LeishMANIAdb
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Protein kinase domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Protein kinase domain-containing protein
Gene product:
protein kinase, putative
Species:
Leishmania braziliensis
UniProt:
A4HG27_LEIBR
TriTrypDb:
LbrM.27.2680 , LBRM2903_270034000 *
Length:
544

Annotations

LeishMANIAdb annotations

A large and apprently artificial collection of diverse kinetoplastid protein kinases. None of them appear to be TM.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 4
Forrest at al. (procyclic) no yes: 4
Silverman et al. no yes: 0
Pissara et al. no yes: 21
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 5
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 10
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 21
NetGPI no yes: 0, no: 21
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 1
GO:0005737 cytoplasm 2 2
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 3
GO:0016020 membrane 2 1
GO:0031974 membrane-enclosed lumen 2 1
GO:0031981 nuclear lumen 5 1
GO:0032838 plasma membrane bounded cell projection cytoplasm 4 1
GO:0043233 organelle lumen 3 1
GO:0070013 intracellular organelle lumen 4 1
GO:0097014 ciliary plasm 5 1
GO:0099568 cytoplasmic region 3 1

Expansion

Sequence features

A4HG27
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HG27

Function

Biological processes
Term Name Level Count
GO:0006468 protein phosphorylation 5 22
GO:0006793 phosphorus metabolic process 3 22
GO:0006796 phosphate-containing compound metabolic process 4 22
GO:0006807 nitrogen compound metabolic process 2 22
GO:0008152 metabolic process 1 22
GO:0009987 cellular process 1 22
GO:0016310 phosphorylation 5 22
GO:0019538 protein metabolic process 3 22
GO:0036211 protein modification process 4 22
GO:0043170 macromolecule metabolic process 3 22
GO:0043412 macromolecule modification 4 22
GO:0044237 cellular metabolic process 2 22
GO:0044238 primary metabolic process 2 22
GO:0071704 organic substance metabolic process 2 22
GO:1901564 organonitrogen compound metabolic process 3 22
GO:0007165 signal transduction 2 2
GO:0018105 peptidyl-serine phosphorylation 6 2
GO:0018193 peptidyl-amino acid modification 5 2
GO:0018209 peptidyl-serine modification 6 2
GO:0035556 intracellular signal transduction 3 2
GO:0046777 protein autophosphorylation 6 1
GO:0050789 regulation of biological process 2 2
GO:0050794 regulation of cellular process 3 2
GO:0065007 biological regulation 1 2
GO:0000281 mitotic cytokinesis 4 1
GO:0000910 cytokinesis 3 1
GO:0022402 cell cycle process 2 1
GO:0061640 cytoskeleton-dependent cytokinesis 4 1
GO:1903047 mitotic cell cycle process 3 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 22
GO:0003824 catalytic activity 1 22
GO:0004672 protein kinase activity 3 22
GO:0005488 binding 1 22
GO:0005524 ATP binding 5 22
GO:0016301 kinase activity 4 22
GO:0016740 transferase activity 2 22
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 22
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 22
GO:0017076 purine nucleotide binding 4 22
GO:0030554 adenyl nucleotide binding 5 22
GO:0032553 ribonucleotide binding 3 22
GO:0032555 purine ribonucleotide binding 4 22
GO:0032559 adenyl ribonucleotide binding 5 22
GO:0035639 purine ribonucleoside triphosphate binding 4 22
