LeishMANIAdb
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Katanin p60 ATPase-containing subunit A1

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Katanin p60 ATPase-containing subunit A1
Gene product:
katanin, putative
Species:
Leishmania braziliensis
UniProt:
A4HG81_LEIBR
TriTrypDb:
LbrM.28.0410 , LBRM2903_280009600
Length:
523

Annotations

LeishMANIAdb annotations

A large and likely artifical grouping of protease domain carrying proteins related to proteasomal proteases. Only a tiny subgroup (the AFG3-related mitochondrail proteins) seem to have a TM segment.. Localization: Cytoplasmic (by homology) / Mitochondrial (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 5
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 12
GO:0005874 microtubule 6 12
GO:0099080 supramolecular complex 2 12
GO:0099081 supramolecular polymer 3 12
GO:0099512 supramolecular fiber 4 12
GO:0099513 polymeric cytoskeletal fiber 5 12
GO:0110165 cellular anatomical entity 1 12
GO:0005856 cytoskeleton 5 1
GO:0015630 microtubule cytoskeleton 6 1
GO:0043226 organelle 2 1
GO:0043228 non-membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043232 intracellular non-membrane-bounded organelle 4 1
GO:0051286 cell tip 3 1
GO:0060187 cell pole 2 1

Expansion

Sequence features

A4HG81
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HG81

Function

Biological processes
Term Name Level Count
GO:0000226 microtubule cytoskeleton organization 3 12
GO:0006996 organelle organization 4 12
GO:0007010 cytoskeleton organization 5 12
GO:0007017 microtubule-based process 2 12
GO:0009987 cellular process 1 12
GO:0016043 cellular component organization 3 12
GO:0051013 microtubule severing 4 12
GO:0071840 cellular component organization or biogenesis 2 12
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 12
GO:0003824 catalytic activity 1 12
GO:0005488 binding 1 12
GO:0005515 protein binding 2 12
GO:0005524 ATP binding 5 12
GO:0008017 microtubule binding 5 12
GO:0008092 cytoskeletal protein binding 3 12
GO:0008568 microtubule severing ATPase activity 2 12
GO:0015631 tubulin binding 4 12
GO:0016462 pyrophosphatase activity 5 12
GO:0016787 hydrolase activity 2 12
GO:0016817 hydrolase activity, acting on acid anhydrides 3 12
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 4 12
GO:0016853 isomerase activity 2 12
GO:0016887 ATP hydrolysis activity 7 12
GO:0017076 purine nucleotide binding 4 12
GO:0017111 ribonucleoside triphosphate phosphatase activity 6 12
GO:0030554 adenyl nucleotide binding 5 12
GO:0032553 ribonucleotide binding 3 12
GO:0032555 purine ribonucleotide binding 4 12
GO:0032559 adenyl ribonucleotide binding 5 12
GO:0035639 purine ribonucleoside triphosphate binding 4 12
GO:0036094 small molecule binding 2 12
GO:0043167 ion binding 2 12
GO:0043168 anion binding 3 12
GO:0097159 organic cyclic compound binding 2 12
GO:0097367 carbohydrate derivative binding 2 12
GO:0140096 catalytic activity, acting on a protein 2 12
GO:0140657 ATP-dependent activity 1 12
GO:0140776 protein-containing complex destabilizing activity 1 12
GO:1901265 nucleoside phosphate binding 3 12
GO:1901363 heterocyclic compound binding 2 12

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 338 342 PF00656 0.305
CLV_NRD_NRD_1 269 271 PF00675 0.391
CLV_NRD_NRD_1 346 348 PF00675 0.402
CLV_NRD_NRD_1 357 359 PF00675 0.275
CLV_NRD_NRD_1 396 398 PF00675 0.328
CLV_NRD_NRD_1 461 463 PF00675 0.313
CLV_NRD_NRD_1 86 88 PF00675 0.608
CLV_PCSK_KEX2_1 248 250 PF00082 0.509
CLV_PCSK_KEX2_1 269 271 PF00082 0.391
CLV_PCSK_KEX2_1 346 348 PF00082 0.402
CLV_PCSK_KEX2_1 357 359 PF00082 0.275
CLV_PCSK_KEX2_1 395 397 PF00082 0.326
CLV_PCSK_KEX2_1 400 402 PF00082 0.339
CLV_PCSK_KEX2_1 461 463 PF00082 0.313
CLV_PCSK_KEX2_1 85 87 PF00082 0.624
CLV_PCSK_PC1ET2_1 248 250 PF00082 0.509
CLV_PCSK_PC1ET2_1 400 402 PF00082 0.332
CLV_PCSK_PC1ET2_1 85 87 PF00082 0.593
CLV_PCSK_PC7_1 396 402 PF00082 0.328
CLV_PCSK_SKI1_1 248 252 PF00082 0.356
CLV_PCSK_SKI1_1 26 30 PF00082 0.503
CLV_PCSK_SKI1_1 273 277 PF00082 0.284
CLV_PCSK_SKI1_1 285 289 PF00082 0.298
CLV_PCSK_SKI1_1 321 325 PF00082 0.284
CLV_PCSK_SKI1_1 357 361 PF00082 0.284
CLV_PCSK_SKI1_1 421 425 PF00082 0.457
CLV_PCSK_SKI1_1 462 466 PF00082 0.407
DEG_APCC_DBOX_1 411 419 PF00400 0.356
DEG_APCC_KENBOX_2 472 476 PF00400 0.429
DOC_CYCLIN_RxL_1 318 325 PF00134 0.284
DOC_MAPK_gen_1 269 277 PF00069 0.298
DOC_MAPK_gen_1 395 406 PF00069 0.299
DOC_MAPK_gen_1 421 431 PF00069 0.406
DOC_MAPK_gen_1 516 523 PF00069 0.508
DOC_MAPK_MEF2A_6 397 406 PF00069 0.284
DOC_PP1_RVXF_1 319 325 PF00149 0.284
DOC_PP2B_LxvP_1 50 53 PF13499 0.333
DOC_PP4_FxxP_1 78 81 PF00568 0.566
DOC_USP7_MATH_1 158 162 PF00917 0.658
DOC_USP7_MATH_1 163 167 PF00917 0.616
DOC_USP7_MATH_1 291 295 PF00917 0.313
DOC_USP7_MATH_1 53 57 PF00917 0.600
DOC_USP7_UBL2_3 417 421 PF12436 0.483
DOC_USP7_UBL2_3 465 469 PF12436 0.303
DOC_WW_Pin1_4 149 154 PF00397 0.586
DOC_WW_Pin1_4 301 306 PF00397 0.290
LIG_14-3-3_CanoR_1 116 122 PF00244 0.751
LIG_14-3-3_CanoR_1 51 61 PF00244 0.453
LIG_APCC_ABBA_1 75 80 PF00400 0.509
LIG_BRCT_BRCA1_1 160 164 PF00533 0.601
LIG_BRCT_BRCA1_1 332 336 PF00533 0.284
LIG_deltaCOP1_diTrp_1 513 519 PF00928 0.284
LIG_FHA_1 332 338 PF00498 0.284
LIG_FHA_1 372 378 PF00498 0.384
LIG_FHA_1 408 414 PF00498 0.449
LIG_FHA_1 418 424 PF00498 0.400
LIG_FHA_1 447 453 PF00498 0.305
LIG_FHA_1 53 59 PF00498 0.324
LIG_FHA_2 235 241 PF00498 0.531
LIG_FHA_2 469 475 PF00498 0.391
LIG_FHA_2 69 75 PF00498 0.467
LIG_GBD_Chelix_1 221 229 PF00786 0.376
LIG_Integrin_RGD_1 313 315 PF01839 0.299
LIG_LIR_Gen_1 237 244 PF02991 0.379
LIG_LIR_Gen_1 428 438 PF02991 0.300
LIG_LIR_Nem_3 237 241 PF02991 0.390
LIG_LIR_Nem_3 263 268 PF02991 0.424
LIG_LIR_Nem_3 298 303 PF02991 0.285
LIG_LIR_Nem_3 428 434 PF02991 0.285
LIG_LYPXL_S_1 256 260 PF13949 0.363
LIG_LYPXL_yS_3 257 260 PF13949 0.368
LIG_MYND_1 258 262 PF01753 0.377
LIG_NRBOX 433 439 PF00104 0.348
LIG_PDZ_Class_2 518 523 PF00595 0.567
LIG_Pex14_1 515 519 PF04695 0.284
LIG_SH2_CRK 265 269 PF00017 0.433
LIG_SH2_CRK 278 282 PF00017 0.238
LIG_SH2_CRK 32 36 PF00017 0.501
LIG_SH2_PTP2 403 406 PF00017 0.284
LIG_SH2_SRC 330 333 PF00017 0.299
LIG_SH2_STAT5 128 131 PF00017 0.586
LIG_SH2_STAT5 22 25 PF00017 0.518
LIG_SH2_STAT5 403 406 PF00017 0.284
LIG_SH3_3 252 258 PF00018 0.351
LIG_TRAF2_1 216 219 PF00917 0.438
LIG_TYR_ITIM 255 260 PF00017 0.359
LIG_UBA3_1 415 421 PF00899 0.411
LIG_UBA3_1 457 465 PF00899 0.411
LIG_WW_1 89 92 PF00397 0.507
MOD_CDK_SPxxK_3 149 156 PF00069 0.594
MOD_CK1_1 120 126 PF00069 0.593
MOD_CK1_1 207 213 PF00069 0.604
MOD_CK1_1 304 310 PF00069 0.299
MOD_CK1_1 4 10 PF00069 0.492
MOD_CK2_1 468 474 PF00069 0.439
MOD_CK2_1 53 59 PF00069 0.559
MOD_CK2_1 68 74 PF00069 0.528
MOD_Cter_Amidation 344 347 PF01082 0.206
MOD_GlcNHglycan 129 132 PF01048 0.707
MOD_GlcNHglycan 160 163 PF01048 0.742
MOD_GlcNHglycan 206 209 PF01048 0.650
MOD_GlcNHglycan 443 446 PF01048 0.412
MOD_GlcNHglycan 97 100 PF01048 0.725
MOD_GSK3_1 117 124 PF00069 0.604
MOD_GSK3_1 158 165 PF00069 0.672
MOD_GSK3_1 291 298 PF00069 0.299
MOD_GSK3_1 38 45 PF00069 0.540
MOD_N-GLC_1 192 197 PF02516 0.633
MOD_N-GLC_1 296 301 PF02516 0.294
MOD_NEK2_1 121 126 PF00069 0.696
MOD_NEK2_1 381 386 PF00069 0.284
MOD_NEK2_2 296 301 PF00069 0.284
MOD_NEK2_2 31 36 PF00069 0.456
MOD_NEK2_2 456 461 PF00069 0.284
MOD_PIKK_1 68 74 PF00454 0.457
MOD_PKA_2 68 74 PF00069 0.457
MOD_Plk_1 296 302 PF00069 0.343
MOD_Plk_1 467 473 PF00069 0.433
MOD_Plk_2-3 468 474 PF00069 0.502
MOD_Plk_4 283 289 PF00069 0.311
MOD_Plk_4 296 302 PF00069 0.284
MOD_Plk_4 331 337 PF00069 0.284
MOD_Plk_4 359 365 PF00069 0.299
MOD_Plk_4 53 59 PF00069 0.538
MOD_ProDKin_1 149 155 PF00069 0.588
MOD_ProDKin_1 301 307 PF00069 0.290
MOD_SUMO_rev_2 240 250 PF00179 0.383
TRG_DiLeu_BaEn_1 220 225 PF01217 0.397
TRG_DiLeu_BaEn_1 246 251 PF01217 0.393
TRG_DiLeu_BaEn_2 73 79 PF01217 0.578
TRG_DiLeu_LyEn_5 246 251 PF01217 0.504
TRG_ENDOCYTIC_2 257 260 PF00928 0.368
TRG_ENDOCYTIC_2 265 268 PF00928 0.401
TRG_ENDOCYTIC_2 32 35 PF00928 0.349
TRG_ENDOCYTIC_2 403 406 PF00928 0.284
TRG_ER_diArg_1 200 203 PF00400 0.711
TRG_ER_diArg_1 268 270 PF00400 0.412
TRG_ER_diArg_1 394 397 PF00400 0.324
TRG_ER_diArg_1 460 462 PF00400 0.317
TRG_NLS_MonoExtC_3 111 116 PF00514 0.719
TRG_NLS_MonoExtN_4 112 117 PF00514 0.776
TRG_Pf-PMV_PEXEL_1 248 252 PF00026 0.370
TRG_Pf-PMV_PEXEL_1 321 325 PF00026 0.284

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HRH8 Leptomonas seymouri 68% 96%
A0A0S4IUM1 Bodo saltans 51% 88%
A0A1X0NYV7 Trypanosomatidae 56% 93%
A0A3Q8IHU1 Leishmania donovani 34% 100%
A0A3Q8IJS0 Leishmania donovani 35% 100%
A0A3S7X163 Leishmania donovani 88% 99%
A0A3S7X2R4 Leishmania donovani 40% 100%
A0A422P1K0 Trypanosoma rangeli 58% 94%
A2VDN5 Bos taurus 39% 85%
A4H6T6 Leishmania braziliensis 37% 100%
A4HHP9 Leishmania braziliensis 41% 100%
A4HME8 Leishmania braziliensis 35% 100%
A4HPV3 Leishmania braziliensis 35% 100%
A4I3C0 Leishmania infantum 88% 87%
A4I4W4 Leishmania infantum 40% 100%
A4IB20 Leishmania infantum 34% 100%
A4IE38 Leishmania infantum 35% 100%
A9RA82 Papio anubis 42% 100%
B2RYN7 Rattus norvegicus 40% 90%
B3EX35 Sorex araneus 42% 100%
B4F6J6 Xenopus tropicalis 34% 100%
B4USW8 Otolemur garnettii 42% 100%
B5X3X5 Salmo salar 42% 100%
B7NZ88 Oryctolagus cuniculus 42% 100%
D0A833 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 58% 94%
E9AEB2 Leishmania major 40% 100%
E9AEU9 Leishmania major 34% 100%
E9ALH4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 42% 100%
E9ATM0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 35% 100%
E9AZK1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 83% 97%
E9B605 Leishmania mexicana (strain MHOM/GT/2001/U1103) 33% 100%
F6QV99 Bos taurus 33% 100%
O61577 Strongylocentrotus purpuratus 43% 100%
O75449 Homo sapiens 42% 100%
Q05AS3 Xenopus tropicalis 41% 87%
Q0IIR9 Xenopus tropicalis 43% 100%
Q1HGK7 Gallus gallus 44% 100%
Q4Q0X8 Leishmania major 35% 100%
Q4Q8N0 Leishmania major 85% 100%
Q4R407 Macaca fascicularis 42% 100%
Q505J9 Rattus norvegicus 33% 100%
Q5RII9 Danio rerio 44% 100%
Q5U3S1 Danio rerio 42% 100%
Q5XIK7 Rattus norvegicus 42% 100%
Q6E0V2 Rattus norvegicus 42% 100%
Q6NW58 Danio rerio 40% 92%
Q719N1 Sus scrofa 37% 85%
Q793F9 Rattus norvegicus 40% 100%
Q7ZZ25 Danio rerio 32% 100%
Q8K0T4 Mus musculus 43% 100%
Q8NBU5 Homo sapiens 33% 100%
Q8VEJ9 Mus musculus 40% 100%
Q9BW62 Homo sapiens 42% 100%
Q9D5T0 Mus musculus 33% 100%
Q9PUL2 Xenopus laevis 43% 100%
Q9QYY8 Mus musculus 40% 85%
Q9SEX2 Arabidopsis thaliana 42% 100%
Q9UBP0 Homo sapiens 40% 85%
Q9UN37 Homo sapiens 40% 100%
Q9WV86 Mus musculus 42% 100%
V5B0U7 Trypanosoma cruzi 57% 94%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS