Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HG23_LEIBR

TriTrypDb:

LbrM.27.2640 , LBRM2903_270033600

Length:

550

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HG23

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HG23

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	147	149	PF00675	0.612
CLV_NRD_NRD_1	186	188	PF00675	0.710
CLV_NRD_NRD_1	206	208	PF00675	0.405
CLV_NRD_NRD_1	293	295	PF00675	0.573
CLV_NRD_NRD_1	324	326	PF00675	0.674
CLV_NRD_NRD_1	534	536	PF00675	0.840
CLV_NRD_NRD_1	60	62	PF00675	0.687
CLV_PCSK_KEX2_1	146	148	PF00082	0.601
CLV_PCSK_KEX2_1	186	188	PF00082	0.710
CLV_PCSK_KEX2_1	206	208	PF00082	0.405
CLV_PCSK_KEX2_1	292	294	PF00082	0.576
CLV_PCSK_KEX2_1	323	325	PF00082	0.826
CLV_PCSK_KEX2_1	534	536	PF00082	0.840
CLV_PCSK_KEX2_1	60	62	PF00082	0.687
CLV_PCSK_PC1ET2_1	323	325	PF00082	0.826
CLV_PCSK_SKI1_1	293	297	PF00082	0.576
CLV_PCSK_SKI1_1	331	335	PF00082	0.683
CLV_PCSK_SKI1_1	343	347	PF00082	0.772
CLV_PCSK_SKI1_1	95	99	PF00082	0.686
DEG_SCF_FBW7_1	432	437	PF00400	0.575
DEG_SPOP_SBC_1	353	357	PF00917	0.572
DEG_SPOP_SBC_1	407	411	PF00917	0.672
DEG_SPOP_SBC_1	539	543	PF00917	0.854
DOC_CKS1_1	192	197	PF01111	0.587
DOC_CYCLIN_RxL_1	245	254	PF00134	0.553
DOC_CYCLIN_RxL_1	289	301	PF00134	0.577
DOC_PP2B_LxvP_1	250	253	PF13499	0.772
DOC_PP2B_LxvP_1	465	468	PF13499	0.595
DOC_PP2B_LxvP_1	480	483	PF13499	0.724
DOC_PP2B_LxvP_1	515	518	PF13499	0.582
DOC_PP4_FxxP_1	461	464	PF00568	0.571
DOC_USP7_MATH_1	108	112	PF00917	0.728
DOC_USP7_MATH_1	269	273	PF00917	0.691
DOC_USP7_MATH_1	285	289	PF00917	0.667
DOC_USP7_MATH_1	304	308	PF00917	0.765
DOC_USP7_MATH_1	332	336	PF00917	0.601
DOC_USP7_MATH_1	377	381	PF00917	0.812
DOC_USP7_MATH_1	408	412	PF00917	0.859
DOC_USP7_MATH_1	443	447	PF00917	0.576
DOC_USP7_MATH_1	474	478	PF00917	0.825
DOC_USP7_MATH_1	528	532	PF00917	0.618
DOC_USP7_MATH_1	72	76	PF00917	0.652
DOC_WW_Pin1_4	178	183	PF00397	0.716
DOC_WW_Pin1_4	191	196	PF00397	0.458
DOC_WW_Pin1_4	219	224	PF00397	0.802
DOC_WW_Pin1_4	260	265	PF00397	0.623
DOC_WW_Pin1_4	306	311	PF00397	0.832
DOC_WW_Pin1_4	314	319	PF00397	0.656
DOC_WW_Pin1_4	373	378	PF00397	0.802
DOC_WW_Pin1_4	400	405	PF00397	0.826
DOC_WW_Pin1_4	424	429	PF00397	0.788
DOC_WW_Pin1_4	430	435	PF00397	0.692
DOC_WW_Pin1_4	438	443	PF00397	0.560
DOC_WW_Pin1_4	498	503	PF00397	0.611
LIG_14-3-3_CanoR_1	147	153	PF00244	0.419
LIG_14-3-3_CanoR_1	331	337	PF00244	0.827
LIG_14-3-3_CanoR_1	416	425	PF00244	0.625
LIG_14-3-3_CanoR_1	54	62	PF00244	0.674
LIG_14-3-3_CanoR_1	68	76	PF00244	0.540
LIG_14-3-3_CanoR_1	95	103	PF00244	0.450
LIG_BIR_II_1	1	5	PF00653	0.649
LIG_BIR_III_2	516	520	PF00653	0.579
LIG_EVH1_1	465	469	PF00568	0.595
LIG_EVH1_1	480	484	PF00568	0.718
LIG_EVH1_2	484	488	PF00568	0.776
LIG_FHA_1	256	262	PF00498	0.641
LIG_FHA_1	439	445	PF00498	0.615
LIG_FHA_1	47	53	PF00498	0.667
LIG_FHA_1	510	516	PF00498	0.601
LIG_FHA_1	520	526	PF00498	0.560
LIG_FHA_1	96	102	PF00498	0.673
LIG_FHA_2	32	38	PF00498	0.674
LIG_FHA_2	540	546	PF00498	0.848
LIG_LIR_Apic_2	459	464	PF02991	0.618
LIG_LIR_Gen_1	19	28	PF02991	0.681
LIG_LIR_Nem_3	19	24	PF02991	0.669
LIG_MYND_1	463	467	PF01753	0.554
LIG_PTAP_UEV_1	242	247	PF05743	0.685
LIG_SH2_NCK_1	172	176	PF00017	0.463
LIG_SH2_STAP1	199	203	PF00017	0.654
LIG_SH2_STAT5	152	155	PF00017	0.685
LIG_SH2_STAT5	381	384	PF00017	0.601
LIG_SH3_2	243	248	PF14604	0.684
LIG_SH3_2	329	334	PF14604	0.621
LIG_SH3_2	530	535	PF14604	0.827
LIG_SH3_3	12	18	PF00018	0.469
LIG_SH3_3	130	136	PF00018	0.537
LIG_SH3_3	162	168	PF00018	0.712
LIG_SH3_3	221	227	PF00018	0.608
LIG_SH3_3	240	246	PF00018	0.745
LIG_SH3_3	258	264	PF00018	0.558
LIG_SH3_3	313	319	PF00018	0.599
LIG_SH3_3	326	332	PF00018	0.566
LIG_SH3_3	371	377	PF00018	0.587
LIG_SH3_3	444	450	PF00018	0.692
LIG_SH3_3	460	466	PF00018	0.517
LIG_SH3_3	478	484	PF00018	0.604
LIG_SH3_3	496	502	PF00018	0.515
LIG_SH3_3	508	514	PF00018	0.671
LIG_SH3_3	527	533	PF00018	0.642
LIG_SUMO_SIM_par_1	248	254	PF11976	0.555
LIG_TRAF2_1	43	46	PF00917	0.394
LIG_WW_2	463	466	PF00397	0.558
LIG_WW_3	403	407	PF00397	0.713
MOD_CDK_SPxK_1	400	406	PF00069	0.716
MOD_CDK_SPxxK_3	424	431	PF00069	0.615
MOD_CK1_1	121	127	PF00069	0.827
MOD_CK1_1	181	187	PF00069	0.514
MOD_CK1_1	222	228	PF00069	0.681
MOD_CK1_1	251	257	PF00069	0.704
MOD_CK1_1	298	304	PF00069	0.836
MOD_CK1_1	306	312	PF00069	0.713
MOD_CK1_1	348	354	PF00069	0.826
MOD_CK1_1	355	361	PF00069	0.716
MOD_CK1_1	376	382	PF00069	0.611
MOD_CK1_1	398	404	PF00069	0.680
MOD_CK1_1	411	417	PF00069	0.819
MOD_CK1_1	418	424	PF00069	0.696
MOD_CK1_1	427	433	PF00069	0.537
MOD_CK1_1	541	547	PF00069	0.844
MOD_CK1_1	55	61	PF00069	0.675
MOD_CK2_1	108	114	PF00069	0.755
MOD_CK2_1	156	162	PF00069	0.585
MOD_CK2_1	285	291	PF00069	0.576
MOD_CK2_1	31	37	PF00069	0.548
MOD_Cter_Amidation	321	324	PF01082	0.609
MOD_GlcNHglycan	125	128	PF01048	0.566
MOD_GlcNHglycan	243	246	PF01048	0.760
MOD_GlcNHglycan	253	256	PF01048	0.656
MOD_GlcNHglycan	269	272	PF01048	0.578
MOD_GlcNHglycan	302	305	PF01048	0.730
MOD_GlcNHglycan	306	309	PF01048	0.778
MOD_GlcNHglycan	310	313	PF01048	0.700
MOD_GlcNHglycan	334	337	PF01048	0.821
MOD_GlcNHglycan	34	37	PF01048	0.559
MOD_GlcNHglycan	363	366	PF01048	0.851
MOD_GlcNHglycan	383	386	PF01048	0.523
MOD_GlcNHglycan	418	421	PF01048	0.712
MOD_GlcNHglycan	436	439	PF01048	0.538
MOD_GlcNHglycan	476	479	PF01048	0.745
MOD_GlcNHglycan	493	496	PF01048	0.511
MOD_GlcNHglycan	54	57	PF01048	0.444
MOD_GSK3_1	117	124	PF00069	0.763
MOD_GSK3_1	251	258	PF00069	0.644
MOD_GSK3_1	260	267	PF00069	0.532
MOD_GSK3_1	269	276	PF00069	0.519
MOD_GSK3_1	295	302	PF00069	0.734
MOD_GSK3_1	304	311	PF00069	0.693
MOD_GSK3_1	345	352	PF00069	0.824
MOD_GSK3_1	353	360	PF00069	0.697
MOD_GSK3_1	373	380	PF00069	0.768
MOD_GSK3_1	381	388	PF00069	0.715
MOD_GSK3_1	395	402	PF00069	0.626
MOD_GSK3_1	407	414	PF00069	0.812
MOD_GSK3_1	415	422	PF00069	0.679
MOD_GSK3_1	423	430	PF00069	0.578
MOD_GSK3_1	434	441	PF00069	0.593
MOD_GSK3_1	541	548	PF00069	0.590
MOD_GSK3_1	63	70	PF00069	0.556
MOD_GSK3_1	72	79	PF00069	0.459
MOD_N-GLC_1	399	404	PF02516	0.588
MOD_NEK2_1	296	301	PF00069	0.835
MOD_NEK2_1	345	350	PF00069	0.826
MOD_NEK2_1	412	417	PF00069	0.652
MOD_NEK2_1	489	494	PF00069	0.814
MOD_NEK2_1	76	81	PF00069	0.404
MOD_NEK2_2	408	413	PF00069	0.604
MOD_PIKK_1	222	228	PF00454	0.681
MOD_PIKK_1	63	69	PF00454	0.681
MOD_PIKK_1	84	90	PF00454	0.661
MOD_PKA_2	415	421	PF00069	0.620
MOD_PKA_2	67	73	PF00069	0.675
MOD_PKB_1	146	154	PF00069	0.429
MOD_Plk_2-3	110	116	PF00069	0.575
MOD_Plk_4	148	154	PF00069	0.429
MOD_Plk_4	256	262	PF00069	0.572
MOD_Plk_4	358	364	PF00069	0.588
MOD_Plk_4	377	383	PF00069	0.526
MOD_ProDKin_1	178	184	PF00069	0.716
MOD_ProDKin_1	191	197	PF00069	0.449
MOD_ProDKin_1	219	225	PF00069	0.803
MOD_ProDKin_1	260	266	PF00069	0.621
MOD_ProDKin_1	306	312	PF00069	0.833
MOD_ProDKin_1	314	320	PF00069	0.654
MOD_ProDKin_1	373	379	PF00069	0.804
MOD_ProDKin_1	400	406	PF00069	0.830
MOD_ProDKin_1	424	430	PF00069	0.789
MOD_ProDKin_1	438	444	PF00069	0.561
MOD_ProDKin_1	498	504	PF00069	0.614
TRG_DiLeu_BaEn_4	12	18	PF01217	0.722
TRG_ER_diArg_1	103	106	PF00400	0.455
TRG_ER_diArg_1	145	148	PF00400	0.599
TRG_ER_diArg_1	186	188	PF00400	0.710
TRG_ER_diArg_1	24	27	PF00400	0.427
TRG_ER_diArg_1	292	294	PF00400	0.576
TRG_ER_diArg_1	533	535	PF00400	0.831
TRG_ER_diArg_1	60	62	PF00400	0.687
TRG_NLS_MonoExtN_4	320	327	PF00514	0.604

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X110	Leishmania donovani	69%	96%
A4I344	Leishmania infantum	69%	96%
E9ACW3	Leishmania major	64%	99%
E9AZF2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	96%