Rab-GAP TBC domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HG67_LEIBR

TriTrypDb:

LbrM.28.0270 , LBRM2903_280008200

Length:

1067

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HG67

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HG67

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	119	123	PF00656	0.614
CLV_NRD_NRD_1	149	151	PF00675	0.574
CLV_NRD_NRD_1	470	472	PF00675	0.570
CLV_NRD_NRD_1	650	652	PF00675	0.575
CLV_NRD_NRD_1	78	80	PF00675	0.514
CLV_NRD_NRD_1	796	798	PF00675	0.513
CLV_NRD_NRD_1	802	804	PF00675	0.469
CLV_NRD_NRD_1	820	822	PF00675	0.472
CLV_NRD_NRD_1	929	931	PF00675	0.470
CLV_NRD_NRD_1	93	95	PF00675	0.522
CLV_NRD_NRD_1	993	995	PF00675	0.438
CLV_PCSK_KEX2_1	149	151	PF00082	0.436
CLV_PCSK_KEX2_1	650	652	PF00082	0.713
CLV_PCSK_KEX2_1	78	80	PF00082	0.495
CLV_PCSK_KEX2_1	796	798	PF00082	0.500
CLV_PCSK_KEX2_1	802	804	PF00082	0.484
CLV_PCSK_KEX2_1	822	824	PF00082	0.347
CLV_PCSK_KEX2_1	929	931	PF00082	0.560
CLV_PCSK_KEX2_1	93	95	PF00082	0.461
CLV_PCSK_KEX2_1	993	995	PF00082	0.438
CLV_PCSK_PC1ET2_1	822	824	PF00082	0.526
CLV_PCSK_SKI1_1	166	170	PF00082	0.448
CLV_PCSK_SKI1_1	27	31	PF00082	0.483
CLV_PCSK_SKI1_1	409	413	PF00082	0.406
CLV_PCSK_SKI1_1	465	469	PF00082	0.448
CLV_PCSK_SKI1_1	606	610	PF00082	0.547
CLV_PCSK_SKI1_1	62	66	PF00082	0.586
CLV_PCSK_SKI1_1	813	817	PF00082	0.504
CLV_PCSK_SKI1_1	907	911	PF00082	0.448
DEG_APCC_DBOX_1	214	222	PF00400	0.410
DEG_APCC_DBOX_1	820	828	PF00400	0.526
DEG_SPOP_SBC_1	1042	1046	PF00917	0.454
DOC_CDC14_PxL_1	335	343	PF14671	0.419
DOC_CKS1_1	12	17	PF01111	0.561
DOC_CKS1_1	350	355	PF01111	0.589
DOC_CKS1_1	734	739	PF01111	0.598
DOC_CYCLIN_RxL_1	462	470	PF00134	0.447
DOC_CYCLIN_RxL_1	480	491	PF00134	0.483
DOC_CYCLIN_RxL_1	904	914	PF00134	0.452
DOC_CYCLIN_yCln2_LP_2	1058	1064	PF00134	0.522
DOC_CYCLIN_yCln2_LP_2	656	662	PF00134	0.550
DOC_MAPK_DCC_7	802	810	PF00069	0.658
DOC_MAPK_DCC_7	819	829	PF00069	0.402
DOC_MAPK_gen_1	170	177	PF00069	0.468
DOC_MAPK_gen_1	631	640	PF00069	0.399
DOC_MAPK_gen_1	802	810	PF00069	0.596
DOC_MAPK_gen_1	819	829	PF00069	0.402
DOC_MAPK_HePTP_8	268	280	PF00069	0.278
DOC_MAPK_JIP1_4	1060	1066	PF00069	0.464
DOC_MAPK_MEF2A_6	170	177	PF00069	0.468
DOC_MAPK_MEF2A_6	271	280	PF00069	0.283
DOC_MAPK_MEF2A_6	300	307	PF00069	0.391
DOC_MAPK_MEF2A_6	821	829	PF00069	0.532
DOC_MAPK_MEF2A_6	868	877	PF00069	0.352
DOC_PP1_RVXF_1	648	655	PF00149	0.539
DOC_PP1_RVXF_1	992	999	PF00149	0.451
DOC_USP7_MATH_1	1042	1046	PF00917	0.544
DOC_USP7_MATH_1	1048	1052	PF00917	0.518
DOC_USP7_MATH_1	114	118	PF00917	0.770
