NYD-SP28 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

nexin-dynein regulatory complex 2

Species:

Leishmania braziliensis

UniProt:

A4HG48_LEIBR

TriTrypDb:

LbrM.28.0060 , LBRM2903_280005900

Length:

512

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005858	axonemal dynein complex	4	12
GO:0005875	microtubule associated complex	2	12
GO:0030286	dynein complex	3	12
GO:0032991	protein-containing complex	1	12
GO:1902494	catalytic complex	2	12
GO:0005737	cytoplasm	2	1
GO:0005929	cilium	4	3
GO:0005930	axoneme	2	1
GO:0042995	cell projection	2	3
GO:0043226	organelle	2	3
GO:0043227	membrane-bounded organelle	3	3
GO:0110165	cellular anatomical entity	1	3
GO:0120025	plasma membrane bounded cell projection	3	3
GO:0031514	motile cilium	5	2

Expansion

Sequence features

A4HG48

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HG48

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	12
GO:0016043	cellular component organization	3	12
GO:0022607	cellular component assembly	4	12
GO:0043933	protein-containing complex organization	4	12
GO:0065003	protein-containing complex assembly	5	12
GO:0070286	axonemal dynein complex assembly	6	12
GO:0071840	cellular component organization or biogenesis	2	12
GO:0001539	cilium or flagellum-dependent cell motility	3	1
GO:0003352	regulation of cilium movement	6	1
GO:0032886	regulation of microtubule-based process	4	1
GO:0048870	cell motility	2	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0060285	cilium-dependent cell motility	4	1
GO:0060632	regulation of microtubule-based movement	5	1
GO:0065007	biological regulation	1	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	392	396	PF00656	0.668
CLV_NRD_NRD_1	13	15	PF00675	0.572
CLV_NRD_NRD_1	263	265	PF00675	0.525
CLV_NRD_NRD_1	382	384	PF00675	0.645
CLV_NRD_NRD_1	86	88	PF00675	0.270
CLV_NRD_NRD_1	94	96	PF00675	0.242
CLV_PCSK_KEX2_1	13	15	PF00082	0.542
CLV_PCSK_KEX2_1	209	211	PF00082	0.559
CLV_PCSK_KEX2_1	306	308	PF00082	0.479
CLV_PCSK_KEX2_1	32	34	PF00082	0.251
CLV_PCSK_KEX2_1	342	344	PF00082	0.499
CLV_PCSK_KEX2_1	381	383	PF00082	0.537
CLV_PCSK_KEX2_1	86	88	PF00082	0.278
CLV_PCSK_PC1ET2_1	209	211	PF00082	0.559
CLV_PCSK_PC1ET2_1	306	308	PF00082	0.479
CLV_PCSK_PC1ET2_1	32	34	PF00082	0.175
CLV_PCSK_PC1ET2_1	342	344	PF00082	0.499
CLV_PCSK_PC1ET2_1	381	383	PF00082	0.537
CLV_PCSK_SKI1_1	115	119	PF00082	0.254
CLV_PCSK_SKI1_1	14	18	PF00082	0.545
CLV_PCSK_SKI1_1	173	177	PF00082	0.479
CLV_PCSK_SKI1_1	282	286	PF00082	0.467
CLV_PCSK_SKI1_1	298	302	PF00082	0.413
CLV_PCSK_SKI1_1	306	310	PF00082	0.420
CLV_PCSK_SKI1_1	383	387	PF00082	0.532
CLV_PCSK_SKI1_1	422	426	PF00082	0.407
CLV_PCSK_SKI1_1	434	438	PF00082	0.424
CLV_Separin_Metazoa	460	464	PF03568	0.515
CLV_Separin_Metazoa	83	87	PF03568	0.442
DEG_APCC_DBOX_1	13	21	PF00400	0.494
DEG_APCC_DBOX_1	172	180	PF00400	0.551
DOC_CYCLIN_RxL_1	32	42	PF00134	0.555
DOC_CYCLIN_RxL_1	342	352	PF00134	0.426
DOC_CYCLIN_RxL_1	431	440	PF00134	0.571
DOC_MAPK_gen_1	13	22	PF00069	0.533
DOC_MAPK_gen_1	209	216	PF00069	0.413
DOC_MAPK_gen_1	32	40	PF00069	0.451
DOC_MAPK_gen_1	342	353	PF00069	0.453
DOC_MAPK_MEF2A_6	209	216	PF00069	0.593
DOC_SPAK_OSR1_1	415	419	PF12202	0.498
DOC_USP7_MATH_1	27	31	PF00917	0.555
DOC_USP7_UBL2_3	5	9	PF12436	0.545
LIG_14-3-3_CanoR_1	463	469	PF00244	0.646
LIG_14-3-3_CanoR_1	86	90	PF00244	0.507
LIG_Actin_WH2_2	160	175	PF00022	0.529
LIG_deltaCOP1_diTrp_1	408	417	PF00928	0.461
LIG_deltaCOP1_diTrp_1	63	69	PF00928	0.450
LIG_FHA_1	134	140	PF00498	0.537
LIG_FHA_1	254	260	PF00498	0.546
LIG_FHA_2	144	150	PF00498	0.382
LIG_FHA_2	198	204	PF00498	0.641
LIG_FHA_2	357	363	PF00498	0.457
LIG_FHA_2	89	95	PF00498	0.514
LIG_LIR_Gen_1	63	72	PF02991	0.450
LIG_LIR_Nem_3	228	234	PF02991	0.456
LIG_LIR_Nem_3	408	413	PF02991	0.503
LIG_LIR_Nem_3	63	69	PF02991	0.450
LIG_PCNA_PIPBox_1	445	454	PF02747	0.460
LIG_PCNA_yPIPBox_3	434	448	PF02747	0.451
LIG_SH2_NCK_1	156	160	PF00017	0.529
LIG_SH2_NCK_1	493	497	PF00017	0.694
LIG_SH2_STAT5	245	248	PF00017	0.576
LIG_SH2_STAT5	451	454	PF00017	0.456
LIG_SH3_3	470	476	PF00018	0.456
LIG_SUMO_SIM_anti_2	81	86	PF11976	0.461
LIG_TRAF2_1	332	335	PF00917	0.554
LIG_UBA3_1	347	355	PF00899	0.438
MOD_CK1_1	271	277	PF00069	0.421
MOD_CK2_1	105	111	PF00069	0.553
MOD_CK2_1	124	130	PF00069	0.385
MOD_CK2_1	143	149	PF00069	0.255
MOD_CK2_1	15	21	PF00069	0.505
MOD_CK2_1	197	203	PF00069	0.685
MOD_CK2_1	214	220	PF00069	0.497
MOD_CK2_1	328	334	PF00069	0.422
MOD_CK2_1	356	362	PF00069	0.452
MOD_GlcNHglycan	17	20	PF01048	0.623
MOD_GlcNHglycan	329	333	PF01048	0.436
MOD_GlcNHglycan	371	374	PF01048	0.651
MOD_GlcNHglycan	386	389	PF01048	0.657
MOD_GlcNHglycan	58	61	PF01048	0.338
MOD_GlcNHglycan	99	102	PF01048	0.308
MOD_GSK3_1	268	275	PF00069	0.441
MOD_GSK3_1	464	471	PF00069	0.581
MOD_GSK3_1	52	59	PF00069	0.454
MOD_GSK3_1	85	92	PF00069	0.508
MOD_N-GLC_1	369	374	PF02516	0.579
MOD_NEK2_1	143	148	PF00069	0.439
MOD_NEK2_1	234	239	PF00069	0.420
MOD_NEK2_1	269	274	PF00069	0.418
MOD_NEK2_1	337	342	PF00069	0.471
MOD_NEK2_1	39	44	PF00069	0.528
MOD_NEK2_1	462	467	PF00069	0.533
MOD_NEK2_1	468	473	PF00069	0.532
MOD_NEK2_1	54	59	PF00069	0.422
MOD_PKA_1	5	11	PF00069	0.630
MOD_PKA_2	197	203	PF00069	0.635
MOD_PKA_2	462	468	PF00069	0.628
MOD_PKA_2	506	512	PF00069	0.465
MOD_PKA_2	85	91	PF00069	0.511
MOD_Plk_1	143	149	PF00069	0.527
MOD_Plk_1	243	249	PF00069	0.347
MOD_Plk_1	298	304	PF00069	0.458
MOD_Plk_1	453	459	PF00069	0.495
MOD_Plk_1	89	95	PF00069	0.511
MOD_Plk_2-3	105	111	PF00069	0.555
MOD_Plk_2-3	453	459	PF00069	0.537
MOD_Plk_4	143	149	PF00069	0.565
MOD_Plk_4	464	470	PF00069	0.563
MOD_SUMO_rev_2	182	190	PF00179	0.511
MOD_SUMO_rev_2	46	54	PF00179	0.494
MOD_SUMO_rev_2	90	98	PF00179	0.371
TRG_DiLeu_BaEn_2	496	502	PF01217	0.625
TRG_DiLeu_BaEn_4	439	445	PF01217	0.433
TRG_DiLeu_BaLyEn_6	343	348	PF01217	0.537
TRG_ENDOCYTIC_2	231	234	PF00928	0.458
TRG_ENDOCYTIC_2	493	496	PF00928	0.599
TRG_ER_diArg_1	12	14	PF00400	0.586
TRG_ER_diArg_1	382	384	PF00400	0.645
TRG_ER_diArg_1	85	87	PF00400	0.461
TRG_NES_CRM1_1	446	460	PF08389	0.580
TRG_Pf-PMV_PEXEL_1	188	192	PF00026	0.456
TRG_Pf-PMV_PEXEL_1	306	310	PF00026	0.572
TRG_Pf-PMV_PEXEL_1	321	325	PF00026	0.561
TRG_Pf-PMV_PEXEL_1	434	438	PF00026	0.511
TRG_Pf-PMV_PEXEL_1	442	446	PF00026	0.501
TRG_Pf-PMV_PEXEL_1	76	81	PF00026	0.317

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5X5	Leptomonas seymouri	74%	100%
A0A0S4J2B0	Bodo saltans	48%	99%
A0A1X0NVC5	Trypanosomatidae	53%	100%
A0A3Q8IHV5	Leishmania donovani	81%	100%
A0A3R7MHP0	Trypanosoma rangeli	54%	100%
A4I378	Leishmania infantum	81%	100%
A8JB22	Chlamydomonas reinhardtii	28%	89%
D0A7Q6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	100%
E9AZG6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q2TA16	Bos taurus	29%	100%
Q4Q8R5	Leishmania major	83%	100%
Q4R7G7	Macaca fascicularis	27%	100%
Q5XIJ8	Rattus norvegicus	28%	100%
Q6DHI2	Danio rerio	26%	100%
Q8IXS2	Homo sapiens	27%	100%
Q8VHI7	Mus musculus	28%	100%
V5AS08	Trypanosoma cruzi	54%	100%