Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HG55_LEIBR

TriTrypDb:

LbrM.28.0140 , LBRM2903_280006900

Length:

182

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	14
GO:0110165	cellular anatomical entity	1	14

Expansion

Sequence features

A4HG55

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HG55

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	173	175	PF00082	0.505
CLV_PCSK_PC1ET2_1	173	175	PF00082	0.487
DEG_Nend_UBRbox_1	1	4	PF02207	0.585
DEG_SCF_TRCP1_1	158	164	PF00400	0.531
DOC_AGCK_PIF_2	103	108	PF00069	0.283
DOC_CDC14_PxL_1	90	98	PF14671	0.356
DOC_CKS1_1	34	39	PF01111	0.321
DOC_MAPK_gen_1	2	10	PF00069	0.618
DOC_MAPK_gen_1	76	86	PF00069	0.478
DOC_MAPK_MEF2A_6	2	10	PF00069	0.559
DOC_MAPK_MEF2A_6	79	88	PF00069	0.489
DOC_PP4_FxxP_1	110	113	PF00568	0.386
DOC_WW_Pin1_4	33	38	PF00397	0.415
LIG_14-3-3_CanoR_1	5	9	PF00244	0.590
LIG_14-3-3_CterR_2	177	182	PF00244	0.551
LIG_Actin_WH2_2	26	43	PF00022	0.385
LIG_EH1_1	15	23	PF00400	0.365
LIG_FHA_1	34	40	PF00498	0.313
LIG_LIR_Apic_2	107	113	PF02991	0.394
LIG_LIR_Gen_1	133	142	PF02991	0.526
LIG_LIR_Gen_1	42	52	PF02991	0.324
LIG_LIR_Nem_3	133	137	PF02991	0.389
LIG_LIR_Nem_3	23	27	PF02991	0.401
LIG_LIR_Nem_3	42	47	PF02991	0.339
LIG_NRBOX	76	82	PF00104	0.603
LIG_Pex14_2	106	110	PF04695	0.355
LIG_Pex14_2	13	17	PF04695	0.421
LIG_SH2_CRK	137	141	PF00017	0.496
LIG_SH2_CRK	15	19	PF00017	0.447
LIG_SH2_PTP2	27	30	PF00017	0.203
LIG_SH2_SRC	27	30	PF00017	0.203
LIG_SH2_STAP1	65	69	PF00017	0.539
LIG_SH2_STAT5	27	30	PF00017	0.379
LIG_SH2_STAT5	44	47	PF00017	0.142
LIG_SUMO_SIM_par_1	17	23	PF11976	0.371
LIG_TYR_ITIM	25	30	PF00017	0.457
LIG_Vh1_VBS_1	39	57	PF01044	0.186
LIG_WRC_WIRS_1	103	108	PF05994	0.481
LIG_WRC_WIRS_1	21	26	PF05994	0.459
MOD_GlcNHglycan	157	161	PF01048	0.510
MOD_GlcNHglycan	41	44	PF01048	0.533
MOD_GlcNHglycan	72	75	PF01048	0.372
MOD_NEK2_1	114	119	PF00069	0.341
MOD_NEK2_1	20	25	PF00069	0.269
MOD_NEK2_1	4	9	PF00069	0.568
MOD_NEK2_1	63	68	PF00069	0.481
MOD_NEK2_1	88	93	PF00069	0.406
MOD_PIKK_1	172	178	PF00454	0.693
MOD_PKA_2	4	10	PF00069	0.597
MOD_PKA_2	75	81	PF00069	0.542
MOD_Plk_4	114	120	PF00069	0.323
MOD_Plk_4	20	26	PF00069	0.288
MOD_ProDKin_1	33	39	PF00069	0.416
TRG_DiLeu_BaEn_2	98	104	PF01217	0.373
TRG_DiLeu_BaLyEn_6	76	81	PF01217	0.581
TRG_ENDOCYTIC_2	137	140	PF00928	0.461
TRG_ENDOCYTIC_2	15	18	PF00928	0.447
TRG_ENDOCYTIC_2	27	30	PF00928	0.449
TRG_ENDOCYTIC_2	44	47	PF00928	0.273
TRG_Pf-PMV_PEXEL_1	153	157	PF00026	0.493

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILT5	Leptomonas seymouri	61%	100%
A0A0N1PC80	Leptomonas seymouri	26%	99%
A0A0S4IY98	Bodo saltans	39%	100%
A0A0S4J4Y6	Bodo saltans	27%	100%
A0A1X0NX01	Trypanosomatidae	39%	99%
A0A1X0NXC4	Trypanosomatidae	29%	100%
A0A3Q8IQ96	Leishmania donovani	69%	100%
A0A3R7JVT6	Trypanosoma rangeli	39%	99%
A4HBK6	Leishmania braziliensis	26%	100%
A4I386	Leishmania infantum	70%	100%
E9AZH4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	69%	100%
Q4Q8Q7	Leishmania major	70%	100%
V5BC06	Trypanosoma cruzi	36%	99%