Putative phopshatase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phopshatase, putative

Species:

Leishmania braziliensis

UniProt:

A4HG58_LEIBR

TriTrypDb:

LbrM.28.0180 , LBRM2903_280007200

Length:

424

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	12
GO:0042995	cell projection	2	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0110165	cellular anatomical entity	1	12
GO:0120025	plasma membrane bounded cell projection	3	12
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

A4HG58

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HG58

Function

Biological processes
Term	Name	Level	Count
GO:0006470	protein dephosphorylation	5	12
GO:0006793	phosphorus metabolic process	3	12
GO:0006796	phosphate-containing compound metabolic process	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016311	dephosphorylation	5	12
GO:0019538	protein metabolic process	3	12
GO:0036211	protein modification process	4	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:0009966	regulation of signal transduction	4	1
GO:0009968	negative regulation of signal transduction	5	1
GO:0010646	regulation of cell communication	4	1
GO:0010648	negative regulation of cell communication	5	1
GO:0023051	regulation of signaling	3	1
GO:0023057	negative regulation of signaling	4	1
GO:0043408	regulation of MAPK cascade	6	1
GO:0043409	negative regulation of MAPK cascade	7	1
GO:0048519	negative regulation of biological process	3	1
GO:0048523	negative regulation of cellular process	4	1
GO:0048583	regulation of response to stimulus	3	1
GO:0048585	negative regulation of response to stimulus	4	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0065007	biological regulation	1	1
GO:1902531	regulation of intracellular signal transduction	5	1
GO:1902532	negative regulation of intracellular signal transduction	6	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004721	phosphoprotein phosphatase activity	3	12
GO:0008138	protein tyrosine/serine/threonine phosphatase activity	4	12
GO:0016787	hydrolase activity	2	12
GO:0016788	hydrolase activity, acting on ester bonds	3	12
GO:0016791	phosphatase activity	5	12
GO:0042578	phosphoric ester hydrolase activity	4	12
GO:0140096	catalytic activity, acting on a protein	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	19	23	PF00656	0.675
CLV_NRD_NRD_1	104	106	PF00675	0.490
CLV_NRD_NRD_1	188	190	PF00675	0.491
CLV_NRD_NRD_1	236	238	PF00675	0.588
CLV_PCSK_KEX2_1	188	190	PF00082	0.478
CLV_PCSK_KEX2_1	236	238	PF00082	0.581
CLV_PCSK_KEX2_1	241	243	PF00082	0.350
CLV_PCSK_KEX2_1	43	45	PF00082	0.484
CLV_PCSK_PC1ET2_1	241	243	PF00082	0.506
CLV_PCSK_PC1ET2_1	43	45	PF00082	0.484
CLV_PCSK_PC7_1	237	243	PF00082	0.564
CLV_PCSK_SKI1_1	242	246	PF00082	0.406
CLV_PCSK_SKI1_1	252	256	PF00082	0.416
