Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HG75_LEIBR

TriTrypDb:

LbrM.28.0350 , LBRM2903_280009000

Length:

1159

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HG75

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HG75

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	627	631	PF00656	0.363
CLV_C14_Caspase3-7	847	851	PF00656	0.428
CLV_NRD_NRD_1	10	12	PF00675	0.419
CLV_NRD_NRD_1	1071	1073	PF00675	0.266
CLV_NRD_NRD_1	239	241	PF00675	0.448
CLV_NRD_NRD_1	471	473	PF00675	0.428
CLV_NRD_NRD_1	60	62	PF00675	0.487
CLV_NRD_NRD_1	908	910	PF00675	0.528
CLV_NRD_NRD_1	975	977	PF00675	0.411
CLV_PCSK_KEX2_1	10	12	PF00082	0.442
CLV_PCSK_KEX2_1	1017	1019	PF00082	0.419
CLV_PCSK_KEX2_1	239	241	PF00082	0.448
CLV_PCSK_KEX2_1	450	452	PF00082	0.474
CLV_PCSK_KEX2_1	471	473	PF00082	0.428
CLV_PCSK_KEX2_1	60	62	PF00082	0.447
CLV_PCSK_KEX2_1	895	897	PF00082	0.324
CLV_PCSK_KEX2_1	908	910	PF00082	0.528
CLV_PCSK_PC1ET2_1	1017	1019	PF00082	0.283
CLV_PCSK_PC1ET2_1	450	452	PF00082	0.298
CLV_PCSK_PC1ET2_1	895	897	PF00082	0.324
CLV_PCSK_SKI1_1	1111	1115	PF00082	0.382
CLV_PCSK_SKI1_1	220	224	PF00082	0.648
CLV_PCSK_SKI1_1	240	244	PF00082	0.273
CLV_PCSK_SKI1_1	410	414	PF00082	0.502
CLV_PCSK_SKI1_1	450	454	PF00082	0.311
CLV_PCSK_SKI1_1	472	476	PF00082	0.442
CLV_PCSK_SKI1_1	639	643	PF00082	0.274
CLV_PCSK_SKI1_1	760	764	PF00082	0.344
CLV_PCSK_SKI1_1	792	796	PF00082	0.409
CLV_PCSK_SKI1_1	840	844	PF00082	0.330
CLV_PCSK_SKI1_1	909	913	PF00082	0.312
DEG_APCC_DBOX_1	1110	1118	PF00400	0.344
DEG_APCC_DBOX_1	1127	1135	PF00400	0.361
DEG_APCC_DBOX_1	239	247	PF00400	0.389
DEG_APCC_DBOX_1	471	479	PF00400	0.439
DEG_APCC_DBOX_1	59	67	PF00400	0.484
DEG_SPOP_SBC_1	419	423	PF00917	0.343
DOC_CKS1_1	263	268	PF01111	0.399
DOC_CKS1_1	87	92	PF01111	0.609
DOC_CYCLIN_RxL_1	603	613	PF00134	0.280
DOC_CYCLIN_yCln2_LP_2	753	759	PF00134	0.245
DOC_MAPK_gen_1	1072	1079	PF00069	0.264
DOC_MAPK_gen_1	123	132	PF00069	0.463
DOC_MAPK_gen_1	294	304	PF00069	0.447
DOC_MAPK_gen_1	450	457	PF00069	0.306
DOC_MAPK_gen_1	908	917	PF00069	0.367
DOC_MAPK_MEF2A_6	23	30	PF00069	0.353
DOC_MAPK_MEF2A_6	711	720	PF00069	0.406
DOC_MAPK_NFAT4_5	23	31	PF00069	0.338
DOC_PP1_RVXF_1	758	764	PF00149	0.229
DOC_PP2B_LxvP_1	494	497	PF13499	0.517
DOC_PP2B_LxvP_1	696	699	PF13499	0.411
DOC_PP2B_LxvP_1	753	756	PF13499	0.259
DOC_PP2B_LxvP_1	795	798	PF13499	0.400
DOC_PP2B_LxvP_1	952	955	PF13499	0.396
DOC_PP4_FxxP_1	87	90	PF00568	0.481
DOC_USP7_MATH_1	1022	1026	PF00917	0.462
DOC_USP7_MATH_1	1027	1031	PF00917	0.456
DOC_USP7_MATH_1	405	409	PF00917	0.403
DOC_USP7_MATH_1	59	63	PF00917	0.561
DOC_USP7_MATH_1	683	687	PF00917	0.421
DOC_USP7_MATH_1	748	752	PF00917	0.494
DOC_USP7_MATH_1	910	914	PF00917	0.526
DOC_USP7_MATH_1	926	930	PF00917	0.399
DOC_USP7_UBL2_3	117	121	PF12436	0.448
DOC_USP7_UBL2_3	977	981	PF12436	0.368
DOC_WW_Pin1_4	204	209	PF00397	0.641
DOC_WW_Pin1_4	262	267	PF00397	0.650
DOC_WW_Pin1_4	323	328	PF00397	0.463
DOC_WW_Pin1_4	375	380	PF00397	0.742
DOC_WW_Pin1_4	48	53	PF00397	0.573
DOC_WW_Pin1_4	580	585	PF00397	0.453
DOC_WW_Pin1_4	646	651	PF00397	0.431
DOC_WW_Pin1_4	751	756	PF00397	0.466
DOC_WW_Pin1_4	86	91	PF00397	0.619
LIG_14-3-3_CanoR_1	100	109	PF00244	0.513
LIG_14-3-3_CanoR_1	1128	1138	PF00244	0.496
LIG_14-3-3_CanoR_1	125	133	PF00244	0.426
LIG_14-3-3_CanoR_1	214	218	PF00244	0.345
LIG_14-3-3_CanoR_1	227	233	PF00244	0.369
LIG_14-3-3_CanoR_1	239	243	PF00244	0.353
LIG_14-3-3_CanoR_1	294	300	PF00244	0.519
LIG_14-3-3_CanoR_1	451	456	PF00244	0.387
LIG_14-3-3_CanoR_1	47	53	PF00244	0.626
LIG_14-3-3_CanoR_1	484	488	PF00244	0.414
LIG_14-3-3_CanoR_1	514	518	PF00244	0.567
LIG_14-3-3_CanoR_1	559	567	PF00244	0.329
LIG_14-3-3_CanoR_1	60	64	PF00244	0.428
LIG_14-3-3_CanoR_1	639	647	PF00244	0.310
LIG_14-3-3_CanoR_1	711	717	PF00244	0.426
LIG_14-3-3_CanoR_1	854	860	PF00244	0.400
LIG_14-3-3_CanoR_1	896	902	PF00244	0.437
LIG_14-3-3_CanoR_1	909	917	PF00244	0.392
LIG_14-3-3_CanoR_1	918	923	PF00244	0.397
LIG_Actin_WH2_2	210	225	PF00022	0.471
LIG_Actin_WH2_2	23	39	PF00022	0.308
LIG_Actin_WH2_2	630	648	PF00022	0.274
LIG_BIR_II_1	1	5	PF00653	0.447
LIG_BRCT_BRCA1_1	920	924	PF00533	0.418
LIG_BRCT_BRCA1_1	928	932	PF00533	0.456
LIG_Clathr_ClatBox_1	538	542	PF01394	0.278
LIG_Clathr_ClatBox_1	681	685	PF01394	0.435
LIG_Clathr_ClatBox_1	92	96	PF01394	0.282
LIG_CSL_BTD_1	446	449	PF09270	0.307
LIG_deltaCOP1_diTrp_1	226	235	PF00928	0.443
LIG_EVH1_2	798	802	PF00568	0.452
LIG_FHA_1	102	108	PF00498	0.539
LIG_FHA_1	1031	1037	PF00498	0.373
LIG_FHA_1	1042	1048	PF00498	0.435
LIG_FHA_1	1140	1146	PF00498	0.555
LIG_FHA_1	144	150	PF00498	0.380
LIG_FHA_1	317	323	PF00498	0.413
LIG_FHA_1	37	43	PF00498	0.626
LIG_FHA_1	4	10	PF00498	0.508
LIG_FHA_1	496	502	PF00498	0.409
LIG_FHA_1	53	59	PF00498	0.398
LIG_FHA_1	561	567	PF00498	0.424
LIG_FHA_1	640	646	PF00498	0.524
LIG_FHA_1	655	661	PF00498	0.463
LIG_FHA_1	713	719	PF00498	0.477
LIG_FHA_1	742	748	PF00498	0.521
LIG_FHA_1	859	865	PF00498	0.483
LIG_FHA_1	87	93	PF00498	0.467
LIG_FHA_1	902	908	PF00498	0.379
LIG_FHA_2	1065	1071	PF00498	0.263
LIG_FHA_2	254	260	PF00498	0.684
LIG_FHA_2	333	339	PF00498	0.324
LIG_FHA_2	415	421	PF00498	0.412
LIG_FHA_2	625	631	PF00498	0.377
LIG_GBD_Chelix_1	720	728	PF00786	0.517
LIG_GBD_Chelix_1	818	826	PF00786	0.370
LIG_LIR_Gen_1	101	107	PF02991	0.301
LIG_LIR_Gen_1	171	181	PF02991	0.436
LIG_LIR_Gen_1	275	285	PF02991	0.398
LIG_LIR_Gen_1	335	345	PF02991	0.384
LIG_LIR_Gen_1	527	538	PF02991	0.277
LIG_LIR_Gen_1	667	676	PF02991	0.358
LIG_LIR_Gen_1	785	795	PF02991	0.421
LIG_LIR_Gen_1	800	810	PF02991	0.264
LIG_LIR_Nem_3	101	106	PF02991	0.295
LIG_LIR_Nem_3	171	176	PF02991	0.368
LIG_LIR_Nem_3	275	280	PF02991	0.386
LIG_LIR_Nem_3	335	340	PF02991	0.406
LIG_LIR_Nem_3	527	533	PF02991	0.285
LIG_LIR_Nem_3	667	671	PF02991	0.384
LIG_LIR_Nem_3	785	790	PF02991	0.425
LIG_LIR_Nem_3	800	805	PF02991	0.262
LIG_LIR_Nem_3	914	920	PF02991	0.501
LIG_LIR_Nem_3	921	927	PF02991	0.461
LIG_LIR_Nem_3	972	978	PF02991	0.288
LIG_NRBOX	606	612	PF00104	0.335
LIG_NRBOX	633	639	PF00104	0.402
LIG_NRBOX	723	729	PF00104	0.382
LIG_NRBOX	817	823	PF00104	0.376
LIG_NRBOX	936	942	PF00104	0.238
LIG_PCNA_yPIPBox_3	603	611	PF02747	0.280
LIG_PCNA_yPIPBox_3	931	941	PF02747	0.256
LIG_Pex14_1	228	232	PF04695	0.491
LIG_PTB_Apo_2	336	343	PF02174	0.458
LIG_PTB_Apo_2	968	975	PF02174	0.471
LIG_PTB_Phospho_1	336	342	PF10480	0.452
LIG_SH2_CRK	787	791	PF00017	0.434
LIG_SH2_CRK	975	979	PF00017	0.390
LIG_SH2_GRB2like	337	340	PF00017	0.447
LIG_SH2_NCK_1	342	346	PF00017	0.534
LIG_SH2_NCK_1	787	791	PF00017	0.452
LIG_SH2_STAP1	103	107	PF00017	0.420
LIG_SH2_STAP1	232	236	PF00017	0.541
LIG_SH2_STAP1	337	341	PF00017	0.440
LIG_SH2_STAP1	899	903	PF00017	0.351
LIG_SH2_STAT5	103	106	PF00017	0.468
LIG_SH2_STAT5	1058	1061	PF00017	0.414
LIG_SH2_STAT5	142	145	PF00017	0.469
LIG_SH2_STAT5	232	235	PF00017	0.286
LIG_SH2_STAT5	289	292	PF00017	0.505
LIG_SH2_STAT5	432	435	PF00017	0.459
LIG_SH2_STAT5	787	790	PF00017	0.409
LIG_SH2_STAT5	867	870	PF00017	0.254
LIG_SH3_3	243	249	PF00018	0.465
LIG_SH3_3	260	266	PF00018	0.438
LIG_SH3_3	324	330	PF00018	0.540
LIG_SH3_3	579	585	PF00018	0.407
LIG_SUMO_SIM_anti_2	127	134	PF11976	0.443
LIG_SUMO_SIM_anti_2	171	178	PF11976	0.383
LIG_SUMO_SIM_anti_2	726	733	PF11976	0.446
LIG_SUMO_SIM_anti_2	91	96	PF11976	0.299
LIG_SUMO_SIM_anti_2	919	924	PF11976	0.355
LIG_SUMO_SIM_par_1	1141	1146	PF11976	0.552
LIG_SUMO_SIM_par_1	309	315	PF11976	0.396
LIG_SUMO_SIM_par_1	38	44	PF11976	0.532
LIG_SUMO_SIM_par_1	498	503	PF11976	0.271
LIG_SUMO_SIM_par_1	714	719	PF11976	0.468
LIG_SUMO_SIM_par_1	723	729	PF11976	0.323
LIG_SUMO_SIM_par_1	91	96	PF11976	0.299
LIG_TRAF2_1	1003	1006	PF00917	0.419
LIG_TRAF2_1	1098	1101	PF00917	0.291
LIG_TRAF2_1	1146	1149	PF00917	0.463
LIG_TRAF2_1	181	184	PF00917	0.339
LIG_TRAF2_1	524	527	PF00917	0.516
LIG_TRAF2_1	70	73	PF00917	0.365
LIG_TYR_ITSM	99	106	PF00017	0.264
LIG_UBA3_1	444	450	PF00899	0.411
LIG_UBA3_1	549	554	PF00899	0.254
MOD_CDK_SPxxK_3	375	382	PF00069	0.661
MOD_CK1_1	1025	1031	PF00069	0.482
MOD_CK1_1	1051	1057	PF00069	0.428
MOD_CK1_1	1064	1070	PF00069	0.450
MOD_CK1_1	1139	1145	PF00069	0.546
MOD_CK1_1	377	383	PF00069	0.708
MOD_CK1_1	41	47	PF00069	0.623
MOD_CK1_1	495	501	PF00069	0.480
MOD_CK1_1	51	57	PF00069	0.463
MOD_CK1_1	623	629	PF00069	0.367
MOD_CK1_1	692	698	PF00069	0.525
MOD_CK1_1	714	720	PF00069	0.493
MOD_CK1_1	751	757	PF00069	0.506
MOD_CK2_1	1143	1149	PF00069	0.476
MOD_CK2_1	238	244	PF00069	0.411
MOD_CK2_1	253	259	PF00069	0.457
MOD_CK2_1	332	338	PF00069	0.476
MOD_CK2_1	420	426	PF00069	0.456
MOD_CK2_1	520	526	PF00069	0.418
MOD_DYRK1A_RPxSP_1	323	327	PF00069	0.455
MOD_GlcNHglycan	1	4	PF01048	0.435
MOD_GlcNHglycan	1145	1148	PF01048	0.577
MOD_GlcNHglycan	164	168	PF01048	0.350
MOD_GlcNHglycan	330	333	PF01048	0.366
MOD_GlcNHglycan	422	425	PF01048	0.434
MOD_GlcNHglycan	494	497	PF01048	0.382
MOD_GlcNHglycan	627	630	PF01048	0.594
MOD_GlcNHglycan	691	694	PF01048	0.570
MOD_GlcNHglycan	750	753	PF01048	0.450
MOD_GlcNHglycan	778	781	PF01048	0.649
MOD_GlcNHglycan	833	836	PF01048	0.387
MOD_GlcNHglycan	876	879	PF01048	0.330
MOD_GSK3_1	1030	1037	PF00069	0.407
MOD_GSK3_1	1041	1048	PF00069	0.399
MOD_GSK3_1	107	114	PF00069	0.498
MOD_GSK3_1	1139	1146	PF00069	0.625
MOD_GSK3_1	159	166	PF00069	0.541
MOD_GSK3_1	198	205	PF00069	0.490
MOD_GSK3_1	238	245	PF00069	0.387
MOD_GSK3_1	255	262	PF00069	0.566
MOD_GSK3_1	312	319	PF00069	0.522
MOD_GSK3_1	328	335	PF00069	0.352
MOD_GSK3_1	370	377	PF00069	0.600
MOD_GSK3_1	414	421	PF00069	0.536
MOD_GSK3_1	48	55	PF00069	0.522
MOD_GSK3_1	516	523	PF00069	0.498
MOD_GSK3_1	620	627	PF00069	0.390
MOD_GSK3_1	684	691	PF00069	0.481
MOD_GSK3_1	858	865	PF00069	0.478
MOD_GSK3_1	897	904	PF00069	0.375
MOD_N-GLC_1	1048	1053	PF02516	0.359
MOD_N-GLC_1	1061	1066	PF02516	0.261
MOD_N-GLC_1	970	975	PF02516	0.349
MOD_NEK2_1	1	6	PF00069	0.538
MOD_NEK2_1	1011	1016	PF00069	0.398
MOD_NEK2_1	1041	1046	PF00069	0.273
MOD_NEK2_1	1105	1110	PF00069	0.285
MOD_NEK2_1	1134	1139	PF00069	0.388
MOD_NEK2_1	143	148	PF00069	0.432
MOD_NEK2_1	149	154	PF00069	0.433
MOD_NEK2_1	197	202	PF00069	0.542
MOD_NEK2_1	213	218	PF00069	0.513
MOD_NEK2_1	316	321	PF00069	0.289
MOD_NEK2_1	413	418	PF00069	0.523
MOD_NEK2_1	483	488	PF00069	0.605
MOD_NEK2_1	640	645	PF00069	0.469
MOD_NEK2_1	684	689	PF00069	0.543
MOD_NEK2_1	712	717	PF00069	0.371
MOD_NEK2_1	786	791	PF00069	0.259
MOD_NEK2_1	874	879	PF00069	0.475
MOD_NEK2_1	891	896	PF00069	0.343
MOD_NEK2_1	970	975	PF00069	0.345
MOD_NEK2_1	98	103	PF00069	0.440
MOD_NEK2_2	59	64	PF00069	0.487
MOD_NEK2_2	926	931	PF00069	0.431
MOD_PIKK_1	107	113	PF00454	0.389
MOD_PIKK_1	1116	1122	PF00454	0.460
MOD_PIKK_1	149	155	PF00454	0.389
MOD_PIKK_1	230	236	PF00454	0.379
MOD_PIKK_1	3	9	PF00454	0.456
MOD_PIKK_1	620	626	PF00454	0.342
MOD_PIKK_1	640	646	PF00454	0.404
MOD_PIKK_1	901	907	PF00454	0.372
MOD_PK_1	1073	1079	PF00069	0.450
MOD_PKA_1	450	456	PF00069	0.477
MOD_PKA_2	124	130	PF00069	0.410
MOD_PKA_2	213	219	PF00069	0.336
MOD_PKA_2	238	244	PF00069	0.427
MOD_PKA_2	36	42	PF00069	0.571
MOD_PKA_2	381	387	PF00069	0.675
MOD_PKA_2	450	456	PF00069	0.356
MOD_PKA_2	46	52	PF00069	0.621
MOD_PKA_2	464	470	PF00069	0.240
MOD_PKA_2	483	489	PF00069	0.489
MOD_PKA_2	513	519	PF00069	0.461
MOD_PKA_2	59	65	PF00069	0.424
MOD_PKA_2	766	772	PF00069	0.501
MOD_PKA_2	853	859	PF00069	0.408
MOD_Plk_1	1048	1054	PF00069	0.580
MOD_Plk_1	143	149	PF00069	0.356
MOD_Plk_1	316	322	PF00069	0.529
MOD_Plk_1	684	690	PF00069	0.490
MOD_Plk_1	970	976	PF00069	0.354
MOD_Plk_2-3	288	294	PF00069	0.328
MOD_Plk_4	1035	1041	PF00069	0.312
MOD_Plk_4	1051	1057	PF00069	0.336
MOD_Plk_4	1139	1145	PF00069	0.678
MOD_Plk_4	143	149	PF00069	0.487
MOD_Plk_4	17	23	PF00069	0.431
MOD_Plk_4	279	285	PF00069	0.298
MOD_Plk_4	389	395	PF00069	0.539
MOD_Plk_4	428	434	PF00069	0.288
MOD_Plk_4	495	501	PF00069	0.379
MOD_Plk_4	548	554	PF00069	0.501
MOD_Plk_4	685	691	PF00069	0.583
MOD_Plk_4	88	94	PF00069	0.452
MOD_Plk_4	880	886	PF00069	0.216
MOD_Plk_4	897	903	PF00069	0.455
MOD_Plk_4	970	976	PF00069	0.454
MOD_ProDKin_1	204	210	PF00069	0.632
MOD_ProDKin_1	262	268	PF00069	0.643
MOD_ProDKin_1	323	329	PF00069	0.457
MOD_ProDKin_1	375	381	PF00069	0.741
MOD_ProDKin_1	48	54	PF00069	0.565
MOD_ProDKin_1	580	586	PF00069	0.450
MOD_ProDKin_1	646	652	PF00069	0.425
MOD_ProDKin_1	751	757	PF00069	0.460
MOD_ProDKin_1	86	92	PF00069	0.614
MOD_SUMO_for_1	22	25	PF00179	0.428
MOD_SUMO_rev_2	110	119	PF00179	0.483
TRG_DiLeu_BaEn_1	1151	1156	PF01217	0.578
TRG_DiLeu_BaEn_1	300	305	PF01217	0.551
TRG_DiLeu_BaEn_1	726	731	PF01217	0.357
TRG_DiLeu_BaEn_3	171	177	PF01217	0.248
TRG_DiLeu_BaEn_4	1148	1154	PF01217	0.513
TRG_DiLeu_BaLyEn_6	603	608	PF01217	0.360
TRG_DiLeu_BaLyEn_6	757	762	PF01217	0.489
TRG_DiLeu_LyEn_5	300	305	PF01217	0.326
TRG_ENDOCYTIC_2	1001	1004	PF00928	0.462
TRG_ENDOCYTIC_2	103	106	PF00928	0.273
TRG_ENDOCYTIC_2	337	340	PF00928	0.312
TRG_ENDOCYTIC_2	787	790	PF00928	0.410
TRG_ENDOCYTIC_2	899	902	PF00928	0.354
TRG_ENDOCYTIC_2	975	978	PF00928	0.336
TRG_ER_diArg_1	764	767	PF00400	0.382
TRG_ER_diArg_1	9	11	PF00400	0.436
TRG_ER_diArg_1	907	909	PF00400	0.511
TRG_NES_CRM1_1	293	308	PF08389	0.507
TRG_NES_CRM1_1	710	726	PF08389	0.371
TRG_NES_CRM1_1	936	950	PF08389	0.458
TRG_Pf-PMV_PEXEL_1	303	308	PF00026	0.400

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD59	Leptomonas seymouri	47%	98%
A0A1X0NVE5	Trypanosomatidae	28%	100%
A0A3Q8IEG5	Leishmania donovani	79%	100%
A0A422N6R4	Trypanosoma rangeli	28%	100%
A4I3B8	Leishmania infantum	79%	100%
D0A7T7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9AZJ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
Q4Q8N6	Leishmania major	79%	99%