GO:0036094 small molecule binding 2 22
GO:0043167 ion binding 2 22
GO:0043168 anion binding 3 22
GO:0097159 organic cyclic compound binding 2 22
GO:0097367 carbohydrate derivative binding 2 22
GO:0140096 catalytic activity, acting on a protein 2 22
GO:1901265 nucleoside phosphate binding 3 22
GO:1901363 heterocyclic compound binding 2 22
GO:0004674 protein serine/threonine kinase activity 4 15
GO:0008270 zinc ion binding 6 1
GO:0043169 cation binding 3 1
GO:0046872 metal ion binding 4 1
GO:0046914 transition metal ion binding 5 1
GO:0004683 calmodulin-dependent protein kinase activity 5 1
GO:0005515 protein binding 2 1
GO:0005516 calmodulin binding 3 1
GO:0009931 calcium-dependent protein serine/threonine kinase activity 5 1
GO:0010857 calcium-dependent protein kinase activity 4 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 115 119 PF00656 0.253
CLV_NRD_NRD_1 202 204 PF00675 0.411
CLV_NRD_NRD_1 436 438 PF00675 0.389
CLV_NRD_NRD_1 505 507 PF00675 0.646
CLV_PCSK_KEX2_1 404 406 PF00082 0.495
CLV_PCSK_PC1ET2_1 404 406 PF00082 0.516
CLV_PCSK_SKI1_1 124 128 PF00082 0.251
CLV_PCSK_SKI1_1 141 145 PF00082 0.447
CLV_PCSK_SKI1_1 305 309 PF00082 0.494
CLV_PCSK_SKI1_1 310 314 PF00082 0.578
CLV_PCSK_SKI1_1 486 490 PF00082 0.562
CLV_PCSK_SKI1_1 509 513 PF00082 0.457
CLV_PCSK_SKI1_1 533 537 PF00082 0.724
DEG_APCC_DBOX_1 123 131 PF00400 0.280
DEG_APCC_DBOX_1 436 444 PF00400 0.372
DEG_SPOP_SBC_1 178 182 PF00917 0.374
DOC_CKS1_1 534 539 PF01111 0.483
DOC_MAPK_gen_1 141 150 PF00069 0.337
DOC_MAPK_gen_1 309 318 PF00069 0.542
DOC_MAPK_gen_1 437 445 PF00069 0.292
DOC_MAPK_JIP1_4 144 150 PF00069 0.292
DOC_MAPK_JIP1_4 276 282 PF00069 0.241
DOC_MAPK_MEF2A_6 438 447 PF00069 0.280
DOC_MAPK_MEF2A_6 90 98 PF00069 0.319
DOC_USP7_MATH_1 154 158 PF00917 0.363
DOC_USP7_MATH_1 423 427 PF00917 0.526
DOC_USP7_MATH_1 510 514 PF00917 0.715
DOC_USP7_UBL2_3 309 313 PF12436 0.447
DOC_USP7_UBL2_3 48 52 PF12436 0.328
DOC_USP7_UBL2_3 54 58 PF12436 0.328
DOC_WW_Pin1_4 152 157 PF00397 0.382
DOC_WW_Pin1_4 183 188 PF00397 0.305
DOC_WW_Pin1_4 255 260 PF00397 0.324
DOC_WW_Pin1_4 267 272 PF00397 0.370
DOC_WW_Pin1_4 329 334 PF00397 0.520
DOC_WW_Pin1_4 533 538 PF00397 0.764
LIG_14-3-3_CanoR_1 244 250 PF00244 0.391
LIG_14-3-3_CanoR_1 340 348 PF00244 0.505
LIG_14-3-3_CanoR_1 35 43 PF00244 0.450
LIG_14-3-3_CanoR_1 475 482 PF00244 0.661
LIG_Actin_WH2_2 136 153 PF00022 0.233
LIG_AP2alpha_1 235 239 PF02296 0.174
LIG_APCC_ABBA_1 409 414 PF00400 0.533
LIG_APCC_ABBAyCdc20_2 136 142 PF00400 0.242
LIG_deltaCOP1_diTrp_1 330 338 PF00928 0.542
LIG_EH1_1 92 100 PF00400 0.242
LIG_eIF4E_1 93 99 PF01652 0.277
LIG_FHA_1 218 224 PF00498 0.260
LIG_FHA_1 276 282 PF00498 0.222
LIG_FHA_1 320 326 PF00498 0.443
LIG_FHA_1 35 41 PF00498 0.311
LIG_FHA_1 62 68 PF00498 0.443
LIG_FHA_2 200 206 PF00498 0.270
LIG_LIR_Apic_2 186 192 PF02991 0.321
LIG_LIR_Apic_2 330 334 PF02991 0.572
LIG_LIR_Gen_1 220 229 PF02991 0.257
LIG_LIR_Gen_1 237 243 PF02991 0.324
LIG_LIR_Gen_1 251 261 PF02991 0.240
LIG_LIR_Gen_1 332 339 PF02991 0.520
LIG_LIR_Gen_1 342 349 PF02991 0.471
LIG_LIR_Gen_1 398 407 PF02991 0.427
LIG_LIR_Nem_3 220 224 PF02991 0.294
LIG_LIR_Nem_3 237 242 PF02991 0.278
LIG_LIR_Nem_3 251 257 PF02991 0.275
LIG_LIR_Nem_3 332 338 PF02991 0.411
LIG_LIR_Nem_3 342 348 PF02991 0.389
LIG_LIR_Nem_3 398 402 PF02991 0.358
LIG_LIR_Nem_3 408 413 PF02991 0.406
LIG_LIR_Nem_3 477 482 PF02991 0.683
LIG_LYPXL_S_1 409 413 PF13949 0.396
LIG_LYPXL_yS_3 410 413 PF13949 0.382
LIG_Pex14_1 331 335 PF04695 0.550
LIG_Pex14_2 235 239 PF04695 0.374
LIG_PTAP_UEV_1 155 160 PF05743 0.261
LIG_PTB_Apo_2 193 200 PF02174 0.193
LIG_SH2_CRK 30 34 PF00017 0.296
LIG_SH2_NCK_1 30 34 PF00017 0.257
LIG_SH2_PTP2 189 192 PF00017 0.313
LIG_SH2_PTP2 221 224 PF00017 0.324
LIG_SH2_PTP2 93 96 PF00017 0.421
LIG_SH2_SRC 177 180 PF00017 0.374
LIG_SH2_STAP1 30 34 PF00017 0.270
LIG_SH2_STAP1 45 49 PF00017 0.334
LIG_SH2_STAT5 177 180 PF00017 0.339
LIG_SH2_STAT5 189 192 PF00017 0.321
LIG_SH2_STAT5 19 22 PF00017 0.371
LIG_SH2_STAT5 221 224 PF00017 0.324
LIG_SH2_STAT5 399 402 PF00017 0.357
LIG_SH2_STAT5 85 88 PF00017 0.326
LIG_SH2_STAT5 93 96 PF00017 0.322
LIG_SH3_3 153 159 PF00018 0.261
LIG_SH3_3 531 537 PF00018 0.494
LIG_SUMO_SIM_anti_2 278 284 PF11976 0.241
LIG_SUMO_SIM_anti_2 66 71 PF11976 0.349
LIG_SUMO_SIM_par_1 94 100 PF11976 0.366
LIG_TRAF2_1 495 498 PF00917 0.449
LIG_TYR_ITIM 219 224 PF00017 0.356
MOD_CDK_SPxxK_3 255 262 PF00069 0.312
MOD_CK1_1 117 123 PF00069 0.271
MOD_CK1_1 162 168 PF00069 0.280
MOD_CK1_1 248 254 PF00069 0.496
MOD_CK1_1 300 306 PF00069 0.501
MOD_CK1_1 474 480 PF00069 0.607
MOD_CK1_1 515 521 PF00069 0.571
MOD_CK2_1 199 205 PF00069 0.270
MOD_CK2_1 300 306 PF00069 0.351
MOD_CK2_1 488 494 PF00069 0.517
MOD_Cter_Amidation 402 405 PF01082 0.469
MOD_DYRK1A_RPxSP_1 533 537 PF00069 0.510
MOD_GlcNHglycan 127 130 PF01048 0.304
MOD_GlcNHglycan 156 159 PF01048 0.202
MOD_GlcNHglycan 224 227 PF01048 0.244
MOD_GlcNHglycan 514 517 PF01048 0.577
MOD_GlcNHglycan 99 102 PF01048 0.328
MOD_GSK3_1 179 186 PF00069 0.364
MOD_GSK3_1 231 238 PF00069 0.280
MOD_GSK3_1 339 346 PF00069 0.494
MOD_GSK3_1 34 41 PF00069 0.210
MOD_GSK3_1 470 477 PF00069 0.580
MOD_GSK3_1 482 489 PF00069 0.618
MOD_GSK3_1 80 87 PF00069 0.378
MOD_NEK2_1 199 204 PF00069 0.194
MOD_NEK2_1 319 324 PF00069 0.412
MOD_NEK2_1 34 39 PF00069 0.287
MOD_NEK2_1 347 352 PF00069 0.280
MOD_NEK2_1 470 475 PF00069 0.548
MOD_NEK2_1 482 487 PF00069 0.584
MOD_NEK2_1 488 493 PF00069 0.609
MOD_NEK2_2 423 428 PF00069 0.338
MOD_PIKK_1 319 325 PF00454 0.589
MOD_PIKK_1 350 356 PF00454 0.394
MOD_PIKK_1 85 91 PF00454 0.261
MOD_PKA_2 245 251 PF00069 0.353
MOD_PKA_2 275 281 PF00069 0.287
MOD_PKA_2 339 345 PF00069 0.511
MOD_PKA_2 34 40 PF00069 0.292
MOD_PKA_2 474 480 PF00069 0.677
MOD_Plk_1 117 123 PF00069 0.349
MOD_Plk_1 423 429 PF00069 0.401
MOD_Plk_4 117 123 PF00069 0.484
MOD_Plk_4 185 191 PF00069 0.313
MOD_Plk_4 321 327 PF00069 0.456
MOD_ProDKin_1 152 158 PF00069 0.382
MOD_ProDKin_1 183 189 PF00069 0.305
MOD_ProDKin_1 255 261 PF00069 0.324
MOD_ProDKin_1 267 273 PF00069 0.370
MOD_ProDKin_1 329 335 PF00069 0.508
MOD_ProDKin_1 533 539 PF00069 0.759
MOD_SUMO_for_1 143 146 PF00179 0.321
MOD_SUMO_rev_2 462 467 PF00179 0.474
TRG_DiLeu_BaEn_2 407 413 PF01217 0.544
TRG_ENDOCYTIC_2 221 224 PF00928 0.356
TRG_ENDOCYTIC_2 30 33 PF00928 0.308
TRG_ENDOCYTIC_2 399 402 PF00928 0.357
TRG_ENDOCYTIC_2 410 413 PF00928 0.382
TRG_ENDOCYTIC_2 93 96 PF00928 0.336
TRG_ER_diArg_1 200 203 PF00400 0.415
TRG_ER_diArg_1 243 246 PF00400 0.300
TRG_NLS_MonoExtC_3 308 313 PF00514 0.401
TRG_NLS_MonoExtN_4 309 314 PF00514 0.419
TRG_NLS_MonoExtN_4 503 510 PF00514 0.450
TRG_Pf-PMV_PEXEL_1 141 146 PF00026 0.328

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PE80 Leptomonas seymouri 73% 97%
A0A0S4J7K4 Bodo saltans 58% 100%
A0A1X0NJV4 Trypanosomatidae 59% 100%
A0A1X0P1A2 Trypanosomatidae 60% 100%
A0A3Q8IC87 Leishmania donovani 33% 100%
A0A3Q8IDK8 Leishmania donovani 84% 97%
A0A3Q8IFK8 Leishmania donovani 27% 100%
A0A3Q8INQ4 Leishmania donovani 29% 100%
A0A3R7RIN5 Trypanosoma rangeli 25% 100%
A0A3S5H5G0 Leishmania donovani 27% 100%
A0A3S5H5U5 Leishmania donovani 22% 100%
A0A3S7X9R4 Leishmania donovani 27% 100%
A4H436 Leishmania braziliensis 24% 100%
A4H459 Leishmania braziliensis 27% 100%
A4H4S9 Leishmania braziliensis 23% 100%
A4HC27 Leishmania braziliensis 24% 100%
A4HCD7 Leishmania braziliensis 33% 100%
A4HED7 Leishmania braziliensis 29% 100%
A4HFF3 Leishmania braziliensis 28% 100%
A4HJT5 Leishmania braziliensis 26% 100%
A4HN71 Leishmania braziliensis 27% 100%
A4HSE2 Leishmania infantum 27% 100%
A4HZV1 Leishmania infantum 33% 100%
A4I1T4 Leishmania infantum 29% 100%
A4I349 Leishmania infantum 84% 96%
A4I7A1 Leishmania infantum 27% 100%
A4IBT4 Leishmania infantum 27% 100%
A4IBT9 Leishmania infantum 27% 100%
C9ZN29 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 50% 100%
E9ACW7 Leishmania major 81% 100%
E9AG71 Leishmania infantum 22% 100%
E9AKB7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 27% 100%
E9AKZ7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 23% 100%
E9AVR5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 33% 100%
E9AXW8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 29% 100%
E9AZF6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 83% 100%
E9B296 Leishmania mexicana (strain MHOM/GT/2001/U1103) 27% 100%
E9B6S4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 100%
E9B6S9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 100%
Q4Q5W2 Leishmania major 27% 100%
Q4Q9K2 Leishmania major 30% 100%
Q4QBR6 Leishmania major 33% 100%
Q4QJJ0 Leishmania major 27% 100%
Q5KQF5 Oryza sativa subsp. japonica 28% 100%
Q6C7U0 Yarrowia lipolytica (strain CLIB 122 / E 150) 25% 77%
Q9GNR4 Leishmania major 27% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS