Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HG69_LEIBR

TriTrypDb:

LbrM.28.0290 , LBRM2903_280008400

Length:

216

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0008023	transcription elongation factor complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0070449	elongin complex	4	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

A4HG69

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HG69

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006511	ubiquitin-dependent protein catabolic process	7	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009987	cellular process	1	1
GO:0019538	protein metabolic process	3	1
GO:0019941	modification-dependent protein catabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043632	modification-dependent macromolecule catabolic process	5	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0051603	proteolysis involved in protein catabolic process	5	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901575	organic substance catabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0030674	protein-macromolecule adaptor activity	2	1
GO:0060090	molecular adaptor activity	1	1
GO:0003676	nucleic acid binding	3	1
GO:0003746	translation elongation factor activity	4	1
GO:0005488	binding	1	1
GO:0008135	translation factor activity, RNA binding	3	1
GO:0045182	translation regulator activity	1	1
GO:0090079	translation regulator activity, nucleic acid binding	2	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	115	117	PF00675	0.552
CLV_NRD_NRD_1	57	59	PF00675	0.481
CLV_PCSK_KEX2_1	115	117	PF00082	0.552
CLV_PCSK_KEX2_1	59	61	PF00082	0.541
CLV_PCSK_PC1ET2_1	59	61	PF00082	0.541
CLV_PCSK_SKI1_1	162	166	PF00082	0.461
CLV_PCSK_SKI1_1	194	198	PF00082	0.594
CLV_PCSK_SKI1_1	54	58	PF00082	0.579
CLV_PCSK_SKI1_1	59	63	PF00082	0.520
CLV_Separin_Metazoa	206	210	PF03568	0.515
DEG_SPOP_SBC_1	83	87	PF00917	0.607
DOC_MAPK_MEF2A_6	156	165	PF00069	0.622
DOC_PP1_RVXF_1	160	166	PF00149	0.522
DOC_PP1_RVXF_1	52	58	PF00149	0.559
DOC_PP4_FxxP_1	197	200	PF00568	0.522
DOC_USP7_MATH_1	33	37	PF00917	0.587
DOC_USP7_MATH_1	77	81	PF00917	0.648
DOC_USP7_MATH_1	83	87	PF00917	0.668
DOC_WW_Pin1_4	47	52	PF00397	0.426
LIG_14-3-3_CanoR_1	209	215	PF00244	0.401
LIG_14-3-3_CanoR_1	60	70	PF00244	0.499
LIG_BIR_II_1	1	5	PF00653	0.630
LIG_FHA_1	19	25	PF00498	0.434
LIG_FHA_1	63	69	PF00498	0.448
LIG_FHA_1	86	92	PF00498	0.513
LIG_FHA_2	148	154	PF00498	0.645
LIG_LIR_Apic_2	20	26	PF02991	0.444
LIG_LIR_Apic_2	7	13	PF02991	0.674
LIG_LIR_Gen_1	178	186	PF02991	0.521
LIG_LIR_Gen_1	28	33	PF02991	0.494
LIG_LIR_Nem_3	178	182	PF02991	0.519
LIG_LIR_Nem_3	28	32	PF02991	0.445
LIG_PDZ_Class_2	211	216	PF00595	0.469
LIG_Pex14_2	6	10	PF04695	0.616
LIG_SH2_GRB2like	23	26	PF00017	0.628
LIG_SH2_NCK_1	139	143	PF00017	0.504
LIG_SH2_PTP2	23	26	PF00017	0.511
LIG_SH2_PTP2	29	32	PF00017	0.427
LIG_SH2_SRC	23	26	PF00017	0.375
LIG_SH2_STAT5	179	182	PF00017	0.445
LIG_SH2_STAT5	18	21	PF00017	0.607
LIG_SH2_STAT5	23	26	PF00017	0.506
LIG_SH2_STAT5	29	32	PF00017	0.392
LIG_SH3_3	10	16	PF00018	0.540
LIG_SH3_3	142	148	PF00018	0.754
LIG_SH3_3	160	166	PF00018	0.351
LIG_SUMO_SIM_par_1	147	154	PF11976	0.662
LIG_TRAF2_1	190	193	PF00917	0.413
LIG_TRAF2_1	203	206	PF00917	0.345
LIG_WRC_WIRS_1	69	74	PF05994	0.339
LIG_WW_1	15	18	PF00397	0.557
MOD_CDK_SPxxK_3	47	54	PF00069	0.426
MOD_CK1_1	85	91	PF00069	0.655
MOD_CK1_1	94	100	PF00069	0.609
MOD_CK2_1	147	153	PF00069	0.646
MOD_CK2_1	33	39	PF00069	0.579
MOD_Cter_Amidation	113	116	PF01082	0.556
MOD_GlcNHglycan	1	4	PF01048	0.578
MOD_GlcNHglycan	128	131	PF01048	0.524
MOD_GlcNHglycan	136	139	PF01048	0.494
MOD_GlcNHglycan	35	38	PF01048	0.546
MOD_GlcNHglycan	79	82	PF01048	0.515
MOD_GlcNHglycan	96	99	PF01048	0.667
MOD_GSK3_1	14	21	PF00069	0.617
MOD_GSK3_1	147	154	PF00069	0.695
MOD_NEK2_1	151	156	PF00069	0.682
MOD_NEK2_1	32	37	PF00069	0.508
MOD_NEK2_2	18	23	PF00069	0.698
MOD_PKA_1	116	122	PF00069	0.553
MOD_PKA_2	151	157	PF00069	0.494
MOD_Plk_1	157	163	PF00069	0.565
MOD_Plk_4	14	20	PF00069	0.689
MOD_Plk_4	172	178	PF00069	0.409
MOD_Plk_4	68	74	PF00069	0.361
MOD_ProDKin_1	47	53	PF00069	0.423
MOD_SUMO_for_1	73	76	PF00179	0.426
MOD_SUMO_rev_2	129	137	PF00179	0.523
TRG_ENDOCYTIC_2	179	182	PF00928	0.571
TRG_ENDOCYTIC_2	29	32	PF00928	0.433
TRG_ER_diArg_1	57	60	PF00400	0.529

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P728	Leptomonas seymouri	48%	96%
A0A1X0NVU1	Trypanosomatidae	30%	100%
A0A3Q8IDQ8	Leishmania donovani	75%	100%
A4I3B2	Leishmania infantum	75%	100%
E9AZI9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	100%
Q4Q8P2	Leishmania major	76%	100%