Pre-mRNA-processing factor 19

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HG28_LEIBR

TriTrypDb:

LbrM.27.2690 , LBRM2903_270034100

Length:

516

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0000974	Prp19 complex	2	11
GO:0005681	spliceosomal complex	3	11
GO:0032991	protein-containing complex	1	11
GO:0140513	nuclear protein-containing complex	2	11
GO:1990904	ribonucleoprotein complex	2	11
GO:0005654	nucleoplasm	2	1
GO:0005684	U2-type spliceosomal complex	4	1
GO:0005730	nucleolus	5	1
GO:0005737	cytoplasm	2	1
GO:0005840	ribosome	5	5
GO:0043226	organelle	2	5
GO:0043228	non-membrane-bounded organelle	3	5
GO:0043229	intracellular organelle	3	5
GO:0043232	intracellular non-membrane-bounded organelle	4	5
GO:0071006	U2-type catalytic step 1 spliceosome	4	1
GO:0071012	catalytic step 1 spliceosome	3	1
GO:0110165	cellular anatomical entity	1	5
GO:1902494	catalytic complex	2	1

Expansion

Sequence features

A4HG28

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HG28

Function

Biological processes
Term	Name	Level	Count
GO:0000209	protein polyubiquitination	8	11
GO:0000375	RNA splicing, via transesterification reactions	8	11
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	11
GO:0000398	mRNA splicing, via spliceosome	8	11
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006259	DNA metabolic process	4	11
GO:0006281	DNA repair	5	11
GO:0006396	RNA processing	6	11
GO:0006397	mRNA processing	7	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0006950	response to stress	2	11
GO:0006974	DNA damage response	4	11
GO:0008152	metabolic process	1	11
GO:0008380	RNA splicing	7	11
GO:0009987	cellular process	1	11
GO:0016070	RNA metabolic process	5	11
GO:0016071	mRNA metabolic process	6	11
GO:0016567	protein ubiquitination	7	11
GO:0019538	protein metabolic process	3	11
GO:0032446	protein modification by small protein conjugation	6	11
GO:0033554	cellular response to stress	3	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0036211	protein modification process	4	11
GO:0043170	macromolecule metabolic process	3	11
GO:0043412	macromolecule modification	4	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044260	obsolete cellular macromolecule metabolic process	3	11
GO:0046483	heterocycle metabolic process	3	11
GO:0050896	response to stimulus	1	11
GO:0051716	cellular response to stimulus	2	11
GO:0070534	protein K63-linked ubiquitination	9	11
GO:0070647	protein modification by small protein conjugation or removal	5	11
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11
GO:1901564	organonitrogen compound metabolic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004842	ubiquitin-protein transferase activity	4	11
GO:0016740	transferase activity	2	11
GO:0019787	ubiquitin-like protein transferase activity	3	11
GO:0061630	ubiquitin protein ligase activity	5	11
GO:0061659	ubiquitin-like protein ligase activity	4	11
GO:0140096	catalytic activity, acting on a protein	2	11
GO:0016746	acyltransferase activity	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	168	170	PF00675	0.363
CLV_NRD_NRD_1	171	173	PF00675	0.377
CLV_PCSK_SKI1_1	208	212	PF00082	0.382
CLV_PCSK_SKI1_1	421	425	PF00082	0.449
DEG_APCC_DBOX_1	420	428	PF00400	0.417
DEG_Nend_Nbox_1	1	3	PF02207	0.495
DEG_SPOP_SBC_1	202	206	PF00917	0.471
DEG_SPOP_SBC_1	467	471	PF00917	0.358
DOC_ANK_TNKS_1	441	448	PF00023	0.480
DOC_MAPK_DCC_7	421	429	PF00069	0.424
DOC_USP7_MATH_1	14	18	PF00917	0.330
DOC_USP7_MATH_1	176	180	PF00917	0.545
DOC_USP7_MATH_1	200	204	PF00917	0.551
DOC_USP7_MATH_1	218	222	PF00917	0.638
DOC_USP7_MATH_1	300	304	PF00917	0.347
DOC_USP7_MATH_1	354	358	PF00917	0.319
DOC_USP7_MATH_1	59	63	PF00917	0.621
DOC_USP7_MATH_1	65	69	PF00917	0.559
DOC_WW_Pin1_4	196	201	PF00397	0.404
DOC_WW_Pin1_4	237	242	PF00397	0.424
DOC_WW_Pin1_4	341	346	PF00397	0.352
DOC_WW_Pin1_4	430	435	PF00397	0.355
LIG_14-3-3_CanoR_1	278	287	PF00244	0.514
LIG_14-3-3_CanoR_1	3	11	PF00244	0.433
LIG_14-3-3_CanoR_1	96	106	PF00244	0.489
LIG_Actin_WH2_2	468	483	PF00022	0.464
LIG_BRCT_BRCA1_1	222	226	PF00533	0.405
LIG_BRCT_BRCA1_1	395	399	PF00533	0.302
LIG_FHA_1	10	16	PF00498	0.485
LIG_FHA_1	252	258	PF00498	0.478
LIG_FHA_1	274	280	PF00498	0.425
LIG_FHA_1	333	339	PF00498	0.495
LIG_FHA_1	475	481	PF00498	0.453
LIG_FHA_2	320	326	PF00498	0.488
LIG_FHA_2	346	352	PF00498	0.485
LIG_FHA_2	468	474	PF00498	0.444
LIG_FHA_2	74	80	PF00498	0.507
LIG_GBD_Chelix_1	260	268	PF00786	0.157
LIG_LIR_LC3C_4	449	452	PF02991	0.357
LIG_LIR_Nem_3	84	88	PF02991	0.428
LIG_Rb_LxCxE_1	344	357	PF01857	0.446
LIG_SH2_CRK	355	359	PF00017	0.310
LIG_SH2_NCK_1	509	513	PF00017	0.464
LIG_SH2_STAP1	355	359	PF00017	0.424
LIG_SH2_STAP1	460	464	PF00017	0.354
LIG_SH2_STAP1	509	513	PF00017	0.473
LIG_SH2_STAT5	311	314	PF00017	0.357
LIG_SH2_STAT5	32	35	PF00017	0.374
LIG_SH3_3	145	151	PF00018	0.445
LIG_SH3_3	331	337	PF00018	0.277
LIG_SH3_3	420	426	PF00018	0.434
LIG_SH3_3	428	434	PF00018	0.453
LIG_SH3_3	8	14	PF00018	0.375
LIG_SUMO_SIM_par_1	14	20	PF11976	0.482
LIG_SUMO_SIM_par_1	318	325	PF11976	0.450
LIG_TRAF2_1	137	140	PF00917	0.611
MOD_CK1_1	17	23	PF00069	0.358
MOD_CK1_1	198	204	PF00069	0.665
MOD_CK1_1	206	212	PF00069	0.465
MOD_CK1_1	228	234	PF00069	0.429
MOD_CK1_1	303	309	PF00069	0.397
MOD_CK1_1	433	439	PF00069	0.391
MOD_CK1_1	463	469	PF00069	0.543
MOD_CK1_1	73	79	PF00069	0.409
MOD_CK2_1	24	30	PF00069	0.384
MOD_CK2_1	267	273	PF00069	0.491
MOD_CK2_1	321	327	PF00069	0.394
MOD_CK2_1	345	351	PF00069	0.460
MOD_CK2_1	467	473	PF00069	0.485
MOD_CK2_1	73	79	PF00069	0.479
MOD_GlcNHglycan	174	177	PF01048	0.461
MOD_GlcNHglycan	179	182	PF01048	0.515
MOD_GlcNHglycan	19	22	PF01048	0.370
MOD_GlcNHglycan	200	203	PF01048	0.627
MOD_GlcNHglycan	205	208	PF01048	0.543
MOD_GlcNHglycan	222	225	PF01048	0.300
MOD_GlcNHglycan	227	230	PF01048	0.472
MOD_GlcNHglycan	269	272	PF01048	0.236
MOD_GlcNHglycan	296	299	PF01048	0.427
MOD_GlcNHglycan	327	330	PF01048	0.502
MOD_GlcNHglycan	395	398	PF01048	0.352
MOD_GlcNHglycan	465	468	PF01048	0.547
MOD_GlcNHglycan	492	495	PF01048	0.502
MOD_GlcNHglycan	65	68	PF01048	0.567
MOD_GSK3_1	172	179	PF00069	0.487
MOD_GSK3_1	196	203	PF00069	0.597
MOD_GSK3_1	285	292	PF00069	0.497
MOD_GSK3_1	321	328	PF00069	0.365
MOD_GSK3_1	332	339	PF00069	0.347
MOD_GSK3_1	341	348	PF00069	0.281
MOD_GSK3_1	389	396	PF00069	0.390
MOD_GSK3_1	433	440	PF00069	0.332
MOD_GSK3_1	463	470	PF00069	0.468
MOD_GSK3_1	508	515	PF00069	0.354
MOD_GSK3_1	59	66	PF00069	0.525
MOD_N-GLC_1	4	9	PF02516	0.432
MOD_NEK2_1	24	29	PF00069	0.469
MOD_NEK2_1	465	470	PF00069	0.520
MOD_NEK2_1	508	513	PF00069	0.440
MOD_NEK2_2	14	19	PF00069	0.472
MOD_PIKK_1	300	306	PF00454	0.435
MOD_PIKK_1	97	103	PF00454	0.487
MOD_PKA_1	172	178	PF00069	0.388
MOD_PKA_2	121	127	PF00069	0.520
MOD_Plk_1	24	30	PF00069	0.341
MOD_Plk_1	273	279	PF00069	0.426
MOD_Plk_1	378	384	PF00069	0.349
MOD_Plk_1	460	466	PF00069	0.362
MOD_Plk_1	59	65	PF00069	0.544
MOD_Plk_4	24	30	PF00069	0.245
MOD_Plk_4	285	291	PF00069	0.562
MOD_Plk_4	460	466	PF00069	0.517
MOD_Plk_4	73	79	PF00069	0.507
MOD_ProDKin_1	196	202	PF00069	0.409
MOD_ProDKin_1	237	243	PF00069	0.425
MOD_ProDKin_1	341	347	PF00069	0.335
MOD_ProDKin_1	430	436	PF00069	0.361
TRG_ENDOCYTIC_2	355	358	PF00928	0.314
TRG_NLS_MonoExtC_3	168	173	PF00514	0.458
TRG_NLS_MonoExtN_4	166	173	PF00514	0.452

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMA9	Leptomonas seymouri	61%	100%
A0A0S4J7B3	Bodo saltans	32%	100%
A0A1X0NFA4	Trypanosomatidae	34%	100%
A0A3Q8IGJ0	Leishmania donovani	83%	100%
A0A3R7NBE4	Trypanosoma rangeli	32%	100%
A4I350	Leishmania infantum	83%	100%
C9ZJM1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9ACW8	Leishmania major	84%	100%
E9AZF7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
O22785	Arabidopsis thaliana	26%	98%
Q08E38	Bos taurus	30%	100%
Q10051	Caenorhabditis elegans	25%	100%
Q5ZMA2	Gallus gallus	29%	100%
Q7KWK5	Dictyostelium discoideum	24%	100%
Q94BR4	Arabidopsis thaliana	25%	99%
Q99KP6	Mus musculus	30%	100%
Q9JMJ4	Rattus norvegicus	30%	100%
Q9UMS4	Homo sapiens	30%	100%