Origin recognition complex subunit 1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

origin recognition complex subunit 1 (ORC1), putative

Species:

Leishmania braziliensis

UniProt:

A4HG46_LEIBR

TriTrypDb:

LbrM.28.0040 , LBRM2903_280005600

Length:

457

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	10
GO:0043226	organelle	2	10
GO:0043227	membrane-bounded organelle	3	10
GO:0043229	intracellular organelle	3	10
GO:0043231	intracellular membrane-bounded organelle	4	10
GO:0110165	cellular anatomical entity	1	10
GO:0000808	origin recognition complex	2	1
GO:0005664	nuclear origin of replication recognition complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

A4HG46

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HG46

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006259	DNA metabolic process	4	11
GO:0006260	DNA replication	5	10
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044260	obsolete cellular macromolecule metabolic process	3	11
GO:0046483	heterocycle metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11
GO:0000075	cell cycle checkpoint signaling	4	1
GO:0000076	DNA replication checkpoint signaling	6	1
GO:0006270	DNA replication initiation	5	1
GO:0007093	mitotic cell cycle checkpoint signaling	4	1
GO:0007165	signal transduction	2	1
GO:0007346	regulation of mitotic cell cycle	5	1
GO:0010389	regulation of G2/M transition of mitotic cell cycle	7	1
GO:0010564	regulation of cell cycle process	5	1
GO:0010948	negative regulation of cell cycle process	6	1
GO:0010972	negative regulation of G2/M transition of mitotic cell cycle	8	1
GO:0022402	cell cycle process	2	1
GO:0031570	DNA integrity checkpoint signaling	5	1
GO:0033314	mitotic DNA replication checkpoint signaling	6	1
GO:0035556	intracellular signal transduction	3	1
GO:0044774	mitotic DNA integrity checkpoint signaling	5	1
GO:0044818	mitotic G2/M transition checkpoint	5	1
GO:0045786	negative regulation of cell cycle	5	1
GO:0045930	negative regulation of mitotic cell cycle	6	1
GO:0048519	negative regulation of biological process	3	1
GO:0048523	negative regulation of cellular process	4	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051726	regulation of cell cycle	4	1
GO:0065007	biological regulation	1	1
GO:1901987	regulation of cell cycle phase transition	6	1
GO:1901988	negative regulation of cell cycle phase transition	7	1
GO:1901990	regulation of mitotic cell cycle phase transition	6	1
GO:1901991	negative regulation of mitotic cell cycle phase transition	7	1
GO:1902749	regulation of cell cycle G2/M phase transition	7	1
GO:1902750	negative regulation of cell cycle G2/M phase transition	8	1
GO:1903047	mitotic cell cycle process	3	1
GO:0051301	cell division	2	6

