LeishMANIAdb
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Lipoprotein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Lipoprotein
Gene product:
Present in the outer mitochondrial membrane proteome 15
Species:
Leishmania braziliensis
UniProt:
A4HG45_LEIBR
TriTrypDb:
LbrM.28.0030 , LBRM2903_280005500 *
Length:
105

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Cellular components
Term Name Level Count
GO:0005741 mitochondrial outer membrane 5 1
GO:0016020 membrane 2 1
GO:0019867 outer membrane 3 1
GO:0031090 organelle membrane 3 1
GO:0031966 mitochondrial membrane 4 1
GO:0031968 organelle outer membrane 4 1
GO:0098588 bounding membrane of organelle 4 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4HG45
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HG45

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 44 46 PF00675 0.425
CLV_NRD_NRD_1 92 94 PF00675 0.559
CLV_PCSK_KEX2_1 91 93 PF00082 0.562
CLV_PCSK_PC1ET2_1 91 93 PF00082 0.562
CLV_PCSK_SKI1_1 23 27 PF00082 0.493
CLV_PCSK_SKI1_1 45 49 PF00082 0.468
CLV_PCSK_SKI1_1 88 92 PF00082 0.503
CLV_PCSK_SKI1_1 93 97 PF00082 0.507
DEG_APCC_DBOX_1 92 100 PF00400 0.471
DOC_CYCLIN_RxL_1 68 78 PF00134 0.534
DOC_PP1_RVXF_1 69 76 PF00149 0.428
LIG_14-3-3_CanoR_1 92 96 PF00244 0.565
LIG_LIR_Nem_3 59 64 PF02991 0.529
LIG_Pex14_1 70 74 PF04695 0.394
LIG_PTB_Apo_2 55 62 PF02174 0.495
LIG_PTB_Phospho_1 55 61 PF10480 0.496
LIG_SH2_CRK 61 65 PF00017 0.495
LIG_SH2_SRC 29 32 PF00017 0.478
LIG_SH2_STAT5 29 32 PF00017 0.478
LIG_SH2_STAT5 74 77 PF00017 0.412
LIG_ULM_U2AF65_1 45 50 PF00076 0.383
MOD_CK1_1 82 88 PF00069 0.361
MOD_GlcNHglycan 58 61 PF01048 0.520
MOD_GSK3_1 79 86 PF00069 0.592
MOD_NMyristoyl 1 7 PF02799 0.405
MOD_PKA_1 91 97 PF00069 0.548
MOD_PKA_2 91 97 PF00069 0.635
MOD_SUMO_rev_2 72 82 PF00179 0.484
TRG_ENDOCYTIC_2 61 64 PF00928 0.658
TRG_NLS_MonoExtC_3 44 50 PF00514 0.375
TRG_NLS_MonoExtN_4 88 95 PF00514 0.550

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P725 Leptomonas seymouri 80% 79%
A0A0S4J1U2 Bodo saltans 51% 81%
A0A1X0NVA8 Trypanosomatidae 75% 80%
A0A3S7X152 Leishmania donovani 86% 79%
A4I375 Leishmania infantum 86% 79%
D0A7Q1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 70% 79%
E9AZG3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 90% 77%
Q4Q8R8 Leishmania major 88% 100%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS