Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HG25_LEIBR

TriTrypDb:

LbrM.27.2660 , LBRM2903_270033800

Length:

442

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HG25

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HG25

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	245	249	PF00656	0.575
CLV_NRD_NRD_1	11	13	PF00675	0.488
CLV_NRD_NRD_1	115	117	PF00675	0.574
CLV_NRD_NRD_1	132	134	PF00675	0.358
CLV_NRD_NRD_1	192	194	PF00675	0.769
CLV_NRD_NRD_1	258	260	PF00675	0.561
CLV_NRD_NRD_1	376	378	PF00675	0.552
CLV_PCSK_FUR_1	130	134	PF00082	0.351
CLV_PCSK_KEX2_1	11	13	PF00082	0.488
CLV_PCSK_KEX2_1	115	117	PF00082	0.479
CLV_PCSK_KEX2_1	132	134	PF00082	0.342
CLV_PCSK_KEX2_1	192	194	PF00082	0.629
CLV_PCSK_KEX2_1	258	260	PF00082	0.512
CLV_PCSK_KEX2_1	376	378	PF00082	0.559
CLV_PCSK_SKI1_1	290	294	PF00082	0.435
CLV_PCSK_SKI1_1	339	343	PF00082	0.448
DEG_APCC_DBOX_1	334	342	PF00400	0.476
DEG_Nend_UBRbox_3	1	3	PF02207	0.634
DOC_CYCLIN_yCln2_LP_2	228	231	PF00134	0.464
DOC_MAPK_MEF2A_6	202	209	PF00069	0.631
DOC_PP2B_LxvP_1	228	231	PF13499	0.635
DOC_USP7_MATH_1	246	250	PF00917	0.702
DOC_USP7_MATH_1	383	387	PF00917	0.662
DOC_USP7_MATH_1	415	419	PF00917	0.678
DOC_WW_Pin1_4	229	234	PF00397	0.699
DOC_WW_Pin1_4	350	355	PF00397	0.590
DOC_WW_Pin1_4	388	393	PF00397	0.692
LIG_14-3-3_CanoR_1	14	23	PF00244	0.512
LIG_14-3-3_CanoR_1	258	268	PF00244	0.617
LIG_14-3-3_CanoR_1	316	323	PF00244	0.580
LIG_14-3-3_CanoR_1	339	345	PF00244	0.483
LIG_14-3-3_CanoR_1	365	370	PF00244	0.527
LIG_14-3-3_CanoR_1	405	410	PF00244	0.600
LIG_BRCT_BRCA1_1	72	76	PF00533	0.299
LIG_deltaCOP1_diTrp_1	434	438	PF00928	0.613
LIG_FHA_1	357	363	PF00498	0.613
LIG_FHA_1	61	67	PF00498	0.333
LIG_FHA_1	85	91	PF00498	0.399
LIG_FHA_2	126	132	PF00498	0.411
LIG_FHA_2	168	174	PF00498	0.662
LIG_FHA_2	366	372	PF00498	0.519
LIG_LIR_Apic_2	434	439	PF02991	0.462
LIG_LIR_Gen_1	353	363	PF02991	0.508
LIG_LIR_Gen_1	364	375	PF02991	0.412
LIG_LIR_Gen_1	410	421	PF02991	0.594
LIG_LIR_Nem_3	237	241	PF02991	0.570
LIG_LIR_Nem_3	410	416	PF02991	0.592
LIG_NRBOX	344	350	PF00104	0.550
LIG_PDZ_Class_1	437	442	PF00595	0.454
LIG_SH2_CRK	98	102	PF00017	0.290
LIG_SH2_PTP2	279	282	PF00017	0.445
LIG_SH2_PTP2	413	416	PF00017	0.592
LIG_SH2_SRC	279	282	PF00017	0.445
LIG_SH2_STAP1	137	141	PF00017	0.484
LIG_SH2_STAP1	38	42	PF00017	0.454
LIG_SH2_STAP1	409	413	PF00017	0.518
LIG_SH2_STAT5	109	112	PF00017	0.326
LIG_SH2_STAT5	143	146	PF00017	0.403
LIG_SH2_STAT5	279	282	PF00017	0.445
LIG_SH2_STAT5	344	347	PF00017	0.341
LIG_SH2_STAT5	413	416	PF00017	0.656
LIG_SH3_2	231	236	PF14604	0.460
LIG_SH3_3	227	233	PF00018	0.488
LIG_SUMO_SIM_anti_2	172	179	PF11976	0.522
LIG_SUMO_SIM_anti_2	54	59	PF11976	0.573
LIG_SUMO_SIM_par_1	203	212	PF11976	0.551
LIG_TRAF2_1	170	173	PF00917	0.664
LIG_TRAF2_1	249	252	PF00917	0.461
LIG_TRAF2_1	282	285	PF00917	0.534
LIG_UBA3_1	206	210	PF00899	0.489
LIG_UBA3_1	66	75	PF00899	0.453
MOD_CDK_SPxxK_3	229	236	PF00069	0.461
MOD_CDK_SPxxK_3	388	395	PF00069	0.462
MOD_CK1_1	250	256	PF00069	0.585
MOD_CK1_1	419	425	PF00069	0.519
MOD_CK2_1	167	173	PF00069	0.477
MOD_CK2_1	213	219	PF00069	0.627
MOD_CK2_1	246	252	PF00069	0.474
MOD_CK2_1	365	371	PF00069	0.468
MOD_CK2_1	405	411	PF00069	0.565
MOD_GlcNHglycan	185	188	PF01048	0.588
MOD_GlcNHglycan	211	216	PF01048	0.612
MOD_GlcNHglycan	244	247	PF01048	0.761
MOD_GlcNHglycan	251	255	PF01048	0.678
MOD_GlcNHglycan	307	310	PF01048	0.456
MOD_GlcNHglycan	397	400	PF01048	0.570
MOD_GlcNHglycan	40	43	PF01048	0.578
MOD_GlcNHglycan	418	421	PF01048	0.586
MOD_GlcNHglycan	426	429	PF01048	0.527
MOD_GSK3_1	14	21	PF00069	0.420
MOD_GSK3_1	220	227	PF00069	0.654
MOD_GSK3_1	242	249	PF00069	0.684
MOD_GSK3_1	294	301	PF00069	0.519
MOD_GSK3_1	315	322	PF00069	0.406
MOD_GSK3_1	361	368	PF00069	0.484
MOD_GSK3_1	381	388	PF00069	0.357
MOD_GSK3_1	395	402	PF00069	0.620
MOD_GSK3_1	405	412	PF00069	0.536
MOD_GSK3_1	415	422	PF00069	0.436
MOD_N-GLC_1	224	229	PF02516	0.489
MOD_N-GLC_1	70	75	PF02516	0.303
MOD_NEK2_1	268	273	PF00069	0.642
MOD_NEK2_1	348	353	PF00069	0.550
MOD_NEK2_1	65	70	PF00069	0.391
MOD_NEK2_2	205	210	PF00069	0.485
MOD_PIKK_1	149	155	PF00454	0.493
MOD_PIKK_1	159	165	PF00454	0.473
MOD_PIKK_1	268	274	PF00454	0.570
MOD_PIKK_1	315	321	PF00454	0.426
MOD_PKA_2	315	321	PF00069	0.569
MOD_PKA_2	84	90	PF00069	0.517
MOD_PKB_1	12	20	PF00069	0.324
MOD_PKB_1	395	403	PF00069	0.474
MOD_Plk_1	149	155	PF00069	0.611
MOD_Plk_1	18	24	PF00069	0.532
MOD_Plk_1	224	230	PF00069	0.484
MOD_Plk_2-3	125	131	PF00069	0.352
MOD_Plk_4	173	179	PF00069	0.484
MOD_Plk_4	18	24	PF00069	0.532
MOD_Plk_4	224	230	PF00069	0.710
MOD_Plk_4	298	304	PF00069	0.535
MOD_Plk_4	340	346	PF00069	0.531
MOD_Plk_4	409	415	PF00069	0.658
MOD_Plk_4	432	438	PF00069	0.462
MOD_Plk_4	51	57	PF00069	0.489
MOD_ProDKin_1	229	235	PF00069	0.700
MOD_ProDKin_1	350	356	PF00069	0.588
MOD_ProDKin_1	388	394	PF00069	0.696
TRG_DiLeu_BaEn_1	284	289	PF01217	0.517
TRG_DiLeu_BaEn_1	52	57	PF01217	0.585
TRG_DiLeu_BaEn_4	284	290	PF01217	0.523
TRG_DiLeu_BaLyEn_6	202	207	PF01217	0.484
TRG_ENDOCYTIC_2	109	112	PF00928	0.380
TRG_ENDOCYTIC_2	413	416	PF00928	0.592
TRG_ENDOCYTIC_2	98	101	PF00928	0.378
TRG_ER_diArg_1	11	14	PF00400	0.509
TRG_ER_diArg_1	115	117	PF00400	0.332
TRG_ER_diArg_1	192	195	PF00400	0.724
TRG_ER_diArg_1	257	259	PF00400	0.619
TRG_ER_diArg_1	376	378	PF00400	0.495
TRG_NES_CRM1_1	49	61	PF08389	0.370
TRG_Pf-PMV_PEXEL_1	121	125	PF00026	0.521
TRG_Pf-PMV_PEXEL_1	146	150	PF00026	0.471

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IB83	Leptomonas seymouri	45%	100%
A0A1X0NF90	Trypanosomatidae	30%	100%
A0A3R7KL96	Trypanosoma rangeli	30%	100%
A0A3S7X122	Leishmania donovani	73%	99%
A4I346	Leishmania infantum	73%	99%
C9ZJL9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9ACW5	Leishmania major	72%	100%
E9AZF4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	99%
V5BB13	Trypanosoma cruzi	29%	100%