Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HG32_LEIBR

TriTrypDb:

LbrM.27.2730 , LBRM2903_270034500

Length:

440

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HG32

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HG32

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	56	60	PF00656	0.563
CLV_NRD_NRD_1	157	159	PF00675	0.613
CLV_NRD_NRD_1	197	199	PF00675	0.723
CLV_NRD_NRD_1	377	379	PF00675	0.569
CLV_NRD_NRD_1	77	79	PF00675	0.758
CLV_PCSK_KEX2_1	156	158	PF00082	0.581
CLV_PCSK_KEX2_1	197	199	PF00082	0.764
CLV_PCSK_KEX2_1	22	24	PF00082	0.656
CLV_PCSK_KEX2_1	377	379	PF00082	0.569
CLV_PCSK_KEX2_1	422	424	PF00082	0.375
CLV_PCSK_KEX2_1	77	79	PF00082	0.758
CLV_PCSK_PC1ET2_1	156	158	PF00082	0.637
CLV_PCSK_PC1ET2_1	22	24	PF00082	0.695
CLV_PCSK_PC1ET2_1	422	424	PF00082	0.375
CLV_PCSK_SKI1_1	128	132	PF00082	0.492
CLV_PCSK_SKI1_1	291	295	PF00082	0.451
CLV_PCSK_SKI1_1	378	382	PF00082	0.588
CLV_PCSK_SKI1_1	67	71	PF00082	0.508
DEG_Nend_UBRbox_3	1	3	PF02207	0.847
DEG_SPOP_SBC_1	10	14	PF00917	0.775
DEG_SPOP_SBC_1	179	183	PF00917	0.707
DEG_SPOP_SBC_1	274	278	PF00917	0.638
DEG_SPOP_SBC_1	80	84	PF00917	0.740
DOC_MAPK_gen_1	313	320	PF00069	0.477
DOC_MAPK_gen_1	422	429	PF00069	0.596
DOC_MAPK_MEF2A_6	128	135	PF00069	0.359
DOC_MAPK_MEF2A_6	404	411	PF00069	0.508
DOC_MAPK_NFAT4_5	404	412	PF00069	0.551
DOC_PP4_FxxP_1	37	40	PF00568	0.503
DOC_USP7_MATH_1	113	117	PF00917	0.737
DOC_USP7_MATH_1	240	244	PF00917	0.544
DOC_USP7_MATH_1	27	31	PF00917	0.681
DOC_USP7_MATH_1	273	277	PF00917	0.579
DOC_USP7_MATH_1	81	85	PF00917	0.624
DOC_USP7_MATH_1	9	13	PF00917	0.554
DOC_WW_Pin1_4	14	19	PF00397	0.706
DOC_WW_Pin1_4	68	73	PF00397	0.628
LIG_14-3-3_CanoR_1	128	134	PF00244	0.419
LIG_ActinCP_TwfCPI_2	37	46	PF01115	0.511
LIG_FHA_2	134	140	PF00498	0.502
LIG_FHA_2	202	208	PF00498	0.718
LIG_LIR_Apic_2	34	40	PF02991	0.492
LIG_NRBOX	406	412	PF00104	0.485
LIG_PCNA_yPIPBox_3	313	324	PF02747	0.597
LIG_Rb_pABgroove_1	31	39	PF01858	0.687
LIG_SH2_STAP1	269	273	PF00017	0.601
LIG_SH2_STAT5	168	171	PF00017	0.497
LIG_SH3_3	107	113	PF00018	0.626
LIG_SH3_3	37	43	PF00018	0.506
LIG_SUMO_SIM_anti_2	180	188	PF11976	0.532
LIG_SUMO_SIM_anti_2	406	413	PF11976	0.451
LIG_SUMO_SIM_par_1	129	134	PF11976	0.349
LIG_TRAF2_1	380	383	PF00917	0.585
MOD_CK1_1	124	130	PF00069	0.496
MOD_CK1_1	17	23	PF00069	0.635
MOD_CK1_1	175	181	PF00069	0.768
MOD_CK1_1	276	282	PF00069	0.664
MOD_CK1_1	306	312	PF00069	0.523
MOD_CK1_1	329	335	PF00069	0.520
MOD_CK1_1	434	440	PF00069	0.655
