD_ProDKin_1	355	361	PF00069	0.593
MOD_ProDKin_1	423	429	PF00069	0.746
MOD_ProDKin_1	517	523	PF00069	0.502
MOD_ProDKin_1	619	625	PF00069	0.495
MOD_ProDKin_1	631	637	PF00069	0.614
MOD_ProDKin_1	77	83	PF00069	0.551
MOD_SUMO_rev_2	229	238	PF00179	0.656
MOD_SUMO_rev_2	358	368	PF00179	0.667
MOD_SUMO_rev_2	94	99	PF00179	0.480
TRG_DiLeu_BaEn_1	654	659	PF01217	0.637
TRG_DiLeu_BaLyEn_6	183	188	PF01217	0.354
TRG_DiLeu_BaLyEn_6	722	727	PF01217	0.742
TRG_ENDOCYTIC_2	104	107	PF00928	0.512
TRG_ENDOCYTIC_2	293	296	PF00928	0.627
TRG_ENDOCYTIC_2	525	528	PF00928	0.433
TRG_ER_diArg_1	192	194	PF00400	0.668
TRG_ER_diArg_1	281	284	PF00400	0.737
TRG_ER_diArg_1	290	292	PF00400	0.619
TRG_ER_diArg_1	386	389	PF00400	0.500
TRG_ER_diArg_1	644	647	PF00400	0.611
TRG_ER_diArg_1	693	696	PF00400	0.489
TRG_NES_CRM1_1	402	417	PF08389	0.493
TRG_Pf-PMV_PEXEL_1	725	729	PF00026	0.712

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCI4	Leptomonas seymouri	42%	100%
A0A3S7X198	Leishmania donovani	69%	100%
A4I3A4	Leishmania infantum	68%	100%
E9AZK4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	67%	100%
Q4Q8M7	Leishmania major	68%	97%