Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HG64_LEIBR

TriTrypDb:

LbrM.28.0240 , LBRM2903_280007900

Length:

336

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HG64

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HG64

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	290	294	PF00656	0.433
CLV_NRD_NRD_1	258	260	PF00675	0.702
CLV_PCSK_KEX2_1	258	260	PF00082	0.639
DOC_MAPK_gen_1	267	277	PF00069	0.496
DOC_PIKK_1	139	147	PF02985	0.562
DOC_PP2B_LxvP_1	157	160	PF13499	0.541
DOC_USP7_MATH_1	198	202	PF00917	0.593
DOC_USP7_MATH_1	207	211	PF00917	0.664
DOC_WW_Pin1_4	102	107	PF00397	0.603
DOC_WW_Pin1_4	244	249	PF00397	0.523
DOC_WW_Pin1_4	44	49	PF00397	0.651
LIG_14-3-3_CanoR_1	199	209	PF00244	0.592
LIG_14-3-3_CanoR_1	224	228	PF00244	0.706
LIG_BIR_II_1	1	5	PF00653	0.552
LIG_BRCT_BRCA1_1	317	321	PF00533	0.640
LIG_BRCT_BRCA1_1	324	328	PF00533	0.546
LIG_eIF4E_1	81	87	PF01652	0.521
LIG_FHA_1	117	123	PF00498	0.622
LIG_FHA_1	178	184	PF00498	0.693
LIG_FHA_1	224	230	PF00498	0.805
LIG_FHA_1	24	30	PF00498	0.551
LIG_FHA_1	251	257	PF00498	0.703
LIG_FHA_1	45	51	PF00498	0.721
LIG_FHA_1	72	78	PF00498	0.661
LIG_FHA_2	147	153	PF00498	0.637
LIG_LIR_Apic_2	162	168	PF02991	0.546
LIG_LIR_Gen_1	11	19	PF02991	0.546
LIG_LIR_Gen_1	92	102	PF02991	0.759
LIG_LIR_Nem_3	11	17	PF02991	0.534
LIG_LIR_Nem_3	299	304	PF02991	0.632
LIG_LIR_Nem_3	92	97	PF02991	0.758
LIG_NRBOX	178	184	PF00104	0.533
LIG_PCNA_PIPBox_1	281	290	PF02747	0.418
LIG_PDZ_Class_2	331	336	PF00595	0.642
LIG_Pex14_2	328	332	PF04695	0.623
LIG_SH2_CRK	165	169	PF00017	0.629
LIG_SH2_NCK_1	165	169	PF00017	0.551
LIG_SH2_STAT5	165	168	PF00017	0.630
LIG_SH3_3	121	127	PF00018	0.686
LIG_SH3_3	152	158	PF00018	0.717
LIG_SH3_3	301	307	PF00018	0.506
LIG_SH3_3	61	67	PF00018	0.556
LIG_SUMO_SIM_par_1	15	20	PF11976	0.537
LIG_TRAF2_1	143	146	PF00917	0.668
LIG_TRAF2_1	159	162	PF00917	0.548
LIG_TRAF2_1	276	279	PF00917	0.608
LIG_TRAF2_1	67	70	PF00917	0.585
MOD_CK1_1	105	111	PF00069	0.537
MOD_CK1_1	116	122	PF00069	0.650
MOD_CK1_1	177	183	PF00069	0.531
MOD_CK1_1	200	206	PF00069	0.720
MOD_CK1_1	233	239	PF00069	0.698
MOD_CK1_1	243	249	PF00069	0.582
MOD_CK1_1	9	15	PF00069	0.535
MOD_CK1_1	90	96	PF00069	0.735
MOD_CK2_1	130	136	PF00069	0.537
MOD_CK2_1	140	146	PF00069	0.594
MOD_CK2_1	166	172	PF00069	0.590
MOD_CK2_1	233	239	PF00069	0.698
MOD_CK2_1	72	78	PF00069	0.644
MOD_CK2_1	86	92	PF00069	0.603
MOD_GlcNHglycan	114	118	PF01048	0.691
MOD_GlcNHglycan	132	135	PF01048	0.536
MOD_GlcNHglycan	176	179	PF01048	0.690
MOD_GlcNHglycan	19	22	PF01048	0.546
MOD_GlcNHglycan	242	245	PF01048	0.610
MOD_GlcNHglycan	296	299	PF01048	0.693
MOD_GlcNHglycan	89	92	PF01048	0.776
MOD_GSK3_1	184	191	PF00069	0.625
MOD_GSK3_1	197	204	PF00069	0.641
MOD_GSK3_1	240	247	PF00069	0.643
MOD_GSK3_1	29	36	PF00069	0.678
MOD_GSK3_1	6	13	PF00069	0.552
MOD_GSK3_1	86	93	PF00069	0.703
MOD_LATS_1	6	12	PF00433	0.522
MOD_N-GLC_1	140	145	PF02516	0.561
MOD_N-GLC_1	244	249	PF02516	0.523
MOD_NEK2_1	115	120	PF00069	0.544
MOD_NEK2_1	130	135	PF00069	0.632
MOD_NEK2_1	17	22	PF00069	0.543
MOD_NEK2_1	240	245	PF00069	0.538
MOD_NEK2_1	315	320	PF00069	0.642
MOD_NEK2_1	86	91	PF00069	0.647
MOD_PIKK_1	105	111	PF00454	0.559
MOD_PIKK_1	146	152	PF00454	0.640
MOD_PIKK_1	218	224	PF00454	0.639
MOD_PKA_2	198	204	PF00069	0.590
MOD_PKA_2	223	229	PF00069	0.544
MOD_Plk_1	140	146	PF00069	0.704
MOD_Plk_1	233	239	PF00069	0.558
MOD_Plk_1	54	60	PF00069	0.726
MOD_Plk_1	9	15	PF00069	0.548
MOD_Plk_2-3	140	146	PF00069	0.561
MOD_Plk_2-3	212	218	PF00069	0.551
MOD_Plk_4	90	96	PF00069	0.715
MOD_ProDKin_1	102	108	PF00069	0.606
MOD_ProDKin_1	244	250	PF00069	0.520
MOD_ProDKin_1	44	50	PF00069	0.651
MOD_SUMO_rev_2	190	198	PF00179	0.558
MOD_SUMO_rev_2	233	243	PF00179	0.534
TRG_DiLeu_BaEn_4	139	145	PF01217	0.561
TRG_DiLeu_BaLyEn_6	178	183	PF01217	0.675
TRG_ER_diArg_1	258	260	PF00400	0.724
TRG_Pf-PMV_PEXEL_1	142	146	PF00026	0.639
TRG_Pf-PMV_PEXEL_1	181	186	PF00026	0.537
TRG_Pf-PMV_PEXEL_1	259	263	PF00026	0.653

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IHW6	Leishmania donovani	55%	100%
A4I396	Leishmania infantum	55%	100%
E9AZI4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	53%	100%
Q4Q8P7	Leishmania major	52%	100%