LeishMANIAdb
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HIT-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
HIT-type domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
A4HG71_LEIBR
TriTrypDb:
LbrM.28.0310 , LBRM2903_280008600 *
Length:
662

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 1
GO:0032991 protein-containing complex 1 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0070761 pre-snoRNP complex 3 1
GO:0110165 cellular anatomical entity 1 1
GO:1990904 ribonucleoprotein complex 2 1

Expansion

Sequence features

A4HG71
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HG71

Function

Biological processes
Term Name Level Count
GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) 10 1
GO:0000470 maturation of LSU-rRNA 9 1
GO:0000491 small nucleolar ribonucleoprotein complex assembly 7 1
GO:0000492 box C/D snoRNP assembly 8 1
GO:0006139 nucleobase-containing compound metabolic process 3 1
GO:0006364 rRNA processing 8 1
GO:0006396 RNA processing 6 1
GO:0006403 RNA localization 3 1
GO:0006725 cellular aromatic compound metabolic process 3 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0008152 metabolic process 1 1
GO:0009987 cellular process 1 1
GO:0016043 cellular component organization 3 1
GO:0016070 RNA metabolic process 5 1
GO:0016072 rRNA metabolic process 7 1
GO:0022607 cellular component assembly 4 1
GO:0022618 ribonucleoprotein complex assembly 6 1
GO:0033036 macromolecule localization 2 1
GO:0034470 ncRNA processing 7 1
GO:0034641 cellular nitrogen compound metabolic process 3 1
GO:0034660 ncRNA metabolic process 6 1
GO:0043170 macromolecule metabolic process 3 1
GO:0043933 protein-containing complex organization 4 1
GO:0044237 cellular metabolic process 2 1
GO:0044238 primary metabolic process 2 1
GO:0046483 heterocycle metabolic process 3 1
GO:0048254 snoRNA localization 4 1
GO:0051179 localization 1 1
GO:0065003 protein-containing complex assembly 5 1
GO:0071704 organic substance metabolic process 2 1
GO:0071826 ribonucleoprotein complex subunit organization 5 1
GO:0071840 cellular component organization or biogenesis 2 1
GO:0090304 nucleic acid metabolic process 4 1
GO:1901360 organic cyclic compound metabolic process 3 1
Molecular functions
Term Name Level Count
GO:0005488 binding 1 10
GO:0043167 ion binding 2 10
GO:0043169 cation binding 3 10
GO:0046872 metal ion binding 4 10
GO:0003676 nucleic acid binding 3 1
GO:0003723 RNA binding 4 1
GO:0097159 organic cyclic compound binding 2 1
GO:1901363 heterocyclic compound binding 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 348 352 PF00656 0.709
CLV_C14_Caspase3-7 404 408 PF00656 0.778
CLV_C14_Caspase3-7 66 70 PF00656 0.748
CLV_NRD_NRD_1 131 133 PF00675 0.431
CLV_NRD_NRD_1 153 155 PF00675 0.466
CLV_NRD_NRD_1 201 203 PF00675 0.396
CLV_NRD_NRD_1 236 238 PF00675 0.464
CLV_NRD_NRD_1 248 250 PF00675 0.479
CLV_NRD_NRD_1 259 261 PF00675 0.435
CLV_NRD_NRD_1 317 319 PF00675 0.583
CLV_NRD_NRD_1 486 488 PF00675 0.549
CLV_NRD_NRD_1 537 539 PF00675 0.539
CLV_NRD_NRD_1 557 559 PF00675 0.259
CLV_NRD_NRD_1 610 612 PF00675 0.433
CLV_PCSK_KEX2_1 153 155 PF00082 0.466
CLV_PCSK_KEX2_1 201 203 PF00082 0.396
CLV_PCSK_KEX2_1 235 237 PF00082 0.414
CLV_PCSK_KEX2_1 250 252 PF00082 0.421
CLV_PCSK_KEX2_1 317 319 PF00082 0.596
CLV_PCSK_KEX2_1 486 488 PF00082 0.425
CLV_PCSK_KEX2_1 539 541 PF00082 0.534
CLV_PCSK_KEX2_1 557 559 PF00082 0.505
CLV_PCSK_KEX2_1 612 614 PF00082 0.459
CLV_PCSK_PC1ET2_1 250 252 PF00082 0.505
CLV_PCSK_PC1ET2_1 539 541 PF00082 0.586
CLV_PCSK_PC1ET2_1 612 614 PF00082 0.459
CLV_PCSK_PC7_1 231 237 PF00082 0.484
CLV_PCSK_PC7_1 553 559 PF00082 0.450
CLV_PCSK_PC7_1 608 614 PF00082 0.556
CLV_PCSK_SKI1_1 332 336 PF00082 0.638
CLV_PCSK_SKI1_1 471 475 PF00082 0.430
CLV_PCSK_SKI1_1 486 490 PF00082 0.268
CLV_PCSK_SKI1_1 557 561 PF00082 0.397
CLV_PCSK_SKI1_1 563 567 PF00082 0.398
CLV_PCSK_SKI1_1 584 588 PF00082 0.337
DEG_APCC_DBOX_1 292 300 PF00400 0.335
DEG_Nend_UBRbox_3 1 3 PF02207 0.537
DEG_SCF_FBW7_2 121 127 PF00400 0.579
DEG_SCF_FBW7_2 429 436 PF00400 0.410
DEG_SCF_TRCP1_1 69 74 PF00400 0.526
DOC_CKS1_1 121 126 PF01111 0.513
DOC_CKS1_1 430 435 PF01111 0.474
DOC_CKS1_1 437 442 PF01111 0.426
DOC_CYCLIN_RxL_1 557 569 PF00134 0.310
DOC_CYCLIN_yCln2_LP_2 223 229 PF00134 0.383
DOC_CYCLIN_yCln2_LP_2 434 440 PF00134 0.454
DOC_PP1_RVXF_1 484 491 PF00149 0.329
DOC_PP2B_LxvP_1 223 226 PF13499 0.391
DOC_USP7_MATH_1 212 216 PF00917 0.567
DOC_USP7_MATH_1 400 404 PF00917 0.703
DOC_USP7_MATH_1 405 409 PF00917 0.673
DOC_USP7_MATH_1 47 51 PF00917 0.781
DOC_USP7_MATH_1 518 522 PF00917 0.501
DOC_USP7_MATH_1 596 600 PF00917 0.382
DOC_USP7_MATH_1 61 65 PF00917 0.605
DOC_WW_Pin1_4 117 122 PF00397 0.656
DOC_WW_Pin1_4 429 434 PF00397 0.537
DOC_WW_Pin1_4 436 441 PF00397 0.496
DOC_WW_Pin1_4 573 578 PF00397 0.490
LIG_14-3-3_CanoR_1 132 139 PF00244 0.436
LIG_14-3-3_CanoR_1 143 149 PF00244 0.370
LIG_14-3-3_CanoR_1 153 159 PF00244 0.393
LIG_14-3-3_CanoR_1 213 217 PF00244 0.537
LIG_14-3-3_CanoR_1 507 511 PF00244 0.454
LIG_14-3-3_CanoR_1 520 524 PF00244 0.588
LIG_14-3-3_CanoR_1 538 545 PF00244 0.368
LIG_14-3-3_CanoR_1 597 601 PF00244 0.344
LIG_14-3-3_CterR_2 658 662 PF00244 0.673
LIG_AP2alpha_2 90 92 PF02296 0.487
LIG_APCC_ABBA_1 161 166 PF00400 0.444
LIG_deltaCOP1_diTrp_1 277 289 PF00928 0.339
LIG_FHA_1 140 146 PF00498 0.359
LIG_FHA_1 253 259 PF00498 0.431
LIG_FHA_1 260 266 PF00498 0.378
LIG_FHA_1 321 327 PF00498 0.469
LIG_FHA_1 376 382 PF00498 0.652
LIG_FHA_1 430 436 PF00498 0.657
LIG_FHA_2 121 127 PF00498 0.758
LIG_FHA_2 346 352 PF00498 0.806
LIG_FHA_2 437 443 PF00498 0.498
LIG_FHA_2 478 484 PF00498 0.330
LIG_FHA_2 510 516 PF00498 0.391
LIG_FHA_2 574 580 PF00498 0.488
LIG_FHA_2 7 13 PF00498 0.495
LIG_LIR_Gen_1 193 198 PF02991 0.397
LIG_LIR_Gen_1 279 288 PF02991 0.389
LIG_LIR_Gen_1 476 485 PF02991 0.350
LIG_LIR_Nem_3 193 197 PF02991 0.400
LIG_LIR_Nem_3 219 223 PF02991 0.375
LIG_LIR_Nem_3 279 285 PF02991 0.402
LIG_LIR_Nem_3 456 460 PF02991 0.437
LIG_LIR_Nem_3 469 475 PF02991 0.364
LIG_LIR_Nem_3 476 481 PF02991 0.397
LIG_LIR_Nem_3 493 497 PF02991 0.298
LIG_Pex14_1 216 220 PF04695 0.493
LIG_Pex14_1 267 271 PF04695 0.325
LIG_Pex14_2 448 452 PF04695 0.438
LIG_Pex14_2 490 494 PF04695 0.311
LIG_SH2_CRK 146 150 PF00017 0.368
LIG_SH2_CRK 220 224 PF00017 0.548
LIG_SH2_CRK 478 482 PF00017 0.412
LIG_SH2_NCK_1 146 150 PF00017 0.368
LIG_SH2_NCK_1 426 430 PF00017 0.526
LIG_SH2_SRC 426 429 PF00017 0.531
LIG_SH2_STAP1 218 222 PF00017 0.396
LIG_SH2_STAT5 146 149 PF00017 0.366
LIG_SH2_STAT5 218 221 PF00017 0.411
LIG_SH2_STAT5 302 305 PF00017 0.342
LIG_SH2_STAT5 325 328 PF00017 0.676
LIG_SH2_STAT5 457 460 PF00017 0.413
LIG_SH2_STAT5 472 475 PF00017 0.296
LIG_SH3_3 118 124 PF00018 0.508
LIG_SH3_3 411 417 PF00018 0.707
LIG_SH3_3 427 433 PF00018 0.579
LIG_SH3_3 434 440 PF00018 0.499
LIG_SH3_3 653 659 PF00018 0.517
LIG_SxIP_EBH_1 573 584 PF03271 0.288
LIG_TRAF2_1 124 127 PF00917 0.672
LIG_TRAF2_1 408 411 PF00917 0.744
LIG_TRAF2_1 425 428 PF00917 0.438
LIG_TRAF2_1 439 442 PF00917 0.311
LIG_TRFH_1 473 477 PF08558 0.419
LIG_WW_3 655 659 PF00397 0.575
MOD_CDK_SPK_2 117 122 PF00069 0.507
MOD_CK1_1 103 109 PF00069 0.617
MOD_CK1_1 183 189 PF00069 0.414
MOD_CK1_1 36 42 PF00069 0.589
MOD_CK1_1 522 528 PF00069 0.604
MOD_CK1_1 59 65 PF00069 0.788
MOD_CK2_1 120 126 PF00069 0.782
MOD_CK2_1 405 411 PF00069 0.597
MOD_CK2_1 436 442 PF00069 0.434
MOD_CK2_1 458 464 PF00069 0.378
MOD_CK2_1 477 483 PF00069 0.277
MOD_CK2_1 538 544 PF00069 0.468
MOD_CK2_1 573 579 PF00069 0.472
MOD_CK2_1 6 12 PF00069 0.673
MOD_CK2_1 67 73 PF00069 0.532
MOD_Cter_Amidation 151 154 PF01082 0.464
MOD_GlcNHglycan 100 105 PF01048 0.559
MOD_GlcNHglycan 107 110 PF01048 0.565
MOD_GlcNHglycan 274 277 PF01048 0.487
MOD_GlcNHglycan 328 331 PF01048 0.647
MOD_GlcNHglycan 351 354 PF01048 0.700
MOD_GlcNHglycan 363 367 PF01048 0.698
MOD_GlcNHglycan 51 54 PF01048 0.639
MOD_GlcNHglycan 60 64 PF01048 0.698
MOD_GlcNHglycan 646 649 PF01048 0.509
MOD_GlcNHglycan 651 654 PF01048 0.511
MOD_GlcNHglycan 69 72 PF01048 0.681
MOD_GlcNHglycan 73 76 PF01048 0.566
MOD_GSK3_1 110 117 PF00069 0.724
MOD_GSK3_1 152 159 PF00069 0.290
MOD_GSK3_1 212 219 PF00069 0.463
MOD_GSK3_1 280 287 PF00069 0.461
MOD_GSK3_1 326 333 PF00069 0.684
MOD_GSK3_1 345 352 PF00069 0.614
MOD_GSK3_1 518 525 PF00069 0.652
MOD_GSK3_1 67 74 PF00069 0.737
MOD_N-GLC_1 115 120 PF02516 0.501
MOD_N-GLC_1 253 258 PF02516 0.395
MOD_N-GLC_1 71 76 PF02516 0.628
MOD_NEK2_1 115 120 PF00069 0.658
MOD_NEK2_1 168 173 PF00069 0.475
MOD_NEK2_1 271 276 PF00069 0.338
MOD_NEK2_1 342 347 PF00069 0.517
MOD_NEK2_1 458 463 PF00069 0.252
MOD_NEK2_1 649 654 PF00069 0.523
MOD_NEK2_2 596 601 PF00069 0.279
MOD_OFUCOSY 151 156 PF10250 0.358
MOD_PIKK_1 345 351 PF00454 0.600
MOD_PIKK_1 500 506 PF00454 0.351
MOD_PKA_1 132 138 PF00069 0.349
MOD_PKA_1 538 544 PF00069 0.576
MOD_PKA_2 131 137 PF00069 0.369
MOD_PKA_2 152 158 PF00069 0.477
MOD_PKA_2 212 218 PF00069 0.516
MOD_PKA_2 259 265 PF00069 0.392
MOD_PKA_2 349 355 PF00069 0.634
MOD_PKA_2 47 53 PF00069 0.782
MOD_PKA_2 506 512 PF00069 0.477
MOD_PKA_2 519 525 PF00069 0.379
MOD_PKA_2 549 555 PF00069 0.449
MOD_PKA_2 596 602 PF00069 0.313
MOD_PKB_1 536 544 PF00069 0.389
MOD_Plk_1 253 259 PF00069 0.393
MOD_Plk_1 280 286 PF00069 0.462
MOD_Plk_2-3 616 622 PF00069 0.394
MOD_Plk_4 261 267 PF00069 0.387
MOD_Plk_4 356 362 PF00069 0.563
MOD_ProDKin_1 117 123 PF00069 0.659
MOD_ProDKin_1 429 435 PF00069 0.523
MOD_ProDKin_1 436 442 PF00069 0.483
MOD_ProDKin_1 573 579 PF00069 0.492
MOD_SUMO_rev_2 166 171 PF00179 0.479
MOD_SUMO_rev_2 253 262 PF00179 0.531
MOD_SUMO_rev_2 513 518 PF00179 0.467
TRG_DiLeu_BaEn_2 492 498 PF01217 0.422
TRG_DiLeu_BaEn_4 546 552 PF01217 0.514
TRG_DiLeu_BaLyEn_6 14 19 PF01217 0.487
TRG_DiLeu_BaLyEn_6 306 311 PF01217 0.481
TRG_DiLeu_BaLyEn_6 430 435 PF01217 0.487
TRG_ENDOCYTIC_2 194 197 PF00928 0.513
TRG_ENDOCYTIC_2 220 223 PF00928 0.563
TRG_ENDOCYTIC_2 426 429 PF00928 0.652
TRG_ENDOCYTIC_2 457 460 PF00928 0.413
TRG_ENDOCYTIC_2 472 475 PF00928 0.296
TRG_ENDOCYTIC_2 478 481 PF00928 0.368
TRG_ER_diArg_1 201 203 PF00400 0.384
TRG_ER_diArg_1 235 237 PF00400 0.510
TRG_ER_diArg_1 248 251 PF00400 0.525
TRG_ER_diArg_1 293 296 PF00400 0.361
TRG_ER_diArg_1 317 319 PF00400 0.598
TRG_ER_diArg_1 485 487 PF00400 0.419
TRG_ER_diArg_1 534 537 PF00400 0.581
TRG_ER_diArg_1 557 559 PF00400 0.384
TRG_ER_diArg_1 625 628 PF00400 0.610
TRG_ER_diArg_1 657 660 PF00400 0.717
TRG_NES_CRM1_1 479 493 PF08389 0.384
TRG_NLS_MonoExtC_3 610 615 PF00514 0.451
TRG_NLS_MonoExtN_4 608 615 PF00514 0.564
TRG_Pf-PMV_PEXEL_1 563 568 PF00026 0.409

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I0N9 Leptomonas seymouri 58% 100%
A0A3Q8IQB2 Leishmania donovani 78% 100%
A0A422N6T6 Trypanosoma rangeli 45% 100%
A4I3B4 Leishmania infantum 78% 100%
D0A7T3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 45% 100%
E9AZJ1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 77% 100%
Q4Q8P0 Leishmania major 77% 100%
V5BJ07 Trypanosoma cruzi 47% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS