Phosphoadenosine phosphosulfate reductase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phosphoadenosine phosphosulfate reductase-like protein

Species:

Leishmania braziliensis

UniProt:

A4HG68_LEIBR

TriTrypDb:

LbrM.28.0280 , LBRM2903_280008300

Length:

215

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	3
GO:0005929	cilium	4	2
GO:0042995	cell projection	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0120025	plasma membrane bounded cell projection	3	2

Expansion

Sequence features

A4HG68

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HG68

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006747	FAD biosynthetic process	7	1
GO:0006753	nucleoside phosphate metabolic process	4	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009058	biosynthetic process	2	1
GO:0009117	nucleotide metabolic process	5	1
GO:0009165	nucleotide biosynthetic process	6	1
GO:0009987	cellular process	1	1
GO:0018130	heterocycle biosynthetic process	4	1
GO:0019438	aromatic compound biosynthetic process	4	1
GO:0019637	organophosphate metabolic process	3	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034654	nucleobase-containing compound biosynthetic process	4	1
GO:0042726	flavin-containing compound metabolic process	4	1
GO:0042727	flavin-containing compound biosynthetic process	5	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044271	cellular nitrogen compound biosynthetic process	4	1
GO:0044281	small molecule metabolic process	2	1
GO:0046443	FAD metabolic process	6	1
GO:0046483	heterocycle metabolic process	3	1
GO:0055086	nucleobase-containing small molecule metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0072387	flavin adenine dinucleotide metabolic process	5	1
GO:0072388	flavin adenine dinucleotide biosynthetic process	6	1
GO:0090407	organophosphate biosynthetic process	4	1
GO:1901293	nucleoside phosphate biosynthetic process	5	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901362	organic cyclic compound biosynthetic process	4	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901566	organonitrogen compound biosynthetic process	4	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0003919	FMN adenylyltransferase activity	6	1
GO:0016740	transferase activity	2	1
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	1
GO:0016779	nucleotidyltransferase activity	4	1
GO:0070566	adenylyltransferase activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	117	119	PF00675	0.233
CLV_NRD_NRD_1	46	48	PF00675	0.413
CLV_PCSK_FUR_1	188	192	PF00082	0.311
CLV_PCSK_KEX2_1	190	192	PF00082	0.487
CLV_PCSK_KEX2_1	46	48	PF00082	0.413
CLV_PCSK_PC1ET2_1	190	192	PF00082	0.351
CLV_PCSK_SKI1_1	111	115	PF00082	0.278
CLV_PCSK_SKI1_1	47	51	PF00082	0.438
CLV_Separin_Metazoa	43	47	PF03568	0.378
DEG_APCC_DBOX_1	97	105	PF00400	0.435
DOC_MAPK_gen_1	46	53	PF00069	0.297
DOC_MAPK_MEF2A_6	36	44	PF00069	0.228
DOC_MAPK_MEF2A_6	46	53	PF00069	0.329
DOC_PP1_RVXF_1	109	115	PF00149	0.513
DOC_USP7_MATH_1	165	169	PF00917	0.513
DOC_WW_Pin1_4	132	137	PF00397	0.536
DOC_WW_Pin1_4	21	26	PF00397	0.261
LIG_14-3-3_CanoR_1	10	16	PF00244	0.390
LIG_14-3-3_CanoR_1	118	122	PF00244	0.502
LIG_14-3-3_CanoR_1	46	52	PF00244	0.407
LIG_14-3-3_CanoR_1	98	102	PF00244	0.388
LIG_Actin_WH2_2	97	113	PF00022	0.420
LIG_BIR_II_1	1	5	PF00653	0.374
LIG_FHA_1	48	54	PF00498	0.391
LIG_FHA_1	92	98	PF00498	0.473
LIG_LIR_Gen_1	171	181	PF02991	0.510
LIG_LIR_Gen_1	66	76	PF02991	0.317
LIG_LIR_Nem_3	135	141	PF02991	0.466
LIG_LIR_Nem_3	171	177	PF02991	0.536
LIG_LIR_Nem_3	18	23	PF02991	0.394
LIG_LIR_Nem_3	66	71	PF02991	0.332
LIG_SH2_CRK	158	162	PF00017	0.438
LIG_SH2_CRK	174	178	PF00017	0.375
LIG_SH2_NCK_1	174	178	PF00017	0.522
LIG_SH2_STAP1	158	162	PF00017	0.473
LIG_SH2_STAT5	158	161	PF00017	0.429
LIG_SH3_1	133	139	PF00018	0.490
LIG_SH3_3	133	139	PF00018	0.520
LIG_SH3_3	46	52	PF00018	0.402
LIG_SUMO_SIM_par_1	37	43	PF11976	0.289
MOD_CK1_1	172	178	PF00069	0.480
MOD_CK1_1	180	186	PF00069	0.519
MOD_CK2_1	165	171	PF00069	0.480
MOD_CK2_1	21	27	PF00069	0.240
MOD_GlcNHglycan	171	174	PF01048	0.280
MOD_GlcNHglycan	179	182	PF01048	0.217
MOD_GSK3_1	165	172	PF00069	0.491
MOD_GSK3_1	173	180	PF00069	0.425
MOD_NEK2_1	114	119	PF00069	0.426
MOD_NEK2_1	148	153	PF00069	0.496
MOD_NEK2_1	169	174	PF00069	0.513
MOD_NEK2_2	165	170	PF00069	0.513
MOD_PKA_2	117	123	PF00069	0.446
MOD_PKA_2	9	15	PF00069	0.356
MOD_PKA_2	97	103	PF00069	0.445
MOD_Plk_4	165	171	PF00069	0.514
MOD_Plk_4	35	41	PF00069	0.309
MOD_Plk_4	97	103	PF00069	0.445
MOD_ProDKin_1	132	138	PF00069	0.536
MOD_ProDKin_1	21	27	PF00069	0.259
MOD_SUMO_for_1	189	192	PF00179	0.307
TRG_AP2beta_CARGO_1	66	75	PF09066	0.436
TRG_ENDOCYTIC_2	158	161	PF00928	0.443
TRG_ENDOCYTIC_2	174	177	PF00928	0.356
TRG_ER_diArg_1	45	47	PF00400	0.403

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7C6	Leptomonas seymouri	59%	86%
A0A0S4IUQ2	Bodo saltans	42%	93%
A0A1X0NVD4	Trypanosomatidae	45%	66%
A0A3S7X154	Leishmania donovani	87%	100%
A4I3B1	Leishmania infantum	87%	100%
D0A7S9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	67%
E9AZI8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
O74841	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	31%	81%
P38913	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	26%	70%
Q4Q8P3	Leishmania major	88%	100%
V5B9Z2	Trypanosoma cruzi	43%	67%