LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
A4HG69_LEIBR
TriTrypDb:
LbrM.28.0290 , LBRM2903_280008400 *
Length:
216

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 7
NetGPI no yes: 0, no: 7
Cellular components
TermNameLevelCount
GO:0008023 transcription elongation factor complex 3 1
GO:0032991 protein-containing complex 1 1
GO:0070449 elongin complex 4 1
GO:0140513 nuclear protein-containing complex 2 1
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Expansion

Sequence features

A4HG69
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HG69

Function

Biological processes
TermNameLevelCount
GO:0006508 proteolysis 4 1
GO:0006511 ubiquitin-dependent protein catabolic process 7 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0008152 metabolic process 1 1
GO:0009056 catabolic process 2 1
GO:0009057 macromolecule catabolic process 4 1
GO:0009987 cellular process 1 1
GO:0019538 protein metabolic process 3 1
GO:0019941 modification-dependent protein catabolic process 6 1
GO:0043170 macromolecule metabolic process 3 1
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Molecular functions
TermNameLevelCount
GO:0003676 nucleic acid binding 3 1
GO:0003746 translation elongation factor activity 4 1
GO:0005488 binding 1 1
GO:0008135 translation factor activity, RNA binding 3 1
GO:0030674 protein-macromolecule adaptor activity 2 1
GO:0045182 translation regulator activity 1 1
GO:0060090 molecular adaptor activity 1 1
GO:0090079 translation regulator activity, nucleic acid binding 2 1
GO:0097159 organic cyclic compound binding 2 1
GO:1901363 heterocyclic compound binding 2 1
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Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_NRD_NRD_1 115 117 PF00675 0.552
CLV_NRD_NRD_1 57 59 PF00675 0.481
CLV_PCSK_KEX2_1 115 117 PF00082 0.552
CLV_PCSK_KEX2_1 59 61 PF00082 0.541
CLV_PCSK_PC1ET2_1 59 61 PF00082 0.541
CLV_PCSK_SKI1_1 162 166 PF00082 0.461
CLV_PCSK_SKI1_1 194 198 PF00082 0.594
CLV_PCSK_SKI1_1 54 58 PF00082 0.579
CLV_PCSK_SKI1_1 59 63 PF00082 0.520
CLV_Separin_Metazoa 206 210 PF03568 0.515
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N0P728 Leptomonas seymouri 48% 96%
A0A1X0NVU1 Trypanosomatidae 30% 100%
A0A3Q8IDQ8 Leishmania donovani 75% 100%
A4I3B2 Leishmania infantum 75% 100%
E9AZI9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 73% 100%
Q4Q8P2 Leishmania major 76% 100%
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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS