C2H2-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HG82_LEIBR

TriTrypDb:

LbrM.28.0420 , LBRM2903_280009700

Length:

655

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HG82

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HG82

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	340	344	PF00656	0.683
CLV_NRD_NRD_1	203	205	PF00675	0.396
CLV_NRD_NRD_1	265	267	PF00675	0.480
CLV_NRD_NRD_1	412	414	PF00675	0.711
CLV_NRD_NRD_1	506	508	PF00675	0.530
CLV_NRD_NRD_1	599	601	PF00675	0.619
CLV_NRD_NRD_1	651	653	PF00675	0.545
CLV_PCSK_KEX2_1	203	205	PF00082	0.396
CLV_PCSK_KEX2_1	265	267	PF00082	0.480
CLV_PCSK_KEX2_1	506	508	PF00082	0.530
CLV_PCSK_KEX2_1	599	601	PF00082	0.619
CLV_PCSK_KEX2_1	650	652	PF00082	0.544
CLV_PCSK_SKI1_1	183	187	PF00082	0.581
CLV_PCSK_SKI1_1	25	29	PF00082	0.532
CLV_PCSK_SKI1_1	366	370	PF00082	0.589
CLV_PCSK_SKI1_1	406	410	PF00082	0.516
CLV_PCSK_SKI1_1	71	75	PF00082	0.436
DEG_APCC_DBOX_1	203	211	PF00400	0.464
DEG_APCC_DBOX_1	269	277	PF00400	0.459
DEG_APCC_DBOX_1	365	373	PF00400	0.598
DEG_SPOP_SBC_1	400	404	PF00917	0.637
DEG_SPOP_SBC_1	493	497	PF00917	0.605
DEG_SPOP_SBC_1	56	60	PF00917	0.583
DEG_SPOP_SBC_1	62	66	PF00917	0.606
DOC_CDC14_PxL_1	536	544	PF14671	0.462
DOC_CKS1_1	301	306	PF01111	0.534
DOC_CYCLIN_RxL_1	363	373	PF00134	0.583
DOC_CYCLIN_yClb5_NLxxxL_5	566	575	PF00134	0.516
DOC_CYCLIN_yCln2_LP_2	368	371	PF00134	0.539
DOC_MAPK_gen_1	411	420	PF00069	0.561
DOC_MAPK_gen_1	506	514	PF00069	0.528
DOC_MAPK_gen_1	611	619	PF00069	0.503
DOC_MAPK_MEF2A_6	161	170	PF00069	0.537
DOC_MAPK_MEF2A_6	519	527	PF00069	0.544
DOC_PP2B_LxvP_1	368	371	PF13499	0.539
DOC_PP2B_LxvP_1	455	458	PF13499	0.376
DOC_PP4_FxxP_1	239	242	PF00568	0.369
DOC_PP4_FxxP_1	97	100	PF00568	0.622
DOC_USP7_MATH_1	308	312	PF00917	0.576
DOC_USP7_MATH_1	371	375	PF00917	0.517
DOC_USP7_MATH_1	400	404	PF00917	0.632
DOC_USP7_MATH_1	472	476	PF00917	0.522
DOC_USP7_MATH_1	485	489	PF00917	0.582
DOC_USP7_MATH_1	61	65	PF00917	0.577
DOC_USP7_UBL2_3	157	161	PF12436	0.487
DOC_USP7_UBL2_3	90	94	PF12436	0.582
DOC_WW_Pin1_4	300	305	PF00397	0.582
DOC_WW_Pin1_4	317	322	PF00397	0.615
DOC_WW_Pin1_4	394	399	PF00397	0.531
DOC_WW_Pin1_4	48	53	PF00397	0.615
DOC_WW_Pin1_4	514	519	PF00397	0.482
LIG_14-3-3_CanoR_1	119	127	PF00244	0.600
LIG_14-3-3_CanoR_1	281	289	PF00244	0.477
LIG_14-3-3_CanoR_1	413	418	PF00244	0.442
LIG_14-3-3_CanoR_1	474	482	PF00244	0.659
LIG_14-3-3_CanoR_1	599	608	PF00244	0.630
LIG_14-3-3_CanoR_1	611	617	PF00244	0.399
LIG_14-3-3_CterR_2	650	655	PF00244	0.455
LIG_BIR_II_1	1	5	PF00653	0.732
LIG_CtBP_PxDLS_1	304	308	PF00389	0.517
LIG_DLG_GKlike_1	413	420	PF00625	0.562
LIG_FHA_1	163	169	PF00498	0.390
LIG_FHA_1	18	24	PF00498	0.420
LIG_FHA_1	30	36	PF00498	0.472
LIG_FHA_1	310	316	PF00498	0.524
LIG_FHA_1	407	413	PF00498	0.761
LIG_FHA_1	43	49	PF00498	0.563
LIG_FHA_1	57	63	PF00498	0.647
LIG_FHA_1	68	74	PF00498	0.586
LIG_FHA_2	200	206	PF00498	0.399
LIG_FHA_2	270	276	PF00498	0.460
LIG_FHA_2	297	303	PF00498	0.677
LIG_FHA_2	371	377	PF00498	0.634
LIG_FHA_2	463	469	PF00498	0.601
LIG_FHA_2	495	501	PF00498	0.500
LIG_LIR_Apic_2	105	109	PF02991	0.545
LIG_LIR_Apic_2	19	24	PF02991	0.418
LIG_LIR_Apic_2	238	242	PF02991	0.366
LIG_LIR_Apic_2	96	100	PF02991	0.622
LIG_LIR_Gen_1	416	421	PF02991	0.468
LIG_LIR_Gen_1	431	440	PF02991	0.445
LIG_LIR_Gen_1	560	568	PF02991	0.366
LIG_LIR_Nem_3	220	226	PF02991	0.549
LIG_LIR_Nem_3	228	234	PF02991	0.408
LIG_LIR_Nem_3	416	420	PF02991	0.475
LIG_LIR_Nem_3	560	565	PF02991	0.452
LIG_LIR_Nem_3	602	608	PF02991	0.545
LIG_LIR_Nem_3	621	626	PF02991	0.476
LIG_LIR_Nem_3	88	92	PF02991	0.516
LIG_LYPXL_yS_3	605	608	PF13949	0.517
LIG_MAD2	547	555	PF02301	0.396
LIG_MYND_1	367	371	PF01753	0.537
LIG_Pex14_2	196	200	PF04695	0.397
LIG_Rb_LxCxE_1	557	573	PF01857	0.515
LIG_SH2_CRK	106	110	PF00017	0.512
LIG_SH2_CRK	223	227	PF00017	0.468
LIG_SH2_CRK	231	235	PF00017	0.388
LIG_SH2_CRK	552	556	PF00017	0.418
LIG_SH2_CRK	568	572	PF00017	0.450
LIG_SH2_GRB2like	219	222	PF00017	0.565
LIG_SH2_NCK_1	106	110	PF00017	0.556
LIG_SH2_NCK_1	92	96	PF00017	0.601
LIG_SH2_PTP2	21	24	PF00017	0.405
LIG_SH2_PTP2	417	420	PF00017	0.472
LIG_SH2_STAP1	219	223	PF00017	0.568
LIG_SH2_STAP1	562	566	PF00017	0.495
LIG_SH2_STAT5	201	204	PF00017	0.383
LIG_SH2_STAT5	206	209	PF00017	0.405
LIG_SH2_STAT5	21	24	PF00017	0.405
LIG_SH2_STAT5	223	226	PF00017	0.346
LIG_SH2_STAT5	417	420	PF00017	0.472
LIG_SH2_STAT5	449	452	PF00017	0.447
LIG_SH2_STAT5	630	633	PF00017	0.471
LIG_SH3_2	181	186	PF14604	0.482
LIG_SH3_3	10	16	PF00018	0.550
LIG_SH3_3	178	184	PF00018	0.399
LIG_SH3_3	207	213	PF00018	0.417
LIG_SH3_3	298	304	PF00018	0.531
LIG_SH3_3	315	321	PF00018	0.755
LIG_SH3_3	364	370	PF00018	0.507
LIG_SH3_3	458	464	PF00018	0.568
LIG_SH3_3	512	518	PF00018	0.474
LIG_SUMO_SIM_anti_2	520	526	PF11976	0.475
LIG_SUMO_SIM_par_1	74	79	PF11976	0.451
LIG_TRAF2_1	636	639	PF00917	0.384
LIG_TYR_ITIM	229	234	PF00017	0.405
LIG_TYR_ITIM	566	571	PF00017	0.515
LIG_WRC_WIRS_1	390	395	PF05994	0.530
MOD_CDK_SPK_2	514	519	PF00069	0.546
MOD_CK1_1	162	168	PF00069	0.397
MOD_CK1_1	296	302	PF00069	0.681
MOD_CK1_1	320	326	PF00069	0.592
MOD_CK1_1	358	364	PF00069	0.552
MOD_CK1_1	402	408	PF00069	0.723
MOD_CK1_1	462	468	PF00069	0.582
MOD_CK1_1	470	476	PF00069	0.614
MOD_CK1_1	517	523	PF00069	0.474
MOD_CK1_1	55	61	PF00069	0.632
MOD_CK1_1	586	592	PF00069	0.647
MOD_CK2_1	269	275	PF00069	0.345
MOD_CK2_1	347	353	PF00069	0.426
MOD_CK2_1	41	47	PF00069	0.611
MOD_CK2_1	428	434	PF00069	0.510
MOD_CK2_1	462	468	PF00069	0.597
MOD_CK2_1	626	632	PF00069	0.479
MOD_GlcNHglycan	101	104	PF01048	0.594
MOD_GlcNHglycan	114	117	PF01048	0.578
MOD_GlcNHglycan	160	164	PF01048	0.428
MOD_GlcNHglycan	214	217	PF01048	0.438
MOD_GlcNHglycan	322	325	PF01048	0.564
MOD_GlcNHglycan	336	340	PF01048	0.663
MOD_GlcNHglycan	357	360	PF01048	0.418
MOD_GlcNHglycan	386	389	PF01048	0.665
MOD_GlcNHglycan	468	472	PF01048	0.672
MOD_GlcNHglycan	47	51	PF01048	0.699
MOD_GlcNHglycan	475	478	PF01048	0.597
MOD_GlcNHglycan	487	490	PF01048	0.648
MOD_GlcNHglycan	59	62	PF01048	0.525
MOD_GlcNHglycan	632	635	PF01048	0.524
MOD_GSK3_1	217	224	PF00069	0.524
MOD_GSK3_1	290	297	PF00069	0.616
MOD_GSK3_1	309	316	PF00069	0.547
MOD_GSK3_1	343	350	PF00069	0.497
MOD_GSK3_1	380	387	PF00069	0.609
MOD_GSK3_1	402	409	PF00069	0.645
MOD_GSK3_1	42	49	PF00069	0.676
MOD_GSK3_1	459	466	PF00069	0.559
MOD_GSK3_1	513	520	PF00069	0.550
MOD_GSK3_1	52	59	PF00069	0.634
MOD_GSK3_1	575	582	PF00069	0.490
MOD_GSK3_1	626	633	PF00069	0.481
MOD_GSK3_1	63	70	PF00069	0.749
MOD_GSK3_1	72	79	PF00069	0.568
MOD_N-GLC_1	217	222	PF02516	0.669
MOD_N-GLC_1	343	348	PF02516	0.536
MOD_N-GLC_2	147	149	PF02516	0.422
MOD_NEK2_1	112	117	PF00069	0.554
MOD_NEK2_1	148	153	PF00069	0.471
MOD_NEK2_1	159	164	PF00069	0.381
MOD_NEK2_1	17	22	PF00069	0.496
MOD_NEK2_1	27	32	PF00069	0.412
MOD_NEK2_1	309	314	PF00069	0.594
MOD_NEK2_1	380	385	PF00069	0.655
MOD_NEK2_1	428	433	PF00069	0.438
MOD_NEK2_1	492	497	PF00069	0.557
MOD_NEK2_1	575	580	PF00069	0.481
MOD_PIKK_1	282	288	PF00454	0.448
MOD_PIKK_1	592	598	PF00454	0.539
MOD_PKA_1	413	419	PF00069	0.573
MOD_PKA_1	599	605	PF00069	0.595
MOD_PKA_2	118	124	PF00069	0.599
MOD_PKA_2	269	275	PF00069	0.466
MOD_PKA_2	473	479	PF00069	0.663
MOD_PKA_2	599	605	PF00069	0.560
MOD_PKB_1	39	47	PF00069	0.646
MOD_Plk_1	380	386	PF00069	0.655
MOD_Plk_1	388	394	PF00069	0.483
MOD_Plk_4	17	23	PF00069	0.430
MOD_Plk_4	269	275	PF00069	0.329
MOD_Plk_4	313	319	PF00069	0.526
MOD_Plk_4	347	353	PF00069	0.506
MOD_Plk_4	358	364	PF00069	0.589
MOD_Plk_4	413	419	PF00069	0.509
MOD_ProDKin_1	300	306	PF00069	0.582
MOD_ProDKin_1	317	323	PF00069	0.616
MOD_ProDKin_1	394	400	PF00069	0.531
MOD_ProDKin_1	48	54	PF00069	0.615
MOD_ProDKin_1	514	520	PF00069	0.478
MOD_SUMO_for_1	185	188	PF00179	0.469
TRG_DiLeu_BaLyEn_6	364	369	PF01217	0.504
TRG_ENDOCYTIC_2	197	200	PF00928	0.407
TRG_ENDOCYTIC_2	223	226	PF00928	0.478
TRG_ENDOCYTIC_2	231	234	PF00928	0.378
TRG_ENDOCYTIC_2	417	420	PF00928	0.472
TRG_ENDOCYTIC_2	562	565	PF00928	0.450
TRG_ENDOCYTIC_2	568	571	PF00928	0.466
TRG_ENDOCYTIC_2	605	608	PF00928	0.522
TRG_ER_diArg_1	174	177	PF00400	0.449
TRG_ER_diArg_1	264	266	PF00400	0.536
TRG_ER_diArg_1	505	507	PF00400	0.528
TRG_ER_diArg_1	599	601	PF00400	0.642
TRG_ER_diArg_1	649	652	PF00400	0.564

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3E5	Leptomonas seymouri	50%	96%
A0A3S7X161	Leishmania donovani	83%	100%
A4I3A7	Leishmania infantum	83%	100%
E9AZK2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4Q8M9	Leishmania major	82%	100%