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003676	nucleic acid binding	3	11
GO:0003677	DNA binding	4	11
GO:0003824	catalytic activity	1	8
GO:0005488	binding	1	11
GO:0005524	ATP binding	5	11
GO:0016462	pyrophosphatase activity	5	8
GO:0016787	hydrolase activity	2	8
GO:0016817	hydrolase activity, acting on acid anhydrides	3	8
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	8
GO:0016887	ATP hydrolysis activity	7	8
GO:0017076	purine nucleotide binding	4	11
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	8
GO:0030554	adenyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032559	adenyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11
GO:0003688	DNA replication origin binding	7	1
GO:0003690	double-stranded DNA binding	5	1
GO:0043565	sequence-specific DNA binding	5	1
GO:1990837	sequence-specific double-stranded DNA binding	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	245	251	PF00089	0.354
CLV_NRD_NRD_1	107	109	PF00675	0.336
CLV_NRD_NRD_1	277	279	PF00675	0.339
CLV_NRD_NRD_1	31	33	PF00675	0.553
CLV_NRD_NRD_1	352	354	PF00675	0.437
CLV_NRD_NRD_1	374	376	PF00675	0.481
CLV_PCSK_FUR_1	29	33	PF00082	0.560
CLV_PCSK_KEX2_1	107	109	PF00082	0.314
CLV_PCSK_KEX2_1	158	160	PF00082	0.276
CLV_PCSK_KEX2_1	277	279	PF00082	0.339
CLV_PCSK_KEX2_1	28	30	PF00082	0.502
CLV_PCSK_KEX2_1	31	33	PF00082	0.468
CLV_PCSK_KEX2_1	354	356	PF00082	0.531
CLV_PCSK_PC1ET2_1	158	160	PF00082	0.267
CLV_PCSK_PC1ET2_1	28	30	PF00082	0.502
CLV_PCSK_PC1ET2_1	354	356	PF00082	0.531
CLV_PCSK_SKI1_1	188	192	PF00082	0.304
CLV_PCSK_SKI1_1	205	209	PF00082	0.258
CLV_PCSK_SKI1_1	242	246	PF00082	0.354
CLV_PCSK_SKI1_1	277	281	PF00082	0.332
CLV_PCSK_SKI1_1	31	35	PF00082	0.662
CLV_PCSK_SKI1_1	318	322	PF00082	0.428
CLV_PCSK_SKI1_1	386	390	PF00082	0.452
CLV_PCSK_SKI1_1	41	45	PF00082	0.377
CLV_PCSK_SKI1_1	93	97	PF00082	0.390
CLV_Separin_Metazoa	394	398	PF03568	0.321
DEG_APCC_DBOX_1	359	367	PF00400	0.369
DEG_Nend_Nbox_1	1	3	PF02207	0.413
DOC_CYCLIN_RxL_1	185	195	PF00134	0.365
DOC_CYCLIN_yCln2_LP_2	430	436	PF00134	0.476
DOC_CYCLIN_yCln2_LP_2	5	11	PF00134	0.389
DOC_MAPK_FxFP_2	7	10	PF00069	0.385
DOC_MAPK_gen_1	107	117	PF00069	0.278
DOC_MAPK_gen_1	220	227	PF00069	0.258
DOC_MAPK_JIP1_4	167	173	PF00069	0.176
DOC_MAPK_MEF2A_6	167	175	PF00069	0.411
DOC_MAPK_MEF2A_6	333	341	PF00069	0.309
DOC_MAPK_MEF2A_6	397	406	PF00069	0.323
DOC_MAPK_MEF2A_6	423	430	PF00069	0.422
DOC_MAPK_RevD_3	339	355	PF00069	0.453
DOC_PP1_RVXF_1	190	197	PF00149	0.258
DOC_PP1_RVXF_1	322	329	PF00149	0.360
DOC_PP1_RVXF_1	384	390	PF00149	0.428
DOC_PP2B_LxvP_1	197	200	PF13499	0.351
DOC_PP4_FxxP_1	299	302	PF00568	0.311
DOC_PP4_FxxP_1	7	10	PF00568	0.385
DOC_PP4_FxxP_1	86	89	PF00568	0.258
DOC_USP7_MATH_1	286	290	PF00917	0.319
DOC_USP7_MATH_1	412	416	PF00917	0.310
DOC_USP7_UBL2_3	181	185	PF12436	0.266
DOC_USP7_UBL2_3	188	192	PF12436	0.246
LIG_14-3-3_CanoR_1	278	287	PF00244	0.307
LIG_14-3-3_CanoR_1	31	40	PF00244	0.504
LIG_14-3-3_CanoR_1	397	402	PF00244	0.461
LIG_Actin_WH2_2	383	399	PF00022	0.427
LIG_AP2alpha_1	321	325	PF02296	0.421
LIG_BIR_III_4	445	449	PF00653	0.423
LIG_EH1_1	413	421	PF00400	0.301
LIG_eIF4E_1	201	207	PF01652	0.338
LIG_FHA_1	236	242	PF00498	0.358
LIG_FHA_1	302	308	PF00498	0.376
LIG_FHA_1	338	344	PF00498	0.349
LIG_FHA_1	346	352	PF00498	0.424
LIG_FHA_1	56	62	PF00498	0.512
LIG_FHA_1	80	86	PF00498	0.409
LIG_FHA_1	92	98	PF00498	0.213
LIG_FHA_2	307	313	PF00498	0.398
LIG_FHA_2	32	38	PF00498	0.507
LIG_IRF3_LxIS_1	47	53	PF10401	0.288
LIG_LIR_Apic_2	296	302	PF02991	0.343
LIG_LIR_Gen_1	195	202	PF02991	0.278
LIG_LIR_Gen_1	323	332	PF02991	0.357
LIG_LIR_Gen_1	424	434	PF02991	0.355
LIG_LIR_Nem_3	127	132	PF02991	0.259
LIG_LIR_Nem_3	195	199	PF02991	0.265
LIG_LIR_Nem_3	271	276	PF02991	0.352
LIG_LIR_Nem_3	323	328	PF02991	0.373
LIG_LIR_Nem_3	424	430	PF02991	0.460
LIG_MAD2	192	200	PF02301	0.258
LIG_PDZ_Class_2	452	457	PF00595	0.436
LIG_Pex14_2	116	120	PF04695	0.390
LIG_Pex14_2	160	164	PF04695	0.258
LIG_Pex14_2	321	325	PF04695	0.421
LIG_Pex14_2	9	13	PF04695	0.556
LIG_Rb_LxCxE_1	57	78	PF01857	0.372
LIG_SH2_CRK	434	438	PF00017	0.454
LIG_SH2_GRB2like	201	204	PF00017	0.371
LIG_SH2_PTP2	427	430	PF00017	0.318
LIG_SH2_STAT3	236	239	PF00017	0.454
LIG_SH2_STAT5	130	133	PF00017	0.302
LIG_SH2_STAT5	427	430	PF00017	0.231
LIG_SH3_3	377	383	PF00018	0.515
LIG_SUMO_SIM_anti_2	340	345	PF11976	0.285
LIG_SUMO_SIM_anti_2	391	397	PF11976	0.330
LIG_SUMO_SIM_par_1	172	178	PF11976	0.258
LIG_SUMO_SIM_par_1	205	210	PF11976	0.258
LIG_SUMO_SIM_par_1	306	312	PF11976	0.327
LIG_SUMO_SIM_par_1	364	370	PF11976	0.400
LIG_TRAF2_1	34	37	PF00917	0.518
LIG_TRAF2_1	415	418	PF00917	0.417
LIG_TRAF2_1	70	73	PF00917	0.355
LIG_UBA3_1	85	93	PF00899	0.302
MOD_CK1_1	16	22	PF00069	0.430
MOD_CK1_1	235	241	PF00069	0.449
MOD_CK1_1	51	57	PF00069	0.429
MOD_CK2_1	151	157	PF00069	0.264
MOD_CK2_1	306	312	PF00069	0.483
MOD_CK2_1	31	37	PF00069	0.508
MOD_CK2_1	397	403	PF00069	0.358
MOD_CK2_1	412	418	PF00069	0.333
MOD_GlcNHglycan	124	127	PF01048	0.272
MOD_GlcNHglycan	281	284	PF01048	0.307
MOD_GSK3_1	205	212	PF00069	0.265
MOD_GSK3_1	231	238	PF00069	0.453
MOD_GSK3_1	264	271	PF00069	0.466
MOD_GSK3_1	27	34	PF00069	0.616
MOD_GSK3_1	378	385	PF00069	0.413
MOD_GSK3_1	48	55	PF00069	0.448
MOD_GSK3_1	9	16	PF00069	0.420
MOD_NEK2_1	231	236	PF00069	0.364
MOD_NEK2_1	27	32	PF00069	0.648
MOD_NEK2_1	279	284	PF00069	0.301
MOD_NEK2_1	328	333	PF00069	0.334
MOD_NEK2_1	337	342	PF00069	0.294
MOD_NEK2_1	367	372	PF00069	0.345
MOD_NEK2_1	378	383	PF00069	0.382
MOD_NEK2_1	447	452	PF00069	0.483
MOD_NEK2_1	50	55	PF00069	0.400
MOD_NEK2_2	306	311	PF00069	0.384
MOD_PIKK_1	235	241	PF00454	0.449
MOD_PIKK_1	264	270	PF00454	0.457
MOD_PIKK_1	31	37	PF00454	0.508
MOD_PIKK_1	367	373	PF00454	0.450
MOD_PKA_1	31	37	PF00069	0.579
MOD_PKA_2	31	37	PF00069	0.539
MOD_PKB_1	29	37	PF00069	0.584
MOD_Plk_4	286	292	PF00069	0.331
MOD_Plk_4	312	318	PF00069	0.471
MOD_Plk_4	397	403	PF00069	0.458
MOD_Plk_4	9	15	PF00069	0.387
MOD_SUMO_rev_2	106	113	PF00179	0.361
MOD_SUMO_rev_2	212	221	PF00179	0.258
MOD_SUMO_rev_2	24	30	PF00179	0.554
TRG_DiLeu_BaEn_1	347	352	PF01217	0.407
TRG_DiLeu_BaEn_1	391	396	PF01217	0.440
TRG_DiLeu_BaEn_4	391	397	PF01217	0.441
TRG_DiLeu_BaLyEn_6	275	280	PF01217	0.322
TRG_DiLeu_BaLyEn_6	362	367	PF01217	0.469
TRG_ENDOCYTIC_2	11	14	PF00928	0.388
TRG_ENDOCYTIC_2	129	132	PF00928	0.258
TRG_ENDOCYTIC_2	273	276	PF00928	0.336
TRG_ENDOCYTIC_2	427	430	PF00928	0.298
TRG_ENDOCYTIC_2	434	437	PF00928	0.379
TRG_ENDOCYTIC_2	80	83	PF00928	0.254
TRG_ER_diArg_1	276	278	PF00400	0.348
TRG_ER_diArg_1	29	32	PF00400	0.537
TRG_ER_diArg_1	352	355	PF00400	0.448
TRG_NES_CRM1_1	391	403	PF08389	0.322
TRG_NLS_MonoExtC_3	27	32	PF00514	0.629
TRG_NLS_MonoExtN_4	25	32	PF00514	0.406
TRG_Pf-PMV_PEXEL_1	277	281	PF00026	0.332
TRG_Pf-PMV_PEXEL_1	41	45	PF00026	0.463
TRG_Pf-PMV_PEXEL_1	69	73	PF00026	0.424

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0M7	Leptomonas seymouri	81%	100%
A0A1X0NVQ9	Trypanosomatidae	54%	100%
A0A3S5H7I5	Leishmania donovani	87%	100%
A0A422NKR1	Trypanosoma rangeli	53%	100%
A4I376	Leishmania infantum	87%	100%
D0A7Q2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	100%
E9AZG4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4JAS8	Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)	23%	100%
Q4Q8R7	Leishmania major	88%	100%
Q8W032	Arabidopsis thaliana	23%	90%
Q975X3	Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)	24%	100%
Q980N4	Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)	24%	100%
V5D7Z4	Trypanosoma cruzi	54%	100%