Palmitoyltransferase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

palmitoyl acyltransferase 9, putative

Species:

Leishmania braziliensis

UniProt:

A4HG63_LEIBR

TriTrypDb:

LbrM.28.0230 , LBRM2903_280007800

Length:

357

Annotations

LeishMANIAdb annotations

Related to many other eukaryotic palmitoyltransferases (e.g. mammalian ZDHHC4/9/14/24)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	15
GO:0110165	cellular anatomical entity	1	15
GO:0005783	endoplasmic reticulum	5	1
GO:0005794	Golgi apparatus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4HG63

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HG63

Function

Biological processes
Term	Name	Level	Count
GO:0006497	protein lipidation	5	1
GO:0006605	protein targeting	5	1
GO:0006612	protein targeting to membrane	5	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006810	transport	3	1
GO:0006886	intracellular protein transport	4	1
GO:0006897	endocytosis	5	1
GO:0008104	protein localization	4	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0016192	vesicle-mediated transport	4	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018198	peptidyl-cysteine modification	6	1
GO:0018230	peptidyl-L-cysteine S-palmitoylation	7	1
GO:0018231	peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine	7	1
GO:0018345	protein palmitoylation	6	1
GO:0019538	protein metabolic process	3	1
GO:0033036	macromolecule localization	2	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043543	protein acylation	5	1
GO:0044238	primary metabolic process	2	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0051668	localization within membrane	3	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071704	organic substance metabolic process	2	1
GO:0071705	nitrogen compound transport	4	1
GO:0072657	protein localization to membrane	4	1
GO:0090150	establishment of protein localization to membrane	4	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	15
GO:0016409	palmitoyltransferase activity	5	15
GO:0016417	S-acyltransferase activity	5	15
GO:0016740	transferase activity	2	15
GO:0016746	acyltransferase activity	3	15
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	15
GO:0019706	protein-cysteine S-palmitoyltransferase activity	4	15
GO:0019707	protein-cysteine S-acyltransferase activity	3	15
GO:0140096	catalytic activity, acting on a protein	2	15

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	341	345	PF00656	0.593
CLV_NRD_NRD_1	173	175	PF00675	0.236
CLV_NRD_NRD_1	309	311	PF00675	0.240
CLV_NRD_NRD_1	313	315	PF00675	0.239
CLV_NRD_NRD_1	65	67	PF00675	0.404
CLV_NRD_NRD_1	77	79	PF00675	0.350
CLV_PCSK_FUR_1	171	175	PF00082	0.210
CLV_PCSK_KEX2_1	173	175	PF00082	0.238
CLV_PCSK_KEX2_1	309	311	PF00082	0.238
CLV_PCSK_KEX2_1	333	335	PF00082	0.301
CLV_PCSK_KEX2_1	65	67	PF00082	0.382
CLV_PCSK_KEX2_1	77	79	PF00082	0.348
CLV_PCSK_PC1ET2_1	333	335	PF00082	0.250
CLV_PCSK_SKI1_1	208	212	PF00082	0.261
CLV_PCSK_SKI1_1	230	234	PF00082	0.491
CLV_PCSK_SKI1_1	320	324	PF00082	0.308
CLV_PCSK_SKI1_1	326	330	PF00082	0.266
CLV_PCSK_SKI1_1	333	337	PF00082	0.383
CLV_PCSK_SKI1_1	70	74	PF00082	0.404
DEG_APCC_DBOX_1	325	333	PF00400	0.591
DEG_Nend_UBRbox_3	1	3	PF02207	0.658
DOC_CDC14_PxL_1	249	257	PF14671	0.162
DOC_CKS1_1	236	241	PF01111	0.286
DOC_CYCLIN_RxL_1	46	58	PF00134	0.575
DOC_CYCLIN_yClb5_NLxxxL_5	327	336	PF00134	0.443
DOC_MAPK_gen_1	205	214	PF00069	0.433
DOC_MAPK_gen_1	46	54	PF00069	0.576
DOC_MAPK_gen_1	77	84	PF00069	0.612
DOC_MAPK_JIP1_4	48	54	PF00069	0.590
DOC_MAPK_MEF2A_6	320	329	PF00069	0.558
DOC_PP1_RVXF_1	203	210	PF00149	0.450
DOC_PP1_RVXF_1	48	55	PF00149	0.581
DOC_PP1_RVXF_1	75	82	PF00149	0.605
DOC_PP2B_LxvP_1	336	339	PF13499	0.554
DOC_USP7_MATH_1	9	13	PF00917	0.639
DOC_USP7_UBL2_3	333	337	PF12436	0.572
DOC_USP7_UBL2_3	46	50	PF12436	0.698
DOC_WW_Pin1_4	235	240	PF00397	0.324
DOC_WW_Pin1_4	41	46	PF00397	0.694
LIG_14-3-3_CanoR_1	208	213	PF00244	0.466
LIG_14-3-3_CanoR_1	314	320	PF00244	0.643
LIG_14-3-3_CanoR_1	65	73	PF00244	0.521
LIG_Actin_WH2_2	135	153	PF00022	0.436
LIG_CtBP_PxDLS_1	40	44	PF00389	0.534
LIG_eIF4E_1	231	237	PF01652	0.303
LIG_eIF4E_1	274	280	PF01652	0.162
LIG_FHA_1	100	106	PF00498	0.286
LIG_FHA_1	123	129	PF00498	0.312
LIG_FHA_1	137	143	PF00498	0.396
LIG_FHA_1	160	166	PF00498	0.391
LIG_FHA_1	209	215	PF00498	0.357
LIG_FHA_1	236	242	PF00498	0.303
LIG_FHA_1	351	357	PF00498	0.693
LIG_FHA_1	88	94	PF00498	0.538
LIG_FHA_2	138	144	PF00498	0.420
LIG_FHA_2	306	312	PF00498	0.447
LIG_HP1_1	325	329	PF01393	0.446
LIG_LIR_Nem_3	12	18	PF02991	0.529
LIG_LIR_Nem_3	51	57	PF02991	0.609
LIG_LIR_Nem_3	75	79	PF02991	0.543
LIG_LYPXL_S_1	146	150	PF13949	0.280
LIG_LYPXL_yS_3	147	150	PF13949	0.485
LIG_MYND_1	41	45	PF01753	0.597
LIG_NRBOX	278	284	PF00104	0.415
LIG_NRBOX	318	324	PF00104	0.619
LIG_NRBOX	331	337	PF00104	0.450
LIG_PCNA_yPIPBox_3	309	323	PF02747	0.547
LIG_Pex14_1	209	213	PF04695	0.277
LIG_Pex14_1	227	231	PF04695	0.277
LIG_Pex14_2	233	237	PF04695	0.317
LIG_Pex14_2	84	88	PF04695	0.514
LIG_SH2_PTP2	299	302	PF00017	0.312
LIG_SH2_STAP1	182	186	PF00017	0.471
LIG_SH2_STAT3	18	21	PF00017	0.540
LIG_SH2_STAT5	122	125	PF00017	0.380
LIG_SH2_STAT5	213	216	PF00017	0.286
LIG_SH2_STAT5	231	234	PF00017	0.300
LIG_SH2_STAT5	299	302	PF00017	0.311
LIG_SH2_STAT5	62	65	PF00017	0.502
LIG_SH2_STAT5	87	90	PF00017	0.532
LIG_SH3_3	53	59	PF00018	0.586
LIG_SH3_4	46	53	PF00018	0.687
LIG_SUMO_SIM_anti_2	99	105	PF11976	0.336
LIG_SUMO_SIM_par_1	280	285	PF11976	0.363
LIG_TRAF2_1	267	270	PF00917	0.277
LIG_TRAF2_1	349	352	PF00917	0.662
LIG_WRC_WIRS_1	1	6	PF05994	0.546
LIG_WW_3	174	178	PF00397	0.477
MOD_CDK_SPK_2	41	46	PF00069	0.653
MOD_CDK_SPxxK_3	41	48	PF00069	0.674
MOD_CK1_1	136	142	PF00069	0.350
MOD_CK1_1	216	222	PF00069	0.321
MOD_CK1_1	25	31	PF00069	0.722
MOD_CK2_1	305	311	PF00069	0.441
MOD_CK2_1	346	352	PF00069	0.616
MOD_CK2_1	65	71	PF00069	0.568
MOD_GlcNHglycan	151	154	PF01048	0.405
MOD_GlcNHglycan	25	28	PF01048	0.540
MOD_GlcNHglycan	30	33	PF01048	0.529
MOD_GSK3_1	128	135	PF00069	0.315
MOD_GSK3_1	213	220	PF00069	0.414
MOD_GSK3_1	240	247	PF00069	0.238
MOD_GSK3_1	251	258	PF00069	0.293
MOD_GSK3_1	300	307	PF00069	0.337
MOD_GSK3_1	338	345	PF00069	0.562
MOD_GSK3_1	346	353	PF00069	0.635
MOD_LATS_1	64	70	PF00433	0.425
MOD_N-GLC_1	66	71	PF02516	0.284
MOD_NEK2_1	10	15	PF00069	0.574
MOD_NEK2_1	129	134	PF00069	0.304
MOD_NEK2_1	137	142	PF00069	0.292
MOD_NEK2_1	218	223	PF00069	0.260
MOD_NEK2_1	255	260	PF00069	0.291
MOD_NEK2_1	302	307	PF00069	0.345
MOD_NEK2_2	213	218	PF00069	0.279
MOD_PIKK_1	159	165	PF00454	0.362
MOD_PIKK_1	17	23	PF00454	0.543
MOD_PIKK_1	255	261	PF00454	0.353
MOD_PKA_1	309	315	PF00069	0.475
MOD_PKA_1	65	71	PF00069	0.502
MOD_PKA_2	262	268	PF00069	0.363
MOD_PKA_2	309	315	PF00069	0.466
MOD_PKA_2	65	71	PF00069	0.598
MOD_Plk_2-3	346	352	PF00069	0.547
MOD_Plk_4	10	16	PF00069	0.636
MOD_Plk_4	133	139	PF00069	0.212
MOD_Plk_4	218	224	PF00069	0.401
MOD_Plk_4	338	344	PF00069	0.529
MOD_ProDKin_1	235	241	PF00069	0.324
MOD_ProDKin_1	41	47	PF00069	0.693
TRG_DiLeu_BaEn_1	352	357	PF01217	0.705
TRG_DiLeu_BaLyEn_6	331	336	PF01217	0.554
TRG_ENDOCYTIC_2	147	150	PF00928	0.481
TRG_ENDOCYTIC_2	299	302	PF00928	0.311
TRG_ER_diArg_1	148	151	PF00400	0.522
TRG_ER_diArg_1	171	174	PF00400	0.436
TRG_ER_diArg_1	323	326	PF00400	0.642
TRG_ER_diArg_1	76	78	PF00400	0.592
TRG_NES_CRM1_1	275	285	PF08389	0.162