MOD_CK1_1	95	101	PF00069	0.673
MOD_CK2_1	133	139	PF00069	0.424
MOD_CK2_1	201	207	PF00069	0.548
MOD_CK2_1	434	440	PF00069	0.606
MOD_CK2_1	9	15	PF00069	0.555
MOD_GlcNHglycan	105	108	PF01048	0.672
MOD_GlcNHglycan	136	139	PF01048	0.541
MOD_GlcNHglycan	170	173	PF01048	0.739
MOD_GlcNHglycan	177	180	PF01048	0.652
MOD_GlcNHglycan	263	266	PF01048	0.507
MOD_GlcNHglycan	285	288	PF01048	0.525
MOD_GlcNHglycan	29	32	PF01048	0.701
MOD_GlcNHglycan	305	308	PF01048	0.264
MOD_GlcNHglycan	328	331	PF01048	0.389
MOD_GlcNHglycan	396	399	PF01048	0.440
MOD_GlcNHglycan	40	43	PF01048	0.731
MOD_GlcNHglycan	83	86	PF01048	0.703
MOD_GSK3_1	10	17	PF00069	0.802
MOD_GSK3_1	129	136	PF00069	0.552
MOD_GSK3_1	168	175	PF00069	0.706
MOD_GSK3_1	178	185	PF00069	0.591
MOD_GSK3_1	221	228	PF00069	0.595
MOD_GSK3_1	27	34	PF00069	0.665
MOD_GSK3_1	81	88	PF00069	0.653
MOD_GSK3_1	92	99	PF00069	0.630
MOD_N-GLC_1	326	331	PF02516	0.569
MOD_N-GLC_2	115	117	PF02516	0.492
MOD_NEK2_1	261	266	PF00069	0.483
MOD_NEK2_1	293	298	PF00069	0.488
MOD_NEK2_1	308	313	PF00069	0.495
MOD_NEK2_2	417	422	PF00069	0.437
MOD_PIKK_1	191	197	PF00454	0.639
MOD_PIKK_1	355	361	PF00454	0.504
MOD_PK_1	423	429	PF00069	0.569
MOD_PKA_2	348	354	PF00069	0.575
MOD_PKA_2	38	44	PF00069	0.607
MOD_Plk_1	179	185	PF00069	0.527
MOD_Plk_1	225	231	PF00069	0.557
MOD_Plk_1	423	429	PF00069	0.598
MOD_Plk_2-3	201	207	PF00069	0.457
MOD_Plk_2-3	221	227	PF00069	0.581
MOD_Plk_4	182	188	PF00069	0.534
MOD_Plk_4	32	38	PF00069	0.526
MOD_Plk_4	423	429	PF00069	0.560
MOD_Plk_4	70	76	PF00069	0.723
MOD_ProDKin_1	14	20	PF00069	0.702
MOD_ProDKin_1	68	74	PF00069	0.629
MOD_SUMO_for_1	403	406	PF00179	0.534
MOD_SUMO_rev_2	286	296	PF00179	0.462
TRG_DiLeu_BaEn_1	406	411	PF01217	0.442
TRG_ER_diArg_1	157	159	PF00400	0.620
TRG_ER_diArg_1	197	199	PF00400	0.708
TRG_ER_diArg_1	4	7	PF00400	0.747
TRG_ER_diArg_1	77	79	PF00400	0.758
TRG_Pf-PMV_PEXEL_1	142	146	PF00026	0.518
TRG_Pf-PMV_PEXEL_1	392	396	PF00026	0.531

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAB8	Leptomonas seymouri	52%	75%
A0A1X0NJU7	Trypanosomatidae	30%	100%
A0A3S5H515	Leishmania donovani	73%	97%
A0A3S7X120	Leishmania donovani	74%	97%
A0A422NAX6	Trypanosoma rangeli	30%	100%
C9ZJ54	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9ACE3	Leishmania major	72%	100%
E9ACX2	Leishmania major	79%	100%
E9AG19	Leishmania infantum	74%	97%
E9AG20	Leishmania infantum	74%	97%
E9AJN1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	70%	97%
V5BA51	Trypanosoma cruzi	31%	100%