Tubulin-tyrosine ligase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

tubulin-tyrosine ligase-like protein

Species:

Leishmania braziliensis

UniProt:

A4HG29_LEIBR

TriTrypDb:

LbrM.27.2700 , LBRM2903_270034200

Length:

508

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005874	microtubule	6	1
GO:0005876	spindle microtubule	7	1
GO:0099080	supramolecular complex	2	1
GO:0099081	supramolecular polymer	3	1
GO:0099512	supramolecular fiber	4	1
GO:0099513	polymeric cytoskeletal fiber	5	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HG29

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HG29

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	10
GO:0008152	metabolic process	1	10
GO:0019538	protein metabolic process	3	10
GO:0036211	protein modification process	4	10
GO:0043170	macromolecule metabolic process	3	10
GO:0043412	macromolecule modification	4	10
GO:0044238	primary metabolic process	2	10
GO:0071704	organic substance metabolic process	2	10
GO:1901564	organonitrogen compound metabolic process	3	10
GO:0000226	microtubule cytoskeleton organization	3	1
GO:0006996	organelle organization	4	1
GO:0007010	cytoskeleton organization	5	1
GO:0007017	microtubule-based process	2	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0071840	cellular component organization or biogenesis	2	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0016874	ligase activity	2	10
GO:0004835	tubulin-tyrosine ligase activity	3	2
GO:0016879	ligase activity, forming carbon-nitrogen bonds	3	2
GO:0016881	acid-amino acid ligase activity	4	2
GO:0140096	catalytic activity, acting on a protein	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	124	130	PF00089	0.288
CLV_NRD_NRD_1	181	183	PF00675	0.292
CLV_NRD_NRD_1	249	251	PF00675	0.273
CLV_NRD_NRD_1	92	94	PF00675	0.515
CLV_PCSK_FUR_1	92	96	PF00082	0.313
CLV_PCSK_KEX2_1	176	178	PF00082	0.243
CLV_PCSK_KEX2_1	181	183	PF00082	0.270
CLV_PCSK_KEX2_1	92	94	PF00082	0.522
CLV_PCSK_PC1ET2_1	176	178	PF00082	0.211
CLV_PCSK_PC1ET2_1	94	96	PF00082	0.419
CLV_PCSK_PC7_1	177	183	PF00082	0.176
CLV_PCSK_SKI1_1	121	125	PF00082	0.489
CLV_PCSK_SKI1_1	181	185	PF00082	0.245
CLV_PCSK_SKI1_1	210	214	PF00082	0.327
CLV_PCSK_SKI1_1	242	246	PF00082	0.275
CLV_PCSK_SKI1_1	26	30	PF00082	0.339
CLV_PCSK_SKI1_1	33	37	PF00082	0.333
CLV_PCSK_SKI1_1	342	346	PF00082	0.291
CLV_PCSK_SKI1_1	347	351	PF00082	0.279
CLV_PCSK_SKI1_1	406	410	PF00082	0.454
DEG_APCC_DBOX_1	181	189	PF00400	0.526
DEG_APCC_DBOX_1	32	40	PF00400	0.307
DEG_APCC_DBOX_1	346	354	PF00400	0.487
DEG_SPOP_SBC_1	417	421	PF00917	0.495
DOC_CYCLIN_yClb3_PxF_3	4	10	PF00134	0.411
DOC_CYCLIN_yCln2_LP_2	260	266	PF00134	0.455
DOC_MAPK_gen_1	250	256	PF00069	0.458
DOC_PP4_FxxP_1	110	113	PF00568	0.383
DOC_SPAK_OSR1_1	109	113	PF12202	0.377
DOC_USP7_MATH_1	123	127	PF00917	0.467
DOC_USP7_MATH_1	413	417	PF00917	0.648
DOC_USP7_MATH_1	65	69	PF00917	0.500
DOC_WW_Pin1_4	17	22	PF00397	0.400
DOC_WW_Pin1_4	259	264	PF00397	0.473
DOC_WW_Pin1_4	387	392	PF00397	0.455
DOC_WW_Pin1_4	4	9	PF00397	0.422
DOC_WW_Pin1_4	445	450	PF00397	0.771
DOC_WW_Pin1_4	452	457	PF00397	0.765
DOC_WW_Pin1_4	55	60	PF00397	0.644
LIG_14-3-3_CanoR_1	142	146	PF00244	0.479
LIG_14-3-3_CanoR_1	215	223	PF00244	0.556
LIG_14-3-3_CanoR_1	275	280	PF00244	0.455
LIG_14-3-3_CanoR_1	464	472	PF00244	0.698
LIG_APCC_ABBA_1	76	81	PF00400	0.361
LIG_BIR_III_2	410	414	PF00653	0.413
LIG_BIR_III_2	494	498	PF00653	0.501
LIG_BRCT_BRCA1_1	124	128	PF00533	0.500
LIG_BRCT_BRCA1_1	6	10	PF00533	0.428
LIG_BRCT_BRCA1_1	72	76	PF00533	0.494
LIG_CSL_BTD_1	162	165	PF09270	0.473
LIG_CSL_BTD_1	314	317	PF09270	0.496
LIG_deltaCOP1_diTrp_1	157	163	PF00928	0.502
LIG_eIF4E_1	239	245	PF01652	0.455
LIG_eIF4E_1	364	370	PF01652	0.473
LIG_FHA_1	129	135	PF00498	0.450
LIG_FHA_1	230	236	PF00498	0.449
LIG_FHA_1	274	280	PF00498	0.434
LIG_FHA_1	30	36	PF00498	0.330
LIG_FHA_1	333	339	PF00498	0.511
LIG_FHA_1	418	424	PF00498	0.703
LIG_FHA_1	460	466	PF00498	0.545
LIG_FHA_1	73	79	PF00498	0.417
LIG_FHA_2	427	433	PF00498	0.730
LIG_GBD_Chelix_1	345	353	PF00786	0.344
LIG_IRF3_LxIS_1	223	229	PF10401	0.376
LIG_LIR_Apic_2	108	113	PF02991	0.371
LIG_LIR_Gen_1	483	492	PF02991	0.274
LIG_LIR_Gen_1	77	86	PF02991	0.341
LIG_LIR_Nem_3	131	136	PF02991	0.343
LIG_LIR_Nem_3	262	267	PF02991	0.456
LIG_LIR_Nem_3	303	308	PF02991	0.400
LIG_LIR_Nem_3	362	367	PF02991	0.447
LIG_LIR_Nem_3	483	489	PF02991	0.491
LIG_LIR_Nem_3	7	13	PF02991	0.442
LIG_LIR_Nem_3	73	79	PF02991	0.365
LIG_Pex14_1	133	137	PF04695	0.496
LIG_Pex14_2	486	490	PF04695	0.390
LIG_Pex14_2	6	10	PF04695	0.428
LIG_Rb_pABgroove_1	403	411	PF01858	0.293
LIG_SH2_CRK	114	118	PF00017	0.395
LIG_SH2_CRK	372	376	PF00017	0.455
LIG_SH2_NCK_1	269	273	PF00017	0.526
LIG_SH2_NCK_1	281	285	PF00017	0.526
LIG_SH2_SRC	168	171	PF00017	0.512
LIG_SH2_SRC	308	311	PF00017	0.388
LIG_SH2_STAP1	264	268	PF00017	0.455
LIG_SH2_STAP1	372	376	PF00017	0.455
LIG_SH2_STAP1	79	83	PF00017	0.368
LIG_SH2_STAT3	234	237	PF00017	0.496
LIG_SH2_STAT5	136	139	PF00017	0.443
LIG_SH2_STAT5	234	237	PF00017	0.448
LIG_SH2_STAT5	239	242	PF00017	0.434
LIG_SH2_STAT5	269	272	PF00017	0.505
LIG_SH2_STAT5	322	325	PF00017	0.473
LIG_SH2_STAT5	69	72	PF00017	0.439
LIG_SH3_3	2	8	PF00018	0.413
LIG_SH3_3	237	243	PF00018	0.455
LIG_SH3_3	323	329	PF00018	0.504
LIG_SUMO_SIM_anti_2	348	354	PF11976	0.471
LIG_SUMO_SIM_par_1	241	247	PF11976	0.526
LIG_TYR_ITIM	112	117	PF00017	0.361
LIG_WRC_WIRS_1	10	15	PF05994	0.432
MOD_CK1_1	126	132	PF00069	0.371
MOD_CK1_1	229	235	PF00069	0.499
MOD_CK1_1	262	268	PF00069	0.472
MOD_CK1_1	273	279	PF00069	0.429
MOD_CK1_1	416	422	PF00069	0.689
MOD_CK1_1	437	443	PF00069	0.567
MOD_CK1_1	463	469	PF00069	0.675
MOD_CK1_1	74	80	PF00069	0.385
MOD_CK1_1	9	15	PF00069	0.434
MOD_CK2_1	426	432	PF00069	0.725
MOD_CK2_1	452	458	PF00069	0.615
MOD_CK2_1	463	469	PF00069	0.543
MOD_CK2_1	74	80	PF00069	0.403
MOD_CMANNOS	160	163	PF00535	0.326
MOD_Cter_Amidation	248	251	PF01082	0.274
MOD_GlcNHglycan	128	131	PF01048	0.378
MOD_GlcNHglycan	203	206	PF01048	0.255
MOD_GlcNHglycan	216	219	PF01048	0.255
MOD_GlcNHglycan	228	231	PF01048	0.203
MOD_GlcNHglycan	415	418	PF01048	0.466
MOD_GlcNHglycan	436	439	PF01048	0.746
MOD_GlcNHglycan	466	469	PF01048	0.713
MOD_GSK3_1	122	129	PF00069	0.397
MOD_GSK3_1	137	144	PF00069	0.456
MOD_GSK3_1	155	162	PF00069	0.473
MOD_GSK3_1	17	24	PF00069	0.391
MOD_GSK3_1	413	420	PF00069	0.720
MOD_GSK3_1	436	443	PF00069	0.730
MOD_GSK3_1	459	466	PF00069	0.538
MOD_GSK3_1	70	77	PF00069	0.428
MOD_GSK3_1	9	16	PF00069	0.444
MOD_N-GLC_1	387	392	PF02516	0.255
MOD_N-GLC_1	440	445	PF02516	0.658
MOD_N-GLC_2	295	297	PF02516	0.255
MOD_NEK2_1	122	127	PF00069	0.480
MOD_NEK2_1	128	133	PF00069	0.374
MOD_NEK2_1	13	18	PF00069	0.427
MOD_NEK2_1	137	142	PF00069	0.382
MOD_NEK2_1	214	219	PF00069	0.476
MOD_NEK2_1	244	249	PF00069	0.565
MOD_NEK2_1	332	337	PF00069	0.528
MOD_NEK2_1	345	350	PF00069	0.496
MOD_NEK2_1	401	406	PF00069	0.416
MOD_NEK2_1	450	455	PF00069	0.739
MOD_NEK2_1	70	75	PF00069	0.382
MOD_NEK2_2	21	26	PF00069	0.372
MOD_PIKK_1	267	273	PF00454	0.556
MOD_PIKK_1	502	508	PF00454	0.416
MOD_PK_1	275	281	PF00069	0.476
MOD_PKA_2	126	132	PF00069	0.390
MOD_PKA_2	141	147	PF00069	0.438
MOD_PKA_2	214	220	PF00069	0.556
MOD_PKA_2	463	469	PF00069	0.721
MOD_PKB_1	45	53	PF00069	0.430
MOD_Plk_2-3	186	192	PF00069	0.376
MOD_Plk_4	159	165	PF00069	0.521
MOD_Plk_4	262	268	PF00069	0.466
MOD_Plk_4	6	12	PF00069	0.428
MOD_Plk_4	65	71	PF00069	0.428
MOD_ProDKin_1	17	23	PF00069	0.398
MOD_ProDKin_1	259	265	PF00069	0.473
MOD_ProDKin_1	387	393	PF00069	0.455
MOD_ProDKin_1	4	10	PF00069	0.428
MOD_ProDKin_1	445	451	PF00069	0.773
MOD_ProDKin_1	452	458	PF00069	0.768
MOD_ProDKin_1	55	61	PF00069	0.641
MOD_SUMO_rev_2	378	385	PF00179	0.452
TRG_DiLeu_BaEn_1	180	185	PF01217	0.526
TRG_DiLeu_BaEn_1	484	489	PF01217	0.522
TRG_DiLeu_BaEn_2	481	487	PF01217	0.537
TRG_DiLeu_BaLyEn_6	240	245	PF01217	0.455
TRG_ENDOCYTIC_2	114	117	PF00928	0.365
TRG_ENDOCYTIC_2	364	367	PF00928	0.462
TRG_ENDOCYTIC_2	372	375	PF00928	0.446
TRG_ENDOCYTIC_2	79	82	PF00928	0.336
TRG_ER_diArg_1	45	48	PF00400	0.423
TRG_ER_diArg_1	91	93	PF00400	0.551
TRG_Pf-PMV_PEXEL_1	182	186	PF00026	0.338
TRG_Pf-PMV_PEXEL_1	406	410	PF00026	0.293
TRG_Pf-PMV_PEXEL_1	84	88	PF00026	0.418

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1A1	Leptomonas seymouri	63%	100%
A0A0S4J6I6	Bodo saltans	41%	100%
A0A1X0NRN8	Trypanosomatidae	33%	100%
A0A3Q8IDP1	Leishmania donovani	79%	95%
A0A422NE52	Trypanosoma rangeli	51%	100%
A0A422NPL9	Trypanosoma rangeli	27%	83%
A4H9E1	Leishmania braziliensis	22%	100%
A4HXR2	Leishmania infantum	21%	100%
A4I351	Leishmania infantum	79%	100%
C9ZJM2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	100%
E9ACW9	Leishmania major	78%	100%
E9AID0	Leishmania braziliensis	24%	68%
E9ARH4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	20%	100%
E9AUL7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	71%
E9AZF8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
P38160	Sus scrofa	37%	100%
P38584	Bos taurus	37%	100%
P38585	Mus musculus	35%	100%
Q4QE05	Leishmania major	21%	100%
Q8NG68	Homo sapiens	37%	100%
Q9QXJ0	Rattus norvegicus	35%	100%
V5BVF5	Trypanosoma cruzi	28%	79%