Metallo-peptidase, Clan MA(E), Family M3

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

metallo-peptidase, Clan MA(E), Family M3

Species:

Leishmania braziliensis

UniProt:

A4HG37_LEIBR

TriTrypDb:

LbrM.27.2780 , LBRM2903_270035200

Length:

494

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 27

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 12

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HG37

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HG37

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	13
GO:0006807	nitrogen compound metabolic process	2	13
GO:0008152	metabolic process	1	13
GO:0019538	protein metabolic process	3	13
GO:0043170	macromolecule metabolic process	3	13
GO:0044238	primary metabolic process	2	13
GO:0071704	organic substance metabolic process	2	13
GO:1901564	organonitrogen compound metabolic process	3	13

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	13
GO:0004175	endopeptidase activity	4	13
GO:0004222	metalloendopeptidase activity	5	13
GO:0005488	binding	1	13
GO:0008233	peptidase activity	3	13
GO:0008237	metallopeptidase activity	4	13
GO:0016787	hydrolase activity	2	13
GO:0043167	ion binding	2	13
GO:0043169	cation binding	3	13
GO:0046872	metal ion binding	4	13
GO:0140096	catalytic activity, acting on a protein	2	13
GO:0004180	carboxypeptidase activity	5	5
GO:0008238	exopeptidase activity	4	5
GO:0008241	peptidyl-dipeptidase activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	168	170	PF00675	0.380
CLV_NRD_NRD_1	207	209	PF00675	0.378
CLV_NRD_NRD_1	261	263	PF00675	0.283
CLV_NRD_NRD_1	4	6	PF00675	0.522
CLV_NRD_NRD_1	477	479	PF00675	0.381
CLV_NRD_NRD_1	95	97	PF00675	0.420
CLV_PCSK_FUR_1	166	170	PF00082	0.315
CLV_PCSK_FUR_1	93	97	PF00082	0.272
CLV_PCSK_KEX2_1	168	170	PF00082	0.315
CLV_PCSK_KEX2_1	207	209	PF00082	0.376
CLV_PCSK_KEX2_1	244	246	PF00082	0.437
CLV_PCSK_KEX2_1	4	6	PF00082	0.406
CLV_PCSK_KEX2_1	95	97	PF00082	0.272
CLV_PCSK_PC1ET2_1	244	246	PF00082	0.437
CLV_PCSK_SKI1_1	191	195	PF00082	0.406
CLV_PCSK_SKI1_1	279	283	PF00082	0.336
CLV_PCSK_SKI1_1	318	322	PF00082	0.538
CLV_PCSK_SKI1_1	40	44	PF00082	0.509
CLV_PCSK_SKI1_1	483	487	PF00082	0.437
CLV_PCSK_SKI1_1	95	99	PF00082	0.416
DEG_APCC_DBOX_1	167	175	PF00400	0.315
DEG_Nend_UBRbox_2	1	3	PF02207	0.392
DOC_MAPK_gen_1	207	213	PF00069	0.376
DOC_MAPK_gen_1	244	252	PF00069	0.538
DOC_MAPK_gen_1	4	11	PF00069	0.522
DOC_MAPK_RevD_3	90	103	PF00069	0.425
DOC_USP7_UBL2_3	479	483	PF12436	0.538
LIG_14-3-3_CanoR_1	207	214	PF00244	0.376
LIG_14-3-3_CanoR_1	255	260	PF00244	0.474
LIG_14-3-3_CanoR_1	386	393	PF00244	0.456
LIG_14-3-3_CanoR_1	4	10	PF00244	0.411
LIG_14-3-3_CanoR_1	458	463	PF00244	0.283
LIG_14-3-3_CanoR_1	95	100	PF00244	0.389
LIG_Actin_WH2_2	82	97	PF00022	0.435
LIG_BRCT_BRCA1_1	408	412	PF00533	0.410
LIG_FHA_1	249	255	PF00498	0.435
LIG_FHA_1	369	375	PF00498	0.437
LIG_FHA_1	4	10	PF00498	0.525
LIG_FHA_1	80	86	PF00498	0.527
LIG_Integrin_RGD_1	76	78	PF01839	0.435
LIG_LIR_Gen_1	289	299	PF02991	0.381
LIG_LIR_Gen_1	319	327	PF02991	0.412
LIG_LIR_Gen_1	409	420	PF02991	0.341
LIG_LIR_Gen_1	428	433	PF02991	0.397
LIG_LIR_Nem_3	159	163	PF02991	0.385
LIG_LIR_Nem_3	289	295	PF02991	0.381
LIG_LIR_Nem_3	319	323	PF02991	0.469
LIG_LIR_Nem_3	329	334	PF02991	0.378
LIG_LIR_Nem_3	409	415	PF02991	0.365
LIG_LIR_Nem_3	422	427	PF02991	0.390
LIG_LIR_Nem_3	428	432	PF02991	0.398
LIG_MLH1_MIPbox_1	408	412	PF16413	0.429
LIG_Pex14_1	158	162	PF04695	0.372
LIG_PTB_Apo_2	302	309	PF02174	0.426
LIG_PTB_Phospho_1	302	308	PF10480	0.495
LIG_SH2_CRK	267	271	PF00017	0.527
LIG_SH2_CRK	308	312	PF00017	0.495
LIG_SH2_CRK	334	338	PF00017	0.538
LIG_SH2_NCK_1	239	243	PF00017	0.437
LIG_SH2_STAP1	163	167	PF00017	0.378
LIG_SH2_STAP1	334	338	PF00017	0.394
LIG_SH2_STAP1	341	345	PF00017	0.359
LIG_SH2_STAP1	420	424	PF00017	0.390
LIG_SH2_STAP1	472	476	PF00017	0.538
LIG_SH2_STAT5	182	185	PF00017	0.412
LIG_SH2_STAT5	379	382	PF00017	0.388
LIG_SH2_STAT5	411	414	PF00017	0.382
LIG_SH2_STAT5	425	428	PF00017	0.431
LIG_SH3_3	210	216	PF00018	0.378
LIG_Sin3_3	120	127	PF02671	0.437
LIG_SUMO_SIM_par_1	370	375	PF11976	0.283
LIG_SUMO_SIM_par_1	42	49	PF11976	0.518
LIG_TRAF2_1	387	390	PF00917	0.354
LIG_TRAF2_2	324	329	PF00917	0.251
LIG_TRFH_1	153	157	PF08558	0.432
LIG_TYR_ITIM	265	270	PF00017	0.527
LIG_TYR_ITIM	306	311	PF00017	0.423
LIG_UBA3_1	123	129	PF00899	0.356
LIG_WW_1	404	407	PF00397	0.378
LIG_WW_3	403	407	PF00397	0.378
MOD_CK1_1	309	315	PF00069	0.538
MOD_CK2_1	101	107	PF00069	0.387
MOD_CK2_1	18	24	PF00069	0.601
MOD_Cter_Amidation	100	103	PF01082	0.435
MOD_Cter_Amidation	242	245	PF01082	0.283
MOD_Cter_Amidation	260	263	PF01082	0.216
MOD_Cter_Amidation	476	479	PF01082	0.372
MOD_GlcNHglycan	118	121	PF01048	0.538
MOD_GlcNHglycan	311	314	PF01048	0.538
MOD_GlcNHglycan	408	411	PF01048	0.410
MOD_GlcNHglycan	443	446	PF01048	0.490
MOD_GSK3_1	307	314	PF00069	0.388
MOD_GSK3_1	441	448	PF00069	0.463
MOD_GSK3_1	458	465	PF00069	0.351
MOD_GSK3_1	79	86	PF00069	0.323
MOD_N-GLC_1	286	291	PF02516	0.315
MOD_N-GLC_1	46	51	PF02516	0.466
MOD_N-GLC_1	79	84	PF02516	0.376
MOD_NEK2_1	306	311	PF00069	0.393
MOD_NEK2_1	441	446	PF00069	0.315
MOD_NEK2_1	53	58	PF00069	0.390
MOD_PIKK_1	322	328	PF00454	0.378
MOD_PIKK_1	46	52	PF00454	0.474
MOD_PK_1	458	464	PF00069	0.283
MOD_PKA_1	95	101	PF00069	0.283
MOD_PKA_2	206	212	PF00069	0.378
MOD_PKA_2	3	9	PF00069	0.529
MOD_PKA_2	385	391	PF00069	0.456
MOD_PKA_2	59	65	PF00069	0.435
MOD_PKA_2	95	101	PF00069	0.387
MOD_PKB_1	456	464	PF00069	0.283
MOD_PKB_1	93	101	PF00069	0.283
MOD_Plk_1	286	292	PF00069	0.437
MOD_Plk_2-3	18	24	PF00069	0.516
MOD_Plk_2-3	217	223	PF00069	0.437
MOD_Plk_4	248	254	PF00069	0.538
MOD_Plk_4	255	261	PF00069	0.423
MOD_Plk_4	287	293	PF00069	0.404
MOD_Plk_4	5	11	PF00069	0.444
MOD_Plk_4	95	101	PF00069	0.283
MOD_SUMO_rev_2	173	181	PF00179	0.443
TRG_DiLeu_BaLyEn_6	49	54	PF01217	0.609
TRG_DiLeu_BaLyEn_6	62	67	PF01217	0.320
TRG_ENDOCYTIC_2	182	185	PF00928	0.437
TRG_ENDOCYTIC_2	267	270	PF00928	0.527
TRG_ENDOCYTIC_2	308	311	PF00928	0.397
TRG_ENDOCYTIC_2	334	337	PF00928	0.511
TRG_ENDOCYTIC_2	379	382	PF00928	0.437
TRG_ENDOCYTIC_2	472	475	PF00928	0.378
TRG_ER_diArg_1	166	169	PF00400	0.315
TRG_ER_diArg_1	455	458	PF00400	0.283
TRG_ER_diArg_1	57	60	PF00400	0.378
TRG_ER_diArg_1	63	66	PF00400	0.359
TRG_ER_diArg_1	92	95	PF00400	0.329
TRG_Pf-PMV_PEXEL_1	169	173	PF00026	0.315
TRG_Pf-PMV_PEXEL_1	431	436	PF00026	0.437

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HT30	Leptomonas seymouri	76%	73%
A0A0N1PBM8	Leptomonas seymouri	27%	72%
A0A0N1PDB7	Leptomonas seymouri	54%	73%
A0A0S4JRG5	Bodo saltans	26%	73%
A0A1X0NTS0	Trypanosomatidae	26%	72%
A0A3S5H4X4	Leishmania donovani	80%	100%
A0A3S5H518	Leishmania donovani	85%	73%
A0A3S7WZY5	Leishmania donovani	26%	72%
A0A422MUB5	Trypanosoma rangeli	25%	72%
A2VDQ5	Bos taurus	29%	70%
A4HF12	Leishmania braziliensis	28%	100%
A4HFS7	Leishmania braziliensis	99%	100%
A4HFS8	Leishmania braziliensis	99%	100%
A4HG35	Leishmania braziliensis	93%	100%
A4HRR9	Leishmania infantum	85%	73%
A4I291	Leishmania infantum	26%	72%
A6H611	Mus musculus	27%	69%
C9ZRP1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	66%
E9AC74	Leishmania major	82%	100%
E9ACE8	Leishmania major	85%	100%
E9AJN6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	73%
E9AYD6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	72%
F4HTQ1	Arabidopsis thaliana	24%	70%
F4KDA5	Arabidopsis thaliana	28%	70%
P24155	Rattus norvegicus	30%	72%
P24171	Escherichia coli (strain K12)	45%	73%
P25375	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	26%	69%
P27236	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	44%	73%
P27237	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	34%	73%
P27298	Escherichia coli (strain K12)	35%	73%
P42675	Oryctolagus cuniculus	30%	70%
P42676	Rattus norvegicus	30%	70%
P44573	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	31%	73%
P47788	Sus scrofa	32%	72%
P52888	Homo sapiens	30%	72%
Q01992	Rattus norvegicus	27%	70%
Q02038	Sus scrofa	30%	70%
Q1JPJ8	Bos taurus	32%	72%
Q4Q937	Leishmania major	26%	100%
Q54DD2	Dictyostelium discoideum	29%	73%
Q5R9V6	Pongo abelii	30%	70%
Q5RF14	Pongo abelii	25%	69%
Q8C1A5	Mus musculus	30%	72%
Q91YP2	Mus musculus	29%	70%
Q949P2	Arabidopsis thaliana	30%	70%
Q99797	Homo sapiens	25%	69%
Q9BYT8	Homo sapiens	30%	70%
V5B1A3	Trypanosoma cruzi	26%	100%