Putative ubiquitin activating enzyme

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ubiquitin activating enzyme, putative

Species:

Leishmania braziliensis

UniProt:

A4HG77_LEIBR

TriTrypDb:

LbrM.28.0370 , LBRM2903_280009200

Length:

287

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0031510	SUMO activating enzyme complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0110165	cellular anatomical entity	1	1
GO:0140513	nuclear protein-containing complex	2	1
GO:1902494	catalytic complex	2	1

Expansion

Sequence features

A4HG77

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HG77

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0016925	protein sumoylation	7	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018205	peptidyl-lysine modification	6	1
GO:0019538	protein metabolic process	3	1
GO:0032446	protein modification by small protein conjugation	6	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044238	primary metabolic process	2	1
GO:0070647	protein modification by small protein conjugation or removal	5	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0008641	ubiquitin-like modifier activating enzyme activity	2	12
GO:0016874	ligase activity	2	12
GO:0016877	ligase activity, forming carbon-sulfur bonds	3	12
GO:0140096	catalytic activity, acting on a protein	2	12
GO:0140657	ATP-dependent activity	1	12
GO:0019948	SUMO activating enzyme activity	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	102	106	PF00656	0.319
CLV_NRD_NRD_1	154	156	PF00675	0.453
CLV_PCSK_KEX2_1	154	156	PF00082	0.551
CLV_PCSK_SKI1_1	184	188	PF00082	0.366
DEG_APCC_DBOX_1	212	220	PF00400	0.407
DEG_Nend_Nbox_1	1	3	PF02207	0.313
DOC_MAPK_gen_1	178	187	PF00069	0.273
DOC_MAPK_MEF2A_6	180	189	PF00069	0.411
DOC_MAPK_MEF2A_6	192	200	PF00069	0.443
DOC_MAPK_MEF2A_6	90	97	PF00069	0.418
DOC_MAPK_NFAT4_5	184	192	PF00069	0.407
DOC_USP7_MATH_1	157	161	PF00917	0.532
DOC_USP7_MATH_1	170	174	PF00917	0.498
LIG_14-3-3_CanoR_1	111	115	PF00244	0.401
LIG_14-3-3_CanoR_1	256	265	PF00244	0.285
LIG_14-3-3_CanoR_1	83	91	PF00244	0.321
LIG_BIR_III_2	122	126	PF00653	0.463
LIG_BRCT_BRCA1_1	196	200	PF00533	0.467
LIG_FHA_1	191	197	PF00498	0.490
LIG_FHA_1	40	46	PF00498	0.226
LIG_FHA_1	66	72	PF00498	0.395
LIG_FHA_2	218	224	PF00498	0.409
LIG_FHA_2	60	66	PF00498	0.395
LIG_FHA_2	94	100	PF00498	0.431
LIG_GBD_Chelix_1	148	156	PF00786	0.460
LIG_IBAR_NPY_1	92	94	PF08397	0.189
LIG_LIR_Gen_1	269	274	PF02991	0.423
LIG_LIR_Gen_1	96	104	PF02991	0.426
LIG_LIR_Nem_3	163	168	PF02991	0.453
LIG_LIR_Nem_3	96	101	PF02991	0.426
LIG_PDZ_Class_2	282	287	PF00595	0.457
LIG_SH2_CRK	153	157	PF00017	0.505
LIG_SH2_CRK	182	186	PF00017	0.367
LIG_SH2_CRK	98	102	PF00017	0.341
LIG_SH2_NCK_1	208	212	PF00017	0.428
LIG_SH2_NCK_1	98	102	PF00017	0.341
LIG_SH2_PTP2	94	97	PF00017	0.189
LIG_SH2_STAP1	9	13	PF00017	0.273
LIG_SH2_STAT3	70	73	PF00017	0.341
LIG_SH2_STAT3	9	12	PF00017	0.285
LIG_SH2_STAT5	70	73	PF00017	0.432
LIG_SH2_STAT5	94	97	PF00017	0.189
LIG_SH3_3	166	172	PF00018	0.487
LIG_TYR_ITSM	94	101	PF00017	0.195
MOD_CK2_1	157	163	PF00069	0.446
MOD_GlcNHglycan	107	110	PF01048	0.535
MOD_GlcNHglycan	236	239	PF01048	0.548
MOD_GlcNHglycan	258	261	PF01048	0.338
MOD_GlcNHglycan	85	88	PF01048	0.385
MOD_GSK3_1	139	146	PF00069	0.413
MOD_GSK3_1	190	197	PF00069	0.498
MOD_NEK2_1	104	109	PF00069	0.526
MOD_NEK2_1	139	144	PF00069	0.399
MOD_NEK2_1	25	30	PF00069	0.337
MOD_NEK2_2	93	98	PF00069	0.341
MOD_PIKK_1	17	23	PF00454	0.278
MOD_PKA_2	110	116	PF00069	0.413
MOD_Plk_4	143	149	PF00069	0.401
MOD_Plk_4	170	176	PF00069	0.430
MOD_Plk_4	93	99	PF00069	0.420
TRG_DiLeu_BaEn_1	280	285	PF01217	0.437
TRG_ENDOCYTIC_2	153	156	PF00928	0.485
TRG_ENDOCYTIC_2	182	185	PF00928	0.368
TRG_ENDOCYTIC_2	208	211	PF00928	0.442
TRG_ENDOCYTIC_2	270	273	PF00928	0.380
TRG_ENDOCYTIC_2	94	97	PF00928	0.299
TRG_ENDOCYTIC_2	98	101	PF00928	0.329
TRG_ER_diArg_1	153	155	PF00400	0.537
TRG_Pf-PMV_PEXEL_1	159	163	PF00026	0.466
TRG_Pf-PMV_PEXEL_1	166	171	PF00026	0.421

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2G3	Leptomonas seymouri	54%	100%
A0A0S4IP88	Bodo saltans	26%	82%
A0A1X0NVF2	Trypanosomatidae	31%	97%
A0A3S7X162	Leishmania donovani	88%	100%
A0A422N6R9	Trypanosoma rangeli	34%	98%
A4HKL5	Leishmania braziliensis	100%	100%
A4I3A8	Leishmania infantum	88%	100%
D0A7U0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	97%
E9AZJ7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4Q8N4	Leishmania major	86%	100%
V5DAI2	Trypanosoma cruzi	39%	98%