Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HG59_LEIBR

TriTrypDb:

LbrM.28.0190 , LBRM2903_280007300

Length:

206

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	7
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4HG59

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HG59

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	140	142	PF00675	0.454
CLV_NRD_NRD_1	34	36	PF00675	0.516
CLV_NRD_NRD_1	6	8	PF00675	0.422
CLV_PCSK_KEX2_1	140	142	PF00082	0.446
CLV_PCSK_KEX2_1	34	36	PF00082	0.519
CLV_PCSK_KEX2_1	40	42	PF00082	0.594
CLV_PCSK_KEX2_1	6	8	PF00082	0.422
CLV_PCSK_PC1ET2_1	40	42	PF00082	0.664
CLV_PCSK_SKI1_1	149	153	PF00082	0.446
CLV_PCSK_SKI1_1	7	11	PF00082	0.496
CLV_PCSK_SKI1_1	90	94	PF00082	0.407
DEG_APCC_DBOX_1	140	148	PF00400	0.535
DOC_CKS1_1	105	110	PF01111	0.281
DOC_CKS1_1	166	171	PF01111	0.485
DOC_CYCLIN_yCln2_LP_2	105	111	PF00134	0.389
DOC_PP1_RVXF_1	4	11	PF00149	0.356
DOC_PP2B_LxvP_1	189	192	PF13499	0.451
DOC_WW_Pin1_4	104	109	PF00397	0.305
DOC_WW_Pin1_4	165	170	PF00397	0.492
DOC_WW_Pin1_4	90	95	PF00397	0.481
LIG_14-3-3_CanoR_1	122	128	PF00244	0.507
LIG_14-3-3_CanoR_1	180	185	PF00244	0.535
LIG_FHA_1	105	111	PF00498	0.343
LIG_FHA_1	87	93	PF00498	0.474
LIG_FHA_2	14	20	PF00498	0.474
LIG_GBD_Chelix_1	97	105	PF00786	0.275
LIG_LIR_Gen_1	113	120	PF02991	0.497
LIG_LIR_Gen_1	19	27	PF02991	0.376
LIG_LIR_Nem_3	163	167	PF02991	0.375
LIG_LIR_Nem_3	19	24	PF02991	0.364
LIG_LYPXL_yS_3	158	161	PF13949	0.538
LIG_NRBOX	100	106	PF00104	0.275
LIG_NRBOX	64	70	PF00104	0.280
LIG_PDZ_Class_3	201	206	PF00595	0.516
LIG_Pex14_2	20	24	PF04695	0.321
LIG_SH2_CRK	167	171	PF00017	0.466
LIG_SH2_GRB2like	114	117	PF00017	0.379
LIG_SH2_STAP1	77	81	PF00017	0.508
LIG_SH2_STAT3	175	178	PF00017	0.324
LIG_SH2_STAT5	114	117	PF00017	0.460
LIG_SH2_STAT5	167	170	PF00017	0.392
LIG_SH2_STAT5	175	178	PF00017	0.427
LIG_SH3_3	163	169	PF00018	0.379
LIG_SUMO_SIM_par_1	107	113	PF11976	0.491
LIG_SUMO_SIM_par_1	158	163	PF11976	0.490
LIG_TYR_ITIM	9	14	PF00017	0.521
LIG_UBA3_1	196	202	PF00899	0.271
LIG_UBA3_1	51	57	PF00899	0.595
MOD_CK1_1	126	132	PF00069	0.594
MOD_CK1_1	44	50	PF00069	0.585
MOD_GSK3_1	179	186	PF00069	0.505
MOD_GSK3_1	86	93	PF00069	0.467
MOD_NEK2_1	13	18	PF00069	0.452
MOD_NEK2_1	160	165	PF00069	0.393
MOD_PKA_2	179	185	PF00069	0.606
MOD_PKA_2	44	50	PF00069	0.448
MOD_Plk_1	132	138	PF00069	0.613
MOD_Plk_2-3	143	149	PF00069	0.495
MOD_Plk_4	126	132	PF00069	0.567
MOD_Plk_4	180	186	PF00069	0.533
MOD_ProDKin_1	104	110	PF00069	0.300
MOD_ProDKin_1	165	171	PF00069	0.491
MOD_ProDKin_1	90	96	PF00069	0.483
TRG_DiLeu_BaLyEn_6	105	110	PF01217	0.491
TRG_DiLeu_BaLyEn_6	156	161	PF01217	0.505
TRG_ENDOCYTIC_2	11	14	PF00928	0.513
TRG_ENDOCYTIC_2	153	156	PF00928	0.447
TRG_ENDOCYTIC_2	158	161	PF00928	0.469
TRG_ENDOCYTIC_2	167	170	PF00928	0.372
TRG_ENDOCYTIC_2	77	80	PF00928	0.476
TRG_ER_diArg_1	34	37	PF00400	0.410
TRG_ER_diArg_1	5	7	PF00400	0.436

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5Y0	Leptomonas seymouri	70%	100%
A0A1X0NVB8	Trypanosomatidae	41%	95%
A0A3S7X140	Leishmania donovani	77%	100%
A0A422N4D7	Trypanosoma rangeli	42%	98%
A4I391	Leishmania infantum	77%	100%
D0A7R7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	98%
E9AZH9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	97%
Q4Q8Q2	Leishmania major	76%	100%
V5AS20	Trypanosoma cruzi	45%	98%