Dynein heavy chain

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Dynein heavy chain

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HG50_LEIBR

TriTrypDb:

LbrM.28.0080 , LBRM2903_280006100

Length:

519

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HG50

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HG50

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	483	487	PF00656	0.487
CLV_NRD_NRD_1	123	125	PF00675	0.466
CLV_NRD_NRD_1	207	209	PF00675	0.338
CLV_NRD_NRD_1	275	277	PF00675	0.409
CLV_NRD_NRD_1	343	345	PF00675	0.504
CLV_NRD_NRD_1	451	453	PF00675	0.429
CLV_NRD_NRD_1	9	11	PF00675	0.677
CLV_NRD_NRD_1	92	94	PF00675	0.395
CLV_PCSK_KEX2_1	123	125	PF00082	0.507
CLV_PCSK_KEX2_1	262	264	PF00082	0.408
CLV_PCSK_KEX2_1	275	277	PF00082	0.350
CLV_PCSK_KEX2_1	430	432	PF00082	0.389
CLV_PCSK_KEX2_1	451	453	PF00082	0.429
CLV_PCSK_KEX2_1	9	11	PF00082	0.677
CLV_PCSK_KEX2_1	92	94	PF00082	0.395
CLV_PCSK_PC1ET2_1	262	264	PF00082	0.440
CLV_PCSK_PC1ET2_1	430	432	PF00082	0.298
CLV_PCSK_PC7_1	271	277	PF00082	0.289
CLV_PCSK_SKI1_1	223	227	PF00082	0.390
CLV_PCSK_SKI1_1	253	257	PF00082	0.407
CLV_PCSK_SKI1_1	332	336	PF00082	0.503
CLV_PCSK_SKI1_1	358	362	PF00082	0.534
DOC_CYCLIN_yCln2_LP_2	57	63	PF00134	0.474
DOC_MAPK_gen_1	262	268	PF00069	0.421
DOC_MAPK_MEF2A_6	27	34	PF00069	0.498
DOC_PP2B_LxvP_1	57	60	PF13499	0.425
DOC_USP7_MATH_1	152	156	PF00917	0.366
DOC_USP7_MATH_1	221	225	PF00917	0.560
DOC_USP7_MATH_1	306	310	PF00917	0.524
DOC_USP7_MATH_1	97	101	PF00917	0.621
DOC_WW_Pin1_4	18	23	PF00397	0.526
DOC_WW_Pin1_4	37	42	PF00397	0.558
LIG_14-3-3_CanoR_1	116	122	PF00244	0.368
LIG_14-3-3_CanoR_1	123	127	PF00244	0.408
LIG_14-3-3_CanoR_1	143	152	PF00244	0.416
LIG_14-3-3_CanoR_1	175	183	PF00244	0.447
LIG_14-3-3_CanoR_1	192	201	PF00244	0.340
LIG_14-3-3_CanoR_1	220	230	PF00244	0.451
LIG_14-3-3_CanoR_1	344	349	PF00244	0.445
LIG_14-3-3_CanoR_1	423	427	PF00244	0.449
LIG_14-3-3_CanoR_1	53	57	PF00244	0.518
LIG_14-3-3_CanoR_1	9	19	PF00244	0.650
LIG_Actin_WH2_2	328	346	PF00022	0.400
LIG_APCC_ABBA_1	374	379	PF00400	0.392
LIG_BIR_II_1	1	5	PF00653	0.552
LIG_BRCT_BRCA1_1	176	180	PF00533	0.283
LIG_CSL_BTD_1	19	22	PF09270	0.610
LIG_EH1_1	51	59	PF00400	0.412
LIG_eIF4E_1	144	150	PF01652	0.452
LIG_FHA_1	116	122	PF00498	0.293
LIG_FHA_1	287	293	PF00498	0.498
LIG_FHA_1	3	9	PF00498	0.481
LIG_FHA_1	390	396	PF00498	0.402
LIG_FHA_1	483	489	PF00498	0.529
LIG_FHA_1	509	515	PF00498	0.469
LIG_FHA_1	73	79	PF00498	0.623
LIG_FHA_1	99	105	PF00498	0.576
LIG_FHA_2	135	141	PF00498	0.244
LIG_FHA_2	151	157	PF00498	0.354
LIG_FHA_2	2	8	PF00498	0.631
LIG_FHA_2	407	413	PF00498	0.525
LIG_FHA_2	466	472	PF00498	0.501
