Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Nucleus and spindle associated protein 1, putative

Species:

Leishmania braziliensis

UniProt:

A4HG80_LEIBR

TriTrypDb:

LbrM.28.0400 , LBRM2903_280009500

Length:

930

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005819	spindle	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HG80

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HG80

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	14	16	PF00675	0.739
CLV_NRD_NRD_1	182	184	PF00675	0.421
CLV_NRD_NRD_1	410	412	PF00675	0.584
CLV_NRD_NRD_1	447	449	PF00675	0.592
CLV_NRD_NRD_1	484	486	PF00675	0.648
CLV_NRD_NRD_1	643	645	PF00675	0.521
CLV_NRD_NRD_1	655	657	PF00675	0.567
CLV_NRD_NRD_1	793	795	PF00675	0.508
CLV_NRD_NRD_1	828	830	PF00675	0.583
CLV_NRD_NRD_1	872	874	PF00675	0.614
CLV_NRD_NRD_1	880	882	PF00675	0.612
CLV_NRD_NRD_1	901	903	PF00675	0.636
CLV_PCSK_FUR_1	878	882	PF00082	0.658
CLV_PCSK_KEX2_1	13	15	PF00082	0.777
CLV_PCSK_KEX2_1	182	184	PF00082	0.401
CLV_PCSK_KEX2_1	328	330	PF00082	0.568
CLV_PCSK_KEX2_1	410	412	PF00082	0.601
CLV_PCSK_KEX2_1	447	449	PF00082	0.629
CLV_PCSK_KEX2_1	549	551	PF00082	0.564
CLV_PCSK_KEX2_1	643	645	PF00082	0.513
CLV_PCSK_KEX2_1	655	657	PF00082	0.567
CLV_PCSK_KEX2_1	793	795	PF00082	0.382
CLV_PCSK_KEX2_1	828	830	PF00082	0.582
CLV_PCSK_KEX2_1	872	874	PF00082	0.549
CLV_PCSK_KEX2_1	880	882	PF00082	0.573
CLV_PCSK_KEX2_1	900	902	PF00082	0.318
CLV_PCSK_PC1ET2_1	328	330	PF00082	0.568
CLV_PCSK_PC1ET2_1	549	551	PF00082	0.660
CLV_PCSK_PC1ET2_1	900	902	PF00082	0.649
CLV_PCSK_SKI1_1	182	186	PF00082	0.522
CLV_PCSK_SKI1_1	207	211	PF00082	0.641
CLV_PCSK_SKI1_1	237	241	PF00082	0.548
CLV_PCSK_SKI1_1	242	246	PF00082	0.538
CLV_PCSK_SKI1_1	307	311	PF00082	0.573
CLV_PCSK_SKI1_1	458	462	PF00082	0.569
CLV_PCSK_SKI1_1	481	485	PF00082	0.560
CLV_PCSK_SKI1_1	592	596	PF00082	0.567
CLV_PCSK_SKI1_1	605	609	PF00082	0.633
CLV_PCSK_SKI1_1	656	660	PF00082	0.568
CLV_PCSK_SKI1_1	673	677	PF00082	0.370
CLV_PCSK_SKI1_1	848	852	PF00082	0.586
CLV_Separin_Metazoa	308	312	PF03568	0.543
DEG_APCC_DBOX_1	604	612	PF00400	0.656
DOC_CKS1_1	113	118	PF01111	0.540
DOC_CKS1_1	55	60	PF01111	0.733
DOC_CYCLIN_RxL_1	791	800	PF00134	0.499
DOC_CYCLIN_RxL_1	842	854	PF00134	0.448
DOC_CYCLIN_yCln2_LP_2	754	760	PF00134	0.733
DOC_CYCLIN_yCln2_LP_2	801	807	PF00134	0.673
DOC_MAPK_gen_1	105	113	PF00069	0.603
DOC_MAPK_gen_1	407	417	PF00069	0.570
DOC_MAPK_gen_1	549	556	PF00069	0.678
DOC_MAPK_MEF2A_6	159	166	PF00069	0.531
DOC_MAPK_MEF2A_6	384	393	PF00069	0.509
DOC_MAPK_MEF2A_6	410	419	PF00069	0.634
DOC_PP1_RVXF_1	551	557	PF00149	0.689
DOC_PP1_RVXF_1	702	708	PF00149	0.500
DOC_USP7_MATH_1	198	202	PF00917	0.586
DOC_USP7_MATH_1	370	374	PF00917	0.440
DOC_USP7_MATH_1	435	439	PF00917	0.496
DOC_USP7_MATH_1	452	456	PF00917	0.293
DOC_USP7_MATH_1	487	491	PF00917	0.568
DOC_USP7_MATH_1	6	10	PF00917	0.735
DOC_USP7_MATH_1	603	607	PF00917	0.626
DOC_USP7_MATH_1	764	768	PF00917	0.662
DOC_USP7_MATH_1	79	83	PF00917	0.586
DOC_WW_Pin1_4	112	117	PF00397	0.550
DOC_WW_Pin1_4	46	51	PF00397	0.708
DOC_WW_Pin1_4	54	59	PF00397	0.692
DOC_WW_Pin1_4	67	72	PF00397	0.686
LIG_14-3-3_CanoR_1	207	212	PF00244	0.568
LIG_14-3-3_CanoR_1	246	253	PF00244	0.578
LIG_14-3-3_CanoR_1	317	321	PF00244	0.382
LIG_14-3-3_CanoR_1	362	368	PF00244	0.550
LIG_14-3-3_CanoR_1	410	419	PF00244	0.537
LIG_14-3-3_CanoR_1	633	638	PF00244	0.382
LIG_Actin_WH2_2	472	487	PF00022	0.588
LIG_BIR_II_1	1	5	PF00653	0.754
LIG_CaM_IQ_9	908	923	PF13499	0.649
LIG_Clathr_ClatBox_1	416	420	PF01394	0.593
LIG_deltaCOP1_diTrp_1	713	717	PF00928	0.605
LIG_EH1_1	159	167	PF00400	0.505
LIG_FHA_1	124	130	PF00498	0.559
LIG_FHA_1	151	157	PF00498	0.599
LIG_FHA_1	183	189	PF00498	0.521
LIG_FHA_1	227	233	PF00498	0.577
LIG_FHA_1	55	61	PF00498	0.742
LIG_FHA_1	787	793	PF00498	0.579
LIG_FHA_2	113	119	PF00498	0.642
LIG_FHA_2	238	244	PF00498	0.630
LIG_FHA_2	278	284	PF00498	0.381
LIG_FHA_2	509	515	PF00498	0.449
LIG_FHA_2	591	597	PF00498	0.572
LIG_LIR_Gen_1	250	261	PF02991	0.603
LIG_LIR_Gen_1	383	393	PF02991	0.543
LIG_LIR_Gen_1	430	437	PF02991	0.570
LIG_LIR_Gen_1	548	557	PF02991	0.425
LIG_LIR_Gen_1	759	768	PF02991	0.616
LIG_LIR_LC3C_4	539	543	PF02991	0.484
LIG_LIR_Nem_3	216	221	PF02991	0.543
LIG_LIR_Nem_3	250	256	PF02991	0.609
LIG_LIR_Nem_3	383	389	PF02991	0.540
LIG_LIR_Nem_3	430	436	PF02991	0.594
LIG_LIR_Nem_3	548	554	PF02991	0.416
LIG_LIR_Nem_3	631	637	PF02991	0.600
LIG_LIR_Nem_3	759	763	PF02991	0.615
LIG_SH2_CRK	208	212	PF00017	0.602
LIG_SH2_CRK	386	390	PF00017	0.572
LIG_SH2_GRB2like	788	791	PF00017	0.402
LIG_SH2_NCK_1	708	712	PF00017	0.516
LIG_SH2_NCK_1	755	759	PF00017	0.724
LIG_SH2_SRC	225	228	PF00017	0.639
LIG_SH2_SRC	708	711	PF00017	0.594
LIG_SH2_SRC	755	758	PF00017	0.722
LIG_SH2_STAP1	144	148	PF00017	0.639
LIG_SH2_STAP1	208	212	PF00017	0.402
LIG_SH2_STAP1	227	231	PF00017	0.558
LIG_SH2_STAP1	401	405	PF00017	0.671
LIG_SH2_STAP1	680	684	PF00017	0.612
LIG_SH2_STAP1	715	719	PF00017	0.592
LIG_SH2_STAP1	788	792	PF00017	0.402
LIG_SH2_STAT3	227	230	PF00017	0.637
LIG_SH2_STAT3	642	645	PF00017	0.623
LIG_SH2_STAT5	247	250	PF00017	0.435
LIG_SH2_STAT5	352	355	PF00017	0.610
LIG_SH2_STAT5	788	791	PF00017	0.565
LIG_SH3_1	13	19	PF00018	0.760
LIG_SH3_3	13	19	PF00018	0.760
LIG_SH3_3	49	55	PF00018	0.731
LIG_SUMO_SIM_anti_2	153	158	PF11976	0.582
LIG_SUMO_SIM_par_1	195	203	PF11976	0.554
LIG_SUMO_SIM_par_1	413	421	PF11976	0.603
LIG_SUMO_SIM_par_1	470	478	PF11976	0.366
LIG_SUMO_SIM_par_1	59	65	PF11976	0.520
LIG_SUMO_SIM_par_1	816	824	PF11976	0.554
LIG_TRAF2_1	125	128	PF00917	0.479
LIG_TRAF2_1	474	477	PF00917	0.425
LIG_TRAF2_1	521	524	PF00917	0.588
LIG_TRAF2_1	537	540	PF00917	0.480
LIG_TRAF2_1	588	591	PF00917	0.605
LIG_TRAF2_1	615	618	PF00917	0.620
LIG_TRAF2_1	698	701	PF00917	0.379
LIG_TRAF2_1	743	746	PF00917	0.647
LIG_WW_3	561	565	PF00397	0.425
MOD_CDK_SPxxK_3	112	119	PF00069	0.545
MOD_CK1_1	131	137	PF00069	0.632
MOD_CK1_1	20	26	PF00069	0.714
MOD_CK1_1	699	705	PF00069	0.593
MOD_CK1_1	892	898	PF00069	0.551
MOD_CK2_1	112	118	PF00069	0.628
MOD_CK2_1	122	128	PF00069	0.519
MOD_CK2_1	143	149	PF00069	0.590
MOD_CK2_1	237	243	PF00069	0.629
MOD_CK2_1	277	283	PF00069	0.587
MOD_CK2_1	508	514	PF00069	0.545
MOD_CK2_1	590	596	PF00069	0.513
MOD_CK2_1	740	746	PF00069	0.664
MOD_CK2_1	763	769	PF00069	0.662
MOD_CK2_1	868	874	PF00069	0.628
MOD_CMANNOS	714	717	PF00535	0.633
MOD_Cter_Amidation	326	329	PF01082	0.594
MOD_Cter_Amidation	445	448	PF01082	0.638
MOD_GlcNHglycan	28	31	PF01048	0.592
MOD_GlcNHglycan	395	398	PF01048	0.564
MOD_GlcNHglycan	489	492	PF01048	0.522
MOD_GlcNHglycan	514	517	PF01048	0.528
MOD_GlcNHglycan	564	567	PF01048	0.662
MOD_GlcNHglycan	605	608	PF01048	0.602
MOD_GlcNHglycan	700	704	PF01048	0.577
MOD_GlcNHglycan	766	769	PF01048	0.483
MOD_GlcNHglycan	810	813	PF01048	0.549
MOD_GlcNHglycan	823	826	PF01048	0.582
MOD_GSK3_1	18	25	PF00069	0.774
MOD_GSK3_1	277	284	PF00069	0.636
MOD_GSK3_1	31	38	PF00069	0.729
MOD_GSK3_1	316	323	PF00069	0.554
MOD_GSK3_1	431	438	PF00069	0.374
MOD_GSK3_1	46	53	PF00069	0.667
MOD_GSK3_1	508	515	PF00069	0.542
MOD_GSK3_1	883	890	PF00069	0.644
MOD_LATS_1	842	848	PF00433	0.414
MOD_N-GLC_1	922	927	PF02516	0.429
MOD_NEK2_1	277	282	PF00069	0.640
MOD_NEK2_1	582	587	PF00069	0.596
MOD_NEK2_1	763	768	PF00069	0.693
MOD_NEK2_1	887	892	PF00069	0.592
MOD_OFUCOSY	579	586	PF10250	0.628
MOD_PIKK_1	20	26	PF00454	0.538
MOD_PIKK_1	226	232	PF00454	0.596
MOD_PIKK_1	248	254	PF00454	0.652
MOD_PIKK_1	370	376	PF00454	0.383
MOD_PIKK_1	650	656	PF00454	0.556
MOD_PIKK_1	688	694	PF00454	0.636
MOD_PIKK_1	889	895	PF00454	0.570
MOD_PKA_1	182	188	PF00069	0.394
MOD_PKA_1	410	416	PF00069	0.588
MOD_PKA_2	123	129	PF00069	0.634
MOD_PKA_2	182	188	PF00069	0.394
MOD_PKA_2	245	251	PF00069	0.533
MOD_PKA_2	316	322	PF00069	0.570
MOD_PKA_2	363	369	PF00069	0.551
MOD_PKA_2	410	416	PF00069	0.588
MOD_PKA_2	468	474	PF00069	0.364
MOD_PKA_2	65	71	PF00069	0.694
MOD_PKA_2	764	770	PF00069	0.488
MOD_PKB_1	15	23	PF00069	0.754
MOD_PKB_1	528	536	PF00069	0.583
MOD_Plk_1	248	254	PF00069	0.652
MOD_Plk_1	475	481	PF00069	0.622
MOD_Plk_1	590	596	PF00069	0.563
MOD_Plk_1	682	688	PF00069	0.360
MOD_Plk_2-3	128	134	PF00069	0.642
MOD_Plk_4	143	149	PF00069	0.625
MOD_Plk_4	277	283	PF00069	0.386
MOD_Plk_4	316	322	PF00069	0.378
MOD_Plk_4	468	474	PF00069	0.534
MOD_Plk_4	892	898	PF00069	0.396
MOD_ProDKin_1	112	118	PF00069	0.546
MOD_ProDKin_1	46	52	PF00069	0.708
MOD_ProDKin_1	54	60	PF00069	0.694
MOD_ProDKin_1	67	73	PF00069	0.684
MOD_SUMO_for_1	521	524	PF00179	0.371
MOD_SUMO_rev_2	909	917	PF00179	0.642
TRG_DiLeu_BaEn_1	262	267	PF01217	0.687
TRG_DiLeu_BaEn_1	725	730	PF01217	0.587
TRG_DiLeu_BaEn_4	590	596	PF01217	0.516
TRG_DiLeu_BaEn_4	864	870	PF01217	0.628
TRG_DiLeu_BaLyEn_6	230	235	PF01217	0.393
TRG_DiLeu_BaLyEn_6	527	532	PF01217	0.589
TRG_DiLeu_LyEn_5	725	730	PF01217	0.631
TRG_ENDOCYTIC_2	208	211	PF00928	0.563
TRG_ENDOCYTIC_2	386	389	PF00928	0.574
TRG_ENDOCYTIC_2	634	637	PF00928	0.430
TRG_ENDOCYTIC_2	708	711	PF00928	0.561
TRG_ER_diArg_1	12	15	PF00400	0.778
TRG_ER_diArg_1	137	140	PF00400	0.521
TRG_ER_diArg_1	274	277	PF00400	0.570
TRG_ER_diArg_1	290	293	PF00400	0.624
TRG_ER_diArg_1	339	342	PF00400	0.511
TRG_ER_diArg_1	447	449	PF00400	0.646
TRG_ER_diArg_1	642	644	PF00400	0.435
TRG_ER_diArg_1	670	673	PF00400	0.429
TRG_ER_diArg_1	741	744	PF00400	0.537
TRG_ER_diArg_1	792	794	PF00400	0.382
TRG_ER_diArg_1	880	882	PF00400	0.641
TRG_ER_diArg_1	901	903	PF00400	0.576
TRG_NES_CRM1_1	155	168	PF08389	0.504
TRG_Pf-PMV_PEXEL_1	163	167	PF00026	0.376
TRG_Pf-PMV_PEXEL_1	233	238	PF00026	0.403
TRG_Pf-PMV_PEXEL_1	264	269	PF00026	0.673
TRG_Pf-PMV_PEXEL_1	464	468	PF00026	0.517
TRG_Pf-PMV_PEXEL_1	794	799	PF00026	0.365
TRG_Pf-PMV_PEXEL_1	901	905	PF00026	0.638

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB25	Leptomonas seymouri	57%	100%
A0A1X0NYM1	Trypanosomatidae	27%	100%
A0A3Q8ICZ1	Leishmania donovani	81%	100%
A0A3R7NTV6	Trypanosoma rangeli	29%	100%
A4I3C1	Leishmania infantum	81%	100%
D0A834	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
E9AZK0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4Q8N1	Leishmania major	80%	100%
V5BKX1	Trypanosoma cruzi	28%	100%