Sugar transporter SWEET

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Sugar efflux transporter for intercellular exchange, putative

Species:

Leishmania braziliensis

UniProt:

A4HG76_LEIBR

TriTrypDb:

LbrM.28.0360 , LBRM2903_280009100

Length:

242

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	17
GO:0110165	cellular anatomical entity	1	17

Expansion

Sequence features

A4HG76

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HG76

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	17
GO:0008643	carbohydrate transport	5	17
GO:0051179	localization	1	17
GO:0051234	establishment of localization	2	17
GO:0071702	organic substance transport	4	17

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	2
GO:0015144	carbohydrate transmembrane transporter activity	3	2
GO:0022857	transmembrane transporter activity	2	2
GO:0051119	sugar transmembrane transporter activity	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	224	226	PF00675	0.283
CLV_NRD_NRD_1	31	33	PF00675	0.217
CLV_NRD_NRD_1	92	94	PF00675	0.277
CLV_PCSK_KEX2_1	224	226	PF00082	0.267
CLV_PCSK_KEX2_1	31	33	PF00082	0.273
CLV_PCSK_KEX2_1	92	94	PF00082	0.307
CLV_PCSK_SKI1_1	140	144	PF00082	0.509
DEG_SPOP_SBC_1	62	66	PF00917	0.160
DOC_CYCLIN_yCln2_LP_2	155	161	PF00134	0.336
DOC_MAPK_RevD_3	18	32	PF00069	0.285
DOC_WW_Pin1_4	154	159	PF00397	0.282
DOC_WW_Pin1_4	22	27	PF00397	0.350
DOC_WW_Pin1_4	236	241	PF00397	0.726
LIG_BIR_II_1	1	5	PF00653	0.344
LIG_BRCT_BRCA1_1	83	87	PF00533	0.264
LIG_eIF4E_1	113	119	PF01652	0.169
LIG_FHA_2	141	147	PF00498	0.377
LIG_LIR_Gen_1	112	121	PF02991	0.297
LIG_LIR_Gen_1	16	26	PF02991	0.260
LIG_LIR_Gen_1	2	11	PF02991	0.376
LIG_LIR_Gen_1	80	90	PF02991	0.282
LIG_LIR_Nem_3	112	118	PF02991	0.297
LIG_LIR_Nem_3	186	191	PF02991	0.315
LIG_LIR_Nem_3	2	7	PF02991	0.353
LIG_LIR_Nem_3	56	60	PF02991	0.284
LIG_LIR_Nem_3	64	70	PF02991	0.230
LIG_LIR_Nem_3	80	85	PF02991	0.281
LIG_LYPXL_yS_3	67	70	PF13949	0.309
LIG_Pex14_2	184	188	PF04695	0.327
LIG_PTAP_UEV_1	225	230	PF05743	0.487
LIG_PTB_Apo_2	182	189	PF02174	0.377
LIG_SH2_CRK	52	56	PF00017	0.310
LIG_SH2_CRK	8	12	PF00017	0.309
LIG_SH2_CRK	82	86	PF00017	0.289
LIG_SH2_NCK_1	52	56	PF00017	0.407
LIG_SH2_STAP1	106	110	PF00017	0.507
LIG_SH2_STAT3	47	50	PF00017	0.303
LIG_SH2_STAT5	113	116	PF00017	0.383
LIG_SH2_STAT5	13	16	PF00017	0.264
LIG_SH2_STAT5	82	85	PF00017	0.289
LIG_SH3_3	170	176	PF00018	0.496
LIG_SH3_3	201	207	PF00018	0.169
LIG_SH3_3	223	229	PF00018	0.526
LIG_SUMO_SIM_anti_2	127	133	PF11976	0.327
LIG_SUMO_SIM_par_1	127	133	PF11976	0.470
LIG_SUMO_SIM_par_1	151	157	PF11976	0.331
LIG_SUMO_SIM_par_1	64	72	PF11976	0.223
LIG_WRC_WIRS_1	1	6	PF05994	0.229
MOD_CK1_1	109	115	PF00069	0.310
MOD_CK1_1	16	22	PF00069	0.371
MOD_CK1_1	2	8	PF00069	0.315
MOD_CK1_1	42	48	PF00069	0.391
MOD_CK1_1	53	59	PF00069	0.330
MOD_CK1_1	97	103	PF00069	0.555
MOD_CK2_1	140	146	PF00069	0.295
MOD_Cter_Amidation	222	225	PF01082	0.250
MOD_GlcNHglycan	132	135	PF01048	0.549
MOD_GlcNHglycan	15	18	PF01048	0.244
MOD_GlcNHglycan	34	38	PF01048	0.313
MOD_GlcNHglycan	52	55	PF01048	0.376
MOD_GlcNHglycan	94	99	PF01048	0.345
MOD_GSK3_1	22	29	PF00069	0.308
MOD_GSK3_1	35	42	PF00069	0.524
MOD_GSK3_1	77	84	PF00069	0.377
MOD_GSK3_1	9	16	PF00069	0.267
MOD_GSK3_1	97	104	PF00069	0.525
MOD_N-GLC_1	22	27	PF02516	0.377
MOD_NEK2_1	101	106	PF00069	0.527
MOD_NEK2_1	124	129	PF00069	0.303
MOD_NEK2_1	183	188	PF00069	0.358
MOD_NEK2_1	33	38	PF00069	0.557
MOD_NEK2_1	63	68	PF00069	0.236
MOD_NEK2_1	69	74	PF00069	0.271
MOD_NEK2_2	26	31	PF00069	0.236
MOD_PKA_1	224	230	PF00069	0.507
MOD_PKA_2	224	230	PF00069	0.492
MOD_Plk_4	106	112	PF00069	0.485
MOD_Plk_4	124	130	PF00069	0.277
MOD_Plk_4	183	189	PF00069	0.301
MOD_Plk_4	81	87	PF00069	0.331
MOD_ProDKin_1	154	160	PF00069	0.282
MOD_ProDKin_1	22	28	PF00069	0.350
MOD_ProDKin_1	236	242	PF00069	0.728
TRG_DiLeu_BaLyEn_6	23	28	PF01217	0.218
TRG_DiLeu_BaLyEn_6	65	70	PF01217	0.309
TRG_ENDOCYTIC_2	113	116	PF00928	0.377
TRG_ENDOCYTIC_2	52	55	PF00928	0.306
TRG_ENDOCYTIC_2	60	63	PF00928	0.272
TRG_ENDOCYTIC_2	67	70	PF00928	0.195
TRG_ENDOCYTIC_2	8	11	PF00928	0.309
TRG_ENDOCYTIC_2	82	85	PF00928	0.289
TRG_ER_diArg_1	224	226	PF00400	0.501
TRG_ER_diArg_1	30	32	PF00400	0.494
TRG_Pf-PMV_PEXEL_1	31	35	PF00026	0.309

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVB3	Leptomonas seymouri	39%	100%
A0A0N1HZ27	Leptomonas seymouri	71%	100%
A0A0S4JK63	Bodo saltans	31%	100%
A0A0S4JP06	Bodo saltans	34%	84%
A0A1X0NHK1	Trypanosomatidae	42%	100%
A0A3Q8IJU9	Leishmania donovani	40%	100%
A0A3R7RTY4	Trypanosoma rangeli	44%	100%
A0A3S7X189	Leishmania donovani	76%	100%
A2X5B4	Oryza sativa subsp. indica	25%	76%
A2YZ24	Oryza sativa subsp. indica	25%	91%
A4HQ04	Leishmania braziliensis	41%	100%
A4I3B9	Leishmania infantum	77%	100%
A4IDR5	Leishmania infantum	40%	100%
D3ZH22	Rattus norvegicus	24%	100%
E9ATS1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	100%
E9AZJ6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
Q0DJY3	Oryza sativa subsp. japonica	24%	98%
Q0J349	Oryza sativa subsp. japonica	25%	91%
Q19VE6	Oryza sativa subsp. indica	24%	79%
Q290X1	Drosophila pseudoobscura pseudoobscura	23%	100%
Q4Q0S5	Leishmania major	42%	100%
Q4Q8N5	Leishmania major	77%	100%
Q54JW5	Dictyostelium discoideum	24%	100%
Q5EB14	Danio rerio	25%	100%
Q5NAZ9	Oryza sativa subsp. japonica	26%	96%
Q6K602	Oryza sativa subsp. japonica	25%	76%
Q6NQN5	Arabidopsis thaliana	22%	92%
Q6YZF3	Oryza sativa subsp. japonica	24%	79%
Q7JVE7	Drosophila melanogaster	23%	100%
Q8LBF7	Arabidopsis thaliana	24%	94%
Q9CXK4	Mus musculus	25%	100%
Q9FY94	Arabidopsis thaliana	24%	83%