LIG_FHA_2	85	91	PF00498	0.516
LIG_LIR_Apic_2	474	479	PF02991	0.491
LIG_LIR_Apic_2	66	70	PF02991	0.564
LIG_LIR_Gen_1	145	152	PF02991	0.439
LIG_LIR_Gen_1	191	202	PF02991	0.572
LIG_LIR_Gen_1	226	235	PF02991	0.424
LIG_LIR_Gen_1	261	269	PF02991	0.350
LIG_LIR_Gen_1	293	303	PF02991	0.526
LIG_LIR_LC3C_4	373	376	PF02991	0.227
LIG_LIR_Nem_3	111	117	PF02991	0.483
LIG_LIR_Nem_3	145	149	PF02991	0.339
LIG_LIR_Nem_3	177	183	PF02991	0.395
LIG_LIR_Nem_3	191	197	PF02991	0.448
LIG_LIR_Nem_3	226	231	PF02991	0.452
LIG_LIR_Nem_3	261	267	PF02991	0.349
LIG_LIR_Nem_3	293	298	PF02991	0.529
LIG_LIR_Nem_3	471	476	PF02991	0.534
LIG_LIR_Nem_3	80	84	PF02991	0.368
LIG_MLH1_MIPbox_1	176	180	PF16413	0.283
LIG_OCRL_FandH_1	427	439	PF00620	0.286
LIG_PDZ_Class_3	514	519	PF00595	0.628
LIG_PTB_Apo_2	466	473	PF02174	0.344
LIG_PTB_Phospho_1	466	472	PF10480	0.350
LIG_SH2_CRK	198	202	PF00017	0.449
LIG_SH2_CRK	264	268	PF00017	0.259
LIG_SH2_CRK	295	299	PF00017	0.505
LIG_SH2_GRB2like	467	470	PF00017	0.339
LIG_SH2_NCK_1	467	471	PF00017	0.349
LIG_SH2_SRC	365	368	PF00017	0.257
LIG_SH2_STAP1	316	320	PF00017	0.389
LIG_SH2_STAP1	365	369	PF00017	0.450
LIG_SH2_STAP1	378	382	PF00017	0.421
LIG_SH2_STAP1	424	428	PF00017	0.307
LIG_SH2_STAP1	473	477	PF00017	0.498
LIG_SH2_STAP1	492	496	PF00017	0.373
LIG_SH2_STAT5	179	182	PF00017	0.320
LIG_SH2_STAT5	184	187	PF00017	0.343
LIG_SH2_STAT5	284	287	PF00017	0.447
LIG_SH2_STAT5	424	427	PF00017	0.314
LIG_SH2_STAT5	467	470	PF00017	0.546
LIG_SH2_STAT5	476	479	PF00017	0.558
LIG_SH3_1	476	482	PF00018	0.604
LIG_SH3_2	479	484	PF14604	0.414
LIG_SH3_3	300	306	PF00018	0.341
LIG_SH3_3	31	37	PF00018	0.456
LIG_SH3_3	396	402	PF00018	0.511
LIG_SH3_3	476	482	PF00018	0.604
LIG_SUMO_SIM_anti_2	244	251	PF11976	0.466
LIG_SUMO_SIM_anti_2	366	371	PF11976	0.223
LIG_SUMO_SIM_par_1	39	45	PF11976	0.629
LIG_TYR_ITIM	376	381	PF00017	0.314
LIG_UBA3_1	248	253	PF00899	0.553
MOD_CK1_1	11	17	PF00069	0.522
MOD_CK1_1	119	125	PF00069	0.523
MOD_CK1_1	155	161	PF00069	0.373
MOD_CK1_1	174	180	PF00069	0.573
MOD_CK1_1	2	8	PF00069	0.561
MOD_CK1_1	229	235	PF00069	0.548
MOD_CK1_1	389	395	PF00069	0.396
MOD_CK2_1	1	7	PF00069	0.637
MOD_CK2_1	134	140	PF00069	0.243
MOD_CK2_1	150	156	PF00069	0.291
MOD_CK2_1	18	24	PF00069	0.510
MOD_CK2_1	307	313	PF00069	0.572
MOD_CK2_1	316	322	PF00069	0.522
MOD_CK2_1	37	43	PF00069	0.525
MOD_CK2_1	406	412	PF00069	0.527
MOD_CK2_1	465	471	PF00069	0.607
MOD_CK2_1	84	90	PF00069	0.418
MOD_GlcNHglycan	10	13	PF01048	0.606
MOD_GlcNHglycan	129	133	PF01048	0.450
MOD_GlcNHglycan	176	179	PF01048	0.503
MOD_GlcNHglycan	194	197	PF01048	0.466
MOD_GlcNHglycan	223	226	PF01048	0.603
MOD_GlcNHglycan	280	283	PF01048	0.509
MOD_GlcNHglycan	291	295	PF01048	0.457
MOD_GlcNHglycan	309	312	PF01048	0.501
MOD_GlcNHglycan	318	321	PF01048	0.617
MOD_GlcNHglycan	395	398	PF01048	0.506
MOD_GSK3_1	10	17	PF00069	0.634
MOD_GSK3_1	115	122	PF00069	0.489
MOD_GSK3_1	150	157	PF00069	0.296
MOD_GSK3_1	200	207	PF00069	0.368
MOD_GSK3_1	226	233	PF00069	0.544
MOD_GSK3_1	247	254	PF00069	0.391
MOD_GSK3_1	286	293	PF00069	0.513
MOD_GSK3_1	389	396	PF00069	0.464
MOD_GSK3_1	406	413	PF00069	0.464
MOD_GSK3_1	422	429	PF00069	0.488
MOD_GSK3_1	482	489	PF00069	0.446
MOD_NEK2_1	1	6	PF00069	0.727
MOD_NEK2_1	115	120	PF00069	0.417
MOD_NEK2_1	142	147	PF00069	0.376
MOD_NEK2_1	204	209	PF00069	0.495
MOD_NEK2_1	307	312	PF00069	0.404
MOD_NEK2_1	343	348	PF00069	0.518
MOD_NEK2_1	352	357	PF00069	0.516
MOD_NEK2_1	426	431	PF00069	0.517
MOD_NEK2_1	52	57	PF00069	0.644
MOD_NEK2_1	8	13	PF00069	0.653
MOD_NEK2_1	84	89	PF00069	0.375
MOD_PKA_1	344	350	PF00069	0.487
MOD_PKA_2	115	121	PF00069	0.408
MOD_PKA_2	122	128	PF00069	0.366
MOD_PKA_2	142	148	PF00069	0.341
MOD_PKA_2	174	180	PF00069	0.434
MOD_PKA_2	278	284	PF00069	0.318
MOD_PKA_2	343	349	PF00069	0.489
MOD_PKA_2	422	428	PF00069	0.424
MOD_PKA_2	52	58	PF00069	0.494
MOD_PKA_2	8	14	PF00069	0.686
MOD_Plk_1	128	134	PF00069	0.371
MOD_Plk_1	290	296	PF00069	0.471
MOD_Plk_1	365	371	PF00069	0.228
MOD_Plk_1	389	395	PF00069	0.422
MOD_Plk_1	507	513	PF00069	0.723
MOD_Plk_4	110	116	PF00069	0.490
MOD_Plk_4	134	140	PF00069	0.386
MOD_Plk_4	200	206	PF00069	0.377
MOD_Plk_4	223	229	PF00069	0.499
MOD_Plk_4	251	257	PF00069	0.489
MOD_Plk_4	370	376	PF00069	0.432
MOD_Plk_4	389	395	PF00069	0.237
MOD_Plk_4	445	451	PF00069	0.456
MOD_Plk_4	52	58	PF00069	0.512
MOD_ProDKin_1	18	24	PF00069	0.524
MOD_ProDKin_1	37	43	PF00069	0.557
TRG_DiLeu_BaEn_1	390	395	PF01217	0.459
TRG_DiLeu_BaEn_1	73	78	PF01217	0.569
TRG_DiLeu_BaLyEn_6	178	183	PF01217	0.377
TRG_ENDOCYTIC_2	179	182	PF00928	0.339
TRG_ENDOCYTIC_2	184	187	PF00928	0.346
TRG_ENDOCYTIC_2	198	201	PF00928	0.499
TRG_ENDOCYTIC_2	264	267	PF00928	0.261
TRG_ENDOCYTIC_2	295	298	PF00928	0.523
TRG_ENDOCYTIC_2	378	381	PF00928	0.387
TRG_ENDOCYTIC_2	81	84	PF00928	0.460
TRG_ER_diArg_1	274	276	PF00400	0.314
TRG_ER_diArg_1	450	452	PF00400	0.436
TRG_ER_diArg_1	8	10	PF00400	0.681
TRG_ER_diArg_1	91	93	PF00400	0.351
TRG_NES_CRM1_1	366	380	PF08389	0.239

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZ13	Leptomonas seymouri	55%	100%
A0A1X0NVA2	Trypanosomatidae	29%	96%
A0A3R7L246	Trypanosoma rangeli	24%	100%
A0A3S7X131	Leishmania donovani	71%	99%
A4I380	Leishmania infantum	72%	99%
E9AZG8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	71%	100%
Q4Q8R3	Leishmania major	72%	100%
V5BGK7	Trypanosoma cruzi	24%	100%