Sacchrp_dh_NADP domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

saccharopine dehydrogenase, putative

Species:

Leishmania braziliensis

UniProt:

A4HG79_LEIBR

TriTrypDb:

LbrM.28.0390 , LBRM2903_280009400

Length:

392

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005811	lipid droplet	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

A4HG79

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HG79

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	1
GO:0006643	membrane lipid metabolic process	4	1
GO:0006664	glycolipid metabolic process	5	1
GO:0008152	metabolic process	1	1
GO:0008610	lipid biosynthetic process	4	1
GO:0009058	biosynthetic process	2	1
GO:0009247	glycolipid biosynthetic process	5	1
GO:0009987	cellular process	1	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044255	cellular lipid metabolic process	3	1
GO:0046467	membrane lipid biosynthetic process	4	1
GO:0071704	organic substance metabolic process	2	1
GO:1901135	carbohydrate derivative metabolic process	3	1
GO:1901137	carbohydrate derivative biosynthetic process	4	1
GO:1901576	organic substance biosynthetic process	3	1
GO:1903509	liposaccharide metabolic process	4	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0016491	oxidoreductase activity	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	66	70	PF00656	0.296
CLV_NRD_NRD_1	114	116	PF00675	0.405
CLV_NRD_NRD_1	235	237	PF00675	0.335
CLV_NRD_NRD_1	25	27	PF00675	0.349
CLV_NRD_NRD_1	278	280	PF00675	0.389
CLV_NRD_NRD_1	282	284	PF00675	0.418
CLV_NRD_NRD_1	346	348	PF00675	0.482
CLV_PCSK_KEX2_1	114	116	PF00082	0.344
CLV_PCSK_KEX2_1	235	237	PF00082	0.376
CLV_PCSK_KEX2_1	278	280	PF00082	0.389
CLV_PCSK_KEX2_1	315	317	PF00082	0.374
CLV_PCSK_PC1ET2_1	315	317	PF00082	0.443
CLV_PCSK_SKI1_1	284	288	PF00082	0.491
CLV_PCSK_SKI1_1	315	319	PF00082	0.361
DOC_CKS1_1	355	360	PF01111	0.313
DOC_MAPK_gen_1	369	377	PF00069	0.365
DOC_MAPK_MEF2A_6	48	55	PF00069	0.402
DOC_USP7_MATH_1	169	173	PF00917	0.442
DOC_USP7_MATH_1	195	199	PF00917	0.513
DOC_USP7_MATH_1	37	41	PF00917	0.402
DOC_USP7_UBL2_3	27	31	PF12436	0.333
DOC_USP7_UBL2_3	344	348	PF12436	0.485
DOC_WW_Pin1_4	189	194	PF00397	0.474
DOC_WW_Pin1_4	204	209	PF00397	0.534
DOC_WW_Pin1_4	354	359	PF00397	0.307
LIG_14-3-3_CanoR_1	18	24	PF00244	0.390
LIG_14-3-3_CanoR_1	235	241	PF00244	0.454
LIG_14-3-3_CanoR_1	260	270	PF00244	0.545
LIG_14-3-3_CanoR_1	316	322	PF00244	0.303
LIG_14-3-3_CanoR_1	347	352	PF00244	0.488
LIG_Actin_WH2_2	244	262	PF00022	0.233
LIG_Actin_WH2_2	336	354	PF00022	0.404
LIG_BIR_II_1	1	5	PF00653	0.455
LIG_DLG_GKlike_1	347	355	PF00625	0.386
LIG_eIF4E_1	328	334	PF01652	0.372
LIG_FHA_1	14	20	PF00498	0.327
LIG_FHA_1	262	268	PF00498	0.343
LIG_FHA_1	377	383	PF00498	0.563
LIG_FHA_1	55	61	PF00498	0.416
LIG_FHA_1	99	105	PF00498	0.266
LIG_FHA_2	185	191	PF00498	0.529
LIG_FHA_2	64	70	PF00498	0.169
LIG_Integrin_isoDGR_2	217	219	PF01839	0.463
LIG_LIR_Gen_1	254	263	PF02991	0.393
LIG_LIR_Nem_3	254	258	PF02991	0.497
LIG_Pex14_2	303	307	PF04695	0.414
LIG_PTB_Apo_2	214	221	PF02174	0.449
LIG_SH2_CRK	85	89	PF00017	0.296
LIG_SH2_GRB2like	215	218	PF00017	0.534
LIG_SH2_SRC	215	218	PF00017	0.475
LIG_SH2_STAP1	328	332	PF00017	0.436
LIG_SH2_STAT5	103	106	PF00017	0.291
LIG_SH2_STAT5	147	150	PF00017	0.308
LIG_SH2_STAT5	163	166	PF00017	0.230
LIG_SH2_STAT5	23	26	PF00017	0.351
LIG_SH2_STAT5	266	269	PF00017	0.495
LIG_SH2_STAT5	285	288	PF00017	0.456
LIG_SH2_STAT5	328	331	PF00017	0.321
LIG_SH3_3	352	358	PF00018	0.337
LIG_SH3_3	85	91	PF00018	0.302
LIG_SUMO_SIM_anti_2	192	198	PF11976	0.499
LIG_SUMO_SIM_anti_2	269	274	PF11976	0.379
LIG_SUMO_SIM_anti_2	3	9	PF11976	0.373
LIG_SUMO_SIM_par_1	192	198	PF11976	0.441
LIG_SUMO_SIM_par_1	378	385	PF11976	0.571
LIG_WRC_WIRS_1	55	60	PF05994	0.402
MOD_CK1_1	172	178	PF00069	0.338
MOD_CK1_1	184	190	PF00069	0.412
MOD_CK1_1	376	382	PF00069	0.475
MOD_CK2_1	225	231	PF00069	0.509
MOD_Cter_Amidation	313	316	PF01082	0.504
MOD_GlcNHglycan	243	246	PF01048	0.447
MOD_GlcNHglycan	312	315	PF01048	0.404
MOD_GlcNHglycan	340	343	PF01048	0.233
MOD_GlcNHglycan	39	42	PF01048	0.370
MOD_GSK3_1	13	20	PF00069	0.379
MOD_GSK3_1	202	209	PF00069	0.447
MOD_GSK3_1	221	228	PF00069	0.504
MOD_GSK3_1	236	243	PF00069	0.453
MOD_GSK3_1	262	269	PF00069	0.261
MOD_GSK3_1	287	294	PF00069	0.522
MOD_N-GLC_1	172	177	PF02516	0.484
MOD_N-GLC_1	184	189	PF02516	0.524
MOD_N-GLC_1	98	103	PF02516	0.358
MOD_NEK2_1	10	15	PF00069	0.302
MOD_NEK2_1	223	228	PF00069	0.449
MOD_NEK2_1	240	245	PF00069	0.309
MOD_NEK2_1	251	256	PF00069	0.480
MOD_NEK2_1	259	264	PF00069	0.313
MOD_NEK2_1	286	291	PF00069	0.541
MOD_NEK2_1	298	303	PF00069	0.397
MOD_NEK2_2	17	22	PF00069	0.402
MOD_PIKK_1	206	212	PF00454	0.447
MOD_PKA_1	347	353	PF00069	0.399
MOD_PKA_2	17	23	PF00069	0.402
MOD_PKA_2	218	224	PF00069	0.355
MOD_PKA_2	234	240	PF00069	0.228
MOD_PKA_2	259	265	PF00069	0.533
MOD_Plk_4	236	242	PF00069	0.345
MOD_Plk_4	262	268	PF00069	0.477
MOD_Plk_4	376	382	PF00069	0.503
MOD_Plk_4	54	60	PF00069	0.395
MOD_ProDKin_1	189	195	PF00069	0.472
MOD_ProDKin_1	204	210	PF00069	0.530
MOD_ProDKin_1	354	360	PF00069	0.312
MOD_SUMO_for_1	388	391	PF00179	0.456
MOD_SUMO_for_1	47	50	PF00179	0.358
TRG_ENDOCYTIC_2	85	88	PF00928	0.288
TRG_ER_diArg_1	113	115	PF00400	0.437
TRG_ER_diArg_1	234	236	PF00400	0.332
TRG_ER_diArg_1	277	279	PF00400	0.386
TRG_ER_diLys_1	389	392	PF00400	0.653

