FIST_C domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HG49_LEIBR

TriTrypDb:

LbrM.28.0070 , LBRM2903_280006000

Length:

485

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HG49

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HG49

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	18	20	PF00675	0.611
CLV_NRD_NRD_1	400	402	PF00675	0.619
CLV_NRD_NRD_1	52	54	PF00675	0.628
CLV_NRD_NRD_1	6	8	PF00675	0.596
CLV_PCSK_FUR_1	43	47	PF00082	0.468
CLV_PCSK_KEX2_1	18	20	PF00082	0.623
CLV_PCSK_KEX2_1	400	402	PF00082	0.645
CLV_PCSK_KEX2_1	45	47	PF00082	0.634
CLV_PCSK_KEX2_1	6	8	PF00082	0.597
CLV_PCSK_PC1ET2_1	45	47	PF00082	0.598
CLV_PCSK_PC7_1	2	8	PF00082	0.708
CLV_PCSK_SKI1_1	297	301	PF00082	0.398
CLV_PCSK_SKI1_1	318	322	PF00082	0.401
CLV_PCSK_SKI1_1	46	50	PF00082	0.624
CLV_PCSK_SKI1_1	54	58	PF00082	0.641
CLV_Separin_Metazoa	34	38	PF03568	0.454
DEG_APCC_DBOX_1	5	13	PF00400	0.735
DEG_Nend_UBRbox_1	1	4	PF02207	0.595
DEG_ODPH_VHL_1	384	395	PF01847	0.690
DEG_SPOP_SBC_1	404	408	PF00917	0.671
DEG_SPOP_SBC_1	473	477	PF00917	0.427
DOC_CDC14_PxL_1	148	156	PF14671	0.517
DOC_CKS1_1	26	31	PF01111	0.637
DOC_MAPK_DCC_7	423	431	PF00069	0.664
DOC_MAPK_gen_1	315	323	PF00069	0.418
DOC_MAPK_gen_1	41	50	PF00069	0.531
DOC_MAPK_gen_1	6	12	PF00069	0.681
DOC_MAPK_MEF2A_6	175	182	PF00069	0.500
DOC_MAPK_MEF2A_6	315	323	PF00069	0.414
DOC_MAPK_MEF2A_6	324	332	PF00069	0.428
DOC_MAPK_MEF2A_6	423	431	PF00069	0.573
DOC_PP1_RVXF_1	51	58	PF00149	0.586
DOC_PP2B_LxvP_1	218	221	PF13499	0.614
DOC_PP4_FxxP_1	345	348	PF00568	0.407
DOC_PP4_FxxP_1	438	441	PF00568	0.606
DOC_PP4_FxxP_1	456	459	PF00568	0.495
DOC_USP7_MATH_1	221	225	PF00917	0.728
DOC_USP7_MATH_1	473	477	PF00917	0.427
DOC_USP7_MATH_1	59	63	PF00917	0.630
DOC_USP7_UBL2_3	41	45	PF12436	0.460
DOC_WW_Pin1_4	115	120	PF00397	0.607
DOC_WW_Pin1_4	173	178	PF00397	0.525
DOC_WW_Pin1_4	25	30	PF00397	0.566
DOC_WW_Pin1_4	455	460	PF00397	0.582
LIG_14-3-3_CanoR_1	19	29	PF00244	0.575
LIG_14-3-3_CanoR_1	297	306	PF00244	0.430
LIG_14-3-3_CanoR_1	474	479	PF00244	0.427
LIG_14-3-3_CanoR_1	6	10	PF00244	0.713
LIG_BIR_III_2	162	166	PF00653	0.544
LIG_BRCT_BRCA1_1	157	161	PF00533	0.574
LIG_BRCT_BRCA1_1	237	241	PF00533	0.574
LIG_BRCT_BRCA1_1	316	320	PF00533	0.447
LIG_BRCT_BRCA1_1	453	457	PF00533	0.417
LIG_Clathr_ClatBox_1	377	381	PF01394	0.527
LIG_EVH1_1	82	86	PF00568	0.602
LIG_FHA_1	264	270	PF00498	0.535
LIG_FHA_1	278	284	PF00498	0.426
LIG_FHA_1	298	304	PF00498	0.394
LIG_FHA_1	90	96	PF00498	0.460
LIG_FHA_2	276	282	PF00498	0.288
LIG_GBD_Chelix_1	372	380	PF00786	0.454
LIG_IRF3_LxIS_1	372	379	PF10401	0.336
LIG_LIR_Apic_2	305	310	PF02991	0.522
LIG_LIR_Apic_2	342	348	PF02991	0.464
LIG_LIR_Apic_2	454	459	PF02991	0.407
LIG_LIR_Gen_1	158	165	PF02991	0.524
LIG_LIR_Gen_1	475	485	PF02991	0.463
LIG_LIR_Nem_3	158	164	PF02991	0.531
LIG_LIR_Nem_3	317	323	PF02991	0.412
LIG_LYPXL_S_1	218	222	PF13949	0.558
LIG_LYPXL_yS_3	219	222	PF13949	0.569
LIG_MLH1_MIPbox_1	237	241	PF16413	0.593
LIG_MLH1_MIPbox_1	453	457	PF16413	0.417
LIG_SH2_CRK	90	94	PF00017	0.656
LIG_SH2_NCK_1	307	311	PF00017	0.571
LIG_SH2_PTP2	143	146	PF00017	0.538
LIG_SH2_STAP1	193	197	PF00017	0.459
LIG_SH2_STAT5	143	146	PF00017	0.538
LIG_SH2_STAT5	478	481	PF00017	0.457
LIG_SH2_STAT5	97	100	PF00017	0.450
LIG_SH3_3	23	29	PF00018	0.514
LIG_SH3_3	325	331	PF00018	0.491
LIG_SH3_3	332	338	PF00018	0.483
LIG_SH3_3	421	427	PF00018	0.654
LIG_SH3_3	80	86	PF00018	0.582
LIG_SUMO_SIM_par_1	427	434	PF11976	0.652
LIG_SUMO_SIM_par_1	91	96	PF11976	0.442
LIG_TRAF2_1	22	25	PF00917	0.473
LIG_TRFH_1	345	349	PF08558	0.511
LIG_TYR_ITIM	191	196	PF00017	0.508
LIG_TYR_ITIM	323	328	PF00017	0.327
LIG_UBA3_1	376	382	PF00899	0.465
LIG_WRC_WIRS_1	1	6	PF05994	0.489
MOD_CK1_1	202	208	PF00069	0.579
MOD_CK1_1	273	279	PF00069	0.444
MOD_CK1_1	430	436	PF00069	0.660
MOD_CK2_1	221	227	PF00069	0.600
MOD_Cter_Amidation	4	7	PF01082	0.678
MOD_GlcNHglycan	197	200	PF01048	0.490
MOD_GlcNHglycan	227	230	PF01048	0.634
MOD_GlcNHglycan	249	252	PF01048	0.454
MOD_GlcNHglycan	275	278	PF01048	0.484
MOD_GlcNHglycan	433	436	PF01048	0.619
MOD_GlcNHglycan	453	456	PF01048	0.420
MOD_GlcNHglycan	61	64	PF01048	0.548
MOD_GSK3_1	153	160	PF00069	0.547
MOD_GSK3_1	195	202	PF00069	0.559
MOD_GSK3_1	221	228	PF00069	0.570
MOD_GSK3_1	264	271	PF00069	0.468
MOD_GSK3_1	273	280	PF00069	0.300
MOD_GSK3_1	293	300	PF00069	0.435
MOD_GSK3_1	351	358	PF00069	0.514
MOD_GSK3_1	372	379	PF00069	0.555
MOD_GSK3_1	427	434	PF00069	0.474
MOD_GSK3_1	447	454	PF00069	0.419
MOD_GSK3_1	55	62	PF00069	0.644
MOD_GSK3_1	91	98	PF00069	0.564
MOD_N-GLC_1	466	471	PF02516	0.321
MOD_N-GLC_2	110	112	PF02516	0.540
MOD_N-GLC_2	87	89	PF02516	0.519
MOD_NEK2_1	184	189	PF00069	0.522
MOD_NEK2_1	204	209	PF00069	0.479
MOD_NEK2_1	235	240	PF00069	0.587
MOD_NEK2_1	343	348	PF00069	0.386
MOD_NEK2_1	411	416	PF00069	0.545
MOD_NEK2_1	431	436	PF00069	0.460
MOD_NEK2_2	287	292	PF00069	0.572
MOD_OFUCOSY	446	451	PF10250	0.587
MOD_PIKK_1	20	26	PF00454	0.723
MOD_PIKK_1	351	357	PF00454	0.314
MOD_PKA_2	247	253	PF00069	0.522
MOD_PKA_2	473	479	PF00069	0.425
MOD_PKA_2	5	11	PF00069	0.667
MOD_Plk_1	46	52	PF00069	0.631
MOD_Plk_1	466	472	PF00069	0.526
MOD_Plk_2-3	157	163	PF00069	0.551
MOD_Plk_4	235	241	PF00069	0.616
MOD_Plk_4	264	270	PF00069	0.462
MOD_Plk_4	372	378	PF00069	0.503
MOD_Plk_4	467	473	PF00069	0.448
MOD_ProDKin_1	115	121	PF00069	0.611
MOD_ProDKin_1	173	179	PF00069	0.516
MOD_ProDKin_1	25	31	PF00069	0.560
MOD_ProDKin_1	455	461	PF00069	0.577
TRG_ENDOCYTIC_2	143	146	PF00928	0.538
TRG_ENDOCYTIC_2	193	196	PF00928	0.490
TRG_ENDOCYTIC_2	219	222	PF00928	0.569
TRG_ENDOCYTIC_2	325	328	PF00928	0.338
TRG_ENDOCYTIC_2	478	481	PF00928	0.439
TRG_ENDOCYTIC_2	90	93	PF00928	0.572
TRG_ENDOCYTIC_2	97	100	PF00928	0.527
TRG_ER_diArg_1	18	20	PF00400	0.616
TRG_ER_diArg_1	66	69	PF00400	0.523
TRG_NES_CRM1_1	367	381	PF08389	0.540
TRG_Pf-PMV_PEXEL_1	46	51	PF00026	0.664

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCN6	Leptomonas seymouri	74%	99%
A0A0S4J200	Bodo saltans	43%	95%
A0A1X0NVX9	Trypanosomatidae	57%	98%
A0A3Q8IDL9	Leishmania donovani	84%	100%
A0A3R7NQD0	Trypanosoma rangeli	53%	96%
A4I379	Leishmania infantum	85%	100%
D0A7Q8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	98%
E9AZG7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4Q8R4	Leishmania major	85%	100%