HTH_Tnp_Tc3_2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania braziliensis

UniProt:

A4HG38_LEIBR

TriTrypDb:

LbrM.27.2790 , LBRM2903_020012700 , LBRM2903_020012800

Length:

514

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 2
NetGPI	no	yes: 0, no: 2

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HG38

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HG38

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	179	183	PF00656	0.567
CLV_C14_Caspase3-7	288	292	PF00656	0.553
CLV_C14_Caspase3-7	444	448	PF00656	0.485
CLV_C14_Caspase3-7	499	503	PF00656	0.572
CLV_C14_Caspase3-7	70	74	PF00656	0.556
CLV_NRD_NRD_1	118	120	PF00675	0.768
CLV_NRD_NRD_1	163	165	PF00675	0.634
CLV_NRD_NRD_1	172	174	PF00675	0.622
CLV_NRD_NRD_1	227	229	PF00675	0.695
CLV_NRD_NRD_1	272	274	PF00675	0.689
CLV_NRD_NRD_1	281	283	PF00675	0.641
CLV_NRD_NRD_1	451	453	PF00675	0.464
CLV_NRD_NRD_1	54	56	PF00675	0.591
CLV_NRD_NRD_1	63	65	PF00675	0.727
CLV_PCSK_FUR_1	161	165	PF00082	0.424
CLV_PCSK_FUR_1	170	174	PF00082	0.476
CLV_PCSK_FUR_1	270	274	PF00082	0.432
CLV_PCSK_FUR_1	279	283	PF00082	0.484
CLV_PCSK_FUR_1	52	56	PF00082	0.427
CLV_PCSK_FUR_1	61	65	PF00082	0.481
CLV_PCSK_KEX2_1	117	119	PF00082	0.775
CLV_PCSK_KEX2_1	163	165	PF00082	0.430
CLV_PCSK_KEX2_1	172	174	PF00082	0.472
CLV_PCSK_KEX2_1	226	228	PF00082	0.576
CLV_PCSK_KEX2_1	272	274	PF00082	0.697
CLV_PCSK_KEX2_1	281	283	PF00082	0.633
CLV_PCSK_KEX2_1	54	56	PF00082	0.433
CLV_PCSK_KEX2_1	63	65	PF00082	0.478
CLV_PCSK_PC7_1	114	120	PF00082	0.778
CLV_PCSK_PC7_1	159	165	PF00082	0.421
CLV_PCSK_PC7_1	223	229	PF00082	0.563
CLV_PCSK_PC7_1	268	274	PF00082	0.426
CLV_PCSK_PC7_1	50	56	PF00082	0.421
CLV_PCSK_SKI1_1	510	514	PF00082	0.571
DEG_Nend_UBRbox_2	1	3	PF02207	0.598
DEG_SPOP_SBC_1	504	508	PF00917	0.571
DOC_CKS1_1	302	307	PF01111	0.558
DOC_CKS1_1	329	334	PF01111	0.549
DOC_CKS1_1	356	361	PF01111	0.531
DOC_CKS1_1	383	388	PF01111	0.531
DOC_CKS1_1	410	415	PF01111	0.538
DOC_CKS1_1	465	470	PF01111	0.568
DOC_MAPK_gen_1	159	168	PF00069	0.425
DOC_MAPK_gen_1	268	277	PF00069	0.635
DOC_MAPK_gen_1	50	59	PF00069	0.427
DOC_SPAK_OSR1_1	157	161	PF12202	0.419
DOC_SPAK_OSR1_1	266	270	PF12202	0.419
DOC_SPAK_OSR1_1	48	52	PF12202	0.417
DOC_USP7_MATH_1	311	315	PF00917	0.704
DOC_USP7_MATH_1	338	342	PF00917	0.469
DOC_USP7_MATH_1	365	369	PF00917	0.483
DOC_USP7_MATH_1	392	396	PF00917	0.490
DOC_USP7_MATH_1	419	423	PF00917	0.488
DOC_USP7_MATH_1	474	478	PF00917	0.687
DOC_WW_Pin1_4	301	306	PF00397	0.561
DOC_WW_Pin1_4	328	333	PF00397	0.572
DOC_WW_Pin1_4	355	360	PF00397	0.537
DOC_WW_Pin1_4	382	387	PF00397	0.534
DOC_WW_Pin1_4	409	414	PF00397	0.544
DOC_WW_Pin1_4	464	469	PF00397	0.571
DOC_WW_Pin1_4	491	496	PF00397	0.581
DOC_WW_Pin1_4	6	11	PF00397	0.583
LIG_14-3-3_CanoR_1	148	158	PF00244	0.409
LIG_14-3-3_CanoR_1	257	267	PF00244	0.459
LIG_14-3-3_CanoR_1	39	49	PF00244	0.635
LIG_14-3-3_CanoR_1	505	512	PF00244	0.572
LIG_Actin_WH2_2	200	216	PF00022	0.549
LIG_Actin_WH2_2	91	107	PF00022	0.555
LIG_EH_1	438	442	PF12763	0.498
LIG_FHA_1	93	99	PF00498	0.551
LIG_FHA_2	193	199	PF00498	0.552
LIG_FHA_2	442	448	PF00498	0.486
LIG_FHA_2	497	503	PF00498	0.572
LIG_FHA_2	84	90	PF00498	0.560
LIG_LIR_Nem_3	169	174	PF02991	0.505
LIG_LIR_Nem_3	278	283	PF02991	0.564
LIG_LIR_Nem_3	436	441	PF02991	0.509
LIG_LIR_Nem_3	491	496	PF02991	0.692
LIG_LIR_Nem_3	60	65	PF02991	0.510
LIG_SH2_NCK_1	146	150	PF00017	0.435
LIG_SH2_NCK_1	255	259	PF00017	0.410
LIG_SH2_NCK_1	37	41	PF00017	0.411
LIG_SH3_1	100	106	PF00018	0.555
LIG_SH3_3	104	110	PF00018	0.530
LIG_SH3_3	204	210	PF00018	0.546
LIG_SH3_3	213	219	PF00018	0.523
LIG_SH3_3	315	321	PF00018	0.480
LIG_SH3_3	95	101	PF00018	0.551
MOD_CDK_SPxxK_3	6	13	PF00069	0.558
MOD_CK1_1	108	114	PF00069	0.731
MOD_CK1_1	217	223	PF00069	0.568
MOD_CK1_1	491	497	PF00069	0.578
MOD_CK2_1	149	155	PF00069	0.416
MOD_CK2_1	258	264	PF00069	0.393
MOD_CK2_1	40	46	PF00069	0.397
MOD_Cter_Amidation	115	118	PF01082	0.570
MOD_Cter_Amidation	224	227	PF01082	0.566
MOD_GlcNHglycan	107	110	PF01048	0.500
MOD_GlcNHglycan	151	154	PF01048	0.488
MOD_GlcNHglycan	204	207	PF01048	0.552
MOD_GlcNHglycan	216	219	PF01048	0.515
MOD_GlcNHglycan	260	263	PF01048	0.389
MOD_GlcNHglycan	42	45	PF01048	0.400
MOD_GlcNHglycan	95	98	PF01048	0.551
MOD_GSK3_1	129	136	PF00069	0.565
MOD_GSK3_1	178	185	PF00069	0.551
MOD_GSK3_1	192	199	PF00069	0.502
MOD_GSK3_1	2	9	PF00069	0.576
MOD_GSK3_1	20	27	PF00069	0.544
MOD_GSK3_1	238	245	PF00069	0.532
MOD_GSK3_1	287	294	PF00069	0.552
MOD_GSK3_1	69	76	PF00069	0.555
MOD_GSK3_1	83	90	PF00069	0.517
MOD_NEK2_1	441	446	PF00069	0.493
MOD_NEK2_1	496	501	PF00069	0.784
MOD_PKA_1	118	124	PF00069	0.550
MOD_PKA_1	227	233	PF00069	0.549
MOD_PKA_2	118	124	PF00069	0.799
MOD_PKA_2	133	139	PF00069	0.515
MOD_PKA_2	227	233	PF00069	0.549
MOD_PKA_2	24	30	PF00069	0.530
MOD_PKA_2	242	248	PF00069	0.448
MOD_PKA_2	504	510	PF00069	0.571
MOD_Plk_4	311	317	PF00069	0.601
MOD_Plk_4	338	344	PF00069	0.648
MOD_Plk_4	365	371	PF00069	0.482
MOD_Plk_4	392	398	PF00069	0.488
MOD_Plk_4	419	425	PF00069	0.516
MOD_Plk_4	474	480	PF00069	0.554
MOD_ProDKin_1	301	307	PF00069	0.559
MOD_ProDKin_1	328	334	PF00069	0.567
MOD_ProDKin_1	355	361	PF00069	0.533
MOD_ProDKin_1	382	388	PF00069	0.533
MOD_ProDKin_1	409	415	PF00069	0.540
MOD_ProDKin_1	464	470	PF00069	0.569
MOD_ProDKin_1	491	497	PF00069	0.578
MOD_ProDKin_1	6	12	PF00069	0.582
TRG_ER_diArg_1	117	119	PF00400	0.801
TRG_ER_diArg_1	158	161	PF00400	0.518
TRG_ER_diArg_1	171	173	PF00400	0.500
TRG_ER_diArg_1	226	228	PF00400	0.589
TRG_ER_diArg_1	267	270	PF00400	0.545
TRG_ER_diArg_1	280	282	PF00400	0.557
TRG_ER_diArg_1	49	52	PF00400	0.414
TRG_ER_diArg_1	62	64	PF00400	0.468
TRG_NLS_Bipartite_1	117	132	PF00514	0.554
TRG_NLS_Bipartite_1	226	241	PF00514	0.554
TRG_NLS_MonoExtC_3	127	133	PF00514	0.551
TRG_NLS_MonoExtC_3	18	24	PF00514	0.563
TRG_NLS_MonoExtC_3	236	242	PF00514	0.770
TRG_NLS_MonoExtN_4	17	23	PF00514	0.572
TRG_Pf-PMV_PEXEL_1	164	169	PF00026	0.440
TRG_Pf-PMV_PEXEL_1	273	278	PF00026	0.447
TRG_Pf-PMV_PEXEL_1	55	60	PF00026	0.446

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4H3G1	Leishmania braziliensis	91%	100%