DOC_USP7_MATH_1	211	215	PF00917	0.315
DOC_USP7_MATH_1	299	303	PF00917	0.460
DOC_USP7_MATH_1	348	352	PF00917	0.511
DOC_USP7_MATH_1	417	421	PF00917	0.364
DOC_USP7_MATH_1	743	747	PF00917	0.541
DOC_USP7_MATH_1	854	858	PF00917	0.463
DOC_USP7_MATH_1	928	932	PF00917	0.465
DOC_WW_Pin1_4	11	16	PF00397	0.517
DOC_WW_Pin1_4	121	126	PF00397	0.585
DOC_WW_Pin1_4	234	239	PF00397	0.388
DOC_WW_Pin1_4	324	329	PF00397	0.518
DOC_WW_Pin1_4	349	354	PF00397	0.720
DOC_WW_Pin1_4	393	398	PF00397	0.426
DOC_WW_Pin1_4	446	451	PF00397	0.469
DOC_WW_Pin1_4	598	603	PF00397	0.635
DOC_WW_Pin1_4	606	611	PF00397	0.518
DOC_WW_Pin1_4	641	646	PF00397	0.457
DOC_WW_Pin1_4	733	738	PF00397	0.616
DOC_WW_Pin1_4	87	92	PF00397	0.596
DOC_WW_Pin1_4	893	898	PF00397	0.527
DOC_WW_Pin1_4	987	992	PF00397	0.507
LIG_14-3-3_CanoR_1	192	201	PF00244	0.405
LIG_14-3-3_CanoR_1	282	289	PF00244	0.378
LIG_14-3-3_CanoR_1	432	438	PF00244	0.390
LIG_14-3-3_CanoR_1	474	480	PF00244	0.670
LIG_14-3-3_CanoR_1	527	534	PF00244	0.470
LIG_14-3-3_CanoR_1	618	624	PF00244	0.608
LIG_14-3-3_CanoR_1	876	884	PF00244	0.600
LIG_14-3-3_CanoR_1	929	935	PF00244	0.449
LIG_Actin_WH2_2	1013	1031	PF00022	0.408
LIG_Actin_WH2_2	863	878	PF00022	0.416
LIG_Actin_WH2_2	901	919	PF00022	0.455
LIG_APCC_ABBA_1	1020	1025	PF00400	0.419
LIG_BIR_III_4	96	100	PF00653	0.618
LIG_BRCT_BRCA1_1	1030	1034	PF00533	0.425
LIG_BRCT_BRCA1_1	1050	1054	PF00533	0.446
LIG_BRCT_BRCA1_1	636	640	PF00533	0.540
LIG_BRCT_BRCA1_1	775	779	PF00533	0.557
LIG_BRCT_BRCA1_2	1030	1036	PF00533	0.436
LIG_deltaCOP1_diTrp_1	719	729	PF00928	0.538
LIG_DLG_GKlike_1	634	641	PF00625	0.547
LIG_EH1_1	610	618	PF00400	0.502
LIG_eIF4E_1	611	617	PF01652	0.391
LIG_eIF4E_1	690	696	PF01652	0.497
LIG_FHA_1	496	502	PF00498	0.481
LIG_FHA_1	527	533	PF00498	0.462
LIG_FHA_1	619	625	PF00498	0.573
LIG_FHA_1	63	69	PF00498	0.694
LIG_FHA_1	853	859	PF00498	0.609
LIG_FHA_1	973	979	PF00498	0.331
LIG_FHA_2	408	414	PF00498	0.301
LIG_FHA_2	548	554	PF00498	0.528
LIG_FHA_2	577	583	PF00498	0.515
LIG_FHA_2	707	713	PF00498	0.516
LIG_FHA_2	838	844	PF00498	0.530
LIG_GBD_Chelix_1	242	250	PF00786	0.407
LIG_GBD_Chelix_1	303	311	PF00786	0.381
LIG_LIR_Apic_2	10	15	PF02991	0.561
LIG_LIR_Apic_2	727	732	PF02991	0.560
LIG_LIR_Gen_1	1009	1020	PF02991	0.339
LIG_LIR_Gen_1	1051	1062	PF02991	0.416
LIG_LIR_Gen_1	180	190	PF02991	0.454
LIG_LIR_Gen_1	207	216	PF02991	0.434
LIG_LIR_Gen_1	266	277	PF02991	0.535
LIG_LIR_Gen_1	477	487	PF02991	0.670
LIG_LIR_Gen_1	495	503	PF02991	0.401
LIG_LIR_Gen_1	510	519	PF02991	0.433
LIG_LIR_Gen_1	559	570	PF02991	0.449
LIG_LIR_Gen_1	688	697	PF02991	0.392
LIG_LIR_Gen_1	719	730	PF02991	0.415
LIG_LIR_Nem_3	1009	1015	PF02991	0.342
LIG_LIR_Nem_3	1051	1057	PF02991	0.479
LIG_LIR_Nem_3	180	185	PF02991	0.501
LIG_LIR_Nem_3	207	212	PF02991	0.427
LIG_LIR_Nem_3	266	272	PF02991	0.483
LIG_LIR_Nem_3	361	366	PF02991	0.276
LIG_LIR_Nem_3	477	482	PF02991	0.733
LIG_LIR_Nem_3	495	500	PF02991	0.302
LIG_LIR_Nem_3	510	515	PF02991	0.428
LIG_LIR_Nem_3	559	565	PF02991	0.438
LIG_LIR_Nem_3	661	666	PF02991	0.535
LIG_LIR_Nem_3	688	693	PF02991	0.387
LIG_LIR_Nem_3	719	725	PF02991	0.496
LIG_LIR_Nem_3	806	812	PF02991	0.454
LIG_LIR_Nem_3	933	938	PF02991	0.401
LIG_LYPXL_yS_3	663	666	PF13949	0.579
LIG_MAD2	271	279	PF02301	0.385
LIG_MYND_1	655	659	PF01753	0.553
LIG_NRBOX	164	170	PF00104	0.443
LIG_NRBOX	245	251	PF00104	0.406
LIG_NRBOX	365	371	PF00104	0.396
LIG_NRBOX	433	439	PF00104	0.333
LIG_NRBOX	759	765	PF00104	0.450
LIG_Pex14_1	359	363	PF04695	0.409
LIG_Pex14_2	779	783	PF04695	0.580
LIG_Pex14_2	810	814	PF04695	0.517
LIG_RPA_C_Fungi	310	322	PF08784	0.316
LIG_SH2_CRK	1012	1016	PF00017	0.396
LIG_SH2_CRK	690	694	PF00017	0.523
LIG_SH2_SRC	381	384	PF00017	0.281
LIG_SH2_STAP1	1012	1016	PF00017	0.396
LIG_SH2_STAP1	423	427	PF00017	0.270
LIG_SH2_STAT3	423	426	PF00017	0.276
LIG_SH2_STAT5	1003	1006	PF00017	0.318
LIG_SH2_STAT5	167	170	PF00017	0.455
LIG_SH2_STAT5	547	550	PF00017	0.574
LIG_SH2_STAT5	809	812	PF00017	0.511
LIG_SH3_3	1036	1042	PF00018	0.538
LIG_SH3_3	1044	1050	PF00018	0.480
LIG_SH3_3	248	254	PF00018	0.288
LIG_SH3_3	273	279	PF00018	0.410
LIG_SH3_3	347	353	PF00018	0.572
LIG_SH3_3	453	459	PF00018	0.396
LIG_SH3_3	979	985	PF00018	0.368
LIG_SH3_5	259	263	PF00018	0.395
LIG_SUMO_SIM_anti_2	116	124	PF11976	0.616
LIG_SUMO_SIM_anti_2	757	765	PF11976	0.467
LIG_SUMO_SIM_anti_2	959	965	PF11976	0.371
LIG_SUMO_SIM_par_1	485	491	PF11976	0.478
LIG_SUMO_SIM_par_1	757	765	PF11976	0.526
LIG_SUMO_SIM_par_1	890	896	PF11976	0.433
LIG_TRAF2_1	713	716	PF00917	0.453
LIG_TRAF2_1	863	866	PF00917	0.504
LIG_TRAF2_1	931	934	PF00917	0.484
LIG_TYR_ITSM	686	693	PF00017	0.389
LIG_UBA3_1	334	343	PF00899	0.337
LIG_ULM_U2AF65_1	650	655	PF00076	0.562
MOD_CDC14_SPxK_1	90	93	PF00782	0.563
MOD_CDK_SPxK_1	87	93	PF00069	0.568
MOD_CDK_SPxK_1	987	993	PF00069	0.500
MOD_CDK_SPxxK_3	393	400	PF00069	0.414
MOD_CDK_SPxxK_3	87	94	PF00069	0.633
MOD_CDK_SPxxK_3	987	994	PF00069	0.493
MOD_CK1_1	196	202	PF00069	0.493
MOD_CK1_1	226	232	PF00069	0.357
MOD_CK1_1	313	319	PF00069	0.366
MOD_CK1_1	342	348	PF00069	0.637
MOD_CK1_1	351	357	PF00069	0.491
MOD_CK1_1	669	675	PF00069	0.567
MOD_CK1_1	759	765	PF00069	0.545
MOD_CK1_1	857	863	PF00069	0.577
MOD_CK1_1	896	902	PF00069	0.389
MOD_CK2_1	121	127	PF00069	0.568
MOD_CK2_1	399	405	PF00069	0.380
MOD_CK2_1	4	10	PF00069	0.459
MOD_CK2_1	547	553	PF00069	0.517
MOD_CK2_1	576	582	PF00069	0.675
MOD_CK2_1	584	590	PF00069	0.558
MOD_CK2_1	669	675	PF00069	0.590
MOD_CK2_1	772	778	PF00069	0.417
MOD_CK2_1	928	934	PF00069	0.414
MOD_Cter_Amidation	648	651	PF01082	0.448
MOD_Cter_Amidation	819	822	PF01082	0.541
MOD_DYRK1A_RPxSP_1	606	610	PF00069	0.547
MOD_GlcNHglycan	1030	1033	PF01048	0.519
MOD_GlcNHglycan	1050	1053	PF01048	0.323
MOD_GlcNHglycan	197	201	PF01048	0.478
MOD_GlcNHglycan	225	228	PF01048	0.512
MOD_GlcNHglycan	297	300	PF01048	0.570
MOD_GlcNHglycan	50	53	PF01048	0.597
MOD_GlcNHglycan	509	512	PF01048	0.308
MOD_GlcNHglycan	523	526	PF01048	0.461
MOD_GlcNHglycan	558	561	PF01048	0.454
MOD_GlcNHglycan	586	589	PF01048	0.621
MOD_GlcNHglycan	593	596	PF01048	0.572
MOD_GlcNHglycan	738	741	PF01048	0.615
MOD_GlcNHglycan	775	778	PF01048	0.516
MOD_GlcNHglycan	816	819	PF01048	0.538
MOD_GlcNHglycan	930	933	PF01048	0.608
MOD_GlcNHglycan	956	959	PF01048	0.449
MOD_GlcNHglycan	96	100	PF01048	0.615
MOD_GlcNHglycan	964	967	PF01048	0.442
MOD_GSK3_1	1002	1009	PF00069	0.364
MOD_GSK3_1	19	26	PF00069	0.462
MOD_GSK3_1	295	302	PF00069	0.589
MOD_GSK3_1	348	355	PF00069	0.640
MOD_GSK3_1	4	11	PF00069	0.623
MOD_GSK3_1	503	510	PF00069	0.319
MOD_GSK3_1	573	580	PF00069	0.601
MOD_GSK3_1	584	591	PF00069	0.551
MOD_GSK3_1	68	75	PF00069	0.612
MOD_GSK3_1	685	692	PF00069	0.577
MOD_GSK3_1	892	899	PF00069	0.455
MOD_GSK3_1	934	941	PF00069	0.528
MOD_GSK3_1	983	990	PF00069	0.514
MOD_N-GLC_1	911	916	PF02516	0.470
MOD_NEK2_1	1016	1021	PF00069	0.223
MOD_NEK2_1	1028	1033	PF00069	0.459
MOD_NEK2_1	144	149	PF00069	0.501
MOD_NEK2_1	362	367	PF00069	0.265
MOD_NEK2_1	4	9	PF00069	0.528
MOD_NEK2_1	433	438	PF00069	0.351
MOD_NEK2_1	461	466	PF00069	0.450
MOD_NEK2_1	467	472	PF00069	0.511
MOD_NEK2_1	617	622	PF00069	0.493
MOD_NEK2_1	696	701	PF00069	0.500
MOD_NEK2_1	772	777	PF00069	0.660
MOD_NEK2_1	814	819	PF00069	0.465
MOD_NEK2_1	875	880	PF00069	0.487
MOD_NEK2_1	916	921	PF00069	0.543
MOD_NEK2_1	962	967	PF00069	0.503
MOD_NEK2_1	972	977	PF00069	0.378
MOD_NEK2_1	996	1001	PF00069	0.518
MOD_NEK2_2	204	209	PF00069	0.521
MOD_NEK2_2	547	552	PF00069	0.507
MOD_NEK2_2	689	694	PF00069	0.520
MOD_PIKK_1	352	358	PF00454	0.594
MOD_PIKK_1	770	776	PF00454	0.484
MOD_PKA_1	596	602	PF00069	0.621
MOD_PKA_2	1028	1034	PF00069	0.512
MOD_PKA_2	19	25	PF00069	0.543
MOD_PKA_2	299	305	PF00069	0.407
MOD_PKA_2	503	509	PF00069	0.497
MOD_PKA_2	526	532	PF00069	0.451
MOD_PKA_2	617	623	PF00069	0.499
MOD_PKA_2	875	881	PF00069	0.513
MOD_PKA_2	916	922	PF00069	0.472
MOD_PKA_2	928	934	PF00069	0.358
MOD_Plk_1	144	150	PF00069	0.378
MOD_Plk_1	634	640	PF00069	0.414
MOD_Plk_1	669	675	PF00069	0.590
MOD_Plk_1	756	762	PF00069	0.507
MOD_Plk_1	834	840	PF00069	0.495
MOD_Plk_1	911	917	PF00069	0.475
MOD_Plk_2-3	934	940	PF00069	0.325
MOD_Plk_4	204	210	PF00069	0.416
MOD_Plk_4	4	10	PF00069	0.464
MOD_Plk_4	407	413	PF00069	0.321
MOD_Plk_4	433	439	PF00069	0.393
MOD_Plk_4	743	749	PF00069	0.581
MOD_Plk_4	756	762	PF00069	0.488
MOD_ProDKin_1	11	17	PF00069	0.513
MOD_ProDKin_1	121	127	PF00069	0.586
MOD_ProDKin_1	234	240	PF00069	0.382
MOD_ProDKin_1	324	330	PF00069	0.513
MOD_ProDKin_1	349	355	PF00069	0.717
MOD_ProDKin_1	393	399	PF00069	0.419
MOD_ProDKin_1	446	452	PF00069	0.459
MOD_ProDKin_1	598	604	PF00069	0.630
MOD_ProDKin_1	606	612	PF00069	0.507
MOD_ProDKin_1	641	647	PF00069	0.445
MOD_ProDKin_1	733	739	PF00069	0.618
MOD_ProDKin_1	87	93	PF00069	0.597
MOD_ProDKin_1	893	899	PF00069	0.517
MOD_ProDKin_1	987	993	PF00069	0.500
TRG_DiLeu_BaEn_1	236	241	PF01217	0.377
TRG_DiLeu_BaEn_2	1029	1035	PF01217	0.424
TRG_DiLeu_BaEn_4	157	163	PF01217	0.494
TRG_DiLeu_BaEn_4	865	871	PF01217	0.479
TRG_DiLeu_BaLyEn_6	245	250	PF01217	0.400
TRG_DiLeu_BaLyEn_6	256	261	PF01217	0.394
TRG_DiLeu_BaLyEn_6	279	284	PF01217	0.306
TRG_DiLeu_BaLyEn_6	429	434	PF01217	0.376
TRG_DiLeu_BaLyEn_6	496	501	PF01217	0.416
TRG_DiLeu_BaLyEn_6	652	657	PF01217	0.553
TRG_ENDOCYTIC_2	1012	1015	PF00928	0.398
TRG_ENDOCYTIC_2	479	482	PF00928	0.475
TRG_ENDOCYTIC_2	663	666	PF00928	0.579
TRG_ENDOCYTIC_2	690	693	PF00928	0.518
TRG_ENDOCYTIC_2	809	812	PF00928	0.511
TRG_ER_diArg_1	148	150	PF00400	0.414
TRG_ER_diArg_1	650	653	PF00400	0.572
TRG_ER_diArg_1	795	797	PF00400	0.571
TRG_ER_diArg_1	821	824	PF00400	0.527
TRG_ER_diArg_1	92	94	PF00400	0.508
TRG_NES_CRM1_1	900	913	PF08389	0.322
TRG_NLS_MonoExtC_3	470	475	PF00514	0.475
TRG_NLS_MonoExtC_3	820	825	PF00514	0.522
TRG_NLS_MonoExtN_4	819	825	PF00514	0.529
TRG_Pf-PMV_PEXEL_1	1026	1030	PF00026	0.453
TRG_Pf-PMV_PEXEL_1	248	252	PF00026	0.287
TRG_Pf-PMV_PEXEL_1	271	275	PF00026	0.407
TRG_Pf-PMV_PEXEL_1	282	286	PF00026	0.403
TRG_Pf-PMV_PEXEL_1	364	368	PF00026	0.422
TRG_Pf-PMV_PEXEL_1	483	488	PF00026	0.535
TRG_Pf-PMV_PEXEL_1	796	800	PF00026	0.552

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I917	Leptomonas seymouri	38%	87%
A0A3Q8IGK9	Leishmania donovani	78%	100%
E9AZI7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
Q4Q8P4	Leishmania major	78%	99%
V5BEI0	Trypanosoma cruzi	23%	100%