Putative RNA binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA binding protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HG57_LEIBR

TriTrypDb:

LbrM.28.0170 , LBRM2903_280007100

Length:

196

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HG57

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HG57

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	9
GO:0005488	binding	1	9
GO:0097159	organic cyclic compound binding	2	9
GO:1901363	heterocyclic compound binding	2	9
GO:0003723	RNA binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	11	13	PF00675	0.493
CLV_NRD_NRD_1	190	192	PF00675	0.590
CLV_NRD_NRD_1	6	8	PF00675	0.556
CLV_NRD_NRD_1	78	80	PF00675	0.496
CLV_PCSK_KEX2_1	10	12	PF00082	0.627
CLV_PCSK_KEX2_1	189	191	PF00082	0.589
CLV_PCSK_KEX2_1	82	84	PF00082	0.443
CLV_PCSK_PC1ET2_1	82	84	PF00082	0.539
CLV_PCSK_PC7_1	7	13	PF00082	0.572
CLV_PCSK_SKI1_1	85	89	PF00082	0.405
CLV_PCSK_SKI1_1	99	103	PF00082	0.428
DOC_MAPK_gen_1	79	89	PF00069	0.443
DOC_MAPK_MEF2A_6	142	150	PF00069	0.423
DOC_USP7_MATH_1	151	155	PF00917	0.410
DOC_USP7_MATH_1	179	183	PF00917	0.378
DOC_USP7_MATH_1	57	61	PF00917	0.605
DOC_USP7_UBL2_3	138	142	PF12436	0.540
LIG_14-3-3_CanoR_1	189	194	PF00244	0.473
LIG_14-3-3_CanoR_1	83	88	PF00244	0.414
LIG_FHA_1	84	90	PF00498	0.409
LIG_FHA_2	105	111	PF00498	0.519
LIG_FHA_2	4	10	PF00498	0.613
LIG_FHA_2	45	51	PF00498	0.681
LIG_PTB_Apo_2	69	76	PF02174	0.432
LIG_SH2_STAT3	118	121	PF00017	0.601
LIG_SH2_STAT5	118	121	PF00017	0.406
LIG_SH2_STAT5	147	150	PF00017	0.484
LIG_SUMO_SIM_anti_2	130	136	PF11976	0.504
MOD_CK2_1	179	185	PF00069	0.435
MOD_CK2_1	3	9	PF00069	0.547
MOD_GlcNHglycan	28	31	PF01048	0.417
MOD_GSK3_1	21	28	PF00069	0.591
MOD_N-GLC_1	179	184	PF02516	0.384
MOD_N-GLC_1	26	31	PF02516	0.528
MOD_N-GLC_1	71	76	PF02516	0.429
MOD_NEK2_1	104	109	PF00069	0.438
MOD_NEK2_1	146	151	PF00069	0.426
MOD_NEK2_1	26	31	PF00069	0.515
MOD_NEK2_1	94	99	PF00069	0.501
MOD_PKA_1	189	195	PF00069	0.441
MOD_PKA_2	189	195	PF00069	0.527
MOD_PKA_2	44	50	PF00069	0.705
MOD_PKB_1	10	18	PF00069	0.602
MOD_Plk_1	26	32	PF00069	0.479
MOD_Plk_4	104	110	PF00069	0.433
MOD_Plk_4	71	77	PF00069	0.542
MOD_SUMO_rev_2	60	64	PF00179	0.632
TRG_ENDOCYTIC_2	147	150	PF00928	0.487
TRG_ER_diArg_1	10	12	PF00400	0.539
TRG_ER_diArg_1	188	191	PF00400	0.584

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IEM8	Leishmania donovani	77%	100%
A0A422N4H9	Trypanosoma rangeli	44%	70%
A4I389	Leishmania infantum	77%	100%
D0A7R5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	67%
E9AZH7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%
Q4Q8Q4	Leishmania major	76%	100%
V5BGL1	Trypanosoma cruzi	45%	70%