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P729	Leptomonas seymouri	30%	100%
A0A0N1HZ19	Leptomonas seymouri	59%	100%
A0A0S4IT15	Bodo saltans	41%	100%
A0A0S4IXZ6	Bodo saltans	29%	100%
A0A0S4JCH4	Bodo saltans	25%	97%
A0A0S4JRL4	Bodo saltans	40%	99%
A0A1X0NX08	Trypanosomatidae	41%	100%
A0A3Q8ICY2	Leishmania donovani	71%	100%
A0A3Q8IIC8	Leishmania donovani	27%	93%
A0A3R7N519	Trypanosoma rangeli	38%	100%
A4HCH5	Leishmania braziliensis	24%	89%
A4HMS9	Leishmania braziliensis	30%	100%
A4I395	Leishmania infantum	71%	100%
A4IBG8	Leishmania infantum	27%	93%
B3DN87	Arabidopsis thaliana	27%	100%
D0A7S1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9AF82	Leishmania major	27%	100%
E9AZI3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	70%	100%
E9B6D8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
O74384	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	100%
O80685	Arabidopsis thaliana	27%	87%
Q06551	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	28%	99%
Q0WQK2	Arabidopsis thaliana	25%	81%
Q4Q8P8	Leishmania major	72%	99%
Q5PNZ1	Arabidopsis thaliana	27%	86%
Q6FSS4	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	29%	100%
Q9FLM3	Arabidopsis thaliana	26%	87%
Q9NXF8	Homo sapiens	24%	100%
V5BC02	Trypanosoma cruzi	40%	100%