TPR_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HG47_LEIBR

TriTrypDb:

LbrM.28.0050 , LBRM2903_280005700 , LBRM2903_280005800

Length:

910

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HG47

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HG47

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	802	806	PF00656	0.443
CLV_NRD_NRD_1	208	210	PF00675	0.617
CLV_NRD_NRD_1	289	291	PF00675	0.448
CLV_NRD_NRD_1	377	379	PF00675	0.324
CLV_NRD_NRD_1	459	461	PF00675	0.479
CLV_NRD_NRD_1	494	496	PF00675	0.407
CLV_NRD_NRD_1	613	615	PF00675	0.362
CLV_NRD_NRD_1	661	663	PF00675	0.320
CLV_NRD_NRD_1	687	689	PF00675	0.643
CLV_NRD_NRD_1	767	769	PF00675	0.524
CLV_NRD_NRD_1	904	906	PF00675	0.573
CLV_PCSK_KEX2_1	288	290	PF00082	0.438
CLV_PCSK_KEX2_1	360	362	PF00082	0.435
CLV_PCSK_KEX2_1	431	433	PF00082	0.353
CLV_PCSK_KEX2_1	494	496	PF00082	0.390
CLV_PCSK_KEX2_1	52	54	PF00082	0.604
CLV_PCSK_KEX2_1	767	769	PF00082	0.507
CLV_PCSK_KEX2_1	904	906	PF00082	0.561
CLV_PCSK_KEX2_1	91	93	PF00082	0.482
CLV_PCSK_PC1ET2_1	288	290	PF00082	0.441
CLV_PCSK_PC1ET2_1	360	362	PF00082	0.370
CLV_PCSK_PC1ET2_1	431	433	PF00082	0.359
CLV_PCSK_PC1ET2_1	52	54	PF00082	0.592
CLV_PCSK_PC1ET2_1	904	906	PF00082	0.561
CLV_PCSK_PC1ET2_1	91	93	PF00082	0.488
CLV_PCSK_PC7_1	356	362	PF00082	0.580
CLV_PCSK_PC7_1	490	496	PF00082	0.456
CLV_PCSK_PC7_1	87	93	PF00082	0.476
CLV_PCSK_SKI1_1	17	21	PF00082	0.461
CLV_PCSK_SKI1_1	173	177	PF00082	0.483
CLV_PCSK_SKI1_1	209	213	PF00082	0.594
CLV_PCSK_SKI1_1	360	364	PF00082	0.380
CLV_PCSK_SKI1_1	408	412	PF00082	0.493
CLV_PCSK_SKI1_1	495	499	PF00082	0.432
CLV_PCSK_SKI1_1	579	583	PF00082	0.557
CLV_PCSK_SKI1_1	614	618	PF00082	0.352
CLV_PCSK_SKI1_1	708	712	PF00082	0.454
CLV_PCSK_SKI1_1	767	771	PF00082	0.541
CLV_PCSK_SKI1_1	790	794	PF00082	0.409
CLV_Separin_Metazoa	592	596	PF03568	0.518
DEG_APCC_DBOX_1	355	363	PF00400	0.526
DEG_APCC_DBOX_1	407	415	PF00400	0.372
DEG_APCC_DBOX_1	494	502	PF00400	0.423
DEG_APCC_DBOX_1	613	621	PF00400	0.358
DEG_APCC_DBOX_1	661	669	PF00400	0.461
DEG_APCC_DBOX_1	91	99	PF00400	0.471
DEG_SCF_FBW7_2	159	165	PF00400	0.588
DOC_CKS1_1	159	164	PF01111	0.491
DOC_CYCLIN_RxL_1	114	122	PF00134	0.640
DOC_CYCLIN_RxL_1	322	331	PF00134	0.298
DOC_CYCLIN_RxL_1	356	368	PF00134	0.438
DOC_CYCLIN_RxL_1	490	502	PF00134	0.516
DOC_CYCLIN_RxL_1	705	715	PF00134	0.503
DOC_CYCLIN_yCln2_LP_2	336	342	PF00134	0.258
DOC_MAPK_gen_1	209	219	PF00069	0.557
DOC_MAPK_gen_1	288	296	PF00069	0.388
DOC_MAPK_gen_1	378	384	PF00069	0.493
DOC_MAPK_gen_1	611	619	PF00069	0.445
DOC_MAPK_gen_1	662	670	PF00069	0.298
DOC_MAPK_gen_1	91	98	PF00069	0.586
DOC_MAPK_MEF2A_6	209	217	PF00069	0.558
DOC_MAPK_MEF2A_6	91	100	PF00069	0.535
DOC_PP1_RVXF_1	15	21	PF00149	0.462
DOC_PP1_RVXF_1	291	297	PF00149	0.558
DOC_PP1_RVXF_1	323	330	PF00149	0.447
DOC_PP1_RVXF_1	646	653	PF00149	0.492
DOC_PP2B_LxvP_1	121	124	PF13499	0.724
DOC_PP2B_LxvP_1	148	151	PF13499	0.486
DOC_PP4_MxPP_1	1	4	PF00568	0.631
DOC_USP7_MATH_1	144	148	PF00917	0.572
DOC_USP7_MATH_1	153	157	PF00917	0.634
DOC_USP7_MATH_1	218	222	PF00917	0.477
DOC_USP7_MATH_1	234	238	PF00917	0.635
DOC_USP7_MATH_1	340	344	PF00917	0.391
DOC_USP7_MATH_1	430	434	PF00917	0.520
DOC_USP7_MATH_1	694	698	PF00917	0.503
DOC_USP7_MATH_1	734	738	PF00917	0.546
DOC_USP7_UBL2_3	284	288	PF12436	0.334
DOC_USP7_UBL2_3	659	663	PF12436	0.310
DOC_USP7_UBL2_3	900	904	PF12436	0.420
DOC_USP7_UBL2_3	906	910	PF12436	0.491
DOC_WW_Pin1_4	107	112	PF00397	0.712
DOC_WW_Pin1_4	142	147	PF00397	0.656
DOC_WW_Pin1_4	158	163	PF00397	0.614
DOC_WW_Pin1_4	796	801	PF00397	0.356
LIG_14-3-3_CanoR_1	109	119	PF00244	0.681
LIG_14-3-3_CanoR_1	289	293	PF00244	0.438
LIG_14-3-3_CanoR_1	300	310	PF00244	0.374
LIG_14-3-3_CanoR_1	332	338	PF00244	0.449
LIG_14-3-3_CanoR_1	347	352	PF00244	0.389
LIG_14-3-3_CanoR_1	494	498	PF00244	0.488
LIG_14-3-3_CanoR_1	579	584	PF00244	0.409
LIG_14-3-3_CanoR_1	595	603	PF00244	0.357
LIG_14-3-3_CanoR_1	662	670	PF00244	0.417
LIG_14-3-3_CanoR_1	716	725	PF00244	0.550
LIG_Actin_WH2_2	123	140	PF00022	0.478
LIG_Actin_WH2_2	643	661	PF00022	0.504
LIG_APCC_ABBA_1	860	865	PF00400	0.424
LIG_CtBP_PxDLS_1	124	128	PF00389	0.633
LIG_deltaCOP1_diTrp_1	855	863	PF00928	0.475
LIG_FHA_1	159	165	PF00498	0.560
LIG_FHA_1	222	228	PF00498	0.487
LIG_FHA_1	289	295	PF00498	0.615
LIG_FHA_1	302	308	PF00498	0.321
LIG_FHA_1	386	392	PF00498	0.426
LIG_FHA_1	466	472	PF00498	0.329
LIG_FHA_1	522	528	PF00498	0.470
LIG_FHA_1	588	594	PF00498	0.451
LIG_FHA_1	806	812	PF00498	0.288
LIG_FHA_1	857	863	PF00498	0.375
LIG_FHA_1	878	884	PF00498	0.446
LIG_FHA_1	890	896	PF00498	0.353
LIG_FHA_2	111	117	PF00498	0.607
LIG_FHA_2	131	137	PF00498	0.610
LIG_FHA_2	150	156	PF00498	0.594
LIG_FHA_2	396	402	PF00498	0.426
LIG_FHA_2	797	803	PF00498	0.423
LIG_Integrin_isoDGR_2	420	422	PF01839	0.278
LIG_LIR_Gen_1	321	329	PF02991	0.272
LIG_LIR_Gen_1	509	517	PF02991	0.351
LIG_LIR_Gen_1	672	683	PF02991	0.556
LIG_LIR_Gen_1	759	769	PF02991	0.405
LIG_LIR_Nem_3	509	515	PF02991	0.348
LIG_LIR_Nem_3	558	564	PF02991	0.492
LIG_LIR_Nem_3	672	678	PF02991	0.440
LIG_LIR_Nem_3	808	812	PF02991	0.362
LIG_MYND_1	146	150	PF01753	0.596
LIG_Pex14_2	390	394	PF04695	0.482
LIG_SH2_CRK	5	9	PF00017	0.448
LIG_SH2_STAP1	39	43	PF00017	0.518
LIG_SH2_STAP1	512	516	PF00017	0.342
LIG_SH2_STAP1	621	625	PF00017	0.357
LIG_SH2_STAT3	39	42	PF00017	0.518
LIG_SH2_STAT3	466	469	PF00017	0.376
LIG_SH2_STAT5	809	812	PF00017	0.467
LIG_SH3_1	117	123	PF00018	0.500
LIG_SH3_3	117	123	PF00018	0.566
LIG_SH3_3	137	143	PF00018	0.590
LIG_SH3_3	156	162	PF00018	0.520
LIG_SH3_3	180	186	PF00018	0.573
LIG_SH3_3	188	194	PF00018	0.572
LIG_SH3_3	748	754	PF00018	0.479
LIG_SH3_3	78	84	PF00018	0.733
LIG_SH3_3	834	840	PF00018	0.446
LIG_Sin3_3	333	340	PF02671	0.276
LIG_SUMO_SIM_anti_2	445	450	PF11976	0.473
LIG_SUMO_SIM_anti_2	719	726	PF11976	0.265
LIG_SUMO_SIM_anti_2	737	743	PF11976	0.384
LIG_TRAF2_1	163	166	PF00917	0.700
LIG_TRAF2_1	230	233	PF00917	0.629
LIG_TRAF2_1	398	401	PF00917	0.369
LIG_TRAF2_1	589	592	PF00917	0.553
LIG_TYR_ITIM	810	815	PF00017	0.227
LIG_UBA3_1	363	371	PF00899	0.304
LIG_UBA3_1	862	868	PF00899	0.308
LIG_WW_1	2	5	PF00397	0.464
MOD_CK1_1	126	132	PF00069	0.612
MOD_CK1_1	221	227	PF00069	0.481
MOD_CK1_1	237	243	PF00069	0.418
MOD_CK1_1	315	321	PF00069	0.398
MOD_CK1_1	385	391	PF00069	0.446
MOD_CK1_1	519	525	PF00069	0.307
MOD_CK1_1	676	682	PF00069	0.606
MOD_CK1_1	737	743	PF00069	0.410
MOD_CK1_1	781	787	PF00069	0.495
MOD_CK1_1	877	883	PF00069	0.462
MOD_CK2_1	110	116	PF00069	0.663
MOD_CK2_1	130	136	PF00069	0.610
MOD_CK2_1	149	155	PF00069	0.553
MOD_CK2_1	395	401	PF00069	0.458
MOD_CK2_1	519	525	PF00069	0.329
MOD_CK2_1	632	638	PF00069	0.442
MOD_CK2_1	796	802	PF00069	0.495
MOD_Cter_Amidation	660	663	PF01082	0.312
MOD_GlcNHglycan	21	24	PF01048	0.425
MOD_GlcNHglycan	237	240	PF01048	0.643
MOD_GlcNHglycan	314	317	PF01048	0.502
MOD_GlcNHglycan	33	37	PF01048	0.503
MOD_GlcNHglycan	333	336	PF01048	0.306
MOD_GlcNHglycan	384	387	PF01048	0.426
MOD_GlcNHglycan	438	441	PF01048	0.526
MOD_GlcNHglycan	473	476	PF01048	0.564
MOD_GlcNHglycan	597	600	PF01048	0.412
MOD_GlcNHglycan	735	739	PF01048	0.413
MOD_GlcNHglycan	747	750	PF01048	0.280
MOD_GlcNHglycan	9	12	PF01048	0.541
MOD_GSK3_1	103	110	PF00069	0.641
MOD_GSK3_1	126	133	PF00069	0.638
MOD_GSK3_1	149	156	PF00069	0.654
MOD_GSK3_1	234	241	PF00069	0.558
MOD_GSK3_1	288	295	PF00069	0.520
MOD_GSK3_1	347	354	PF00069	0.396
MOD_GSK3_1	432	439	PF00069	0.554
MOD_GSK3_1	465	472	PF00069	0.392
MOD_GSK3_1	485	492	PF00069	0.493
MOD_GSK3_1	632	639	PF00069	0.364
MOD_GSK3_1	771	778	PF00069	0.383
MOD_GSK3_1	779	786	PF00069	0.360
MOD_LATS_1	577	583	PF00433	0.407
MOD_N-GLC_1	241	246	PF02516	0.398
MOD_N-GLC_1	469	474	PF02516	0.290
MOD_N-GLC_1	636	641	PF02516	0.569
MOD_N-GLC_1	771	776	PF02516	0.341
MOD_N-GLC_1	796	801	PF02516	0.366
MOD_N-GLC_1	805	810	PF02516	0.387
MOD_NEK2_1	130	135	PF00069	0.661
MOD_NEK2_1	32	37	PF00069	0.556
MOD_NEK2_1	382	387	PF00069	0.399
MOD_NEK2_1	449	454	PF00069	0.423
MOD_NEK2_1	471	476	PF00069	0.509
MOD_NEK2_1	632	637	PF00069	0.430
MOD_NEK2_1	763	768	PF00069	0.431
MOD_NEK2_1	783	788	PF00069	0.483
MOD_NEK2_1	866	871	PF00069	0.313
MOD_NEK2_2	856	861	PF00069	0.425
MOD_PIKK_1	110	116	PF00454	0.497
MOD_PIKK_1	449	455	PF00454	0.544
MOD_PIKK_1	465	471	PF00454	0.381
MOD_PIKK_1	519	525	PF00454	0.439
MOD_PIKK_1	877	883	PF00454	0.393
MOD_PKA_1	288	294	PF00069	0.497
MOD_PKA_2	288	294	PF00069	0.442
MOD_PKA_2	331	337	PF00069	0.532
MOD_PKA_2	449	455	PF00069	0.466
MOD_PKA_2	489	495	PF00069	0.508
MOD_PKA_2	668	674	PF00069	0.523
MOD_PKA_2	676	682	PF00069	0.580
MOD_Plk_1	241	247	PF00069	0.501
MOD_Plk_1	298	304	PF00069	0.578
MOD_Plk_1	507	513	PF00069	0.403
MOD_Plk_1	636	642	PF00069	0.377
MOD_Plk_1	734	740	PF00069	0.302
MOD_Plk_1	771	777	PF00069	0.430
MOD_Plk_1	805	811	PF00069	0.434
MOD_Plk_1	829	835	PF00069	0.285
MOD_Plk_1	85	91	PF00069	0.672
MOD_Plk_4	126	132	PF00069	0.488
MOD_Plk_4	318	324	PF00069	0.412
MOD_Plk_4	507	513	PF00069	0.403
MOD_Plk_4	694	700	PF00069	0.639
MOD_Plk_4	737	743	PF00069	0.361
MOD_Plk_4	775	781	PF00069	0.347
MOD_Plk_4	784	790	PF00069	0.367
MOD_Plk_4	805	811	PF00069	0.343
MOD_Plk_4	874	880	PF00069	0.487
MOD_ProDKin_1	107	113	PF00069	0.716
MOD_ProDKin_1	142	148	PF00069	0.657
MOD_ProDKin_1	158	164	PF00069	0.612
MOD_ProDKin_1	796	802	PF00069	0.364
MOD_SUMO_for_1	896	899	PF00179	0.467
MOD_SUMO_rev_2	165	175	PF00179	0.617
MOD_SUMO_rev_2	354	362	PF00179	0.366
TRG_DiLeu_BaEn_4	266	272	PF01217	0.477
TRG_DiLeu_BaEn_4	400	406	PF01217	0.418
TRG_DiLeu_BaLyEn_6	91	96	PF01217	0.555
TRG_ENDOCYTIC_2	512	515	PF00928	0.344
TRG_ENDOCYTIC_2	761	764	PF00928	0.373
TRG_ENDOCYTIC_2	812	815	PF00928	0.305
TRG_ER_diArg_1	346	349	PF00400	0.371
TRG_ER_diArg_1	493	495	PF00400	0.409
TRG_ER_diArg_1	767	769	PF00400	0.444
TRG_ER_diLys_1	906	910	PF00400	0.509
TRG_NES_CRM1_1	701	715	PF08389	0.514
TRG_NLS_MonoCore_2	903	908	PF00514	0.511
TRG_NLS_MonoExtC_3	208	213	PF00514	0.689
TRG_NLS_MonoExtC_3	903	908	PF00514	0.511
TRG_NLS_MonoExtN_4	904	910	PF00514	0.542
TRG_Pf-PMV_PEXEL_1	117	122	PF00026	0.504
TRG_Pf-PMV_PEXEL_1	173	177	PF00026	0.391
TRG_Pf-PMV_PEXEL_1	254	258	PF00026	0.351
TRG_Pf-PMV_PEXEL_1	361	365	PF00026	0.443
TRG_Pf-PMV_PEXEL_1	495	500	PF00026	0.455
TRG_Pf-PMV_PEXEL_1	534	539	PF00026	0.386
TRG_Pf-PMV_PEXEL_1	688	692	PF00026	0.455
TRG_Pf-PMV_PEXEL_1	884	888	PF00026	0.279

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PF72	Leptomonas seymouri	60%	99%
A0A0S4J1J7	Bodo saltans	29%	85%
A0A1X0NWQ3	Trypanosomatidae	37%	97%
A0A3Q8ICX2	Leishmania donovani	75%	100%
A0A3R7LZ16	Trypanosoma rangeli	37%	95%
A4I377	Leishmania infantum	74%	100%
D0A7Q3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	96%
E9AZG5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	99%
Q4Q8R6	Leishmania major	74%	100%
V5BBZ0	Trypanosoma cruzi	38%	96%