Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HG33_LEIBR

TriTrypDb:

LbrM.27.2740 , LBRM2903_270034600

Length:

928

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0005856	cytoskeleton	5	2
GO:0005930	axoneme	2	1
GO:0043226	organelle	2	3
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	3
GO:0005929	cilium	4	1
GO:0031514	motile cilium	5	1
GO:0042995	cell projection	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

A4HG33

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HG33

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	205	207	PF00675	0.523
CLV_NRD_NRD_1	258	260	PF00675	0.542
CLV_NRD_NRD_1	324	326	PF00675	0.476
CLV_NRD_NRD_1	345	347	PF00675	0.511
CLV_NRD_NRD_1	359	361	PF00675	0.467
CLV_NRD_NRD_1	590	592	PF00675	0.463
CLV_NRD_NRD_1	621	623	PF00675	0.497
CLV_NRD_NRD_1	625	627	PF00675	0.519
CLV_NRD_NRD_1	663	665	PF00675	0.320
CLV_NRD_NRD_1	764	766	PF00675	0.512
CLV_NRD_NRD_1	859	861	PF00675	0.610
CLV_NRD_NRD_1	86	88	PF00675	0.530
CLV_PCSK_KEX2_1	149	151	PF00082	0.528
CLV_PCSK_KEX2_1	205	207	PF00082	0.504
CLV_PCSK_KEX2_1	258	260	PF00082	0.505
CLV_PCSK_KEX2_1	324	326	PF00082	0.476
CLV_PCSK_KEX2_1	345	347	PF00082	0.485
CLV_PCSK_KEX2_1	359	361	PF00082	0.427
CLV_PCSK_KEX2_1	559	561	PF00082	0.493
CLV_PCSK_KEX2_1	590	592	PF00082	0.483
CLV_PCSK_KEX2_1	621	623	PF00082	0.495
CLV_PCSK_KEX2_1	625	627	PF00082	0.522
CLV_PCSK_KEX2_1	663	665	PF00082	0.320
CLV_PCSK_KEX2_1	764	766	PF00082	0.498
CLV_PCSK_KEX2_1	859	861	PF00082	0.613
CLV_PCSK_PC1ET2_1	149	151	PF00082	0.543
CLV_PCSK_PC1ET2_1	559	561	PF00082	0.556
CLV_PCSK_PC7_1	621	627	PF00082	0.346
CLV_PCSK_SKI1_1	102	106	PF00082	0.572
CLV_PCSK_SKI1_1	242	246	PF00082	0.577
CLV_PCSK_SKI1_1	346	350	PF00082	0.476
CLV_PCSK_SKI1_1	562	566	PF00082	0.519
CLV_PCSK_SKI1_1	610	614	PF00082	0.566
CLV_PCSK_SKI1_1	634	638	PF00082	0.432
CLV_PCSK_SKI1_1	639	643	PF00082	0.476
CLV_PCSK_SKI1_1	658	662	PF00082	0.330
CLV_PCSK_SKI1_1	704	708	PF00082	0.548
CLV_PCSK_SKI1_1	73	77	PF00082	0.442
CLV_PCSK_SKI1_1	896	900	PF00082	0.668
DEG_APCC_DBOX_1	839	847	PF00400	0.555
DEG_SPOP_SBC_1	897	901	PF00917	0.488
DOC_CKS1_1	871	876	PF01111	0.615
DOC_CYCLIN_RxL_1	70	80	PF00134	0.325
DOC_MAPK_gen_1	559	566	PF00069	0.531
DOC_MAPK_gen_1	576	585	PF00069	0.367
DOC_MAPK_gen_1	753	762	PF00069	0.570
DOC_MAPK_HePTP_8	573	585	PF00069	0.325
DOC_MAPK_MEF2A_6	576	585	PF00069	0.504
DOC_MAPK_MEF2A_6	699	707	PF00069	0.481
DOC_MAPK_RevD_3	749	765	PF00069	0.592
DOC_PP4_FxxP_1	3	6	PF00568	0.461
DOC_PP4_FxxP_1	891	894	PF00568	0.644
DOC_USP7_MATH_1	171	175	PF00917	0.630
DOC_USP7_MATH_1	339	343	PF00917	0.537
DOC_USP7_MATH_1	36	40	PF00917	0.593
DOC_USP7_MATH_1	774	778	PF00917	0.603
DOC_USP7_MATH_1	844	848	PF00917	0.350
DOC_WW_Pin1_4	2	7	PF00397	0.720
DOC_WW_Pin1_4	870	875	PF00397	0.740
DOC_WW_Pin1_4	879	884	PF00397	0.611
DOC_WW_Pin1_4	901	906	PF00397	0.573
LIG_14-3-3_CanoR_1	102	111	PF00244	0.575
LIG_14-3-3_CanoR_1	126	134	PF00244	0.613
LIG_14-3-3_CanoR_1	19	23	PF00244	0.475
LIG_14-3-3_CanoR_1	194	199	PF00244	0.602
LIG_14-3-3_CanoR_1	293	301	PF00244	0.443
LIG_14-3-3_CanoR_1	522	532	PF00244	0.507
LIG_14-3-3_CanoR_1	639	648	PF00244	0.525
LIG_14-3-3_CanoR_1	859	866	PF00244	0.524
LIG_14-3-3_CanoR_1	87	96	PF00244	0.552
LIG_14-3-3_CanoR_1	896	905	PF00244	0.722
LIG_Actin_WH2_2	127	144	PF00022	0.585
LIG_APCC_ABBA_1	734	739	PF00400	0.670
LIG_BIR_II_1	1	5	PF00653	0.667
LIG_BIR_III_4	271	275	PF00653	0.367
LIG_CaM_IQ_9	751	767	PF13499	0.588
LIG_Clathr_ClatBox_1	52	56	PF01394	0.459
LIG_FHA_1	542	548	PF00498	0.313
LIG_FHA_1	709	715	PF00498	0.528
LIG_FHA_1	745	751	PF00498	0.542
LIG_FHA_2	103	109	PF00498	0.507
LIG_FHA_2	22	28	PF00498	0.548
LIG_FHA_2	229	235	PF00498	0.447
LIG_FHA_2	453	459	PF00498	0.594
LIG_FHA_2	500	506	PF00498	0.553
LIG_LIR_Apic_2	2	6	PF02991	0.460
LIG_LIR_Gen_1	29	36	PF02991	0.482
LIG_LIR_Gen_1	45	55	PF02991	0.433
LIG_LIR_Gen_1	526	536	PF02991	0.532
LIG_LIR_Gen_1	680	687	PF02991	0.309
LIG_LIR_Nem_3	29	34	PF02991	0.455
LIG_LIR_Nem_3	295	301	PF02991	0.460
LIG_LIR_Nem_3	39	44	PF02991	0.470
LIG_LIR_Nem_3	45	51	PF02991	0.471
LIG_LIR_Nem_3	526	532	PF02991	0.527
LIG_LIR_Nem_3	67	71	PF02991	0.447
LIG_LIR_Nem_3	680	684	PF02991	0.314
LIG_NRBOX	702	708	PF00104	0.593
LIG_OCRL_FandH_1	831	843	PF00620	0.591
LIG_PCNA_yPIPBox_3	507	519	PF02747	0.481
LIG_REV1ctd_RIR_1	822	830	PF16727	0.583
LIG_SH2_CRK	298	302	PF00017	0.472
LIG_SH2_CRK	529	533	PF00017	0.472
LIG_SH2_CRK	681	685	PF00017	0.567
LIG_SH2_GRB2like	782	785	PF00017	0.368
LIG_SH2_SRC	48	51	PF00017	0.582
LIG_SH2_STAP1	44	48	PF00017	0.493
LIG_SH2_STAP1	497	501	PF00017	0.331
LIG_SH2_STAP1	525	529	PF00017	0.411
LIG_SH2_STAT3	44	47	PF00017	0.526
LIG_SH2_STAT3	497	500	PF00017	0.331
LIG_SH2_STAT3	669	672	PF00017	0.550
LIG_SH2_STAT5	347	350	PF00017	0.568
LIG_SH2_STAT5	460	463	PF00017	0.603
LIG_SH2_STAT5	525	528	PF00017	0.538
LIG_SH3_3	868	874	PF00018	0.781
LIG_SH3_3	889	895	PF00018	0.638
LIG_SUMO_SIM_anti_2	220	226	PF11976	0.362
LIG_SUMO_SIM_par_1	161	167	PF11976	0.568
LIG_TRAF2_1	166	169	PF00917	0.630
LIG_TRAF2_1	231	234	PF00917	0.503
LIG_TRAF2_1	311	314	PF00917	0.569
LIG_TRAF2_1	447	450	PF00917	0.595
LIG_TRAF2_1	455	458	PF00917	0.548
LIG_TYR_ITIM	679	684	PF00017	0.573
LIG_Vh1_VBS_1	85	103	PF01044	0.511
LIG_WRC_WIRS_1	693	698	PF05994	0.318
LIG_WW_3	893	897	PF00397	0.618
MOD_CDK_SPK_2	870	875	PF00069	0.762
MOD_CK1_1	2	8	PF00069	0.644
MOD_CK1_1	21	27	PF00069	0.559
MOD_CK1_1	212	218	PF00069	0.596
MOD_CK1_1	262	268	PF00069	0.353
MOD_CK1_1	552	558	PF00069	0.577
MOD_CK1_1	78	84	PF00069	0.533
MOD_CK2_1	102	108	PF00069	0.405
MOD_CK2_1	11	17	PF00069	0.588
MOD_CK2_1	119	125	PF00069	0.549
MOD_CK2_1	21	27	PF00069	0.612
MOD_CK2_1	226	232	PF00069	0.569
MOD_CK2_1	444	450	PF00069	0.623
MOD_CK2_1	452	458	PF00069	0.540
MOD_CK2_1	482	488	PF00069	0.520
MOD_CK2_1	499	505	PF00069	0.383
MOD_CK2_1	510	516	PF00069	0.510
MOD_CK2_1	552	558	PF00069	0.318
MOD_CK2_1	91	97	PF00069	0.409
MOD_DYRK1A_RPxSP_1	875	879	PF00069	0.650
MOD_GlcNHglycan	13	16	PF01048	0.659
MOD_GlcNHglycan	194	197	PF01048	0.363
MOD_GlcNHglycan	477	480	PF01048	0.333
MOD_GlcNHglycan	554	557	PF01048	0.317
MOD_GlcNHglycan	741	744	PF01048	0.679
MOD_GlcNHglycan	861	864	PF01048	0.633
MOD_GlcNHglycan	879	882	PF01048	0.605
MOD_GSK3_1	121	128	PF00069	0.574
MOD_GSK3_1	209	216	PF00069	0.617
MOD_GSK3_1	234	241	PF00069	0.355
MOD_GSK3_1	262	269	PF00069	0.534
MOD_GSK3_1	36	43	PF00069	0.446
MOD_GSK3_1	366	373	PF00069	0.524
MOD_GSK3_1	377	384	PF00069	0.552
MOD_GSK3_1	440	447	PF00069	0.706
MOD_GSK3_1	510	517	PF00069	0.463
MOD_GSK3_1	71	78	PF00069	0.464
MOD_GSK3_1	87	94	PF00069	0.485
MOD_GSK3_1	875	882	PF00069	0.650
MOD_GSK3_1	897	904	PF00069	0.660
MOD_LATS_1	119	125	PF00433	0.364
MOD_N-GLC_1	212	217	PF02516	0.349
MOD_N-GLC_1	708	713	PF02516	0.569
MOD_N-GLC_1	806	811	PF02516	0.375
MOD_NEK2_1	1	6	PF00069	0.704
MOD_NEK2_1	514	519	PF00069	0.502
MOD_NEK2_1	71	76	PF00069	0.454
MOD_NEK2_1	824	829	PF00069	0.492
MOD_NEK2_2	144	149	PF00069	0.368
MOD_NEK2_2	171	176	PF00069	0.706
MOD_NEK2_2	339	344	PF00069	0.463
MOD_PIKK_1	200	206	PF00454	0.537
MOD_PIKK_1	262	268	PF00454	0.540
MOD_PIKK_1	377	383	PF00454	0.649
MOD_PIKK_1	397	403	PF00454	0.405
MOD_PIKK_1	824	830	PF00454	0.602
MOD_PKA_1	859	865	PF00069	0.655
MOD_PKA_1	87	93	PF00069	0.506
MOD_PKA_2	113	119	PF00069	0.627
MOD_PKA_2	125	131	PF00069	0.518
MOD_PKA_2	18	24	PF00069	0.425
MOD_PKA_2	252	258	PF00069	0.507
MOD_PKA_2	292	298	PF00069	0.464
MOD_PKA_2	521	527	PF00069	0.501
MOD_PKA_2	858	864	PF00069	0.670
MOD_Plk_1	107	113	PF00069	0.540
MOD_Plk_1	219	225	PF00069	0.361
MOD_Plk_1	36	42	PF00069	0.422
MOD_Plk_1	562	568	PF00069	0.333
MOD_Plk_2-3	91	97	PF00069	0.591
MOD_Plk_4	18	24	PF00069	0.425
MOD_Plk_4	219	225	PF00069	0.402
MOD_Plk_4	234	240	PF00069	0.307
MOD_Plk_4	440	446	PF00069	0.756
MOD_Plk_4	510	516	PF00069	0.504
MOD_ProDKin_1	2	8	PF00069	0.723
MOD_ProDKin_1	870	876	PF00069	0.735
MOD_ProDKin_1	879	885	PF00069	0.609
MOD_ProDKin_1	901	907	PF00069	0.571
MOD_SUMO_for_1	120	123	PF00179	0.562
MOD_SUMO_for_1	382	385	PF00179	0.658
MOD_SUMO_for_1	406	409	PF00179	0.586
MOD_SUMO_rev_2	246	252	PF00179	0.553
MOD_SUMO_rev_2	485	492	PF00179	0.531
MOD_SUMO_rev_2	767	773	PF00179	0.443
TRG_DiLeu_BaEn_1	185	190	PF01217	0.526
TRG_DiLeu_BaEn_1	702	707	PF01217	0.537
TRG_DiLeu_BaEn_1	746	751	PF01217	0.632
TRG_DiLeu_BaLyEn_6	81	86	PF01217	0.453
TRG_DiLeu_BaLyEn_6	913	918	PF01217	0.507
TRG_ENDOCYTIC_2	298	301	PF00928	0.457
TRG_ENDOCYTIC_2	48	51	PF00928	0.570
TRG_ENDOCYTIC_2	529	532	PF00928	0.458
TRG_ENDOCYTIC_2	68	71	PF00928	0.434
TRG_ENDOCYTIC_2	681	684	PF00928	0.571
TRG_ENDOCYTIC_2	737	740	PF00928	0.696
TRG_ENDOCYTIC_2	888	891	PF00928	0.660
TRG_ER_diArg_1	205	207	PF00400	0.524
TRG_ER_diArg_1	258	260	PF00400	0.576
TRG_ER_diArg_1	345	347	PF00400	0.600
TRG_ER_diArg_1	662	664	PF00400	0.321
TRG_Pf-PMV_PEXEL_1	150	154	PF00026	0.437
TRG_Pf-PMV_PEXEL_1	176	180	PF00026	0.674
TRG_Pf-PMV_PEXEL_1	376	381	PF00026	0.427
TRG_Pf-PMV_PEXEL_1	712	717	PF00026	0.468
TRG_Pf-PMV_PEXEL_1	759	763	PF00026	0.526

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3J7	Leptomonas seymouri	24%	100%
A0A0N1HZ56	Leptomonas seymouri	63%	99%
A0A0N1I2V1	Leptomonas seymouri	25%	90%
A0A0S4JMK5	Bodo saltans	25%	100%
A0A0S4KGN1	Bodo saltans	33%	97%
A0A1X0NJT4	Trypanosomatidae	37%	100%
A0A381MLP4	Leishmania infantum	75%	99%
A0A3Q8IAS8	Leishmania donovani	76%	99%
A0A422NB26	Trypanosoma rangeli	35%	100%
A0A451EJK4	Leishmania donovani	75%	99%
A8HUA1	Chlamydomonas reinhardtii	27%	100%
B2RW38	Mus musculus	25%	100%
C9ZJ55	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	90%
E9ACE4	Leishmania major	77%	100%
E9ACX3	Leishmania major	77%	100%
E9AJN2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	99%
E9AJR6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	92%
V5D614	Trypanosoma cruzi	37%	99%