CLV_PCSK_SKI1_1	356	360	PF00082	0.337
CLV_PCSK_SKI1_1	368	372	PF00082	0.309
CLV_Separin_Metazoa	414	418	PF03568	0.500
DEG_APCC_DBOX_1	198	206	PF00400	0.528
DOC_CDC14_PxL_1	147	155	PF14671	0.403
DOC_CYCLIN_yCln2_LP_2	223	229	PF00134	0.462
DOC_MAPK_DCC_7	261	271	PF00069	0.354
DOC_MAPK_gen_1	241	247	PF00069	0.449
DOC_MAPK_gen_1	352	360	PF00069	0.372
DOC_PP4_FxxP_1	148	151	PF00568	0.406
DOC_USP7_MATH_1	94	98	PF00917	0.468
DOC_USP7_UBL2_3	55	59	PF12436	0.711
DOC_WW_Pin1_4	178	183	PF00397	0.374
DOC_WW_Pin1_4	34	39	PF00397	0.673
LIG_14-3-3_CanoR_1	105	110	PF00244	0.285
LIG_14-3-3_CanoR_1	199	205	PF00244	0.265
LIG_14-3-3_CanoR_1	291	297	PF00244	0.375
LIG_14-3-3_CanoR_1	44	49	PF00244	0.695
LIG_14-3-3_CanoR_1	91	99	PF00244	0.423
LIG_Actin_WH2_2	278	293	PF00022	0.328
LIG_Actin_WH2_2	367	383	PF00022	0.475
LIG_AP2alpha_1	341	345	PF02296	0.475
LIG_APCC_ABBA_1	296	301	PF00400	0.413
LIG_APCC_ABBA_1	409	414	PF00400	0.262
LIG_BIR_II_1	1	5	PF00653	0.721
LIG_BRCT_BRCA1_1	164	168	PF00533	0.527
LIG_BRCT_BRCA1_1	41	45	PF00533	0.564
LIG_deltaCOP1_diTrp_1	258	268	PF00928	0.311
LIG_FHA_1	135	141	PF00498	0.490
LIG_FHA_1	238	244	PF00498	0.557
LIG_FHA_1	293	299	PF00498	0.333
LIG_FHA_1	369	375	PF00498	0.385
LIG_FHA_1	60	66	PF00498	0.628
LIG_FHA_2	66	72	PF00498	0.614
LIG_FHA_2	7	13	PF00498	0.626
LIG_IRF3_LxIS_1	60	66	PF10401	0.417
LIG_LIR_Apic_2	146	151	PF02991	0.475
LIG_LIR_Gen_1	126	135	PF02991	0.506
LIG_LIR_Gen_1	165	175	PF02991	0.568
LIG_LIR_Gen_1	212	223	PF02991	0.517
LIG_LIR_Gen_1	228	235	PF02991	0.437
LIG_LIR_Gen_1	265	276	PF02991	0.434
LIG_LIR_Gen_1	283	290	PF02991	0.413
LIG_LIR_Gen_1	297	307	PF02991	0.413
LIG_LIR_Gen_1	342	351	PF02991	0.229
LIG_LIR_Gen_1	42	53	PF02991	0.467
LIG_LIR_Gen_1	8	15	PF02991	0.637
LIG_LIR_Nem_3	126	130	PF02991	0.496
LIG_LIR_Nem_3	165	171	PF02991	0.567
LIG_LIR_Nem_3	206	210	PF02991	0.365
LIG_LIR_Nem_3	228	232	PF02991	0.533
LIG_LIR_Nem_3	265	271	PF02991	0.443
LIG_LIR_Nem_3	283	287	PF02991	0.400
LIG_LIR_Nem_3	297	302	PF02991	0.226
LIG_LIR_Nem_3	342	348	PF02991	0.345
LIG_LIR_Nem_3	42	48	PF02991	0.480
LIG_LIR_Nem_3	8	13	PF02991	0.611
LIG_LYPXL_L_2	276	285	PF13949	0.423
LIG_Pex14_2	341	345	PF04695	0.348
LIG_PTB_Apo_2	121	128	PF02174	0.511
LIG_SH2_CRK	229	233	PF00017	0.585
LIG_SH2_SRC	149	152	PF00017	0.441
LIG_SH2_SRC	412	415	PF00017	0.358
LIG_SH2_STAP1	412	416	PF00017	0.363
LIG_SH2_STAT5	149	152	PF00017	0.512
LIG_SH2_STAT5	284	287	PF00017	0.371
LIG_SH2_STAT5	306	309	PF00017	0.344
LIG_SH2_STAT5	376	379	PF00017	0.328
LIG_SH3_3	112	118	PF00018	0.541
LIG_SH3_3	179	185	PF00018	0.500
LIG_SH3_3	314	320	PF00018	0.413
LIG_Sin3_3	388	395	PF02671	0.449
LIG_SUMO_SIM_anti_2	386	393	PF11976	0.449
LIG_SUMO_SIM_par_1	113	119	PF11976	0.468
LIG_SUMO_SIM_par_1	200	206	PF11976	0.517
LIG_SUMO_SIM_par_1	325	331	PF11976	0.279
LIG_SUMO_SIM_par_1	61	71	PF11976	0.391
LIG_TYR_ITIM	227	232	PF00017	0.558
LIG_TYR_ITIM	282	287	PF00017	0.522
LIG_UBA3_1	377	381	PF00899	0.449
LIG_WRC_WIRS_1	45	50	PF05994	0.463
LIG_WRC_WIRS_1	7	12	PF05994	0.644
MOD_CK1_1	123	129	PF00069	0.297
MOD_CK1_1	162	168	PF00069	0.508
MOD_CK1_1	228	234	PF00069	0.301
MOD_CK1_1	23	29	PF00069	0.690
MOD_CK1_1	289	295	PF00069	0.328
MOD_CK1_1	31	37	PF00069	0.693
MOD_CK1_1	61	67	PF00069	0.607
MOD_CK1_1	79	85	PF00069	0.407
MOD_CK2_1	105	111	PF00069	0.537
MOD_CK2_1	113	119	PF00069	0.512
MOD_CK2_1	200	206	PF00069	0.517
MOD_CK2_1	6	12	PF00069	0.653
MOD_CK2_1	63	69	PF00069	0.569
MOD_CK2_1	71	77	PF00069	0.522
MOD_CK2_1	78	84	PF00069	0.460
MOD_GlcNHglycan	87	90	PF01048	0.431
MOD_GlcNHglycan	92	95	PF01048	0.455
MOD_GSK3_1	134	141	PF00069	0.406
MOD_GSK3_1	25	32	PF00069	0.727
MOD_GSK3_1	364	371	PF00069	0.328
MOD_GSK3_1	39	46	PF00069	0.741
MOD_GSK3_1	59	66	PF00069	0.511
MOD_GSK3_1	90	97	PF00069	0.465
MOD_N-GLC_1	123	128	PF02516	0.558
MOD_N-GLC_1	159	164	PF02516	0.451
MOD_N-GLC_1	20	25	PF02516	0.725
MOD_N-GLC_1	29	34	PF02516	0.668
MOD_N-GLC_1	85	90	PF02516	0.398
MOD_NEK2_1	286	291	PF00069	0.435
MOD_NEK2_1	366	371	PF00069	0.337
MOD_NEK2_1	90	95	PF00069	0.500
MOD_PKA_1	105	111	PF00069	0.519
MOD_PKA_1	236	242	PF00069	0.500
MOD_PKA_1	43	49	PF00069	0.538
MOD_PKA_2	236	242	PF00069	0.526
MOD_PKA_2	43	49	PF00069	0.688
MOD_PKA_2	90	96	PF00069	0.414
MOD_Plk_1	159	165	PF00069	0.442
MOD_Plk_1	333	339	PF00069	0.475
MOD_Plk_1	85	91	PF00069	0.370
MOD_Plk_2-3	225	231	PF00069	0.529
MOD_Plk_2-3	343	349	PF00069	0.358
MOD_Plk_2-3	71	77	PF00069	0.345
MOD_Plk_4	143	149	PF00069	0.400
MOD_Plk_4	200	206	PF00069	0.517
MOD_Plk_4	294	300	PF00069	0.388
MOD_Plk_4	99	105	PF00069	0.316
MOD_ProDKin_1	178	184	PF00069	0.360
MOD_ProDKin_1	34	40	PF00069	0.674
MOD_SUMO_rev_2	108	115	PF00179	0.468
MOD_SUMO_rev_2	12	18	PF00179	0.684
TRG_DiLeu_BaEn_1	387	392	PF01217	0.358
TRG_DiLeu_LyEn_5	206	211	PF01217	0.270
TRG_ENDOCYTIC_2	229	232	PF00928	0.536
TRG_ENDOCYTIC_2	284	287	PF00928	0.470
TRG_ENDOCYTIC_2	299	302	PF00928	0.186
TRG_ENDOCYTIC_2	412	415	PF00928	0.449
TRG_ER_diArg_1	187	189	PF00400	0.517
TRG_ER_diArg_1	235	237	PF00400	0.551
TRG_ER_diArg_1	250	253	PF00400	0.463
TRG_ER_diArg_1	416	419	PF00400	0.491
TRG_Pf-PMV_PEXEL_1	255	259	PF00026	0.452

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE85	Leptomonas seymouri	64%	100%
A0A0S4IVI6	Bodo saltans	32%	100%
A0A1X0NVC7	Trypanosomatidae	46%	100%
A0A3Q8IEF5	Leishmania donovani	82%	100%
A0A3R7KS85	Trypanosoma rangeli	46%	100%
A4I390	Leishmania infantum	82%	100%
D0A7R6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
E9AZH8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4Q8Q3	Leishmania major	82%	100%
V5B7J4	Trypanosoma cruzi	48%	100%