DNA-directed RNA polymerase III subunit RPC3

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HG31_LEIBR

TriTrypDb:

LbrM.27.2720 , LBRM2903_020012600

Length:

602

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0000428	DNA-directed RNA polymerase complex	4	10
GO:0005666	RNA polymerase III complex	4	10
GO:0030880	RNA polymerase complex	3	10
GO:0032991	protein-containing complex	1	10
GO:0055029	nuclear DNA-directed RNA polymerase complex	3	10
GO:0061695	transferase complex, transferring phosphorus-containing groups	4	10
GO:0140513	nuclear protein-containing complex	2	10
GO:0140535	intracellular protein-containing complex	2	10
GO:1902494	catalytic complex	2	10
GO:1990234	transferase complex	3	10

Expansion

Sequence features

A4HG31

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HG31

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	10
GO:0003677	DNA binding	4	10
GO:0003697	single-stranded DNA binding	5	10
GO:0005488	binding	1	10
GO:0097159	organic cyclic compound binding	2	10
GO:1901363	heterocyclic compound binding	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	61	65	PF00656	0.551
CLV_NRD_NRD_1	299	301	PF00675	0.508
CLV_NRD_NRD_1	328	330	PF00675	0.660
CLV_NRD_NRD_1	351	353	PF00675	0.346
CLV_PCSK_KEX2_1	298	300	PF00082	0.499
CLV_PCSK_KEX2_1	328	330	PF00082	0.681
CLV_PCSK_KEX2_1	351	353	PF00082	0.346
CLV_PCSK_PC7_1	295	301	PF00082	0.567
CLV_PCSK_SKI1_1	155	159	PF00082	0.361
CLV_PCSK_SKI1_1	174	178	PF00082	0.371
CLV_PCSK_SKI1_1	288	292	PF00082	0.564
CLV_PCSK_SKI1_1	390	394	PF00082	0.612
CLV_PCSK_SKI1_1	436	440	PF00082	0.390
CLV_PCSK_SKI1_1	461	465	PF00082	0.385
CLV_PCSK_SKI1_1	466	470	PF00082	0.406
CLV_PCSK_SKI1_1	487	491	PF00082	0.549
CLV_PCSK_SKI1_1	49	53	PF00082	0.384
CLV_PCSK_SKI1_1	511	515	PF00082	0.432
CLV_PCSK_SKI1_1	580	584	PF00082	0.510
CLV_PCSK_SKI1_1	594	598	PF00082	0.360
CLV_Separin_Metazoa	477	481	PF03568	0.565
DEG_APCC_DBOX_1	287	295	PF00400	0.573
DEG_APCC_DBOX_1	350	358	PF00400	0.326
DEG_APCC_DBOX_1	460	468	PF00400	0.385
DEG_SCF_FBW7_1	196	203	PF00400	0.585
DOC_CDC14_PxL_1	220	228	PF14671	0.397
DOC_CKS1_1	372	377	PF01111	0.516
DOC_CYCLIN_RxL_1	591	600	PF00134	0.508
DOC_CYCLIN_yCln2_LP_2	357	363	PF00134	0.580
DOC_MAPK_gen_1	487	495	PF00069	0.424
DOC_MAPK_gen_1	509	518	PF00069	0.467
DOC_MAPK_MEF2A_6	147	156	PF00069	0.438
DOC_MAPK_MEF2A_6	189	196	PF00069	0.495
DOC_MAPK_MEF2A_6	426	434	PF00069	0.394
DOC_MAPK_MEF2A_6	594	601	PF00069	0.484
DOC_PP1_RVXF_1	153	159	PF00149	0.474
DOC_USP7_MATH_1	310	314	PF00917	0.608
DOC_USP7_MATH_1	376	380	PF00917	0.745
DOC_USP7_MATH_1	450	454	PF00917	0.524
DOC_USP7_MATH_1	479	483	PF00917	0.600
DOC_USP7_MATH_1	489	493	PF00917	0.421
DOC_USP7_MATH_1	544	548	PF00917	0.688
DOC_WW_Pin1_4	196	201	PF00397	0.567
DOC_WW_Pin1_4	232	237	PF00397	0.615
DOC_WW_Pin1_4	371	376	PF00397	0.705
DOC_WW_Pin1_4	377	382	PF00397	0.761
DOC_WW_Pin1_4	540	545	PF00397	0.679
LIG_14-3-3_CanoR_1	133	139	PF00244	0.309
LIG_14-3-3_CanoR_1	288	294	PF00244	0.568
LIG_14-3-3_CanoR_1	298	303	PF00244	0.542
LIG_14-3-3_CanoR_1	49	57	PF00244	0.363
LIG_14-3-3_CanoR_1	5	13	PF00244	0.679
LIG_14-3-3_CanoR_1	511	517	PF00244	0.440
LIG_Actin_WH2_2	44	62	PF00022	0.533
LIG_AP2alpha_1	468	472	PF02296	0.527
LIG_BRCT_BRCA1_1	379	383	PF00533	0.758
LIG_Clathr_ClatBox_1	596	600	PF01394	0.473
LIG_EH1_1	208	216	PF00400	0.453
LIG_eIF4E_1	148	154	PF01652	0.512
LIG_eIF4E_1	209	215	PF01652	0.285
LIG_FHA_1	125	131	PF00498	0.442
LIG_FHA_1	135	141	PF00498	0.474
LIG_FHA_1	197	203	PF00498	0.503
LIG_FHA_1	233	239	PF00498	0.661
LIG_FHA_1	306	312	PF00498	0.640
LIG_FHA_1	322	328	PF00498	0.426
LIG_FHA_1	337	343	PF00498	0.731
LIG_FHA_1	35	41	PF00498	0.536
LIG_FHA_1	387	393	PF00498	0.685
LIG_FHA_1	479	485	PF00498	0.610
LIG_FHA_1	513	519	PF00498	0.442
LIG_FHA_1	88	94	PF00498	0.672
LIG_FHA_2	33	39	PF00498	0.460
LIG_FHA_2	446	452	PF00498	0.514
LIG_GBD_Chelix_1	289	297	PF00786	0.496
LIG_LIR_Apic_2	216	222	PF02991	0.525
LIG_LIR_Gen_1	208	215	PF02991	0.530
LIG_LIR_Gen_1	313	322	PF02991	0.581
LIG_LIR_Gen_1	380	391	PF02991	0.743
LIG_LIR_Gen_1	517	526	PF02991	0.509
LIG_LIR_LC3C_4	127	131	PF02991	0.552
LIG_LIR_Nem_3	208	212	PF02991	0.525
LIG_LIR_Nem_3	313	317	PF02991	0.516
LIG_LIR_Nem_3	425	430	PF02991	0.497
LIG_LIR_Nem_3	517	523	PF02991	0.508
LIG_NRBOX	591	597	PF00104	0.482
LIG_PCNA_PIPBox_1	265	274	PF02747	0.289
LIG_PCNA_yPIPBox_3	258	272	PF02747	0.288
LIG_PCNA_yPIPBox_3	580	593	PF02747	0.538
LIG_PDZ_Class_3	597	602	PF00595	0.491
LIG_Pex14_2	468	472	PF04695	0.527
LIG_SH2_CRK	209	213	PF00017	0.533
LIG_SH2_CRK	29	33	PF00017	0.290
LIG_SH2_CRK	427	431	PF00017	0.487
LIG_SH2_SRC	284	287	PF00017	0.619
LIG_SH2_STAP1	144	148	PF00017	0.438
LIG_SH2_STAP1	307	311	PF00017	0.644
LIG_SH2_STAT5	307	310	PF00017	0.684
LIG_SH2_STAT5	457	460	PF00017	0.534
LIG_SH2_STAT5	494	497	PF00017	0.490
LIG_SH3_3	153	159	PF00018	0.474
LIG_SH3_3	18	24	PF00018	0.420
LIG_SH3_3	182	188	PF00018	0.528
LIG_SH3_3	218	224	PF00018	0.506
LIG_SH3_3	369	375	PF00018	0.640
LIG_SH3_3	530	536	PF00018	0.528
LIG_Sin3_3	158	165	PF02671	0.506
LIG_SUMO_SIM_par_1	594	600	PF11976	0.356
LIG_TRAF2_1	313	316	PF00917	0.589
LIG_TYR_ITIM	207	212	PF00017	0.526
LIG_WRC_WIRS_1	311	316	PF05994	0.610
LIG_WW_3	186	190	PF00397	0.540
MOD_CDK_SPxxK_3	232	239	PF00069	0.519
MOD_CK1_1	305	311	PF00069	0.681
MOD_CK1_1	34	40	PF00069	0.467
MOD_CK1_1	341	347	PF00069	0.427
MOD_CK1_1	453	459	PF00069	0.534
MOD_CK1_1	566	572	PF00069	0.615
MOD_CK2_1	310	316	PF00069	0.584
MOD_CK2_1	445	451	PF00069	0.512
MOD_GlcNHglycan	149	152	PF01048	0.486
MOD_GlcNHglycan	254	257	PF01048	0.432
MOD_GlcNHglycan	330	334	PF01048	0.656
MOD_GlcNHglycan	343	346	PF01048	0.574
MOD_GlcNHglycan	481	484	PF01048	0.665
MOD_GlcNHglycan	486	490	PF01048	0.594
MOD_GlcNHglycan	500	503	PF01048	0.495
MOD_GlcNHglycan	53	56	PF01048	0.599
MOD_GlcNHglycan	530	533	PF01048	0.606
MOD_GlcNHglycan	546	549	PF01048	0.545
MOD_GlcNHglycan	552	555	PF01048	0.599
MOD_GlcNHglycan	565	568	PF01048	0.508
MOD_GlcNHglycan	83	86	PF01048	0.588
MOD_GSK3_1	134	141	PF00069	0.364
MOD_GSK3_1	194	201	PF00069	0.556
MOD_GSK3_1	298	305	PF00069	0.471
MOD_GSK3_1	336	343	PF00069	0.663
MOD_GSK3_1	377	384	PF00069	0.713
MOD_GSK3_1	4	11	PF00069	0.554
MOD_GSK3_1	485	492	PF00069	0.537
MOD_GSK3_1	496	503	PF00069	0.460
MOD_GSK3_1	51	58	PF00069	0.468
MOD_GSK3_1	540	547	PF00069	0.626
MOD_GSK3_1	580	587	PF00069	0.487
MOD_GSK3_1	83	90	PF00069	0.650
MOD_N-GLC_1	381	386	PF02516	0.516
MOD_NEK2_1	289	294	PF00069	0.528
MOD_NEK2_1	31	36	PF00069	0.376
MOD_NEK2_1	498	503	PF00069	0.497
MOD_NEK2_1	51	56	PF00069	0.249
MOD_NEK2_1	512	517	PF00069	0.320
MOD_NEK2_1	568	573	PF00069	0.544
MOD_NEK2_1	99	104	PF00069	0.581
MOD_NEK2_2	489	494	PF00069	0.417
MOD_PIKK_1	49	55	PF00454	0.318
MOD_PIKK_1	575	581	PF00454	0.467
MOD_PKA_1	298	304	PF00069	0.553
MOD_PKA_2	11	17	PF00069	0.497
MOD_PKA_2	298	304	PF00069	0.553
MOD_PKA_2	4	10	PF00069	0.538
MOD_PKA_2	479	485	PF00069	0.639
MOD_PKA_2	81	87	PF00069	0.664
MOD_Plk_1	381	387	PF00069	0.517
MOD_Plk_1	406	412	PF00069	0.322
MOD_Plk_1	445	451	PF00069	0.512
MOD_Plk_2-3	109	115	PF00069	0.606
MOD_Plk_2-3	445	451	PF00069	0.512
MOD_Plk_4	289	295	PF00069	0.535
MOD_Plk_4	453	459	PF00069	0.560
MOD_Plk_4	489	495	PF00069	0.395
MOD_Plk_4	500	506	PF00069	0.385
MOD_Plk_4	588	594	PF00069	0.432
MOD_ProDKin_1	196	202	PF00069	0.559
MOD_ProDKin_1	232	238	PF00069	0.615
MOD_ProDKin_1	371	377	PF00069	0.709
MOD_ProDKin_1	540	546	PF00069	0.679
TRG_DiLeu_BaEn_1	216	221	PF01217	0.481
TRG_DiLeu_BaLyEn_6	156	161	PF01217	0.432
TRG_DiLeu_BaLyEn_6	433	438	PF01217	0.400
TRG_DiLeu_BaLyEn_6	591	596	PF01217	0.484
TRG_ENDOCYTIC_2	209	212	PF00928	0.526
TRG_ENDOCYTIC_2	29	32	PF00928	0.414
TRG_ENDOCYTIC_2	427	430	PF00928	0.495
TRG_ER_diArg_1	166	169	PF00400	0.345
TRG_ER_diArg_1	297	300	PF00400	0.481
TRG_ER_diArg_1	327	329	PF00400	0.659
TRG_ER_diArg_1	350	352	PF00400	0.350
TRG_NES_CRM1_1	462	477	PF08389	0.540
TRG_Pf-PMV_PEXEL_1	436	440	PF00026	0.409
TRG_Pf-PMV_PEXEL_1	447	451	PF00026	0.388
TRG_Pf-PMV_PEXEL_1	49	53	PF00026	0.531
TRG_Pf-PMV_PEXEL_1	570	574	PF00026	0.610

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HS15	Leptomonas seymouri	65%	100%
A0A1X0NK92	Trypanosomatidae	31%	100%
A0A3R7KAG0	Trypanosoma rangeli	32%	100%
A0A3S7X119	Leishmania donovani	84%	100%
C9ZJ53	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9ACX1	Leishmania major	84%	100%
E9AZG1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
V5BEQ8	Trypanosoma cruzi	33%	100%