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYN7	Leptomonas seymouri	63%	100%
A0A0S4IJU8	Bodo saltans	42%	99%
A0A1X0NQA2	Trypanosomatidae	41%	99%
A0A3R7KXD1	Trypanosoma rangeli	44%	100%
A0A3S7X166	Leishmania donovani	83%	100%
A0A422NEM4	Trypanosoma rangeli	40%	100%
A0PQ21	Mycobacterium ulcerans (strain Agy99)	32%	94%
A1KMU7	Mycobacterium bovis (strain BCG / Pasteur 1173P2)	31%	94%
A4I3C3	Leishmania infantum	84%	100%
A5U6W1	Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra)	31%	94%
E9AZJ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
O53176	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	33%	94%
P9WGV4	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	31%	94%
P9WGV5	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	31%	94%
Q3T067	Bos taurus	28%	91%
Q4Q8N2	Leishmania major	83%	100%
Q5R5C9	Pongo abelii	27%	91%
Q6AY30	Rattus norvegicus	27%	91%
Q7D745	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	33%	94%
Q7TXK2	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)	31%	94%
Q8LGI2	Arabidopsis thaliana	26%	86%
Q8NBX0	Homo sapiens	27%	91%
Q8R127	Mus musculus	27%	91%
Q9CD87	Mycobacterium leprae (strain TN)	33%	94%
Q9GZE9	Caenorhabditis elegans	26%	92%
V5AMR3	Trypanosoma cruzi	40%	100%
V5CHW2	Trypanosoma cruzi	40%	100%