Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HG70_LEIBR

TriTrypDb:

LbrM.28.0300 , LBRM2903_280008500

Length:

252

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HG70

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HG70

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	111	115	PF00656	0.481
CLV_NRD_NRD_1	164	166	PF00675	0.581
CLV_NRD_NRD_1	2	4	PF00675	0.649
CLV_PCSK_KEX2_1	2	4	PF00082	0.649
CLV_PCSK_PC1ET2_1	2	4	PF00082	0.649
CLV_PCSK_SKI1_1	49	53	PF00082	0.724
DEG_APCC_DBOX_1	152	160	PF00400	0.523
DEG_Kelch_actinfilin_1	168	172	PF01344	0.601
DEG_Nend_UBRbox_1	1	4	PF02207	0.650
DEG_ODPH_VHL_1	179	191	PF01847	0.478
DOC_CYCLIN_yCln2_LP_2	189	195	PF00134	0.478
DOC_MAPK_gen_1	150	158	PF00069	0.668
DOC_MAPK_gen_1	165	172	PF00069	0.571
DOC_MAPK_gen_1	213	219	PF00069	0.467
DOC_MAPK_gen_1	46	54	PF00069	0.448
DOC_MAPK_MEF2A_6	150	158	PF00069	0.522
DOC_USP7_MATH_1	108	112	PF00917	0.493
DOC_USP7_MATH_1	181	185	PF00917	0.733
DOC_USP7_MATH_1	28	32	PF00917	0.601
DOC_USP7_MATH_1	42	46	PF00917	0.567
DOC_WW_Pin1_4	116	121	PF00397	0.575
DOC_WW_Pin1_4	144	149	PF00397	0.611
DOC_WW_Pin1_4	174	179	PF00397	0.727
DOC_WW_Pin1_4	69	74	PF00397	0.595
LIG_14-3-3_CanoR_1	39	45	PF00244	0.464
LIG_BIR_III_2	117	121	PF00653	0.627
LIG_CtBP_PxDLS_1	21	25	PF00389	0.570
LIG_eIF4E_1	198	204	PF01652	0.512
LIG_FHA_1	198	204	PF00498	0.512
LIG_FHA_1	6	12	PF00498	0.600
LIG_FHA_2	147	153	PF00498	0.668
LIG_FHA_2	28	34	PF00498	0.636
LIG_FHA_2	70	76	PF00498	0.636
LIG_LIR_Gen_1	106	115	PF02991	0.492
LIG_LIR_Gen_1	238	249	PF02991	0.454
LIG_LIR_Nem_3	106	112	PF02991	0.620
LIG_LIR_Nem_3	238	244	PF02991	0.544
LIG_SH2_STAT5	47	50	PF00017	0.485
LIG_SH3_1	4	10	PF00018	0.559
LIG_SH3_3	167	173	PF00018	0.613
LIG_SH3_3	175	181	PF00018	0.601
LIG_SH3_3	191	197	PF00018	0.482
LIG_SH3_3	4	10	PF00018	0.743
LIG_WRC_WIRS_1	109	114	PF05994	0.608
MOD_CDK_SPxK_1	144	150	PF00069	0.612
MOD_CK2_1	116	122	PF00069	0.599
MOD_CK2_1	27	33	PF00069	0.763
MOD_CK2_1	63	69	PF00069	0.592
MOD_GlcNHglycan	161	164	PF01048	0.509
MOD_GlcNHglycan	227	230	PF01048	0.671
MOD_GlcNHglycan	235	238	PF01048	0.541
MOD_GlcNHglycan	30	33	PF01048	0.607
MOD_GlcNHglycan	65	68	PF01048	0.516
MOD_GSK3_1	71	78	PF00069	0.707
MOD_GSK3_1	84	91	PF00069	0.516
MOD_NEK2_1	158	163	PF00069	0.517
MOD_PKA_1	2	8	PF00069	0.572
MOD_PKA_2	2	8	PF00069	0.572
MOD_Plk_4	108	114	PF00069	0.590
MOD_Plk_4	127	133	PF00069	0.649
MOD_Plk_4	244	250	PF00069	0.605
MOD_ProDKin_1	116	122	PF00069	0.577
MOD_ProDKin_1	144	150	PF00069	0.612
MOD_ProDKin_1	174	180	PF00069	0.731
MOD_ProDKin_1	69	75	PF00069	0.595
MOD_SUMO_rev_2	160	168	PF00179	0.589
TRG_DiLeu_BaEn_1	22	27	PF01217	0.565
TRG_NLS_MonoExtC_3	212	218	PF00514	0.530

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7G9	Leptomonas seymouri	47%	96%
A0A3S7X157	Leishmania donovani	76%	100%
A4I3B3	Leishmania infantum	78%	100%
E9AZJ0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
Q4Q8P1	Leishmania major	73%	100%