LeishMANIAdb
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Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Transmembrane protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
A4HG72_LEIBR
TriTrypDb:
LbrM.28.0320 , LBRM2903_280008700 *
Length:
344

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0016020 membrane 2 10
GO:0110165 cellular anatomical entity 1 10

Expansion

Sequence features

A4HG72
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HG72

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 114 116 PF00675 0.325
CLV_NRD_NRD_1 160 162 PF00675 0.588
CLV_NRD_NRD_1 200 202 PF00675 0.398
CLV_NRD_NRD_1 86 88 PF00675 0.519
CLV_PCSK_FUR_1 84 88 PF00082 0.560
CLV_PCSK_KEX2_1 114 116 PF00082 0.325
CLV_PCSK_KEX2_1 160 162 PF00082 0.580
CLV_PCSK_KEX2_1 200 202 PF00082 0.381
CLV_PCSK_KEX2_1 330 332 PF00082 0.408
CLV_PCSK_KEX2_1 84 86 PF00082 0.532
CLV_PCSK_PC1ET2_1 330 332 PF00082 0.454
CLV_PCSK_SKI1_1 135 139 PF00082 0.609
CLV_PCSK_SKI1_1 200 204 PF00082 0.249
CLV_PCSK_SKI1_1 280 284 PF00082 0.282
CLV_PCSK_SKI1_1 55 59 PF00082 0.493
DEG_Nend_UBRbox_3 1 3 PF02207 0.642
DOC_CKS1_1 149 154 PF01111 0.450
DOC_MAPK_gen_1 278 285 PF00069 0.520
DOC_MAPK_gen_1 328 335 PF00069 0.528
DOC_MAPK_MEF2A_6 172 179 PF00069 0.362
DOC_MAPK_MEF2A_6 254 262 PF00069 0.355
DOC_PP2B_LxvP_1 177 180 PF13499 0.447
DOC_PP2B_LxvP_1 283 286 PF13499 0.355
DOC_USP7_MATH_1 21 25 PF00917 0.604
DOC_USP7_MATH_1 9 13 PF00917 0.681
DOC_USP7_UBL2_3 324 328 PF12436 0.456
DOC_USP7_UBL2_3 340 344 PF12436 0.693
DOC_WW_Pin1_4 148 153 PF00397 0.450
DOC_WW_Pin1_4 229 234 PF00397 0.390
DOC_WW_Pin1_4 4 9 PF00397 0.760
LIG_14-3-3_CanoR_1 200 208 PF00244 0.449
LIG_BRCT_BRCA1_1 222 226 PF00533 0.378
LIG_deltaCOP1_diTrp_1 111 117 PF00928 0.683
LIG_FHA_1 186 192 PF00498 0.405
LIG_FHA_1 51 57 PF00498 0.638
LIG_FHA_2 97 103 PF00498 0.718
LIG_LIR_Gen_1 296 307 PF02991 0.588
LIG_LIR_Nem_3 296 302 PF02991 0.596
LIG_LYPXL_S_1 119 123 PF13949 0.480
LIG_LYPXL_yS_3 120 123 PF13949 0.480
LIG_SH2_NCK_1 299 303 PF00017 0.479
LIG_SH2_SRC 193 196 PF00017 0.509
LIG_SH2_SRC 299 302 PF00017 0.484
LIG_SH2_STAP1 187 191 PF00017 0.480
LIG_SH2_STAP1 234 238 PF00017 0.356
LIG_SH2_STAP1 52 56 PF00017 0.617
LIG_SH2_STAT3 29 32 PF00017 0.609
LIG_SH2_STAT5 128 131 PF00017 0.379
LIG_SH2_STAT5 187 190 PF00017 0.447
LIG_SH2_STAT5 193 196 PF00017 0.597
LIG_SH2_STAT5 29 32 PF00017 0.697
LIG_SH2_STAT5 52 55 PF00017 0.633
LIG_SH3_3 146 152 PF00018 0.442
LIG_SH3_3 170 176 PF00018 0.362
LIG_SH3_3 252 258 PF00018 0.440
LIG_SUMO_SIM_anti_2 38 49 PF11976 0.676
LIG_SUMO_SIM_par_1 187 192 PF11976 0.430
LIG_TYR_ITIM 118 123 PF00017 0.440
LIG_TYR_ITIM 126 131 PF00017 0.456
LIG_UBA3_1 132 138 PF00899 0.310
MOD_CK1_1 211 217 PF00069 0.355
MOD_CK1_1 232 238 PF00069 0.360
MOD_CK1_1 3 9 PF00069 0.657
MOD_CK2_1 96 102 PF00069 0.686
MOD_Cter_Amidation 158 161 PF01082 0.610
MOD_GlcNHglycan 11 14 PF01048 0.408
MOD_GlcNHglycan 2 5 PF01048 0.438
MOD_GlcNHglycan 250 253 PF01048 0.349
MOD_GlcNHglycan 62 65 PF01048 0.494
MOD_GSK3_1 185 192 PF00069 0.344
MOD_GSK3_1 23 30 PF00069 0.751
MOD_GSK3_1 4 11 PF00069 0.676
MOD_GSK3_1 41 48 PF00069 0.682
MOD_GSK3_1 56 63 PF00069 0.678
MOD_NEK2_1 104 109 PF00069 0.700
MOD_NEK2_1 140 145 PF00069 0.429
MOD_NEK2_1 189 194 PF00069 0.406
MOD_NEK2_1 219 224 PF00069 0.474
MOD_NEK2_1 294 299 PF00069 0.411
MOD_NEK2_1 322 327 PF00069 0.335
MOD_PIKK_1 217 223 PF00454 0.492
MOD_PIKK_1 232 238 PF00454 0.426
MOD_PIKK_1 50 56 PF00454 0.695
MOD_PKA_1 200 206 PF00069 0.405
MOD_PKA_2 200 206 PF00069 0.405
MOD_PKA_2 33 39 PF00069 0.746
MOD_Plk_1 39 45 PF00069 0.757
MOD_Plk_1 96 102 PF00069 0.703
MOD_Plk_4 165 171 PF00069 0.389
MOD_Plk_4 189 195 PF00069 0.465
MOD_Plk_4 208 214 PF00069 0.353
MOD_Plk_4 220 226 PF00069 0.283
MOD_Plk_4 294 300 PF00069 0.411
MOD_Plk_4 41 47 PF00069 0.703
MOD_ProDKin_1 148 154 PF00069 0.448
MOD_ProDKin_1 229 235 PF00069 0.389
MOD_ProDKin_1 4 10 PF00069 0.762
TRG_DiLeu_BaLyEn_6 255 260 PF01217 0.366
TRG_ENDOCYTIC_2 120 123 PF00928 0.447
TRG_ENDOCYTIC_2 128 131 PF00928 0.447
TRG_ENDOCYTIC_2 299 302 PF00928 0.485
TRG_ER_diArg_1 113 115 PF00400 0.539
TRG_ER_diArg_1 160 162 PF00400 0.386
TRG_ER_diArg_1 200 202 PF00400 0.581
TRG_ER_diArg_1 83 86 PF00400 0.724
TRG_Pf-PMV_PEXEL_1 68 72 PF00026 0.541

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P732 Leptomonas seymouri 56% 99%
A0A1X0NVF3 Trypanosomatidae 31% 100%
A0A3Q8IAV0 Leishmania donovani 84% 100%
A0A3R7KTP8 Trypanosoma rangeli 34% 100%
A4I3B5 Leishmania infantum 84% 100%
D0A7T4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 32% 100%
E9AZJ2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 84% 100%
Q4Q8N9 Leishmania major 82% 100%
V5DAH6 Trypanosoma cruzi 36% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS